Bernard Fisher

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi Role of science in the treatment of breast cancer when tumor multicentricity is present
    Bernard Fisher
    Department of Surgery, University of Pittsburgh, Forbes Tower Ste 7098, 200 Lothrop St, Pittsburgh, PA 15213, USA
    J Natl Cancer Inst 103:1292-8. 2011
  2. ncbi Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study
    Bernard Fisher
    Operations Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    J Natl Cancer Inst 97:1652-62. 2005
  3. doi Biological research in the evolution of cancer surgery: a personal perspective
    Bernard Fisher
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Res 68:10007-20. 2008
  4. ncbi Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Operations Center, USA
    J Natl Cancer Inst 96:1823-31. 2004
  5. ncbi Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
    N Engl J Med 347:1233-41. 2002
  6. ncbi Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28
    Eleftherios P Mamounas
    National Surgical Adjuvant Breast and Bowel Project, Operations Office and Biostatistical Center, Pittsburgh, PA, USA
    J Clin Oncol 23:3686-96. 2005
  7. pmc Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in patients treated by breast-conserving therapy in five National Surgical Adjuvant Breast and Bowel Project protocols of node-negative breast cancer
    Stewart J Anderson
    Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Clin Oncol 27:2466-73. 2009
  8. ncbi Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials
    Bernard Fisher
    Operations Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Lancet 364:858-68. 2004
  9. pmc Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20
    Eleftherios P Mamounas
    National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Departmentof Biostatistics, Graduate School of Public Health, University of Pittsburgh, USA
    J Clin Oncol 28:1677-83. 2010
  10. ncbi Pathobiology of small invasive breast cancers without metastases (T1a/b, N0, M0): National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-21
    Edwin R Fisher
    National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, Pennsylvania, USA
    Cancer 110:1929-36. 2007

