Research Topics
| Marc FisherSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Detail Information
Publications
Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imagingJames Bouley
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Neurosci Lett 412:185-90. 2007..These inter-model variations must be taken into account when assessing new therapeutic approaches on ischemic lesion evolution in the rat MCAO model...
Advanced imaging to extend the therapeutic time window of acute ischemic strokeMarc Fisher
Department of Neurology, University of Massachusetts School of Medicine, Worcester, MA
Ann Neurol 73:4-9. 2013..We predict that these trials will confirm the hypothesis that penumbral imaging can enhance patient selection and extend the therapeutic time window for acute ischemic stroke. ANN NEUROL 2013...- Identifying and utilizing the ischemic penumbraMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Neurology 79:S79-85. 2012..Another article in this supplement addresses the clinical implication and the current understanding and application of this concept into clinical practice of endovascular ischemic stroke therapy... - Neuroprotective effects of statins: evidence from preclinical and clinical studiesMarc Fisher
UMass Memorial Healthcare, 119 Belmont Street, Worcester, MA, 01545, USA
Curr Treat Options Cardiovasc Med 14:252-9. 2012..Additionally, improved outcome needs to be established in cardioembolic stroke patients before routine use of statins in this stroke subtype can be recommended... 
Animal models of focal brain ischemiaKenneth M Sicard
Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01453, USA
Exp Transl Stroke Med 1:7. 2009..A large number of stroke models have been developed and are currently used in laboratories around the world. These models are overviewed as are approaches for measuring infarct size and functional outcome...- Update of the stroke therapy academic industry roundtable preclinical recommendationsMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Stroke 40:2244-50. 2009..Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success... - The MATCH study results in the context of secondary stroke preventionMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Memorial Health Care, Worcester, Mass 01605-2982, USA
Stroke 35:2609. 2004 - Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trialsMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Neurol Neurosci Rep 7:35-41. 2007..Translating these basic science and clinical trial design advances into effective and safe therapies will require increased interaction and cooperation between basic scientists and clinical researchers... - Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomesMarc Fisher
University of Massachusetts, Worcester, MA 01605-2982, USA
Stroke 38:245-8. 2007 - New approaches to neuroprotective drug developmentMarc Fisher
Department of Neurology, UMass Memorial Healthcare, Worcester, MA 01545, USA
Stroke 42:S24-7. 2011..To maximize outcome after stroke, the combined use or reperfusion and neuroprotection is likely to be needed, so we must begin to perform carefully designed trials with this combination... - NXY-059 for acute ischemic stroke: the promise of neuroprotection is finally realized?Marc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Stroke 37:2651-2. 2006 - Use of animal models has not contributed to development of acute stroke therapies: conMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Stroke 36:2324-5. 2005 - The ischemic penumbra: a new opportunity for neuroprotectionMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, 01605, USA
Cerebrovasc Dis 21:64-70. 2006..Perfusion CT may also have similar capabilities. Use of these imaging modalities in clinical trials and ultimately in clinical practice will likely help in the development and utilization of novel neuroprotective drugs... - Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologistMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Arch Neurol 63:20-4. 2006.... - Developing and implementing future stroke therapies: the potential of telemedicineMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Ann Neurol 58:666-71. 2005..The implementation of future drug therapies through telemedicine-organized stroke networks will likely substantially influence the future of acute stroke therapy... - Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtableMarc Fisher
UMass Memorial Healthcare Center, 119 Belmont St, Worcester, MA 01605, USA
Stroke 36:1808-13. 2005..A fourth (STAIR-IV) was held to discuss relevant issues related to acute stroke drug development and regulatory approval... - The ischemic penumbra: identification, evolution and treatment conceptsMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cerebrovasc Dis 17:1-6. 2004.... - Stem cell transplantation for stroke: does it work, and if so, how?Marc Fisher
Department of Neurology, University of Massachusetts Medical School, UMass Memorial Health Care, 119 Belmont St, Worcester, Mass 01606 2982, USA
Stroke 34:2083. 2003 - New perspectives on developing acute stroke therapyMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester 01605, USA
Ann Neurol 53:10-20. 2003..Combining knowledge from these three areas provides optimism that additional acute stroke therapies can be developed to maximize beneficial functional outcome in the greatest proportion of acute stroke patients possible... - Stroke and TIA: epidemiology, risk factors, and the need for early interventionMarc Fisher
