Research Topics
| D N FishSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Stability of sumatriptan succinate in extemporaneously prepared oral liquidsD N Fish
Department of Pharmacy Practice, University of Colorado Health Sciences Center, Denver 80262, USA
Am J Health Syst Pharm 54:1619-22. 1997..Sumatriptan 5 mg/mL (as the succinate salt) in three oral suspensions was stable for up to 21 days when stored without light at 4 degrees C...
Levofloxacin: update and perspectives on one of the original 'respiratory quinolones'Douglas N Fish
University of Colorado Health Sciences Center, School of Pharmacy, Campus Box C 238 4200 East Ninth Avenue, Denver, CO 80262, USA
Expert Rev Anti Infect Ther 1:371-87. 2003....
Pharmacokinetics and pharmacodynamics of imipenem during continuous renal replacement therapy in critically ill patientsDouglas N Fish
University of Colorado Health Sciences Center, Department of Clinical Pharmacy, School of Pharmacy, Campus Box C 238, 4200 East Ninth Avenue, Denver, CO 80262, USA
Antimicrob Agents Chemother 49:2421-8. 2005..Higher doses should only be used after consideration of potential central nervous system toxicities or other risks of therapy in these severely ill patients...
Evaluation of gatifloxacin pharmacokinetics and pharmacodynamics in severely ill adults in a medical Intensive Care UnitDouglas N Fish
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C 238, Denver, CO, USA
Int J Antimicrob Agents 29:715-23. 2007..5 microg/mL) associated with community-acquired infections in severely ill ICU patients; less susceptible pathogens (MIC>or=1 microg/mL) do not appear to be optimally treated with currently approved doses...
Optimal antimicrobial therapy for sepsisDouglas N Fish
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C 238, Denver, CO 80262, USA
Am J Health Syst Pharm 59:S13-9. 2002..The role of monotherapy versus combination therapy is controversial. Routine use of vancomycin and antifungal therapy as part of initial regimens should be discouraged but may be justified in specific circumstances...
Pharmacokinetics of a clarithromycin suspension administered via nasogastric tube to seriously ill patientsD N Fish
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado, USA
Antimicrob Agents Chemother 43:1277-80. 1999..Minimal intrapatient variability of pharmacokinetic parameters was observed in these seriously ill patients...
Stability of valacyclovir hydrochloride in extemporaneously prepared oral liquidsD N Fish
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
Am J Health Syst Pharm 56:1957-60. 1999..All the liquids were free of microbial growth for at least 28 days...
Management of protease inhibitor-associated diarrheaD S Sherman
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Clin Infect Dis 30:908-14. 2000..Management of diarrhea is crucial to improving QOL, controlling weight loss, and enhancing overall efficacy of antiretroviral therapy...
Pharmacokinetics of levofloxacin and ciprofloxacin during continuous renal replacement therapy in critically ill patientsR S Malone
Department of Pharmacy Practice and Science, School of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ, USA
Antimicrob Agents Chemother 45:2949-54. 2001..The results of this study suggest that doses of levofloxacin of 250 mg/day and ciprofloxacin of 400 mg/day are sufficient to maintain effective drug concentrations in the plasma of patients undergoing CVVH or CVVHDF...
Surveillance of multi-drug resistant Pseudomonas aeruginosa in an urban tertiary-care teaching hospitalR Jung
Antimicrobial Research Laboratory, Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C 238 Denver, CO 80262, USA
J Hosp Infect 57:105-11. 2004..On-going surveillance within individual institutions is critical for the selection of appropriate empiric antimicrobial therapy...
Gatifloxacin, an advanced 8-methoxy fluoroquinoloneD N Fish
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
Pharmacotherapy 21:35-59. 2001..Gatifloxacin should prove to be a safe and effective agent for a wide variety of infections...
Use of enteral nutrition for stress ulcer prophylaxisR MacLaren
School of Pharmacy, C238, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262 0001, USA
Ann Pharmacother 35:1614-23. 2001..To review the controversies involving the use of enteral nutrition support for stress ulcer prophylaxis and formulate recommendations...
Fluoroquinolone adverse effects and drug interactionsD N Fish
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
Pharmacotherapy 21:253S-272S. 2001....
Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutritionJames Landzinski
Department of Pharmacy, Georgetown University Hospital, Washington, DC, USA
JPEN J Parenter Enteral Nutr 32:45-50. 2008..This study evaluated gastric emptying in patients with limited GRV (tolerant group) vs volumes > or =150 mL (intolerant group) and whether prokinetic therapy improves gastric motility in intolerant patients...
Antimicrobial resistance: factors and outcomesDouglas N Fish
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Campus Box C-238, 4200 East Ninth Avenue, Denver, CO 80262, USA
Crit Care Clin 22:291-311, vii. 2006..Combinations of various approaches may offer the best potential for effectively intervening in and reducing the spread of resistant pathogens in critically ill patients...
