Marc Fisher

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging
    James Bouley
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Neurosci Lett 412:185-90. 2007
  2. doi request reprint Imaging of experimental stroke models
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Transl Stroke Res 3:16-21. 2012
  3. doi request reprint The spectrum of translational stroke research
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, MA, USA
    Neurol Res 35:443-7. 2013
  4. doi request reprint Advanced imaging to extend the therapeutic time window of acute ischemic stroke
    Marc Fisher
    Department of Neurology, University of Massachusetts School of Medicine, Worcester, USA
    Ann Neurol 73:4-9. 2013
  5. ncbi request reprint Identifying and utilizing the ischemic penumbra
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Neurology 79:S79-85. 2012
  6. ncbi request reprint Neuroprotective effects of statins: evidence from preclinical and clinical studies
    Marc Fisher
    UMass Memorial Healthcare, 119 Belmont Street, Worcester, MA, 01545, USA
    Curr Treat Options Cardiovasc Med 14:252-9. 2012
  7. pmc Animal models of focal brain ischemia
    Kenneth M Sicard
    Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01453, USA
    Exp Transl Stroke Med 1:7. 2009
  8. ncbi request reprint Developing and implementing future stroke therapies: the potential of telemedicine
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Ann Neurol 58:666-71. 2005
  9. pmc Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
  10. ncbi request reprint Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable
    Marc Fisher
    UMass Memorial Healthcare Center, 119 Belmont St, Worcester, MA 01605, USA
    Stroke 36:1808-13. 2005

Detail Information

Publications92

  1. ncbi request reprint Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging
    James Bouley
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Neurosci Lett 412:185-90. 2007
    ..These inter-model variations must be taken into account when assessing new therapeutic approaches on ischemic lesion evolution in the rat MCAO model...
  2. doi request reprint Imaging of experimental stroke models
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Transl Stroke Res 3:16-21. 2012
    ..The use of these advanced MRI techniques in animal experiments will help to advance clinical imaging of the ischemic penumbra and hopefully contribute to the extension of the therapeutic time window in stroke patients. ..
  3. doi request reprint The spectrum of translational stroke research
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, MA, USA
    Neurol Res 35:443-7. 2013
    ..No matter how translational stroke research is conducted, this type of research is critical for the future and involves multidisciplinary teams that need to have productive and insightful ideas and communications...
  4. doi request reprint Advanced imaging to extend the therapeutic time window of acute ischemic stroke
    Marc Fisher
    Department of Neurology, University of Massachusetts School of Medicine, Worcester, USA
    Ann Neurol 73:4-9. 2013
    ..We predict that these trials will confirm the hypothesis that penumbral imaging can enhance patient selection and extend the therapeutic time window for acute ischemic stroke...
  5. ncbi request reprint Identifying and utilizing the ischemic penumbra
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Neurology 79:S79-85. 2012
    ..Another article in this supplement addresses the clinical implication and the current understanding and application of this concept into clinical practice of endovascular ischemic stroke therapy...
  6. ncbi request reprint Neuroprotective effects of statins: evidence from preclinical and clinical studies
    Marc Fisher
    UMass Memorial Healthcare, 119 Belmont Street, Worcester, MA, 01545, USA
    Curr Treat Options Cardiovasc Med 14:252-9. 2012
    ..Additionally, improved outcome needs to be established in cardioembolic stroke patients before routine use of statins in this stroke subtype can be recommended...
  7. pmc Animal models of focal brain ischemia
    Kenneth M Sicard
    Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01453, USA
    Exp Transl Stroke Med 1:7. 2009
    ..A large number of stroke models have been developed and are currently used in laboratories around the world. These models are overviewed as are approaches for measuring infarct size and functional outcome...
  8. ncbi request reprint Developing and implementing future stroke therapies: the potential of telemedicine
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Ann Neurol 58:666-71. 2005
    ..The implementation of future drug therapies through telemedicine-organized stroke networks will likely substantially influence the future of acute stroke therapy...
  9. pmc Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
    ..Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success...
  10. ncbi request reprint Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable
    Marc Fisher
    UMass Memorial Healthcare Center, 119 Belmont St, Worcester, MA 01605, USA
    Stroke 36:1808-13. 2005
    ..A fourth (STAIR-IV) was held to discuss relevant issues related to acute stroke drug development and regulatory approval...