University of Massachusetts Medical School, University of Massachusetts Memorial Medical Center, USA
Am J Manag Care 14:S204-11. 2008..Facilitating the initiation of effective secondary preventive therapy must become a priority in managed care... - Emerging therapies for acute ischemic stroke: new therapies on trialMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Memorial Healthcare, Worcester, Mass 01605, USA
Stroke 34:359-61. 2003 - Developing therapy for acute ischemic strokeM Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, USA
Therapie 57:564-8. 2002..Developing new acute stroke therapies will be a difficult but necessary task to meet the large unmet need for this important and under treated disorder... - Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3Marc Fisher
Department of Neurology, UMass Memorial Healthcare, 119 Belmont St, Worcester, Mass 01605, USA
Stroke 34:1539-46. 2003..The development of acute stroke therapy has proven to be a daunting task, with a few successful and many unsuccessful trials. New strategies need to be considered to enhance the chances for success in future trials... - New pathways for evaluating potential acute stroke therapiesMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Int J Stroke 1:52-8. 2006..Demonstrating a treatment effect on a relevant imaging-based biomarker should provide supportive evidence for a new drug application, if a subsequent phase III trial with a clinical outcome demonstrates a significant treatment effect... - Treating acute ischemic strokeMarc Fisher
UMass Memorial Healthcare, 119 Belmont Street, Worcester, MA 01605, USA
Curr Opin Drug Discov Devel 11:626-32. 2008..Many neuroprotective drugs have been evaluated as potential acute stroke therapies, but none have shown efficacy, hence the future of neuroprotection as a strategy for acute ischemic stroke therapy remains uncertain... - Acute ischemic coronary artery disease and ischemic stroke: similarities and differencesMarc Fisher
Department of Neurology, Division of Cardiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Am J Ther 15:137-49. 2008..An ongoing study is directly comparing the combination of aspirin plus extended-release dipyridamole with clopidogrel for the prevention of recurrent stroke... - Emerging therapies for cerebrovascular disordersMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester 01605, USA
Stroke 35:367-9. 2004 - Advances in Stroke 2007: introductionMarc Fisher
University of Massachusetts Medical School, Worcester, MA, USA
Stroke 39:250-1. 2008 - Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic strokeNils Henninger
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Exp Neurol 215:290-7. 2009..Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after embolic stroke (ES) in rats... - Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemiaXiangjun Meng
Department of Neurology, University of Massachusetts Medical School, Worcester, 01605, USA
Ann Neurol 55:207-12. 2004..There was a significant difference in 24- hour infarct volumes between the permanent and temporary occlusion groups... - Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imagingJuergen Bardutzky
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Stroke 38:1336-44. 2007.... - Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke modelNils Henninger
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Cereb Blood Flow Metab 29:119-29. 2009..05), respectively. Our results suggest that early NBO treatment in combination with tPA at a later time point may represent a safe and effective strategy for acute stroke treatment... - Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolutionJuergen Bardutzky
Department of Neurology, University of Massachusetts Medical School, Boston, MA 02125, USA
Brain Res 1043:155-62. 2005..Low-resolution reasonably evaluated the temporal and spatial evolution of ischemia when thresholds were used... - Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trialsMaria Philip
Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
Stroke 40:577-81. 2009..We analyzed the quality and adequacy of animal studies supporting the efficacy of NXY-059 and other neuroprotective agents that are currently being investigated in phase II/III trials... - Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in ratsKenneth M Sicard
Center for Comparative NeuroImaging, University of Massachusetts Medical School, 303 Belmont St, Worcester, MA 01604, USA
Stroke 37:2593-600. 2006..We assessed the evolution of ischemic injury, behavioral status, and brain activity at acute to chronic periods after transient middle cerebral artery occlusion (tMCAO) in rats... - Statistical prediction of tissue fate in acute ischemic brain injuryQiang Shen
Department of Neurology, Imaging Center at Yerkes Research Center, Emory University, Atlanta, Georgia 30329, USA
J Cereb Blood Flow Metab 25:1336-45. 2005..It is suggested that this approach can be applied to stroke patients in a computationally inexpensive manner... - The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in ratsTibo Gerriets
