Bradford D Fischer

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Pain 6:425-33. 2005
  2. ncbi Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    J Pharmacol Exp Ther 318:1300-6. 2006
  3. ncbi Morphine in combination with metabotropic glutamate receptor antagonists on schedule-controlled responding and thermal nociception
    Bradford D Fischer
    Department of Psychology, CB 3270, Davie Hall, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    J Pharmacol Exp Ther 324:732-9. 2008
  4. ncbi Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 198:271-8. 2008
  5. ncbi Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropharmacology 58:544-50. 2010
  6. ncbi Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice
    Linda A Dykstra
    Behavioral Neuroscience Program, Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Behav Pharmacol 22:540-7. 2011
  7. ncbi Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys
    Carrie A Bowen
    Alcohol and Drug Abuse Research Center, McLean Hospital-Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 302:264-73. 2002

Research Grants

  1. Morphine/NMDA interactions: Antinociceptive and discriminative stimulus effects
    BRADFORD FISCHER; Fiscal Year: 2007

Detail Information

Publications7

  1. ncbi Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Pain 6:425-33. 2005
    ..PERSPECTIVE: The inclusion of low-dose NMDA receptor antagonists to opioids might be beneficial for the treatment of acute pain by enhancing the antinociceptive effects of the opioid...
  2. ncbi Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    J Pharmacol Exp Ther 318:1300-6. 2006
    ..In addition, these data confirm that the behavioral effects of drug mixtures depend on the relative concentrations of the drugs in the mixture and on the endpoint under study...
  3. ncbi Morphine in combination with metabotropic glutamate receptor antagonists on schedule-controlled responding and thermal nociception
    Bradford D Fischer
    Department of Psychology, CB 3270, Davie Hall, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    J Pharmacol Exp Ther 324:732-9. 2008
    ..In addition, these data confirm that the behavioral effects of drug mixtures depend on the endpoint under study...
  4. ncbi Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 198:271-8. 2008
    ..Recent experimental data suggest that metabotropic glutamate receptor (mGluR) antagonists with selectivity for mGluR1 and mGluR2/3 enhance morphine-induced antinociception...
  5. ncbi Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropharmacology 58:544-50. 2010
    ..These results suggest that CP-55940 and LY235959 produce additive or supra-additive attenuation of morphine antinociceptive tolerance after repeated morphine administration, depending on their relative concentrations...
  6. ncbi Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice
    Linda A Dykstra
    Behavioral Neuroscience Program, Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Behav Pharmacol 22:540-7. 2011
    ..These results indicate that the NR1 subunit of the NMDA receptor does not play a prominent role in μ opioid tolerance...
  7. ncbi Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys
    Carrie A Bowen
    Alcohol and Drug Abuse Research Center, McLean Hospital-Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 302:264-73. 2002
    ....

Research Grants1

  1. Morphine/NMDA interactions: Antinociceptive and discriminative stimulus effects
    BRADFORD FISCHER; Fiscal Year: 2007
    ..Findings from these experiments may have important clinical implications, and may lead to new pharmacotherapeutic strategies in the treatment of pain and drug abuse. ..