  11. ncbi request reprint Use of animal models has not contributed to development of acute stroke therapies: con
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Stroke 36:2324-5. 2005
  12. ncbi request reprint Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Arch Neurol 63:20-4. 2006
    ....
  13. ncbi request reprint The ischemic penumbra: a new opportunity for neuroprotection
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, 01605, USA
    Cerebrovasc Dis 21:64-70. 2006
    ..Perfusion CT may also have similar capabilities. Use of these imaging modalities in clinical trials and ultimately in clinical practice will likely help in the development and utilization of novel neuroprotective drugs...
  14. doi request reprint Advances in Stroke 2007: introduction
    Marc Fisher
    University of Massachusetts Medical School, Worcester, MA, USA
    Stroke 39:250-1. 2008
  15. doi request reprint Acute ischemic coronary artery disease and ischemic stroke: similarities and differences
    Marc Fisher
    Department of Neurology, Division of Cardiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Am J Ther 15:137-49. 2008
    ..An ongoing study is directly comparing the combination of aspirin plus extended-release dipyridamole with clopidogrel for the prevention of recurrent stroke...
  16. ncbi request reprint Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Neurol Neurosci Rep 7:35-41. 2007
    ..Translating these basic science and clinical trial design advances into effective and safe therapies will require increased interaction and cooperation between basic scientists and clinical researchers...
  17. ncbi request reprint Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes
    Marc Fisher
    University of Massachusetts, Worcester, MA 01605 2982, USA
    Stroke 38:245-8. 2007
  18. ncbi request reprint Stroke and TIA: epidemiology, risk factors, and the need for early intervention
    Marc Fisher
    University of Massachusetts Medical School, University of Massachusetts Memorial Medical Center, USA
    Am J Manag Care 14:S204-11. 2008
    ..Facilitating the initiation of effective secondary preventive therapy must become a priority in managed care...
  19. doi request reprint New pathways for evaluating potential acute stroke therapies
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Int J Stroke 1:52-8. 2006
    ..Demonstrating a treatment effect on a relevant imaging-based biomarker should provide supportive evidence for a new drug application, if a subsequent phase III trial with a clinical outcome demonstrates a significant treatment effect...
  20. ncbi request reprint NXY-059 for acute ischemic stroke: the promise of neuroprotection is finally realized?
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Stroke 37:2651-2. 2006
  21. ncbi request reprint Treating acute ischemic stroke
    Marc Fisher
    UMass Memorial Healthcare, 119 Belmont Street, Worcester, MA 01605, USA
    Curr Opin Drug Discov Devel 11:626-32. 2008
    ..Many neuroprotective drugs have been evaluated as potential acute stroke therapies, but none have shown efficacy, hence the future of neuroprotection as a strategy for acute ischemic stroke therapy remains uncertain...
  22. doi request reprint New approaches to neuroprotective drug development
    Marc Fisher
    Department of Neurology, UMass Memorial Healthcare, Worcester, MA 01545, USA
    Stroke 42:S24-7. 2011
    ..To maximize outcome after stroke, the combined use or reperfusion and neuroprotection is likely to be needed, so we must begin to perform carefully designed trials with this combination...
  23. ncbi request reprint The MATCH study results in the context of secondary stroke prevention
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Memorial Health Care, Worcester, Mass 01605 2982, USA
    Stroke 35:2609. 2004
  24. ncbi request reprint Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3
    Marc Fisher
    Department of Neurology, UMass Memorial Healthcare, 119 Belmont St, Worcester, Mass 01605, USA
    Stroke 34:1539-46. 2003
    ..The development of acute stroke therapy has proven to be a daunting task, with a few successful and many unsuccessful trials. New strategies need to be considered to enhance the chances for success in future trials...
  25. ncbi request reprint Stem cell transplantation for stroke: does it work, and if so, how?
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, UMass Memorial Health Care, 119 Belmont St, Worcester, Mass 01606 2982, USA
    Stroke 34:2083. 2003
  26. ncbi request reprint Developing therapy for acute ischemic stroke
    M Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, USA
    Therapie 57:564-8. 2002
    ..Developing new acute stroke therapies will be a difficult but necessary task to meet the large unmet need for this important and under treated disorder...
