Mark J Fisher

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The role of pericytes in blood-brain barrier function and stroke
    Shuo Liu
    Departments of Neurology, University of California Irvine, USA
    Curr Pharm Des 18:3653-62. 2012
  2. doi request reprint Stroke. Geometry is destiny for carotid atherosclerotic plaques
    Mark Fisher
    Department of Neurology, Anatomy and Neurobiology, and Pathology and Laboratory Medicine, University of California Irvine School of Medicine, 101 The City Drive South, Orange, CA 92868, USA
    Nat Rev Neurol 8:127-9. 2011
  3. pmc Cerebral microbleeds in the elderly: a pathological analysis
    Mark Fisher
    Department of Neurology, University of California, Irvine, CA 92868, USA
    Stroke 41:2782-5. 2010
  4. ncbi request reprint Carotid plaque pathology: thrombosis, ulceration, and stroke pathogenesis
    Mark Fisher
    Department of Neurology, University of Southern California School of Medicine, Los Angeles, Calif, USA
    Stroke 36:253-7. 2005
  5. pmc Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy
    Mark Fisher
    Department of Neurology, University of California Irvine, Irvine, CA, USA
    Stroke 42:3300-3. 2011
  6. doi request reprint The challenge of mixed cerebrovascular disease
    Mark Fisher
    Department of Neurology, University of California at Irvine, Irvine, California, USA
    Ann N Y Acad Sci 1207:18-22. 2010
  7. pmc Pericyte signaling in the neurovascular unit
    Mark Fisher
    Department of Neurology, UC Irvine Medical Center, 101 The City Drive South, Shanbrom Hall, Room 121, Orange, CA 92868, USA
    Stroke 40:S13-5. 2009
  8. pmc PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cells
    Fan Yang
    Department of Anatomy and Neurobiology, University of California, Irvine, USA
    Thromb Res 129:750-3. 2012
  9. pmc Phosphodiesterase inhibitor modulation of brain microvascular endothelial cell barrier properties
    Shuo Liu
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, United States
    J Neurol Sci 320:45-51. 2012
  10. doi request reprint Tissue plasminogen activator expression and barrier properties of human brain microvascular endothelial cells
    Fan Yang
    Departments of Neurology, University of California Irvine, 101 The City Drive South, Orange, CA 92868, USA
    Cell Physiol Biochem 28:631-8. 2011

Research Grants

  1. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark J Fisher; Fiscal Year: 2010
  2. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2007
  3. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2004
  4. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2000
  5. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2009

