Patricia W FinnSummaryAffiliation: University of California Country: USA Publications
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Publications
(R)-albuterol decreases immune responses: role of activated T cellsMarcela A Ferrada
Pulmonary and Critical Care Division, University of California San Diego, La Jolla, USA
Respir Res 9:3. 2008..In activated T cells, (R)-albuterol administration decreased levels of inflammatory cytokines and NF-kappaB activity. These studies suggest that (R)-albuterol decreases cytokine secretion and NF-kappaB activity in T cells...- Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expressionBianca Schaub
University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
Respir Res 7:40. 2006..However, little is known about the immunological effects of microbial stimulation on early immune responses and in association with maternal atopy... - Innate immunity and asthmaPatricia W Finn
University of California, San Diego, La Jolla, CA 92093 0643, USA
Proc Am Thorac Soc 6:260-5. 2009..Here we will highlight innate receptors and cells in the context of allergic responses. Reviewing animal models and human studies, we focus on interactions of innate and adaptive immunity... 
Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammationRuth S S Arestides
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Eur J Immunol 32:2874-80. 2002..Levels of allergen-induced Th1 as well as Th2 cytokines were also significantly reduced. Together, the data support a critical role for OX40L signals in allergic responses...- Hubs in biological interaction networks exhibit low changes in expression in experimental asthmaXin Lu
Department of Family and Preventive Medicine, University of California at San Diego, San Diego, CA, USA
Mol Syst Biol 3:98. 2007..Thus, our analysis suggests that a combination of differential gene expression plus topological characteristics of the interaction network provides enhanced understanding of the biology in our model of experimental asthma... - Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responsesBing Wang
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77th Avenue Louis Pasteur, Boston, MA 02115, USA
J Immunol 177:5779-84. 2006.... - Immunomodulation of allergic responses by targeting costimulatory moleculesKai Yu Jen
Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of California, San Diego, California, USA
Curr Opin Allergy Clin Immunol 6:489-94. 2006..SUMMARY: Immune-mediated disorders, including allergic diseases, have been increasing in prevalence. Unravelling these immune pathways may suggest new targets for immunomodulation... - CD45RB ligation inhibits allergic pulmonary inflammation by inducing CTLA4 transcriptionKai Yu Jen
Department of Medicine, Pulmonary and Critical Medicine, School of Medicine, University of California, San Diego, CA 92093, USA
J Immunol 179:4212-8. 2007..Together, these findings suggest that CD45RB signals mediate a novel role in the modulation of allergic inflammation, orchestrated by T cells through induction of CTLA4 transcription... - Graft produced interleukin-6 functions as a danger signal and promotes rejection after transplantationYurong Liang
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Transplantation 84:771-7. 2007..Interleukin (IL)-6 is a pleiotropic cytokine that functions in both the innate and adaptive immune responses. However, the role of IL-6 in allograft rejection remains poorly understood... 
Costimulation and allergic responses: immune and bioinformatic analysesVipul V Jain
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92093, United States
Pharmacol Ther 117:385-92. 2008..Also, we discuss both immune and bioinformatic approaches as potential strategies for analyzing multiple costimulatory pathways relevant to asthma...- Innate immune mechanism in allergic asthmaCarlos J Suarez
Division of Pulmonary and Critical Care, University of California, San Diego, 9500 Gilman Drive 0643, La Jolla, CA 92096 0643, USA
Curr Allergy Asthma Rep 8:451-9. 2008.... - New costimulatory families: signaling lymphocytic activation molecule in adaptive allergic responsesSamir S Makani
Department of Medicine, Pulmonary and Critical Medicine, School of Medicine, University of California, San Diego, CA 92093, USA
Curr Mol Med 8:359-64. 2008..Understanding the role of costimulatory molecules, including SLAM and SLAM family members, may elucidate mechanisms involved in the allergic immune response, and suggest potential therapeutic opportunities... - The costimulatory molecule SLAM is critical for pulmonary allergic responsesNinghai Wang
Division of Immunology, Reth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Respir Cell Mol Biol 35:206-10. 2006..Allergen-induced Th2 cytokines and Th1 cytokines were decreased in SLAM-deficient mice. These data support the concept that SLAM plays a crucial role in allergic responses... - The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretionFiona K Gibbons
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
J Clin Immunol 25:437-44. 2005..018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response... - Infant home endotoxin is associated with reduced allergen-stimulated lymphocyte proliferation and IL-13 production in childhoodJoseph H Abraham
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
J Allergy Clin Immunol 116:431-7. 2005..Early-life endotoxin-related reduction of IL-13 production might represent one pathway through which increased endotoxin decreases the risk of allergic disease and allergy in later childhood... - Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lungGerburg M Spiekermann
The Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, MA 02115, USA