  27. ncbi request reprint Emerging therapies for acute ischemic stroke: new therapies on trial
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Memorial Healthcare, Worcester, Mass 01605, USA
    Stroke 34:359-61. 2003
  28. ncbi request reprint Emerging therapies for cerebrovascular disorders
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester 01605, USA
    Stroke 35:367-9. 2004
  29. ncbi request reprint The ischemic penumbra: identification, evolution and treatment concepts
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cerebrovasc Dis 17:1-6. 2004
    ....
  30. ncbi request reprint New perspectives on developing acute stroke therapy
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester 01605, USA
    Ann Neurol 53:10-20. 2003
    ..Combining knowledge from these three areas provides optimism that additional acute stroke therapies can be developed to maximize beneficial functional outcome in the greatest proportion of acute stroke patients possible...
  31. doi request reprint Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Exp Neurol 215:290-7. 2009
    ..Laser Doppler flowmetry (LDF) is increasingly used to assess adequate occlusion after embolic stroke (ES) in rats...
  32. pmc Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution
    Juergen Bardutzky
    Department of Neurology, University of Massachusetts Medical School, Boston, MA 02125, USA
    Brain Res 1043:155-62. 2005
    ..Low-resolution reasonably evaluated the temporal and spatial evolution of ischemia when thresholds were used...
  33. doi request reprint Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cereb Blood Flow Metab 29:119-29. 2009
    ..05), respectively. Our results suggest that early NBO treatment in combination with tPA at a later time point may represent a safe and effective strategy for acute stroke treatment...
  34. pmc Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging
    Juergen Bardutzky
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Stroke 38:1336-44. 2007
    ....
  35. pmc Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia
    Xiangjun Meng
    Department of Neurology, University of Massachusetts Medical School, Worcester, 01605, USA
    Ann Neurol 55:207-12. 2004
    ..There was a significant difference in 24- hour infarct volumes between the permanent and temporary occlusion groups...
  36. doi request reprint Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps
    Bernt Tore BrĂ¥tane
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Brain Res 1279:182-8. 2009
    ..Ischemic lesion determination by ADC was more accurate in final infarct prediction, rater independent, and provided exclusive information on ischemic lesion reversibility...
  37. pmc Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats
    Kenneth M Sicard
    Center for Comparative NeuroImaging, University of Massachusetts Medical School, 303 Belmont St, Worcester, MA 01604, USA
    Stroke 37:2593-600. 2006
    ..We assessed the evolution of ischemic injury, behavioral status, and brain activity at acute to chronic periods after transient middle cerebral artery occlusion (tMCAO) in rats...
  38. ncbi request reprint The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats
    Tibo Gerriets
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Neurosci Methods 122:201-11. 2003
    ..This technique causes hypothalamic injury resulting in hyperthermia, which can worsen outcome and obscure neuroprotective effects. Herein, we introduce a new MCAO model that avoids these disadvantages...
  39. pmc Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model
    Juergen Bardutzky
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cereb Blood Flow Metab 25:968-77. 2005
    ..This effect was mainly observed in the cortex. Our data suggest that DMSO represents an interesting candidate for acute stroke treatment...
  40. pmc Statistical prediction of tissue fate in acute ischemic brain injury
    Qiang Shen
    Department of Neurology, Imaging Center at Yerkes Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Cereb Blood Flow Metab 25:1336-45. 2005
    ..It is suggested that this approach can be applied to stroke patients in a computationally inexpensive manner...
  41. doi request reprint Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials
    Maria Philip
    Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Stroke 40:577-81. 2009
    ..We analyzed the quality and adequacy of animal studies supporting the efficacy of NXY-059 and other neuroprotective agents that are currently being investigated in phase II/III trials...
  42. pmc Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging
    Qiang Shen
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    J Cereb Blood Flow Metab 23:1479-88. 2003
    ..04 mL x g(-1) x min(-1)), surprisingly similar to the TTC-derived thresholds. Together, these results illustrate an analysis approach to systemically track the pixel-by-pixel spatiotemporal progression of acute ischemic brain injury...
  43. pmc Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model
    Hongxia Ren
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
    Magn Reson Med 52:1328-35. 2004
    ....
  44. pmc Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging
    Qiang Shen
    Center for Comparative NeuroImaging, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    J Cereb Blood Flow Metab 24:280-90. 2004
    ..This study demonstrated a simple but powerful approach to evaluate, on a pixel-by-pixel basis, the spatio-temporal evolution of ischemic brain injury, and a potential for statistical prediction of tissue fate...
