T H Fischer

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Primary and secondary hemostatic functionalities of rehydrated, lyophilized platelets
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Transfusion 46:1943-50. 2006
  2. pmc Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets
    Christopher M Scull
    Francis Owen Blood Research Lab, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 125 University Lake Rd, Chapel Hill, NC 27516, USA
    J Inflamm (Lond) 7:53. 2010
  3. ncbi request reprint Intracellular function in rehydrated lyophilized platelets
    T H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Br J Haematol 111:167-74. 2000
  4. pmc The design and testing of a dual fiber textile matrix for accelerating surface hemostasis
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Biomed Mater Res B Appl Biomater 91:381-9. 2009
  5. doi request reprint The interaction of factor VIIa with rehydrated, lyophilized platelets
    Thomas H Fischer
    Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, 125 University Lake Dr, University of North Carolina at Chapel Hill, NC 27516, USA
    Platelets 19:182-91. 2008
  6. ncbi request reprint Hemostatic properties of glucosamine-based materials
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    J Biomed Mater Res A 80:167-74. 2007
  7. ncbi request reprint Synergistic platelet integrin signaling and factor XII activation in poly-N-acetyl glucosamine fiber-mediated hemostasis
    Thomas H Fischer
    Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 350 S Old Fayetteville Rd, Chapel Hill, NC 27516, USA
    Biomaterials 26:5433-43. 2005
  8. ncbi request reprint Evidence that rehydrated, lyophilized red blood cells are sufficiently deformable for normal microcirculation transit
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, Francis Owen Blood Research Laboratory, 350 S Old Fayetteville Rd, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Microsc Res Tech 65:62-71. 2004
  9. pmc Poly-N-acetylglucosamine fibers amplify the effectiveness of recombinant factor VIIA on clot formation in hemophilia B canine blood
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    J Trauma 71:S171-5. 2011
  10. ncbi request reprint Comparison of structural and hemostatic properties of the poly-N-acetyl glucosamine Syvek Patch with products containing chitosan
    Thomas H Fischer
    Department of Pathobiology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Microsc Res Tech 63:168-74. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Primary and secondary hemostatic functionalities of rehydrated, lyophilized platelets
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Transfusion 46:1943-50. 2006
    ....
  2. pmc Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets
    Christopher M Scull
    Francis Owen Blood Research Lab, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 125 University Lake Rd, Chapel Hill, NC 27516, USA
    J Inflamm (Lond) 7:53. 2010
    ..In the present study, we tested the hypothesis that macrophage interaction with activated platelets results in an inflammatory response that differs from the response following phagocytosis of apoptotic cells...
  3. ncbi request reprint Intracellular function in rehydrated lyophilized platelets
    T H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Br J Haematol 111:167-74. 2000
    ..Taken together, our results indicate that RL platelets retain some of the haemostatic stimulus-response functions of fresh platelets and are capable of feedback amplification in coagulation...
  4. pmc The design and testing of a dual fiber textile matrix for accelerating surface hemostasis
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Biomed Mater Res B Appl Biomater 91:381-9. 2009
    ..These results indicate that hemostatic textiles can be designed that mimic gauze in form but surpass gauze in ability to accelerate hemostatic reactions...
  5. doi request reprint The interaction of factor VIIa with rehydrated, lyophilized platelets
    Thomas H Fischer
    Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, 125 University Lake Dr, University of North Carolina at Chapel Hill, NC 27516, USA
    Platelets 19:182-91. 2008
    ..These studies indicate that rFVIIa-RL platelets are worthy of preclinical and clinical development as an infusion agent for severe bleeding...
  6. ncbi request reprint Hemostatic properties of glucosamine-based materials
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    J Biomed Mater Res A 80:167-74. 2007
    ..The unique natural microalgal fibers were found to have strongly prohemostatic activity compared to the other materials studied...
  7. ncbi request reprint Synergistic platelet integrin signaling and factor XII activation in poly-N-acetyl glucosamine fiber-mediated hemostasis
    Thomas H Fischer
    Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 350 S Old Fayetteville Rd, Chapel Hill, NC 27516, USA
    Biomaterials 26:5433-43. 2005
    ....
  8. ncbi request reprint Evidence that rehydrated, lyophilized red blood cells are sufficiently deformable for normal microcirculation transit
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, Francis Owen Blood Research Laboratory, 350 S Old Fayetteville Rd, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Microsc Res Tech 65:62-71. 2004
    ..When considered with safety data from previously reported studies in dogs, the results of these studies indicate that paraformaldehyde-modified RL RBCs have visco-elastic deformability properties that are in the nonpathological range...
  9. pmc Poly-N-acetylglucosamine fibers amplify the effectiveness of recombinant factor VIIA on clot formation in hemophilia B canine blood
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    J Trauma 71:S171-5. 2011
    ..These observations suggest that pGlcNAc nanofibers may amplify the activity of rFVIIa in hemophilic blood...