Evaluation of bivalirudin treatment for heparin-induced thrombocytopenia in critically ill patients with hepatic and/or renal dysfunctionTyree H Kiser
Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Pharmacotherapy 26:452-60. 2006..To evaluate the safety, effectiveness, and dosing of bivalirudin for treatment of heparin-induced thrombocytopenia (HIT) in critically ill patients with hepatic and/or renal dysfunction...
Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopeniaTyree H Kiser
Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Pharmacotherapy 25:1736-45. 2005..Platelet-aggregation tests were least useful for evaluating HIT. Appropriate diagnostic strategies should be used to avoid unnecessary drug use...
Levofloxacin pharmacokinetics and pharmacodynamics in patients with severe burn injuryTyree H Kiser
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, 80262, USA
Antimicrob Agents Chemother 50:1937-45. 2006..Alternative antibiotics or treatment strategies should be considered for infections due to these pathogens...
Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patientsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
JPEN J Parenter Enteral Nutr 32:412-9. 2008..The purpose of this study is to evaluate erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric enteral nutrition (EN)...
Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unitJill A Rebuck
Department of Pharmacotherapy, Fletcher Allen Health Care, University of Vermont, Burlington, USA
Pharmacotherapy 22:1216-25. 2002..Orally administered levofloxacin appears to be well absorbed in selected ICU patients and has pharmacokinetics similar to those of intravenously administered levofloxacin...
Synergistic activities of moxifloxacin combined with piperacillin-tazobactam or cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii clinical isolatesRose Jung
Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Antimicrob Agents Chemother 48:1055-7. 2004..Combinations including moxifloxacin demonstrated enhanced bactericidal activity compared with that of either agent tested alone...
Synergic activity of cephalosporins plus fluoroquinolones against Pseudomonas aeruginosa with resistance to one or both drugsDouglas N Fish
University of Colorado Health Sciences Center, Antimicrobial Research Laboratory, Department of Pharmacy Practice, 4200 E. 9th Ave, Box C238, Denver, CO 80262, USA
J Antimicrob Chemother 50:1045-9. 2002..There were no differences noted between different cephalosporin and fluoroquinolone combinations. Concentrations used in this study are clinically achievable with recommended regimens in most cases...
Pharmacology, clinical efficacy, and safety of drotrecogin alfa (activated)Maria I Rudis
Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
Pharmacotherapy 22:182S-195S. 2002..Drotrecogin alfa (activated) is an important advancement in the treatment of adult patients with severe sepsis...
Acyclovir concentrations in human breast milk after valaciclovir administrationJeanne S Sheffield
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 75390 9032, USA
Am J Obstet Gynecol 186:100-2. 2002..The purpose of this study was to determine the valaciclovir and acyclovir pharmacokinetic profiles in serum and breast milk after valaciclovir administration to women after delivery...
Enteral glutamine supplementation in critically ill patients with burn injuries: a retrospective case-control evaluationPaul Juang
Department of Pharmacy Practice, St Louis College of Pharmacy, St Louis, Missouri 63110 1088, USA
Pharmacotherapy 27:11-9. 2007....
Assessing renal function in cirrhotic patients: problems and pitfallsDeb S Sherman
Department of Pharmacy, University of Colorado Hospital, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO, USA
Am J Kidney Dis 41:269-78. 2003....
Bronchoscopic sampling of drug concentrations: penetration to tissue is the issueDouglas N Fish
Am J Respir Crit Care Med 168:1263-5. 2003
Nosocomial infections due to multidrug-resistant Pseudomonas aeruginosa: epidemiology and treatment optionsMarilee D Obritsch
Department of Clinical and Administrative Services, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Pharmacotherapy 25:1353-64. 2005....
Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective studyTyree H Kiser
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
Nephrol Dial Transplant 20:1813-20. 2005..No adverse effects related to AVP therapy were observed. CONCLUSION: When compared with OCT, HRS patients treated with AVP had significantly higher recovery rates, improved survival and were more likely to receive a liver transplant...
Telithromycin: do we really need this antimicrobial?Douglas N Fish
Am J Health Syst Pharm 62:901. 2005
National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993 to 2002Marilee D Obritsch
Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Antimicrob Agents Chemother 48:4606-10. 2004..Ongoing surveillance studies are crucial in monitoring antimicrobial susceptibility patterns and selecting empirical treatment regimens...
Effects of continuous vasopressin infusion in patients with septic shockMarilee D Obritsch
University of Colorado Hospital, Denver, CO 80262, USA
Ann Pharmacother 38:1117-22. 2004..In the meantime, vasopressin infusion at <or=0.03 units/min should be considered only if response to 1 or 2 catecholamine vasopressors is inadequate or as a method to reduce the dose of these therapies...