  45. ncbi request reprint HMG-CoA reductase inhibitors improve acute ischemic stroke outcome
    Majaz Moonis
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Stroke 36:1298-300. 2005
    ..Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored...
  46. pmc Functional, perfusion and diffusion MRI of acute focal ischemic brain injury
    Qiang Shen
    Department of Neurology, Yerkes Primate Research Center, Emory University, Atlanta, Georgia, USA
    J Cereb Blood Flow Metab 25:1265-79. 2005
    ..This approach provides valuable information regarding ischemic tissue viability, vascular coupling, and functional integrity associated with ischemic injury and could have potential clinical applications...
  47. pmc Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy
    Ronn P Walvick
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Stroke 42:1110-5. 2011
    ..The purpose of this study was to develop a novel MRI method for imaging clot lysis in a rat embolic stroke model and to compare tissue plasminogen activator (tPA)-based clot lysis with and without recombinant Annexin-2 (rA2)...
  48. ncbi request reprint The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neurosci Lett 398:300-5. 2006
    ..9+/-141.3 mm3 (control; p=0.002). In conclusion, VELCADE treatment inhibited whole blood proteasome activity and achieved significant neuroprotection in two rat models of focal cerebral ischemia at various time points poststroke...
  49. ncbi request reprint Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1632-42. 2007
    ..Our data suggest that NBO may represent a promising strategy for acute stroke treatment...
  50. ncbi request reprint Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat
    Bernt T Bratane
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Stroke 40:3102-6. 2009
    ..G-CSF acts as a growth factor in the central nervous system, counteracts apoptosis, and is neuroprotective in rodent transient ischemia models...
  51. ncbi request reprint Enhancement in cognitive function recovery by granulocyte-colony stimulating factor in a rodent model of traumatic brain injury
    Elif M Sikoglu
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Behav Brain Res 259:354-6. 2014
    ..Our model suggests that early G-CSF exposure may be a promising therapeutic approach in recovery of cognitive deficits due to TBI...
  52. doi request reprint Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitor
    Bernt T Bratane
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Stroke 42:3265-70. 2011
    ..The purpose of this study was to determine whether neuroprotection is feasible without cerebral blood flow augmentation in experimental permanent middle cerebral artery occlusion...
  53. ncbi request reprint Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain
    Matthew D Silva
    Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, USA
    Magn Reson Med 48:826-37. 2002
    ..70 +/- 0.05 (EC+IC), 0.69 +/- 0.06 (IC), 0.45 +/- 0.06 (EC+IC), and 0.44 +/- 0.06 (IC), respectively. These results suggest that the IC water ADC determines the overall water ADC value in normal and ischemic rat brain...
  54. ncbi request reprint Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann Neurol 61:396-402. 2007
    ..We discuss new suggestions to bridge the chasm between preclinical animal modeling and acute human stroke trials to potentially enhance the future assessment of novel neuroprotective drugs...
  55. ncbi request reprint Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats
    Mark Kazemi
    Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA
    Magn Reson Imaging 22:653-9. 2004
    ..Experimental and data analysis issues for improving and validating the usefulness of DWI as a surrogate endpoint for the quantification of ischemic lesion volume are discussed...
  56. pmc Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats
    Kenneth M Sicard
    Department of Psychiatry, Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Cereb Blood Flow Metab 26:1451-62. 2006
    ....
  57. ncbi request reprint Prophylactic neuroprotection
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Drug Targets 8:846-9. 2007
    ..This review will focus on which target populations should be considered for prophylactic neuroprotection trials and which drugs might be used in such trials...
  58. pmc Clot injection technique affects thrombolytic efficacy in a rat embolic stroke model: implications for translaboratory collaborations
    Marilena Marinescu
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cereb Blood Flow Metab 34:677-82. 2014
    ..001) and hemispheric swelling (P<0.05). Outcome and response to thrombolysis after ES are operator dependent, which needs to be considered when comparing results obtained from different laboratories...
  59. ncbi request reprint Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices
    Sean I Savitz
    Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 26:156-62. 2008
    ..Recent studies have introduced more sensitive outcome measures such as the shift analysis to detect a treatment effect in AIS trials and are also including imaging as a surrogate of injury...
  60. pmc Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data
    Qiang Shen
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    J Cereb Blood Flow Metab 24:887-97. 2004
    ....
  61. ncbi request reprint Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Cerebrovasc Dis 27:9-14. 2009
    ..It is highly likely that telemedicine stroke care will substantially enhance acute stroke therapy for remote and underserved populations...