Collaborators

Detail Information

Publications33

  1. doi Role of science in the treatment of breast cancer when tumor multicentricity is present
    Bernard Fisher
    Department of Surgery, University of Pittsburgh, Forbes Tower Ste 7098, 200 Lothrop St, Pittsburgh, PA 15213, USA
    J Natl Cancer Inst 103:1292-8. 2011
    ....
  2. ncbi Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study
    Bernard Fisher
    Operations Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    J Natl Cancer Inst 97:1652-62. 2005
    ..Side effects of varying clinical significance were observed. The trial was unblinded because of the positive results, and follow-up continued. This report updates our initial findings...
  3. doi Biological research in the evolution of cancer surgery: a personal perspective
    Bernard Fisher
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Res 68:10007-20. 2008
    ..Although technological developments will continue to play a role in cancer therapy, research in molecular biology and genetics will dictate the future status of cancer treatment and, ultimately, the future of surgery...
  4. ncbi Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Operations Center, USA
    J Natl Cancer Inst 96:1823-31. 2004
    ..This report presents updated findings from those trials, relates the results to age and menopausal status, and estimates the extent of progress made in treating such patients...
  5. ncbi Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
    N Engl J Med 347:1233-41. 2002
    ..In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer...
  6. ncbi Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28
    Eleftherios P Mamounas
    National Surgical Adjuvant Breast and Bowel Project, Operations Office and Biostatistical Center, Pittsburgh, PA, USA
    J Clin Oncol 23:3686-96. 2005
    ....
  7. pmc Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in patients treated by breast-conserving therapy in five National Surgical Adjuvant Breast and Bowel Project protocols of node-negative breast cancer
    Stewart J Anderson
    Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Clin Oncol 27:2466-73. 2009
    ..Locoregional failure (LRF) after breast-conserving therapy (BCT) is associated with increased risk of distant disease and death. The magnitude of this risk has not been adequately characterized in patients with lymph node-negative disease...
  8. ncbi Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials
    Bernard Fisher
    Operations Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Lancet 364:858-68. 2004
    ..We present long-term findings from those trials and relate them to age, menopausal status, and tumour oestrogen-receptor concentrations. We also discuss the extent of progress made in the treatment of such patients...
  9. pmc Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20
    Eleftherios P Mamounas
    National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Departmentof Biostatistics, Graduate School of Public Health, University of Pittsburgh, USA
    J Clin Oncol 28:1677-83. 2010
    ....
  10. ncbi Pathobiology of small invasive breast cancers without metastases (T1a/b, N0, M0): National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-21
    Edwin R Fisher
    National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, Pennsylvania, USA
    Cancer 110:1929-36. 2007
    ..Uncertainties continue to exist concerning the outcomes and management of small (T1a/b N0 M0) invasive breast cancers...
  11. doi Evolution of knowledge related to breast cancer heterogeneity: a 25-year retrospective
    Bernard Fisher
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Oncol 26:2068-71. 2008
  12. ncbi Health-related quality of life in axillary node-negative, estrogen receptor-negative breast cancer patients undergoing AC versus CMF chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel Project B-23
    Stephanie R Land
    NSABP Biostatistical Center, Pittsburgh, USA Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
    Breast Cancer Res Treat 86:153-64. 2004
    ..QOL information was considered especially relevant given the possibility that the two chemotherapy regimens would prove equivalent in terms of clinical outcome...
  13. ncbi Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project Biostatistical Center, Division of Pathology, and Breast Committee, Pittsburgh, PA, USA
    J Clin Oncol 20:4141-9. 2002
    ....
  14. ncbi Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in five National Surgical Adjuvant Breast and Bowel Project node-positive adjuvant breast cancer trials
    Irene L Wapnir
    National Surgical Adjuvant Breast and Bowel Project Operations Office and Biostatistical Center, Pittsburgh, PA, USA
    J Clin Oncol 24:2028-37. 2006
    ..Locoregional failure after breast-conserving surgery is associated with increased risk of distant disease and death. The magnitude of this risk in patients receiving chemotherapy has not been adequately characterized...
  15. ncbi Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27
    Harry D Bear
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    J Clin Oncol 24:2019-27. 2006
    ..This study was designed to determine the effect of adding docetaxel (T) to preoperative doxorubicin and cyclophosphamide (AC) on breast cancer response rates and disease-free survival (DFS) and overall survival (OS)...
  16. ncbi The incidence of lung carcinoma after surgery for breast carcinoma with and without postoperative radiotherapy. Results of National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trials B-04 and B-06
