Patricia W Finn

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc (R)-albuterol decreases immune responses: role of activated T cells
    Marcela A Ferrada
    Pulmonary and Critical Care Division, University of California San Diego, La Jolla, USA
    Respir Res 9:3. 2008
  2. pmc Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression
    Bianca Schaub
    University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
    Respir Res 7:40. 2006
  3. pmc Innate immunity and asthma
    Patricia W Finn
    University of California, San Diego, La Jolla, CA 92093 0643, USA
    Proc Am Thorac Soc 6:260-5. 2009
  4. ncbi request reprint Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation
    Ruth S S Arestides
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur J Immunol 32:2874-80. 2002
  5. pmc Hubs in biological interaction networks exhibit low changes in expression in experimental asthma
    Xin Lu
    Department of Family and Preventive Medicine, University of California at San Diego, San Diego, CA, USA
    Mol Syst Biol 3:98. 2007
  6. ncbi request reprint Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses
    Bing Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77th Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:5779-84. 2006
  7. ncbi request reprint Immunomodulation of allergic responses by targeting costimulatory molecules
    Kai Yu Jen
    Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of California, San Diego, California, USA
    Curr Opin Allergy Clin Immunol 6:489-94. 2006
  8. ncbi request reprint CD45RB ligation inhibits allergic pulmonary inflammation by inducing CTLA4 transcription
    Kai Yu Jen
    Department of Medicine, Pulmonary and Critical Medicine, School of Medicine, University of California, San Diego, CA 92093, USA
    J Immunol 179:4212-8. 2007
  9. ncbi request reprint Graft produced interleukin-6 functions as a danger signal and promotes rejection after transplantation
    Yurong Liang
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Transplantation 84:771-7. 2007
  10. doi request reprint Costimulation and allergic responses: immune and bioinformatic analyses
    Vipul V Jain
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92093, United States
    Pharmacol Ther 117:385-92. 2008

Research Grants

  1. OX40L Interactions with Innate Immunity
    Patricia Finn; Fiscal Year: 2007
  2. Innate Immunity and Allergy: Modulation by CTLA4
    Patricia Finn; Fiscal Year: 2007
  3. Multidisciplinary Research Training in Lung Biology
    Patricia Finn; Fiscal Year: 2007
  4. Innate Immunity In Allergic and Non-Allergic Responses
    Patricia Finn; Fiscal Year: 2007
  5. Innate Immunity and Allergy: Modulation by CTLA4
    Patricia Finn; Fiscal Year: 2007
  6. Pulmonary Interactions with Innate Immunity
    DAVID LINN PERKINS; Fiscal Year: 2010
  7. COSTIMULATORY MOLECULES IN A MURINE MODEL OF ASTHMA
    Patricia Finn; Fiscal Year: 2001
  8. Modification of Allergic Immunologic Response by Leukot
    Patricia Finn; Fiscal Year: 2004
  9. Pulmonary Interactions with Innate Immunity
    Patricia Finn; Fiscal Year: 2009