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Neurosci Methods 122:201-11. 2003..This technique causes hypothalamic injury resulting in hyperthermia, which can worsen outcome and obscure neuroprotective effects. Herein, we introduce a new MCAO model that avoids these disadvantages... - Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion modelJuergen Bardutzky
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Cereb Blood Flow Metab 25:968-77. 2005..This effect was mainly observed in the cortex. Our data suggest that DMSO represents an interesting candidate for acute stroke treatment... - Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke modelHongxia Ren
Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
Magn Reson Med 52:1328-35. 2004.... - Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imagingQiang Shen
Center for Comparative NeuroImaging, University of Massachusetts Medical Center, Worcester, MA 01655, USA
J Cereb Blood Flow Metab 24:280-90. 2004..This study demonstrated a simple but powerful approach to evaluate, on a pixel-by-pixel basis, the spatio-temporal evolution of ischemic brain injury, and a potential for statistical prediction of tissue fate... - Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient mapsBernt Tore Bråtane
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Brain Res 1279:182-8. 2009..Ischemic lesion determination by ADC was more accurate in final infarct prediction, rater independent, and provided exclusive information on ischemic lesion reversibility... - Functional, perfusion and diffusion MRI of acute focal ischemic brain injuryQiang Shen
Department of Neurology, Yerkes Primate Research Center, Emory University, Atlanta, Georgia, USA
J Cereb Blood Flow Metab 25:1265-79. 2005..This approach provides valuable information regarding ischemic tissue viability, vascular coupling, and functional integrity associated with ischemic injury and could have potential clinical applications... - HMG-CoA reductase inhibitors improve acute ischemic stroke outcomeMajaz Moonis
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Stroke 36:1298-300. 2005..Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored... - Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacyRonn P Walvick
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Stroke 42:1110-5. 2011..The purpose of this study was to develop a novel MRI method for imaging clot lysis in a rat embolic stroke model and to compare tissue plasminogen activator (tPA)-based clot lysis with and without recombinant Annexin-2 (rA2)... - The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemiaNils Henninger
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Neurosci Lett 398:300-5. 2006..9+/-141.3 mm3 (control; p=0.002). In conclusion, VELCADE treatment inhibited whole blood proteasome activity and achieved significant neuroprotection in two rat models of focal cerebral ischemia at various time points poststroke... - Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imagingQiang Shen
Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
J Cereb Blood Flow Metab 23:1479-88. 2003..04 mL x g(-1) x min(-1)), surprisingly similar to the TTC-derived thresholds. Together, these results illustrate an analysis approach to systemically track the pixel-by-pixel spatiotemporal progression of acute ischemic brain injury... - Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in ratsNils Henninger
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Cereb Blood Flow Metab 27:1632-42. 2007..Our data suggest that NBO may represent a promising strategy for acute stroke treatment... - Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the ratBernt T Bratane
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01604, USA
Stroke 40:3102-6. 2009..G-CSF acts as a growth factor in the central nervous system, counteracts apoptosis, and is neuroprotective in rodent transient ischemia models... - Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitorBernt T Bratane
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Stroke 42:3265-70. 2011..The purpose of this study was to determine whether neuroprotection is feasible without cerebral blood flow augmentation in experimental permanent middle cerebral artery occlusion... - Future of neuroprotection for acute stroke: in the aftermath of the SAINT trialsSean I Savitz
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Ann Neurol 61:396-402. 2007..We discuss new suggestions to bridge the chasm between preclinical animal modeling and acute human stroke trials to potentially enhance the future assessment of novel neuroprotective drugs... - Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brainMatthew D Silva
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, USA
Magn Reson Med 48:826-37. 2002..70 +/- 0.05 (EC+IC), 0.69 +/- 0.06 (IC), 0.45 +/- 0.06 (EC+IC), and 0.44 +/- 0.06 (IC), respectively. These results suggest that the IC water ADC determines the overall water ADC value in normal and ischemic rat brain... - Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of ratsMark Kazemi
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA
Magn Reson Imaging 22:653-9. 2004..Experimental and data analysis issues for improving and validating the usefulness of DWI as a surrogate endpoint for the quantification of ischemic lesion volume are discussed... - Prophylactic neuroprotectionSean I Savitz
