Research Topics
Species | T H FischerSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Primary and secondary hemostatic functionalities of rehydrated, lyophilized plateletsThomas H Fischer
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
Transfusion 46:1943-50. 2006....
Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous plateletsChristopher M Scull
Francis Owen Blood Research Lab, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 125 University Lake Rd, Chapel Hill, NC 27516, USA
J Inflamm (Lond) 7:53. 2010..In the present study, we tested the hypothesis that macrophage interaction with activated platelets results in an inflammatory response that differs from the response following phagocytosis of apoptotic cells...- Intracellular function in rehydrated lyophilized plateletsT H Fischer
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
Br J Haematol 111:167-74. 2000..Taken together, our results indicate that RL platelets retain some of the haemostatic stimulus-response functions of fresh platelets and are capable of feedback amplification in coagulation... - The design and testing of a dual fiber textile matrix for accelerating surface hemostasisThomas H Fischer
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Biomed Mater Res B Appl Biomater 91:381-9. 2009..These results indicate that hemostatic textiles can be designed that mimic gauze in form but surpass gauze in ability to accelerate hemostatic reactions... 
The interaction of factor VIIa with rehydrated, lyophilized plateletsThomas H Fischer
Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, 125 University Lake Dr, University of North Carolina at Chapel Hill, NC 27516, USA
Platelets 19:182-91. 2008..These studies indicate that rFVIIa-RL platelets are worthy of preclinical and clinical development as an infusion agent for severe bleeding...- Hemostatic properties of glucosamine-based materialsThomas H Fischer
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
J Biomed Mater Res A 80:167-74. 2007..The unique natural microalgal fibers were found to have strongly prohemostatic activity compared to the other materials studied... - Synergistic platelet integrin signaling and factor XII activation in poly-N-acetyl glucosamine fiber-mediated hemostasisThomas H Fischer
Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 350 S Old Fayetteville Rd, Chapel Hill, NC 27516, USA
Biomaterials 26:5433-43. 2005.... - Evidence that rehydrated, lyophilized red blood cells are sufficiently deformable for normal microcirculation transitThomas H Fischer
Department of Pathology and Laboratory Medicine, Francis Owen Blood Research Laboratory, 350 S Old Fayetteville Rd, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
Microsc Res Tech 65:62-71. 2004..When considered with safety data from previously reported studies in dogs, the results of these studies indicate that paraformaldehyde-modified RL RBCs have visco-elastic deformability properties that are in the nonpathological range... - Poly-N-acetylglucosamine fibers amplify the effectiveness of recombinant factor VIIA on clot formation in hemophilia B canine bloodThomas H Fischer
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
J Trauma 71:S171-5. 2011..These observations suggest that pGlcNAc nanofibers may amplify the activity of rFVIIa in hemophilic blood... - Comparison of structural and hemostatic properties of the poly-N-acetyl glucosamine Syvek Patch with products containing chitosanThomas H Fischer
Department of Pathobiology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
Microsc Res Tech 63:168-74. 2004..Syvek pGlcNAc fibers have structural and chemical properties that provide a unique basis for their ability to interact with blood components to cause hemostasis. Chitosan does not have the same properties and capabilities... - The ras-binding domain of ral GDS-like protein-2 as a ras inhibitor in smooth muscle cellsThomas H Fischer
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Biochem Biophys Res Commun 305:934-40. 2003.... - Splenic clearance mechanisms of rehydrated, lyophilized plateletsT H Fischer
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA
Artif Cells Blood Substit Immobil Biotechnol 29:439-51. 2001..These studies provide a rational basis for prolonging the circulation time of RL platelets and other platelet substitutes... - Thrombus formation with rehydrated, lyophilized plateletsThomas H Fischer
Department of Pathology, 350 Old Fayetteville Road, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA
Hematology 7:359-69. 2002..Our results help explain how RL platelets restore hemostasis in vivo, and indicate that these cells might be a viable alternative to fresh stored platelets in transfusion medicine... - Correction of the bleeding time with lyophilized platelet infusions in dogs on cardiopulmonary bypassArthur P Bode
Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858, USA
Clin Appl Thromb Hemost 14:38-54. 2008..01). These results in this setting indicate the possible effectiveness of similar human lyophilized platelet preparations in reducing postoperative bleeding in open heart surgery... - Magnetic and contrast properties of labeled platelets for magnetomotive optical coherence tomographyAmy L Oldenburg
Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC, USA
Biophys J 99:2374-83. 2010..This may enable new technologies for in vivo monitoring of the adherence of SPIO-RL platelets to sites of bleeding and vascular damage, which is broadly applicable for assessing trauma and cardiovascular diseases... - A novel approach to improving recombinant factor VIIa activity with a preserved platelet preparationRobert A Campbell
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Br J Haematol 138:82-93. 2007..These results suggest that RL platelets can support rFVIIa-mediated thrombin generation, and that co-administration of RL platelets with rFVIIa may increase the efficacy of rFVIIa in some patients... - Lyophilized platelets: fifty years in the makingArthur P Bode
Department of Pathology and Laboratory Medicine, East Carolina University, The Brody School of Medicine, Greenville, NC 27858, USA
Artif Cells Blood Substit Immobil Biotechnol 35:125-33. 2007.... - Rap1b is required for normal platelet function and hemostasis in miceMagdalena Chrzanowska-Wodnicka
Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Clin Invest 115:680-7. 2005..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target... - Differential effect of materials for surface hemostasis on red blood cell morphologyCarr J Smith
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Microsc Res Tech 71:721-9. 2008.... - Non-classical processes in surface hemostasis: mechanisms for the poly-N-acetyl glucosamine-induced alteration of red blood cell morphology and surface prothrombogenicityThomas H Fischer
Francis Owen Blood Research Laboratory, Department of Pathology and Laboratory Medicine, 125 University Lake Dr, CB 3114, University of North Carolina at Chapel Hill, NC, USA
Biomed Mater 3:015009. 2008.... - Role of nuclear factor-kappa B (NF-kappa B) in inflammation, periodontitis, and atherogenesisT C Nichols
Department of Pathology and Laboratory Medicine, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
Ann Periodontol 6:20-9. 2001..Further understanding of the mechanisms involved in the activation of NF-kappa B in atherosclerosis could lead to important therapeutic applications especially as it relates to the impact of periodontitis... - Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP)Eva H N Olsen
Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA
Blood 102:436-41. 2003..Treatment with rhIL-11 with or without DDAVP may provide an alternative to plasma-derived products for some VWD and hemophilia A patients if it is shown safe in clinical trials... - Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injuryJoseph Pye
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27516, USA
Am J Physiol Heart Circ Physiol 284:H919-26. 2003..These data show that myocardial reperfusion injury can be inhibited by using proteasome inhibitors, which likely function through the inhibition of NF-kappaB activation... - S-nitrosothiol-modified dendrimers as nitric oxide delivery vehiclesNathan A Stasko
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Biomacromolecules 9:834-41. 2008.... - G-protein binding features and regulation of the RalGDS family member, RGL2Elisa Ferro
Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, 53100 Siena, Italy
Biochem J 415:145-54. 2008.... - Mechanisms of poly-N-acetyl glucosamine polymer-mediated hemostasis: platelet interactionsHemant S Thatte
Department Surgery, VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical Schools, Boston, MA, USA
J Trauma 57:S13-21. 2004..Antibody inhibitors of the platelet alphaIIbbeta3 integrin inhibited p-GlcNAc to stimulate fibrin polymerization. CONCLUSION: Poly-N-acetyl glucosamine fiber material promotes hemostasis by the activation of platelets...