Collaborators

  • Bianca Schaub
  • Diane R Gold
  • Hsiou Chi Liou
  • Xin Lu
  • Aaron Deykin
  • M A Exley
  • David L Perkins
  • DAVID LINN PERKINS
  • Yurong Liang
  • Hongzhen He
  • Kai Yu Jen
  • Kenneth Christopher
  • Abdelouahab Bellou
  • Kathleen J Haley
  • Samir S Makani
  • Vipul V Jain
  • Monica Campo
  • German Velasco
  • Richard J Riese
  • Ruth S S Arestides
  • Marcela A Ferrada
  • Carlos J Suarez
  • Ninghai Wang
  • Bing Wang
  • Fiona K Gibbons
  • Joseph H Abraham
  • Leon Ting
  • Rachel A DeFina
  • Rachel DeFina
  • Qiang Ye
  • Gerburg M Spiekermann
  • Leesa M Barone
  • Erin L Gordon
  • Sepideh Amirifeli
  • Hong Zhen He
  • Nathan J Parker
  • Kai Y Jen
  • David M Rothstein
  • Yolonda L Colson
  • Caroline Fleming
  • Cox Terhorst
  • Samir Makani
  • Min Yang
  • Richard Riese
  • Richard Bucala
  • Jiusong Sun
  • Paul J Wolters
  • Harold A Chapman
  • Shiro Kitamoto
  • John R David
  • Xiaozhu Huang
  • Guo Ping Shi
  • Lin Leng
  • Oscar J Manrique
  • Louise M Ryan
  • Donald K Milton
  • Elliot Israel
  • Hong Z He
  • Thomas F Mueller
  • Steven D Shapiro
  • Justin Cidado
  • Elizabeth K Bikoff
  • Ruth Sweeney
  • E Sally Ward
  • Jennifer Dumont
  • Wayne I Lencer
  • Andy I Chen
  • Alex Ciota
  • Richard S Blumberg
  • Mark R Boothby
  • Arlene H Sharpe
  • Robert M Westlake
  • Johanna P Contreras
  • Bonny L Dickinson