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Curr Drug Targets 8:846-9. 2007..This review will focus on which target populations should be considered for prophylactic neuroprotection trials and which drugs might be used in such trials... - Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in ratsKenneth M Sicard
Department of Psychiatry, Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Cereb Blood Flow Metab 26:1451-62. 2006.... - Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the ratNils Henninger
Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Crit Care Med 35:2607-14. 2007..The relationship between cerebral integrity, recovery of brain function, and neurologic status after mild traumatic brain injury is incompletely characterized... - Use of telemedicine to increase thrombolysis and advance care in acute ischemic strokeNils Henninger
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Cerebrovasc Dis 27:9-14. 2009..It is highly likely that telemedicine stroke care will substantially enhance acute stroke therapy for remote and underserved populations... - Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trialsJeffrey L Saver
Department of Neurology, Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Stroke 40:2594-600. 2009..a. thrombolysis or devices may be acceptable. Statistical considerations and definitions of successful recanalization/reperfusion are suggested for these trials... - Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imagingNils Henninger
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01604, USA
Stroke 37:1283-7. 2006..Using diffusion and perfusion imaging, we compared the spatiotemporal evolution of ischemia in Sprague Dawley rats after permanent suture MCAO (sMCAO; n=8) and embolic MCAO (eMCAO; n=8)... - Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choicesSean I Savitz
Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
Cerebrovasc Dis 26:156-62. 2008..Recent studies have introduced more sensitive outcome measures such as the shift analysis to detect a treatment effect in AIS trials and are also including imaging as a surrogate of injury... - Acute ischemic stroke therapyNils Henninger
Department of Neurology, University of Massachusetts Medical Center, 55 Lake Avenue, North Worcester, MA 01655, USA
Expert Rev Cardiovasc Ther 8:1389-98. 2010..Imaging-guided selection of appropriate patients will likely be a key factor for extending the therapeutic time window and both diffusion/perfusion MRI and perfusion computed tomography will be useful imaging modalities in this effort... - Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion dataQiang Shen
Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
J Cereb Blood Flow Metab 24:887-97. 2004.... - Considering the role of heparin and low-molecular-weight heparins in acute ischemic strokeMajaz Moonis
Department of Neurology, University of Massachusetts Memorial Health Care, Worcester, Mass 01655, USA
Stroke 33:1927-33. 2002..Beneficial treatment effects may occur in subgroups such as patients with large artery atherothrombotic stroke, but further studies will be needed to prove this possibility... - Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of useMajaz Moonis
Department of Neurology, University of Massachusetts Medical School, Worcester 01655, USA
Expert Rev Cardiovasc Ther 1:611-5. 2003 - Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental strokeNils Henninger
Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655, USA
Stroke 38:2779-86. 2007.... - Emerging drugs for acute ischemic strokeKenneth M Sicard
University of Massachusetts Medical School, Worcester, MA 01655, USA
Expert Opin Emerg Drugs 14:33-42. 2009..Overall, the most important findings are that future advances in stroke treatment will probably include combination therapies that will be administered in specialized stroke care units to maximize patient outcome... - Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of strokeTimothy Q Duong
Center for Comparative NeuroImaging, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Curr Atheroscler Rep 6:267-73. 2004..This review focuses on recent advances with experimental and clinical applications of perfusion and diffusion imaging and their utility in identifying potentially salvageable ischemic tissue in rat stroke model and stroke patients... - Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley ratsNils Henninger
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Cereb Blood Flow Metab 27:1756-63. 2007..This study may facilitate our understanding of the pathophysiological mechanisms by which early, spontaneous reperfusion affects tissue fate and neurological function... - Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASLBernt T Bratane
Department of Neurology, Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Cereb Blood Flow Metab 30:336-42. 2010..The ischemic volume as defined by dynamic susceptibility contrast (DSC), was only statistically different from the CASL-derived ischemic volume when using Magnevist at post-reperfusion time points... - Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic strokeRamy El Khoury
Department of Neurology, University of Texas in Houston, Houston, Texas 77030, USA
Stroke 41:2038-43. 2010..Clinical trials are assessing the efficacy of fibrinolysis in extended time windows for acute ischemic stroke... - HMG CoA reductase inhibitors (statins): use in stroke prevention and outcome after strokeMajaz Moonis
University of Massachusetts Medical School, Worcester, MA 01655, USA
