Walter E Finkbeiner

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells
    Walter E Finkbeiner
    Department of Pathology, University of California, San Francisco, 94110, USA
    Am J Physiol Lung Cell Mol Physiol 301:L402-14. 2011
  2. pmc Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching
    Nico Derichs
    Department of Medicine, University of California, San Francisco, California, USA
    FASEB J 25:2325-32. 2011
  3. pmc In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye
    Wan Namkung
    Departments of Medicine and Physiology, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:15916-26. 2009
  4. pmc CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures
    Wan Namkung
    Department of Medicine and Physiology, University of California, San Francisco, CA 94143, USA
    Mol Biol Cell 21:2639-48. 2010
  5. pmc Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function
    Yuanlin Song
    Department of Anesthesia and Perioperative Care, Univ of California, San Francisco, 94143 0521, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1131-40. 2009
  6. pmc Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
    Wan Namkung
    Department of Medicine and Physiology, University of California, San Francisco, California 94143 0521, USA
    FASEB J 25:4048-62. 2011
  7. pmc Cultures of human tracheal gland cells of mucous or serous phenotype
    Walter E Finkbeiner
    Department of Pathology, University of California, San Francisco, CA, USA
    In Vitro Cell Dev Biol Anim 46:450-6. 2010
  8. doi request reprint Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways
    Lili Zhang
    Francis I Proctor Foundation, San Francisco, California, USA
    Am J Pathol 182:1986-95. 2013
  9. doi request reprint Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1
    Lili Zhang
    Francis I Proctor Foundation, University of California, San Francisco, California, USA
    J Pathol 229:74-86. 2013
  10. pmc Airway epithelial miRNA expression is altered in asthma
    Owen D Solberg
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 186:965-74. 2012

Collaborators

Detail Information

Publications14

  1. pmc Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells
    Walter E Finkbeiner
    Department of Pathology, University of California, San Francisco, 94110, USA
    Am J Physiol Lung Cell Mol Physiol 301:L402-14. 2011
    ....
  2. pmc Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching
    Nico Derichs
    Department of Medicine, University of California, San Francisco, California, USA
    FASEB J 25:2325-32. 2011
    ..Our results challenge the view that the PCL is a relatively watery, nonviscous fluid layer in contact with a more viscous ML, and offer an explanation for CF lung disease in the gland-free lower airways...
  3. pmc In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye
    Wan Namkung
    Departments of Medicine and Physiology, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:15916-26. 2009
    ..Our results provide the first noninvasive measurements of [K(+)] in the ASL and indicate the involvement of apical and basolateral membrane ion transporters in maintaining a high ASL [K(+)]...
  4. pmc CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures
    Wan Namkung
    Department of Medicine and Physiology, University of California, San Francisco, CA 94143, USA
    Mol Biol Cell 21:2639-48. 2010
    ..We further conclude that CFTR is the principal chloride secretory pathway in non-CF airways for both cAMP and Ca(2+) agonists, providing a novel mechanism to link CFTR dysfunction to CF lung disease...
  5. pmc Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function
    Yuanlin Song
    Department of Anesthesia and Perioperative Care, Univ of California, San Francisco, 94143 0521, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1131-40. 2009
    ..We suggest that CF lung disease may be caused by the inability of CFTR-deficient airways to increase their ASL depth transiently following secretory stimuli that in non-CF airways produce transient increases in ASL depth...
  6. pmc Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
    Wan Namkung
    Department of Medicine and Physiology, University of California, San Francisco, California 94143 0521, USA
    FASEB J 25:4048-62. 2011
    ..Small-molecule, TMEM16A-targeted activators may be useful for drug therapy of cystic fibrosis, dry mouth, and gastrointestinal hypomotility disorders, and for pharmacological dissection of TMEM16A function...
  7. pmc Cultures of human tracheal gland cells of mucous or serous phenotype
    Walter E Finkbeiner
    Department of Pathology, University of California, San Francisco, CA, USA
    In Vitro Cell Dev Biol Anim 46:450-6. 2010
    ..Measurements of transepithelial resistance and short-circuit current showed that both "serous" and "mucous" cell cultures possessed tight junctions, had become polarized, and were actively secreting Cl...
  8. doi request reprint Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways
    Lili Zhang
    Francis I Proctor Foundation, San Francisco, California, USA
    Am J Pathol 182:1986-95. 2013
    ..Thus, Rac1 may provide an omnipotent therapeutic target in reversing cell migration during the early (intact p120ctn) and late (loss of p120ctn) stages of lung carcinogenesis...
  9. doi request reprint Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1
    Lili Zhang
    Francis I Proctor Foundation, University of California, San Francisco, California, USA
    J Pathol 229:74-86. 2013
    ..Novel therapeutics designed to inhibit MUC1-CT/p120ctn complex formation may prevent EMT in the smoker's airway...
  10. pmc Airway epithelial miRNA expression is altered in asthma
    Owen D Solberg
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 186:965-74. 2012
    ..Changes in airway epithelial cell differentiation, driven in part by IL-13, are important in asthma. Micro-RNAs (miRNAs) regulate cell differentiation in many systems and could contribute to epithelial abnormalities in asthma...
  11. pmc Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
    Fen Huang
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:16354-9. 2012
    ..TMEM16A-CaCC blockers, including those identified here, may positively impact multiple causes of asthma symptoms...
  12. pmc In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects
    Nilceia Lopez-Souza
    Department of Medicine, University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 123:1384-90.e2. 2009
    ..Human rhinoviruses (HRVs) characteristically cause upper respiratory tract infection, but they also infect the lower airways, causing acute bronchitis and exacerbating asthma...
  13. ncbi request reprint Submucosal gland dysfunction as a primary defect in cystic fibrosis
    Danieli Salinas
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    FASEB J 19:431-3. 2005
    ..Our results suggest that defective airway submucosal gland function is an early, primary defect in CF. Therapies directed at normalizing gland fluid secretion early in CF may thus reduce lung disease...
  14. ncbi request reprint Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins
    Marc H Levin
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 281:25803-12. 2006
    ..Our data provide evidence against the mechanism proposed by Donaldson et al. to account for the effects of amiloride and hypertonic saline in CF lung disease, indicating the need to identify alternate mechanisms...