Detail Information

Publications26

  1. pmc (R)-albuterol decreases immune responses: role of activated T cells
    Marcela A Ferrada
    Pulmonary and Critical Care Division, University of California San Diego, La Jolla, USA
    Respir Res 9:3. 2008
    ..In activated T cells, (R)-albuterol administration decreased levels of inflammatory cytokines and NF-kappaB activity. These studies suggest that (R)-albuterol decreases cytokine secretion and NF-kappaB activity in T cells...
  2. pmc Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression
    Bianca Schaub
    University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
    Respir Res 7:40. 2006
    ..However, little is known about the immunological effects of microbial stimulation on early immune responses and in association with maternal atopy...
  3. pmc Innate immunity and asthma
    Patricia W Finn
    University of California, San Diego, La Jolla, CA 92093 0643, USA
    Proc Am Thorac Soc 6:260-5. 2009
    ..Here we will highlight innate receptors and cells in the context of allergic responses. Reviewing animal models and human studies, we focus on interactions of innate and adaptive immunity...
  4. ncbi request reprint Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation
    Ruth S S Arestides
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur J Immunol 32:2874-80. 2002
    ..Levels of allergen-induced Th1 as well as Th2 cytokines were also significantly reduced. Together, the data support a critical role for OX40L signals in allergic responses...
  5. pmc Hubs in biological interaction networks exhibit low changes in expression in experimental asthma
    Xin Lu
    Department of Family and Preventive Medicine, University of California at San Diego, San Diego, CA, USA
    Mol Syst Biol 3:98. 2007
    ..Thus, our analysis suggests that a combination of differential gene expression plus topological characteristics of the interaction network provides enhanced understanding of the biology in our model of experimental asthma...
  6. ncbi request reprint Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses
    Bing Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77th Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:5779-84. 2006
    ....
  7. ncbi request reprint Immunomodulation of allergic responses by targeting costimulatory molecules
    Kai Yu Jen
    Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of California, San Diego, California, USA
    Curr Opin Allergy Clin Immunol 6:489-94. 2006
    ..This review focuses on putative targets, including costimulatory and additional pathways involving T regulatory cells, that may be critical for modifying allergic responses...
  8. ncbi request reprint CD45RB ligation inhibits allergic pulmonary inflammation by inducing CTLA4 transcription
    Kai Yu Jen
    Department of Medicine, Pulmonary and Critical Medicine, School of Medicine, University of California, San Diego, CA 92093, USA
    J Immunol 179:4212-8. 2007
    ..Together, these findings suggest that CD45RB signals mediate a novel role in the modulation of allergic inflammation, orchestrated by T cells through induction of CTLA4 transcription...
  9. ncbi request reprint Graft produced interleukin-6 functions as a danger signal and promotes rejection after transplantation
    Yurong Liang
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Transplantation 84:771-7. 2007
    ..Interleukin (IL)-6 is a pleiotropic cytokine that functions in both the innate and adaptive immune responses. However, the role of IL-6 in allograft rejection remains poorly understood...
  10. doi request reprint Costimulation and allergic responses: immune and bioinformatic analyses
    Vipul V Jain
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92093, United States
    Pharmacol Ther 117:385-92. 2008
    ..Also, we discuss both immune and bioinformatic approaches as potential strategies for analyzing multiple costimulatory pathways relevant to asthma...
  11. ncbi request reprint Innate immune mechanism in allergic asthma
    Carlos J Suarez
    Division of Pulmonary and Critical Care, University of California, San Diego, 9500 Gilman Drive 0643, La Jolla, CA 92096 0643, USA
    Curr Allergy Asthma Rep 8:451-9. 2008
    ....
  12. ncbi request reprint New costimulatory families: signaling lymphocytic activation molecule in adaptive allergic responses
    Samir S Makani
    Department of Medicine, Pulmonary and Critical Medicine, School of Medicine, University of California, San Diego, CA 92093, USA
    Curr Mol Med 8:359-64. 2008
    ..Understanding the role of costimulatory molecules, including SLAM and SLAM family members, may elucidate mechanisms involved in the allergic immune response, and suggest potential therapeutic opportunities...
  13. pmc The costimulatory molecule SLAM is critical for pulmonary allergic responses
    Ninghai Wang
    Division of Immunology, Reth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Respir Cell Mol Biol 35:206-10. 2006
    ..Allergen-induced Th2 cytokines and Th1 cytokines were decreased in SLAM-deficient mice. These data support the concept that SLAM plays a crucial role in allergic responses...
  14. ncbi request reprint The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion
    Fiona K Gibbons
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    J Clin Immunol 25:437-44. 2005
    ..018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response...
  15. ncbi request reprint Infant home endotoxin is associated with reduced allergen-stimulated lymphocyte proliferation and IL-13 production in childhood
    Joseph H Abraham
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Allergy Clin Immunol 116:431-7. 2005
    ..Infant endotoxin exposure has been proposed as a factor that might protect against allergy and the early childhood immune responses that increase the risk of IgE production to allergens...
  16. pmc Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung
    Gerburg M Spiekermann
    The Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Boston, MA 02115, USA
    J Exp Med 196:303-10. 2002
    ..These data show that mucosal surfaces that express FcRn reabsorb IgG and explain a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens for processing in the lamina propria or systemically...
  17. ncbi request reprint Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunity
    Patricia W Finn
    Pulmonary Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Leukoc Biol 72:1054-62. 2002
    ....
  18. ncbi request reprint MHC class II-associated invariant chain isoforms regulate pulmonary immune responses
    Qiang Ye
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:1473-80. 2003
    ..These findings reveal a crucial role of Ii and H2-M in controlling the immune response within the lung, and suggest that p31 Ii and p41 Ii manifest nonredundant roles in development of immunity...
  19. ncbi request reprint Toll receptors modulate allergic responses: interaction with dendritic cells, T cells and mast cells
    Abdelouahab Bellou
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Allergy Clin Immunol 3:487-94. 2003
    ..The discovery of Toll-like receptors has generated much interest in understanding the impact of innate immunity on adaptive immune responses, including allergic diseases...
  20. ncbi request reprint Analysis of cytokine functions in graft rejection by gene expression profiles
    Yurong Liang
    Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA
    Transplantation 76:1749-58. 2003
    ..Previous studies have suggested that IFNgamma can promote rejection and be important in tolerance induction...
  21. ncbi request reprint Influenza and asthma: adding to the respiratory burden
    Richard J Riese
    Pulmonary and Critical Care Division, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 5:243-4. 2004
  22. ncbi request reprint Analysis of immunoglobulin and T-cell receptor gene deficiency in graft rejection by gene expression profiles
    Rachel A DeFina
    Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Transplantation 77:580-6. 2004
    ..Some members of the immunoglobulin superfamily (e.g., alphabeta T-cell receptors [TCR]) are known to be crucial for acute allograft rejection, but the role of other members remains poorly defined...
  23. ncbi request reprint Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles
    Kenneth Christopher
    Laboratory of Molecular Immunology, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Transplantation 78:788-98. 2004
    ..The precise role of major histocompatibility complex (MHC) molecules in graft rejection remains incompletely understood. The important role of foreign peptides in the alloimmune response was recently recognized...
  24. ncbi request reprint Toll-like receptor 4 or 2 agonists decrease allergic inflammation
    German Velasco
    Respiratory and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 32:218-24. 2005
    ..Our findings also demonstrate that both TLR4 and TLR2 agonists decrease allergic responses, supporting the concept that exposure to bacterial components under defined conditions may protect against allergic disease...
  25. ncbi request reprint Costimulation: critical pathways in the immunologic regulation of asthma
    Abdelouahab Bellou
    Pulmonary and Critical Care Division, Brigham and Women Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 5:149-54. 2005
    ..In this review, we describe the fundamental properties of costimulatory molecules and address the influence of costimulatory signals on allergic responses...
  26. ncbi request reprint Alterations in lung collectins in an adaptive allergic immune response
    Kathleen J Haley
    Respiratory Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L573-84. 2002
    ..Our findings support a model in which surfactant apoproteins A and D are important to both innate immunity and adaptive immune responses to allergens...