Expert Rev Neurother 4:241-7. 2004..Finally, based on the present information, an evidence-based perspective about current and future use of statins in the short- and long-term management of ischemic stroke is presented... - Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trialsSean I Savitz
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Stroke 38:3205-12. 2007..The SAINT I trial that showed a significant benefit of the neuroprotectant NXY-059 used a novel outcome for acute ischemic stroke trials: a shift toward good functional outcome on the 7-category modified Rankin scale (mRS)... - Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in ratsFuhai Li
Department of Neurology, UMass Memorial Health Care and University of Massachusetts Medical School, Memorial Campus, 119 Belmont Street, Worcester, MA 01605, USA
AJNR Am J Neuroradiol 23:180-8. 2002..Conversely, the morphologic changes of astrocytes and neurons progressively worsen over time, although ADC values show a biphasic change... - Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic strokeAnthony J Furlan
Department of Neurology, University of Massachusetts Medical School, Worcester, Mass 01605-2982, USA
Stroke 36:398-9. 2005 - Acute stroke imaging research roadmapMax Wintermark
University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
Stroke 39:1621-8. 2008..The present article summarizes these recommendations and examines practical steps to achieve them... - Thrombolytic therapy for acute ischemic stroke: 3 h and beyondVasantha Padma
All India Institute of Medical Sciences, Delhi, India
Expert Rev Neurother 5:223-33. 2005..Development of an effective neuroprotective drug would greatly enhance the stability of the penumbra and offer further opportunities for extending the time window for reperfusion... - Emerging therapies for cerebrovascular disordersAntoni Davalos
Department of Neurosciences, Universitat Autonoma de Barcelona, Spain
Stroke 36:208-10. 2005 - Antihypertensive medications for risk reduction of first and recurrent ischemic strokeVasamtha Padma
All India Institute of Medical Sciences, New Delhi, India
Expert Rev Cardiovasc Ther 2:867-76. 2004..This review will critically assess the scientific basis and rationale of the use of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in primary and secondary stroke prevention... - Microsphere-induced embolic stroke: an MRI studyOrna Mayzel-Oreg
School of Chemistry, Tel-Aviv University, Tel-Aviv, Israel
Magn Reson Med 51:1232-8. 2004..05), and to 57% +/- 2% of the contralateral mean at 24 hr (P < 0.001). The lesion development in the microsphere-induced stroke model was found to be slower than in the MCAO model, and continued up to the 24-48-hr time point... - Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in ratsTibo Gerriets
Department of Radiology Experimental Neurology Research Group Kerckhoff Klinik Bad Nauheim, Germany
Brain Res Brain Res Protoc 12:137-43. 2004..It does not permit reperfusion. This technique might provide information about the pathophysiological processes in the hyperacute phase of stroke... - Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imagingJuergen Bardutzky
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 36:2000-5. 2005..We investigated, in 2 commonly used rat strains (Sprague-Dawley [SD] and Wistar-Kyoto [WK]), the spatiotemporal evolution of ischemia after permanent suture MCAO using diffusion and perfusion imaging... - Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI SubstudySteven Warach
National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1063, USA
Cerebrovasc Dis 21:106-11. 2006..A planned MRI substudy within these trials investigated the effect of gavestinel on infarct volume... - Role of heparin and low-molecular-weight heparins in the management of acute ischemic strokeVasantha Padma
All India Institute of Medical Science, Dehli, India
Expert Rev Cardiovasc Ther 4:405-15. 2006..High-quality, randomized trials that adequately study heparin use in patients using modern technology for vascular lesions and stroke subtypes are lacking, and need to be performed... - NXY-059: brain or vessel protectionMarc Fisher
Acute Stroke Programme, Nuffield Department of Medicine, Level 7, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
Stroke 37:2189-90. 2006 - Is penumbral imaging useful for extending the treatment window for intravenous tissue plasminogen activator?Marc Fisher
Ann Neurol 60:499-501. 2006 - Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1)Yair Lampl
Wolfson Medical Center, Department of Neurology, Holon, Israel
Stroke 38:1843-9. 2007..The NeuroThera Laser System therapeutic approach involves use of infrared laser technology and has shown significant and sustained beneficial effects in animal models of ischemic stroke... - Stroke prevention: a challenging but rewarding taskTurgut Tatlisumak
Curr Drug Targets 8:784-5. 2007 - NXY-059 for the treatment of strokeSean I Savitz
N Engl J Med 357:2198; author reply 2198-9. 2007 - Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemiaVictor E Shashoua
CereMedix, Inc, 317 Egan Research Center, Northeastern University, 120 Forsyth Street, Boston, MA 02115, USA
Brain Res 963:214-23. 2003..These studies illustrate that a small peptide can function as a neuroprotective agent and an activator of a beneficial signal transduction pathway...