J Exp Med 196:303-10. 2002..These data show that mucosal surfaces that express FcRn reabsorb IgG and explain a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens for processing in the lamina propria or systemically... - Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunityPatricia W Finn
Pulmonary Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Leukoc Biol 72:1054-62. 2002.... - MHC class II-associated invariant chain isoforms regulate pulmonary immune responsesQiang Ye
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:1473-80. 2003..These findings reveal a crucial role of Ii and H2-M in controlling the immune response within the lung, and suggest that p31 Ii and p41 Ii manifest nonredundant roles in development of immunity... - Toll receptors modulate allergic responses: interaction with dendritic cells, T cells and mast cellsAbdelouahab Bellou
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Curr Opin Allergy Clin Immunol 3:487-94. 2003.... - Analysis of cytokine functions in graft rejection by gene expression profilesYurong Liang
Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA
Transplantation 76:1749-58. 2003..Thus, these genes become candidates for essential functions during rejection... - Influenza and asthma: adding to the respiratory burdenRichard J Riese
Pulmonary and Critical Care Division, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 5:243-4. 2004 - Analysis of immunoglobulin and T-cell receptor gene deficiency in graft rejection by gene expression profilesRachel A DeFina
Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Transplantation 77:580-6. 2004..In addition, several genes are identified that are candidates as necessary for rejection. This has crucial implications for developing clinical therapies that target specific mechanisms for prolonging graft survival... - Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profilesKenneth Christopher
Laboratory of Molecular Immunology, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Transplantation 78:788-98. 2004..The precise role of major histocompatibility complex (MHC) molecules in graft rejection remains incompletely understood. The important role of foreign peptides in the alloimmune response was recently recognized... - Toll-like receptor 4 or 2 agonists decrease allergic inflammationGerman Velasco
Respiratory and Critical Care Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 32:218-24. 2005..Our findings also demonstrate that both TLR4 and TLR2 agonists decrease allergic responses, supporting the concept that exposure to bacterial components under defined conditions may protect against allergic disease... - Costimulation: critical pathways in the immunologic regulation of asthmaAbdelouahab Bellou
Pulmonary and Critical Care Division, Brigham and Women' Hospital, 75 Francis Street, Boston, MA 02115, USA
Curr Allergy Asthma Rep 5:149-54. 2005..In this review, we describe the fundamental properties of costimulatory molecules and address the influence of costimulatory signals on allergic responses... - Alterations in lung collectins in an adaptive allergic immune responseKathleen J Haley
Respiratory Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 282:L573-84. 2002..Our findings support a model in which surfactant apoproteins A and D are important to both innate immunity and adaptive immune responses to allergens...
Research Grants
- OX40L Interactions with Innate ImmunityPatricia Finn; Fiscal Year: 2007..abstract_text> ..
- Innate Immunity and Allergy: Modulation by CTLA4Patricia Finn; Fiscal Year: 2007..The objective of this project is to identify novel pathways, and potential therapeutic targets by which innate immunity modulates allergic asthma. ..
- Multidisciplinary Research Training in Lung BiologyPatricia Finn; Fiscal Year: 2007..Special attention is given to ethical conduct of research through formal coursework; to mentoring fellows and junior faculty; and to recruitment of underrepresented minorities (one of four entering fellows in 2003 is African American). ..
- Innate Immunity In Allergic and Non-Allergic ResponsesPatricia Finn; Fiscal Year: 2007..In Aims 3 and 4, we focus on the effect of TLR2 signals on markers of Tregs, and allergic inflammation. The fundamental strategy is to examine the contribution of the key molecule TLR2 in the modulation of allergic immune responses. ..
- Innate Immunity and Allergy: Modulation by CTLA4Patricia Finn; Fiscal Year: 2007..The objective of this project is to identify novel pathways, and potential therapeutic targets by which innate immunity modulates allergic asthma. ..
- Pulmonary Interactions with Innate ImmunityDAVID LINN PERKINS; Fiscal Year: 2010..We will examine the roles of immune molecule in decreasing immune responses, including immune (T cell) activation in an animal model of asthma and with samples from human asthmatics. ..
- COSTIMULATORY MOLECULES IN A MURINE MODEL OF ASTHMAPatricia Finn; Fiscal Year: 2001..The mechanisms that regulate B7/CD28 and B7/CTLA4 functions may be key targets for the design of novel therapies to treat asthma. The present study is designed to elucidate these mechanisms. ..
- Modification of Allergic Immunologic Response by LeukotPatricia Finn; Fiscal Year: 2004..Aim 2 will investigate changes in the immunoregulation of costimulatory ligands, CD80, CD86 and B7-h. Aim 3 will identify differentially expressed T lymphocyte genes using expression array analysis. ..
- Pulmonary Interactions with Innate ImmunityPatricia Finn; Fiscal Year: 2009..We will examine the roles of immune molecule in decreasing immune responses, including immune (T cell) activation in an animal model of asthma and with samples from human asthmatics. ..