    Melvin Deutsch
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Cancer 98:1362-8. 2003
    ....
  17. ncbi Solving the dilemma of the immunohistochemical and other methods used for scoring estrogen receptor and progesterone receptor in patients with invasive breast carcinoma
    Edwin R Fisher
    National Surgical Adjuvant Breast and Bowel Project Pathology Center and Allegheny General Hospital, West Penn Allegheny Health System, Pittsburgh, Pennsylvania 15212, USA
    Cancer 103:164-73. 2005
    ..The authors attempted to resolve the dilemma posed by the lack of unanimity concerning the optimal immunohistochemical (IHC) method for determining and scoring estrogen receptor (ER) and progesterone receptor (PR)...
  18. ncbi Pathologic variables predictive of breast events in patients with ductal carcinoma in situ
    Edwin R Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    Am J Clin Pathol 128:86-91. 2007
    ..The similar predictive role of comedo necrosis in this study and that reported previously from NSABP B-17 (total of 2,079 patients) strongly supports its role as a simple high-risk predictor for ipsilateral breast tumor recurrences...
  19. ncbi Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: twelve-year observations concerning lobular carcinoma in situ
    Edwin R Fisher
    Pathology Center, National Surgical Adjuvant Breast and Bowel Project Pathology Center, Pittsburgh, Pennsylvania, USA
    Cancer 100:238-44. 2004
    ..The current report represents a 12-year clinicopathologic update of an earlier 5-year analysis of 180 patients with lobular carcinoma in situ (LCIS) who were treated with local excision and subsequent surveillance only...
  20. ncbi Is tamoxifen a risk factor for retinal vaso-occlusive disease?
    Michael B Gorin
    Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Retina 25:523-6. 2005
  21. ncbi Sentinel node biopsy after neoadjuvant chemotherapy in breast cancer: results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27
    Eleftherios P Mamounas
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    J Clin Oncol 23:2694-702. 2005
    ..Experience with sentinel node biopsy (SNB) after neoadjuvant chemotherapy is limited. We examined the feasibility and accuracy of this procedure within a randomized trial in patients treated with neoadjuvant chemotherapy...
  22. ncbi Pathobiology of preoperative chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel (NSABP) protocol B-18
    Edwin R Fisher
    National Surgical Adjuvant Breast and Bowel Project Pathology Center, Pittsburgh, Pennsylvania, USA
    Cancer 95:681-95. 2002
    ....
  23. ncbi Lack of influence of cytokeratin-positive mini micrometastases in "Negative Node" patients with colorectal cancer: findings from the national surgical adjuvant breast and bowel projects protocols R-01 and C-01
    Edwin R Fisher
    National Surgical Adjuvant Breast and Bowel Project NSABP, Pathology, Biostatistical and Headquarters Centers, Pittsburgh, Pennsylvania, USA
    Dis Colon Rectum 46:1021-5; discussion 1025-6. 2003
    ....
  24. ncbi Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
    N Engl J Med 347:567-75. 2002
    ..We report 25-year findings of a randomized trial initiated in 1971 to determine whether less extensive surgery with or without radiation therapy was as effective as the Halsted radical mastectomy...
  25. ncbi Bernard Fisher reflects on a half-century's worth of breast cancer research
    Kate Travis
    J Natl Cancer Inst 97:1636-7. 2005
  26. ncbi Association of tamoxifen and uterine sarcoma
    D Lawrence Wickerham
    J Clin Oncol 20:2758-60. 2002
  27. ncbi Estrogen receptor status of primary breast cancer is predictive of estrogen receptor status of contralateral breast cancer
    Sandra M Swain
    National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 96:516-23. 2004
    ....
  28. ncbi Obesity, tamoxifen use, and outcomes in women with estrogen receptor-positive early-stage breast cancer
    James J Dignam
    Department of Health Studies and Cancer Research Center, The University of Chicago, Chicago, IL 60637, USA
    J Natl Cancer Inst 95:1467-76. 2003
    ..We evaluated the association of obesity with outcomes and with tamoxifen efficacy in women with early-stage, hormone-responsive breast cancer participating in a multicenter cancer cooperative group clinical trial...
  29. ncbi Effects of tamoxifen on benign breast disease in women at high risk for breast cancer
    Elizabeth Tan-Chiu
    Cancer Research Network, 350 84th Avenue, Suite 305, Plantation, FL 33324, USA
    J Natl Cancer Inst 95:302-7. 2003
    ..We examined the effect of tamoxifen treatment on the incidence of benign breast disease and the number of breast biopsies in the same group of women...
  30. ncbi Modeling human exposures to air pollution control (APC) residues released from landfills in England and Wales
    Christopher Macleod
    Institute of Grassland and Environmental Research, IGER, North Wyke, Devon, EX20 2SB, UK
    Environ Int 32:500-9. 2006
    ....
  31. ncbi Local therapy and survival in breast cancer
    Bernard Fisher
    N Engl J Med 357:1051; author reply 1052. 2007
  32. ncbi The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27
    Harry D Bear
    Virginia Commonwealth University, Medical College of Virginia School of Medicine, Richmond, VA, USA
    J Clin Oncol 21:4165-74. 2003
    ....
  33. ncbi A vignette from breast cancer history: one hundred years after the Greenough report
    Bernard Fisher
    J Am Coll Surg 200:484-6. 2005