Research Topics
| Walter E FinkbeinerSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cellsWalter E Finkbeiner
Department of Pathology, University of California, San Francisco, 94110, USA
Am J Physiol Lung Cell Mol Physiol 301:L402-14. 2011....- In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dyeWan Namkung
Departments of Medicine and Physiology, University of California, San Francisco, California 94143, USA
J Biol Chem 284:15916-26. 2009..Our results provide the first noninvasive measurements of [K(+)] in the ASL and indicate the involvement of apical and basolateral membrane ion transporters in maintaining a high ASL [K(+)]... - Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleachingNico Derichs
Department of Medicine, University of California, San Francisco, California, USA
FASEB J 25:2325-32. 2011..Our results challenge the view that the PCL is a relatively watery, nonviscous fluid layer in contact with a more viscous ML, and offer an explanation for CF lung disease in the gland-free lower airways... - CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell culturesWan Namkung
Department of Medicine and Physiology, University of California, San Francisco, CA 94143, USA
Mol Biol Cell 21:2639-48. 2010..We further conclude that CFTR is the principal chloride secretory pathway in non-CF airways for both cAMP and Ca(2+) agonists, providing a novel mechanism to link CFTR dysfunction to CF lung disease... - Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel functionYuanlin Song
Department of Anesthesia and Perioperative Care, Univ of California, San Francisco, 94143 0521, USA
Am J Physiol Lung Cell Mol Physiol 297:L1131-40. 2009..We suggest that CF lung disease may be caused by the inability of CFTR-deficient airways to increase their ASL depth transiently following secretory stimuli that in non-CF airways produce transient increases in ASL depth... - Cultures of human tracheal gland cells of mucous or serous phenotypeWalter E Finkbeiner
Department of Pathology, University of California, San Francisco, CA, USA
In Vitro Cell Dev Biol Anim 46:450-6. 2010..Measurements of transepithelial resistance and short-circuit current showed that both "serous" and "mucous" cell cultures possessed tight junctions, had become polarized, and were actively secreting Cl... - Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contractionWan Namkung
Department of Medicine and Physiology, University of California, San Francisco, California 94143 0521, USA
FASEB J 25:4048-62. 2011..Small-molecule, TMEM16A-targeted activators may be useful for drug therapy of cystic fibrosis, dry mouth, and gastrointestinal hypomotility disorders, and for pharmacological dissection of TMEM16A function... 
Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1Lili Zhang
Francis I Proctor Foundation, University of California, San Francisco, California, USA
J Pathol 229:74-86. 2013..Novel therapeutics designed to inhibit MUC1-CT/p120ctn complex formation may prevent EMT in the smoker's airway...- Airway epithelial miRNA expression is altered in asthmaOwen D Solberg
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
Am J Respir Crit Care Med 186:965-74. 2012..Changes in airway epithelial cell differentiation, driven in part by IL-13, are important in asthma. Micro-RNAs (miRNAs) regulate cell differentiation in many systems and could contribute to epithelial abnormalities in asthma... - Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contractionFen Huang
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 109:16354-9. 2012..TMEM16A-CaCC blockers, including those identified here, may positively impact multiple causes of asthma symptoms... - In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjectsNilceia Lopez-Souza
Department of Medicine, University of California, San Francisco, Calif, USA
J Allergy Clin Immunol 123:1384-90.e2. 2009..Human rhinoviruses (HRVs) characteristically cause upper respiratory tract infection, but they also infect the lower airways, causing acute bronchitis and exacerbating asthma... 
Submucosal gland dysfunction as a primary defect in cystic fibrosisDanieli Salinas
Department of Medicine, University of California, San Francisco, California 94143-0521, USA
FASEB J 19:431-3. 2005..Our results suggest that defective airway submucosal gland function is an early, primary defect in CF. Therapies directed at normalizing gland fluid secretion early in CF may thus reduce lung disease...- Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporinsMarc H Levin
Department of Medicine, University of California, San Francisco, California 94143-0521, USA
J Biol Chem 281:25803-12. 2006..Our data provide evidence against the mechanism proposed by Donaldson et al. to account for the effects of amiloride and hypertonic saline in CF lung disease, indicating the need to identify alternate mechanisms...