Alfred L Fisher

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms
    Alfred L Fisher
    Division of Geriatrics, Department of Medicine, University of California, San Francisco, 94121, USA
    Aging Cell 5:127-38. 2006
  2. pmc The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia
    Alfred L Fisher
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Biol Chem 283:9127-35. 2008
  3. pmc skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans
    Annabel A Ferguson
    University of Pittsburgh, Department of Medicine, Division of Geriatric Medicine, 3471 5th Ave, Suite 500, Pittsburgh, PA 15260, USA
    Mol Cell Biol 30:2651-67. 2010
  4. doi request reprint Improved vectors for selection of transgenic Caenorhabditis elegans
    Annabel A Ferguson
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 940:87-102. 2013
  5. pmc Identification of novel genes involved in sarcopenia through RNAi screening in Caenorhabditis elegans
    Luv Kashyap
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Gerontol A Biol Sci Med Sci 67:56-65. 2012
  6. pmc Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes
    Liquan Cai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    J Biol Chem 286:35915-21. 2011
  7. pmc The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation
    Anna A Powolny
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Gerontol 46:441-52. 2011
  8. pmc A simplified, robust, and streamlined procedure for the production of C. elegans transgenes via recombineering
    Yue Zhang
    University of Pittsburgh, Department of Medicine, Division of Geriatric Medicine and Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15260, USA
    BMC Dev Biol 8:119. 2008
  9. pmc DAF-12 regulates a connected network of genes to ensure robust developmental decisions
    Daniel Hochbaum
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania, United States of America
    PLoS Genet 7:e1002179. 2011
  10. pmc TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans
    Annabel A Ferguson
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Genet 9:e1004020. 2013

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms
    Alfred L Fisher
    Division of Geriatrics, Department of Medicine, University of California, San Francisco, 94121, USA
    Aging Cell 5:127-38. 2006
    ..Our results point to daf-12 modulating aging and stress responses in part through the repression of specific genes, and emphasize the role that the repression of genes that curtail maximal lifespan plays in lifespan determination...
  2. pmc The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia
    Alfred L Fisher
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Biol Chem 283:9127-35. 2008
    ..We also use our model to identify genes that suppress the damage produced by K10C2.4 RNAi in a pilot genetic screen. Our results establish worms as a model for the study of type I tyrosinemia...
  3. pmc skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans
    Annabel A Ferguson
    University of Pittsburgh, Department of Medicine, Division of Geriatric Medicine, 3471 5th Ave, Suite 500, Pittsburgh, PA 15260, USA
    Mol Cell Biol 30:2651-67. 2010
    ..These may be triggered by proteosome dysfunction, as we find that this event links the multiple inducers of aip-1. Together, our results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways...
  4. doi request reprint Improved vectors for selection of transgenic Caenorhabditis elegans
    Annabel A Ferguson
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 940:87-102. 2013
    ..Here we describe methods to circumvent these limitations and use either homologous recombination or Cre-LoxP mediated recombination in Escherichia coli to insert the unc-119 marker on to a variety of vector backbones...
  5. pmc Identification of novel genes involved in sarcopenia through RNAi screening in Caenorhabditis elegans
    Luv Kashyap
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Gerontol A Biol Sci Med Sci 67:56-65. 2012
    ..The nematode Caenorhabditis elegans might be a novel animal model for sarcopenia as worms experience sarcopenia during aging and mutations affecting the daf-2/insulin-like signaling pathway are able to delay this process...
  6. pmc Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes
    Liquan Cai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    J Biol Chem 286:35915-21. 2011
    ..Together, these results reveal important roles for the eaf-1 and ell-1 genes in the regulation of extracellular matrix components...
  7. pmc The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation
    Anna A Powolny
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Gerontol 46:441-52. 2011
    ..Together our data suggest that DATS is able to increase worm lifespan by enhancing the function of the pro-longevity transcription factor skn-1...
  8. pmc A simplified, robust, and streamlined procedure for the production of C. elegans transgenes via recombineering
    Yue Zhang
    University of Pittsburgh, Department of Medicine, Division of Geriatric Medicine and Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15260, USA
    BMC Dev Biol 8:119. 2008
    ..Additionally, some groups have encountered problems with employing these techniques. Hence, we sought identify ways to improve the simplicity and reliability of the procedure...
  9. pmc DAF-12 regulates a connected network of genes to ensure robust developmental decisions
    Daniel Hochbaum
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania, United States of America
    PLoS Genet 7:e1002179. 2011
    ..Together these data are consistent with daf-12 acting to ensure developmental robustness by committing the animal to adult or dauer developmental programs despite variable internal or external conditions...
  10. pmc TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans
    Annabel A Ferguson
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Genet 9:e1004020. 2013
    ..Our findings point to a novel role for tyrosine as a developmental regulator and modulator of longevity, and support a model where elevated tyrosine levels play a causal role in the development of diabetes and cancer in people. ..
  11. ncbi request reprint Of worms and women: sarcopenia and its role in disability and mortality
    Alfred L Fisher
    Department of Medicine, Division of Geriatrics, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 52:1185-90. 2004
    ..These findings also suggest that C. elegans will develop into an important model system in which to study the biochemical and genetics events responsible for sarcopenia and to test therapeutics designed to prevent or reverse sarcopenia...
  12. ncbi request reprint DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid
    Jason M Held
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 5:283-91. 2006
    ..These data suggest that carboxylated sterols may be key determinants of life history...
  13. ncbi request reprint Lipophilic regulator of a developmental switch in Caenorhabditis elegans
    Matthew S Gill
    Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 3:413-21. 2004
    ..We propose that the dauer rescuing activity is a hormone synthesized by DAF-9 that acts through DAF-12...

Research Grants4

  1. daf-12 Target Genes during C. elegans aging
    Alfred Fisher; Fiscal Year: 2005
    ..abstract_text> ..
  2. Dopamine, Tryosine, and their Metabolites in Aging in Neurodegenerative Disease
    Alfred Fisher; Fiscal Year: 2007
    ....