Collaborators

Detail Information

Publications18

  1. ncbi request reprint The role of pericytes in blood-brain barrier function and stroke
    Shuo Liu
    Departments of Neurology, University of California Irvine, USA
    Curr Pharm Des 18:3653-62. 2012
    ..Pericytes thus appear to orchestrate multiple critical functions in stroke, involving blood flow, permeability, and repair of the neurovascular unit...
  2. doi request reprint Stroke. Geometry is destiny for carotid atherosclerotic plaques
    Mark Fisher
    Department of Neurology, Anatomy and Neurobiology, and Pathology and Laboratory Medicine, University of California Irvine School of Medicine, 101 The City Drive South, Orange, CA 92868, USA
    Nat Rev Neurol 8:127-9. 2011
    ..A recent study has shown that the upstream carotid plaque undergoes profound biochemical and apoptotic changes that are closely linked to the development of stroke symptoms...
  3. pmc Cerebral microbleeds in the elderly: a pathological analysis
    Mark Fisher
    Department of Neurology, University of California, Irvine, CA 92868, USA
    Stroke 41:2782-5. 2010
    ..Cerebral microbleeds in the elderly are routinely identified by brain MRI. The purpose of this study was to better characterize the pathological basis of microbleeds...
  4. ncbi request reprint Carotid plaque pathology: thrombosis, ulceration, and stroke pathogenesis
    Mark Fisher
    Department of Neurology, University of Southern California School of Medicine, Los Angeles, Calif, USA
    Stroke 36:253-7. 2005
    ..To determine the relationship between ulceration, thrombus, and calcification of carotid artery atherosclerotic plaques and symptoms of ipsilateral or contralateral stroke...
  5. pmc Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy
    Mark Fisher
    Department of Neurology, University of California Irvine, Irvine, CA, USA
    Stroke 42:3300-3. 2011
    ..To develop new therapeutic strategies for this disorder, we studied cerebral microhemorrhage in a well-characterized mouse model of cerebral amyloid angiopathy...
  6. doi request reprint The challenge of mixed cerebrovascular disease
    Mark Fisher
    Department of Neurology, University of California at Irvine, Irvine, California, USA
    Ann N Y Acad Sci 1207:18-22. 2010
    ..Emphasizing mixed cerebrovascular disease as a conceptual framework allows for a focus on common underlying mechanisms and new therapeutic strategies...
  7. pmc Pericyte signaling in the neurovascular unit
    Mark Fisher
    Department of Neurology, UC Irvine Medical Center, 101 The City Drive South, Shanbrom Hall, Room 121, Orange, CA 92868, USA
    Stroke 40:S13-5. 2009
    ..Improvement in pericyte identification is likely to lead to marked increase in appreciation of the role of pericytes in the neurovascular unit...
  8. pmc PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cells
    Fan Yang
    Department of Anatomy and Neurobiology, University of California, Irvine, USA
    Thromb Res 129:750-3. 2012
    ..We studied PDE4 regulation of tPA expression by human brain microvascular endothelial cells in a variety of conditions, including an in vitro model of ischemia...
  9. pmc Phosphodiesterase inhibitor modulation of brain microvascular endothelial cell barrier properties
    Shuo Liu
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, United States
    J Neurol Sci 320:45-51. 2012
    ..To develop new strategies for these disorders, we analyzed the effects of several phosphodiesterase (PDE) inhibitors on human brain microvascular endothelial cells (HBECs)...
  10. doi request reprint Tissue plasminogen activator expression and barrier properties of human brain microvascular endothelial cells
    Fan Yang
    Departments of Neurology, University of California Irvine, 101 The City Drive South, Orange, CA 92868, USA
    Cell Physiol Biochem 28:631-8. 2011
    ..We hypothesized that brain microvascular tPA expression and barrier properties of endothelial cells are substantially related...
  11. ncbi request reprint Brain endothelial hemostasis regulation by pericytes
    Jeong Ai Kim
    Department of Neurology, University of California, Irvine, California, USA
    J Cereb Blood Flow Metab 26:209-17. 2006
    ..These in vitro findings suggest that pericytes negatively regulate brain endothelial cell fibrinolysis, while pericyte expression of PN-1 may provide endogenous anticoagulant activity...
  12. ncbi request reprint Minimally oxidized low-density lipoprotein regulates hemostasis factors of brain capillary endothelial cells
    Jeong Ai Kim
    Department of Neurology, University of California, Irvine, College of Medicine, 101 The City Drive South, Building 55, Rm 121, Orange, CA 92868 5120, USA
    J Neurol Sci 217:135-41. 2004
    ..These results suggest that MM-LDL may contribute to thrombus formation in the brain...
  13. pmc Ancrod and fibrin formation: perspectives on mechanisms of action
    Shuo Liu
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, CA, USA
    Stroke 42:3277-80. 2011
    ..We studied the actions of ancrod on fibrinolysis pathways in patient plasma samples and endothelial cell culture systems...
  14. ncbi request reprint Astrocyte regulation of human brain capillary endothelial fibrinolysis
    Jeong Ai Kim
    Department of Neurology, University of California, Irvine, College of Medicine, Irvine, CA, USA
    Thromb Res 112:159-65. 2003
    ..The purpose of this study is to define the fibrinolytic regulatory role of human astrocytes on human brain capillary endothelial cells...
  15. ncbi request reprint Injuries to the vascular endothelium: vascular wall and endothelial dysfunction
    Mark Fisher
    Department of Neurology and Anatomy, University of California, Irvine, CA, USA
    Rev Neurol Dis 5:S4-11. 2008
    ..Optimal clinical responses for protection of brain vascular endothelium may use preconditioning as a model, and will likely require combined protection against apoptosis, ROS, and inflammation...
  16. pmc Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy
    Vitaly Vasilevko
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA
    Ann N Y Acad Sci 1207:58-70. 2010
    ..Thus, there is a critical need for new strategies that improve BBB function and limit the development of β-amyloidosis in the cerebral vasculature...
  17. ncbi request reprint The endothelium, platelets, and brain ischemia
    Louis R Caplan
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 4:113-21. 2007
    ..In patients with penetrating artery disease, agents with substantial endothelial effects have a theoretical advantage...
  18. ncbi request reprint Dipyridamole enhances tissue plasminogen activator release by brain capillary endothelial cells
    Jeong A Kim
    Department of Neurology, University of California, Irvine, Orange, CA 92868 5120, USA
    Thromb Res 115:435-8. 2005

Research Grants11

  1. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark J Fisher; Fiscal Year: 2010
    ....
  2. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2007
    ....
  3. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2004
    ..abstract_text> ..
  4. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2000
    ..Our findings will define pathways of brain regulation of hemostasis and pave the way for pharmacotherapies designed to prevent and treat strike by enhancement of the brain~s endogenous anticoagulant system. ..
  5. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2009
    ....