Research Grants32

  1. OX40L Interactions with Innate Immunity
    Patricia Finn; Fiscal Year: 2007
    ..abstract_text> ..
  2. Innate Immunity and Allergy: Modulation by CTLA4
    Patricia Finn; Fiscal Year: 2007
    ..The objective of this project is to identify novel pathways, and potential therapeutic targets by which innate immunity modulates allergic asthma. ..
  3. Multidisciplinary Research Training in Lung Biology
    Patricia Finn; Fiscal Year: 2007
    ..Special attention is given to ethical conduct of research through formal coursework; to mentoring fellows and junior faculty; and to recruitment of underrepresented minorities (one of four entering fellows in 2003 is African American). ..
  4. Innate Immunity In Allergic and Non-Allergic Responses
    Patricia Finn; Fiscal Year: 2007
    ..In Aims 3 and 4, we focus on the effect of TLR2 signals on markers of Tregs, and allergic inflammation. The fundamental strategy is to examine the contribution of the key molecule TLR2 in the modulation of allergic immune responses. ..
  5. Innate Immunity and Allergy: Modulation by CTLA4
    Patricia Finn; Fiscal Year: 2007
    ..The objective of this project is to identify novel pathways, and potential therapeutic targets by which innate immunity modulates allergic asthma. ..
  6. Pulmonary Interactions with Innate Immunity
    DAVID LINN PERKINS; Fiscal Year: 2010
    ..We will examine the roles of immune molecule in decreasing immune responses, including immune (T cell) activation in an animal model of asthma and with samples from human asthmatics. ..
  7. COSTIMULATORY MOLECULES IN A MURINE MODEL OF ASTHMA
    Patricia Finn; Fiscal Year: 2001
    ..The mechanisms that regulate B7/CD28 and B7/CTLA4 functions may be key targets for the design of novel therapies to treat asthma. The present study is designed to elucidate these mechanisms. ..
  8. Modification of Allergic Immunologic Response by Leukot
    Patricia Finn; Fiscal Year: 2004
    ..Aim 2 will investigate changes in the immunoregulation of costimulatory ligands, CD80, CD86 and B7-h. Aim 3 will identify differentially expressed T lymphocyte genes using expression array analysis. ..
  9. Pulmonary Interactions with Innate Immunity
    Patricia Finn; Fiscal Year: 2009
    ..We will examine the roles of immune molecule in decreasing immune responses, including immune (T cell) activation in an animal model of asthma and with samples from human asthmatics. ..