  10. ncbi request reprint Comparison of structural and hemostatic properties of the poly-N-acetyl glucosamine Syvek Patch with products containing chitosan
    Thomas H Fischer
    Department of Pathobiology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Microsc Res Tech 63:168-74. 2004
    ..Syvek pGlcNAc fibers have structural and chemical properties that provide a unique basis for their ability to interact with blood components to cause hemostasis. Chitosan does not have the same properties and capabilities...
  11. ncbi request reprint The ras-binding domain of ral GDS-like protein-2 as a ras inhibitor in smooth muscle cells
    Thomas H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem Biophys Res Commun 305:934-40. 2003
    ....
  12. ncbi request reprint Splenic clearance mechanisms of rehydrated, lyophilized platelets
    T H Fischer
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA
    Artif Cells Blood Substit Immobil Biotechnol 29:439-51. 2001
    ..These studies provide a rational basis for prolonging the circulation time of RL platelets and other platelet substitutes...
  13. ncbi request reprint Thrombus formation with rehydrated, lyophilized platelets
    Thomas H Fischer
    Department of Pathology, 350 Old Fayetteville Road, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA
    Hematology 7:359-69. 2002
    ..Our results help explain how RL platelets restore hemostasis in vivo, and indicate that these cells might be a viable alternative to fresh stored platelets in transfusion medicine...
  14. ncbi request reprint Correction of the bleeding time with lyophilized platelet infusions in dogs on cardiopulmonary bypass
    Arthur P Bode
    Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858, USA
    Clin Appl Thromb Hemost 14:38-54. 2008
    ..01). These results in this setting indicate the possible effectiveness of similar human lyophilized platelet preparations in reducing postoperative bleeding in open heart surgery...
  15. pmc Magnetic and contrast properties of labeled platelets for magnetomotive optical coherence tomography
    Amy L Oldenburg
    Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC, USA
    Biophys J 99:2374-83. 2010
    ..This may enable new technologies for in vivo monitoring of the adherence of SPIO-RL platelets to sites of bleeding and vascular damage, which is broadly applicable for assessing trauma and cardiovascular diseases...
  16. ncbi request reprint A novel approach to improving recombinant factor VIIa activity with a preserved platelet preparation
    Robert A Campbell
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Br J Haematol 138:82-93. 2007
    ..These results suggest that RL platelets can support rFVIIa-mediated thrombin generation, and that co-administration of RL platelets with rFVIIa may increase the efficacy of rFVIIa in some patients...
  17. ncbi request reprint Lyophilized platelets: fifty years in the making
    Arthur P Bode
    Department of Pathology and Laboratory Medicine, East Carolina University, The Brody School of Medicine, Greenville, NC 27858, USA
    Artif Cells Blood Substit Immobil Biotechnol 35:125-33. 2007
    ....
  18. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
    ..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target...
  19. doi request reprint Differential effect of materials for surface hemostasis on red blood cell morphology
    Carr J Smith
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Microsc Res Tech 71:721-9. 2008
    ....
  20. doi request reprint Non-classical processes in surface hemostasis: mechanisms for the poly-N-acetyl glucosamine-induced alteration of red blood cell morphology and surface prothrombogenicity
    Thomas H Fischer
    Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, 125 University Lake Dr, CB 3114, University of North Carolina at Chapel Hill, NC, USA
    Biomed Mater 3:015009. 2008
    ....
  21. ncbi request reprint Role of nuclear factor-kappa B (NF-kappa B) in inflammation, periodontitis, and atherogenesis
    T C Nichols
    Department of Pathology and Laboratory Medicine, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Ann Periodontol 6:20-9. 2001
    ..Further understanding of the mechanisms involved in the activation of NF-kappa B in atherosclerosis could lead to important therapeutic applications especially as it relates to the impact of periodontitis...
  22. ncbi request reprint Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP)
    Eva H N Olsen
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA
    Blood 102:436-41. 2003
    ..Treatment with rhIL-11 with or without DDAVP may provide an alternative to plasma-derived products for some VWD and hemophilia A patients if it is shown safe in clinical trials...
  23. ncbi request reprint Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury
    Joseph Pye
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27516, USA
    Am J Physiol Heart Circ Physiol 284:H919-26. 2003
    ..These data show that myocardial reperfusion injury can be inhibited by using proteasome inhibitors, which likely function through the inhibition of NF-kappaB activation...
  24. pmc S-nitrosothiol-modified dendrimers as nitric oxide delivery vehicles
    Nathan A Stasko
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biomacromolecules 9:834-41. 2008
    ....
  25. doi request reprint G-protein binding features and regulation of the RalGDS family member, RGL2
    Elisa Ferro
    Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, 53100 Siena, Italy
    Biochem J 415:145-54. 2008
    ....
  26. ncbi request reprint Mechanisms of poly-N-acetyl glucosamine polymer-mediated hemostasis: platelet interactions
    Hemant S Thatte
    Department Surgery, VA Boston Healthcare System, Brigham and Women s Hospital, Harvard Medical Schools, Boston, MA, USA
    J Trauma 57:S13-21. 2004
    ..Investigations were performed to determine whether poly-N-acetyl glucosamine (p-GlcNAc) induces hemostasis by the activation of platelets...