  62. ncbi request reprint Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Stroke 37:1283-7. 2006
    ..Using diffusion and perfusion imaging, we compared the spatiotemporal evolution of ischemia in Sprague Dawley rats after permanent suture MCAO (sMCAO; n=8) and embolic MCAO (eMCAO; n=8)...
  63. ncbi request reprint Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat
    Nils Henninger
    Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Crit Care Med 35:2607-14. 2007
    ..The relationship between cerebral integrity, recovery of brain function, and neurologic status after mild traumatic brain injury is incompletely characterized...
  64. pmc Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials
    Jeffrey L Saver
    Department of Neurology, Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Stroke 40:2594-600. 2009
    ..a. thrombolysis or devices may be acceptable. Statistical considerations and definitions of successful recanalization/reperfusion are suggested for these trials...
  65. doi request reprint Acute ischemic stroke therapy
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical Center, 55 Lake Avenue, North Worcester, MA 01655, USA
    Expert Rev Cardiovasc Ther 8:1389-98. 2010
    ..Imaging-guided selection of appropriate patients will likely be a key factor for extending the therapeutic time window and both diffusion/perfusion MRI and perfusion computed tomography will be useful imaging modalities in this effort...
  66. ncbi request reprint Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke
    Majaz Moonis
    Department of Neurology, University of Massachusetts Memorial Health Care, Worcester, Mass 01655, USA
    Stroke 33:1927-33. 2002
    ..Beneficial treatment effects may occur in subgroups such as patients with large artery atherothrombotic stroke, but further studies will be needed to prove this possibility...
  67. pmc Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL
    Bernt T Bratane
    Department of Neurology, Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Cereb Blood Flow Metab 30:336-42. 2010
    ..The ischemic volume as defined by dynamic susceptibility contrast (DSC), was only statistically different from the CASL-derived ischemic volume when using Magnevist at post-reperfusion time points...
  68. ncbi request reprint Emerging drugs for acute ischemic stroke
    Kenneth M Sicard
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Expert Opin Emerg Drugs 14:33-42. 2009
    ..Overall, the most important findings are that future advances in stroke treatment will probably include combination therapies that will be administered in specialized stroke care units to maximize patient outcome...
  69. ncbi request reprint Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1756-63. 2007
    ..This study may facilitate our understanding of the pathophysiological mechanisms by which early, spontaneous reperfusion affects tissue fate and neurological function...
  70. pmc Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke
    Timothy Q Duong
    Center for Comparative NeuroImaging, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Curr Atheroscler Rep 6:267-73. 2004
    ..This review focuses on recent advances with experimental and clinical applications of perfusion and diffusion imaging and their utility in identifying potentially salvageable ischemic tissue in rat stroke model and stroke patients...
  71. ncbi request reprint Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of use
    Majaz Moonis
    Department of Neurology, University of Massachusetts Medical School, Worcester 01655, USA
    Expert Rev Cardiovasc Ther 1:611-5. 2003
  72. ncbi request reprint Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke
    Nils Henninger
    Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655, USA
    Stroke 38:2779-86. 2007
    ....
  73. ncbi request reprint Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke
    Ramy El Khoury
    Department of Neurology, University of Texas in Houston, Houston, Texas 77030, USA
    Stroke 41:2038-43. 2010
    ..Clinical trials are assessing the efficacy of fibrinolysis in extended time windows for acute ischemic stroke...
  74. ncbi request reprint HMG CoA reductase inhibitors (statins): use in stroke prevention and outcome after stroke
    Majaz Moonis
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Expert Rev Neurother 4:241-7. 2004
    ..Finally, based on the present information, an evidence-based perspective about current and future use of statins in the short- and long-term management of ischemic stroke is presented...
  75. ncbi request reprint Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke
    Anthony J Furlan
    Department of Neurology, University of Massachusetts Medical School, Worcester, Mass 01605 2982, USA
    Stroke 36:398-9. 2005
  76. ncbi request reprint Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Stroke 38:3205-12. 2007
    ..The SAINT I trial that showed a significant benefit of the neuroprotectant NXY-059 used a novel outcome for acute ischemic stroke trials: a shift toward good functional outcome on the 7-category modified Rankin scale (mRS)...
  77. ncbi request reprint Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats
    Fuhai Li
    Department of Neurology, UMass Memorial Health Care and University of Massachusetts Medical School, Memorial Campus, 119 Belmont Street, Worcester, MA 01605, USA
    AJNR Am J Neuroradiol 23:180-8. 2002
    ..We sought to determine if reperfusion-induced renormalization of initially abnormal values indicates reversal of cellular, morphologic changes that occur during acute ischemia...
  78. ncbi request reprint Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1)
    Yair Lampl
    Wolfson Medical Center, Department of Neurology, Holon, Israel
    Stroke 38:1843-9. 2007
    ..The NeuroThera Laser System therapeutic approach involves use of infrared laser technology and has shown significant and sustained beneficial effects in animal models of ischemic stroke...
  79. ncbi request reprint Microsphere-induced embolic stroke: an MRI study
    Orna Mayzel-Oreg
    School of Chemistry, Tel Aviv University, Tel Aviv, Israel
    Magn Reson Med 51:1232-8. 2004
    ..05), and to 57% +/- 2% of the contralateral mean at 24 hr (P < 0.001). The lesion development in the microsphere-induced stroke model was found to be slower than in the MCAO model, and continued up to the 24-48-hr time point...
  80. pmc Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging
    Juergen Bardutzky
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 36:2000-5. 2005
    ..We investigated, in 2 commonly used rat strains (Sprague-Dawley [SD] and Wistar-Kyoto [WK]), the spatiotemporal evolution of ischemia after permanent suture MCAO using diffusion and perfusion imaging...
  81. ncbi request reprint NXY-059 for the treatment of stroke
    Sean I Savitz
    N Engl J Med 357:2198; author reply 2198-9. 2007
  82. ncbi request reprint Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats
    Tibo Gerriets
    Department of Radiology Experimental Neurology Research Group Kerckhoff Klinik Bad Nauheim, Germany
    Brain Res Brain Res Protoc 12:137-43. 2004
    ..It does not permit reperfusion. This technique might provide information about the pathophysiological processes in the hyperacute phase of stroke...
  83. ncbi request reprint Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia
    Victor E Shashoua
    CereMedix, Inc, 317 Egan Research Center, Northeastern University, 120 Forsyth Street, Boston, MA 02115, USA
    Brain Res 963:214-23. 2003
    ..These studies illustrate that a small peptide can function as a neuroprotective agent and an activator of a beneficial signal transduction pathway...
  84. ncbi request reprint Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  85. ncbi request reprint Antihypertensive medications for risk reduction of first and recurrent ischemic stroke
    Vasamtha Padma
    All India Institute of Medical Sciences, New Delhi, India
    Expert Rev Cardiovasc Ther 2:867-76. 2004
    ..This review will critically assess the scientific basis and rationale of the use of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in primary and secondary stroke prevention...
  86. ncbi request reprint Emerging therapies for cerebrovascular disorders
    Antoni Davalos
    Department of Neurosciences, Universitat Autonoma de Barcelona, Spain
    Stroke 36:208-10. 2005
  87. ncbi request reprint Is penumbral imaging useful for extending the treatment window for intravenous tissue plasminogen activator?
    Marc Fisher
    Ann Neurol 60:499-501. 2006
  88. ncbi request reprint NXY-059: brain or vessel protection
    Marc Fisher
    Acute Stroke Programme, Nuffield Department of Medicine, Level 7, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Stroke 37:2189-90. 2006
  89. ncbi request reprint Thrombolytic therapy for acute ischemic stroke: 3 h and beyond
    Vasantha Padma
    All India Institute of Medical Sciences, Delhi, India
    Expert Rev Neurother 5:223-33. 2005
    ..Development of an effective neuroprotective drug would greatly enhance the stability of the penumbra and offer further opportunities for extending the time window for reperfusion...
  90. ncbi request reprint Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke
    Vasantha Padma
    All India Institute of Medical Science, Dehli, India
    Expert Rev Cardiovasc Ther 4:405-15. 2006
    ..High-quality, randomized trials that adequately study heparin use in patients using modern technology for vascular lesions and stroke subtypes are lacking, and need to be performed...
  91. ncbi request reprint Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy
    Steven Warach
    National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1063, USA
    Cerebrovasc Dis 21:106-11. 2006
    ..A planned MRI substudy within these trials investigated the effect of gavestinel on infarct volume...
  92. ncbi request reprint Stroke prevention: a challenging but rewarding task
    Turgut Tatlisumak
    Curr Drug Targets 8:784-5. 2007