Research Topics
Species | David FinkSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathyMunmun Chattopadhyay
Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
Mol Pain 8:17. 2012....- Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in ratsWenwen Zheng
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Mol Pain 7:40. 2011..Glia activation in the spinal cord has become an attractive target for attenuating chronic pain. This study will investigate the role of spinal TNFα released from glia in HIV-related neuropathic pain... - HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic painShuanglin Hao
Department of Neurology, University of Michigan Health System, 1500 E, Medical Center Drive, Room 1914 TC, Ann Arbor, Michigan 48109 0316, USA
Mol Pain 2:6. 2006.... - Gene therapy for pain: results of a phase I clinical trialDavid J Fink
Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
Ann Neurol 70:207-12. 2011..This clinical trial was carried out to assess the safety and explore the potential efficacy of this approach in humans... - HSV gene transfer in the treatment of chronic painDavid J Fink
University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
Sheng Li Xue Bao 60:610-6. 2008..A phase 1 trial of this therapy in patients is set to begin soon... - Neuroprotective effect of herpes simplex virus-mediated gene transfer of erythropoietin in hyperglycemic dorsal root ganglion neuronsMunmun Chattopadhyay
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Brain 132:879-88. 2009..Herpes simplex virus-mediated transfer of erythropoietin to dorsal root ganglia may prove useful in treatment of diabetic neuropathy... 
Cell and gene therapy in the treatment of painDavid Fink
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
Adv Drug Deliv Rev 55:1055-64. 2003..The data from animal models are reviewed, and the prospect for development of human therapies based on this approach is considered...- Prolonged biologically active transgene expression driven by HSV LAP2 in brain in vivoVeljko Puskovic
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Mol Ther 10:67-75. 2004.... - Replication-defective genomic HSV gene therapy vectors: design, production and CNS applicationsEdward A Burton
University of Pittsburgh, Department of Neurology, E1246 Bioscience Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Curr Opin Mol Ther 7:326-36. 2005..In this review, we summarize recent progress in the areas of vector development and vector production, and in developing gene transfer therapeutics to treat malignant glioma... - Release of GABA from sensory neurons transduced with a GAD67-expressing vector occurs by non-vesicular mechanismsJun Liu
Department of Neurology, University of Michigan, 1500 E. Medical Center Drive, Room 1914 TC, Ann Arbor, MI 48109-0316, USA
Brain Res 1073:297-304. 2006..We conclude that QHGAD67-mediated GABA release from dorsal root ganglion neurons is non-vesicular, independent of electrical depolarization, and that this efflux is mediated through reversal of the GABA transporter... - Gene transfer of glutamic acid decarboxylase reduces neuropathic painShuanglin Hao
Department of Neurology, University of Michigan Health System and Ann Arbor VA Healthcare System, Ann Arbor, MI 48109-0316, USA
Ann Neurol 57:914-8. 2005..QHGAD67 inoculation also suppressed induction of c-Fos and phosphorylated extracellular signal-regulated kinase 1 and 2 in the spinal cord... - Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury painJun Liu
Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Ther 10:57-66. 2004..These results suggest that HSV-mediated gene transfer to DRG could be used to treat below-level central neuropathic pain after incomplete SCI... - Gene therapy for the treatment of sensory neuropathyMarina Mata
Department of Neurology, University of Michigan Health System, Ann Arbor, MI 48109-0316, USA
Expert Opin Biol Ther 6:499-507. 2006..Evidence supporting the trial and the challenges facing this therapy are reviewed... - Vector-mediated gene transfer to express inhibitory neurotransmitters in dorsal root ganglion reduces pain in a rodent model of lumbar radiculopathyJohn Y K Lee
Penn Neurological Institute, PA Hospital, Philadelphia, PA, USA
Spine 31:1555-8. 2006..CONCLUSIONS: HSV-mediated gene transfer provides a novel method for treating chronic neuropathic pain related to lumbar root injury in rodents... - Engineering an endomorphin-2 gene for use in neuropathic pain therapyDarren Wolfe
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1240 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Pain 133:29-38. 2007.... - Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathyMunmun Chattopadhyay
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 0316, USA
J Neurosci 28:6652-8. 2008..7 in DRG through inhibition of PKC and p38. These results establish a novel interaction between the delta-opioid receptor and voltage-gated sodium channels... - HSV vectors for gene therapy of chronic painRahul Srinivasan
University of Pittsburgh School of Medicine, Department of Molecular Genetics and Biochemistry, Pittsburgh, PA 15261, USA
Curr Opin Mol Ther 10:449-55. 2008..Data from preclinical animal models as well as studies that support early phase clinical trials from 2002 to 2008 are described... - Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injuryXiang-min Peng
Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, 48109-0316, USA
Ann Neurol 59:843-51. 2006.... - Protective effect of herpes simplex virus-mediated neurotrophin gene transfer in cisplatin neuropathyMunmun Chattopadhyay
Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Brain 127:929-39. 2004..Iatrogenic neuropathy caused by administration of chemotherapeutic drugs represents an excellent target for a human trial to assess the potential of gene therapy to prevent neuropathy... - Gene therapy: novel treatments for polyneuropathy and chronic painMarina Mata
Department of Neurology, University of Pittsburgh, S-520 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Curr Neurol Neurosci Rep 4:1-2. 2004 - In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3Munmun Chattopadhyay
Department of Neurology, University of Pittsburgh, PA, USA
Ann Neurol 51:19-27. 2002..In vivo gene transfer using herpes simplex virus vectors provides a unique option for treatment of diseases of the sensory peripheral nervous system... - Development of HSV-mediated gene transfer for the treatment of chronic painMarina Mata
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
Exp Neurol 184:S25-9. 2003..We have demonstrated that an HSV-based vector expressing proenkephalin reduces pain-related responses in rodent models of inflammatory pain, neuropathic pain, and pain resulting from cancer in bone. A human trial has been proposed... - Targeted gene delivery to the nervous system using herpes simplex virus vectorsMarina Mata
Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Physiol Behav 77:483-8. 2002..Targeted gene delivery using HSV-based vectors offers a means to utilize short-lived peptides to produce specific effects in the nervous system... - Exploiting the neurotherapeutic potential of peptides: targeted delivery using HSV vectorsJoseph C Glorioso
Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Expert Opin Biol Ther 3:1233-9. 2003..The first human trial of HSV-mediated gene transfer to DRG is about to commence. HSV-mediated gene transfer may allow the therapeutic potential of these peptides for the treatment of neurologic disease to be realised... - Therapeutic gene transfer with herpes-based vectors: studies in Parkinson's disease and motor nerve regenerationDavid J Fink
Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Exp Neurol 184:S19-24. 2003..Gene transfer may be useful in the treatment of neurologic disorders in which neuronal cell death occurs in a restricted anatomic distribution... - HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic painShuanglin Hao
Department of Neurology, Pittsburgh, Pennsylvania 15213, USA
Mol Ther 8:367-75. 2003..Gene transfer to produce a trophic factor offers a novel approach to the treatment of neuropathic pain that may be appropriate for human therapy... - Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic painShuanglin Hao
Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Pain 102:135-42. 2003..The pharmacologic analysis demonstrates that transgene-mediated expression and local release of opioid peptides produce some effects that are distinct from peptide analogues delivered pharmacologically... - Use of HSV vectors to modify the nervous systemJoseph C Glorioso
Department of Molecular Genetics and Biochemistry, University of Pittsburgh, VA Medical Center, Pittsburgh, PA 15213, USA
Curr Opin Drug Discov Devel 5:289-95. 2002..With these applications and the clinical experience in human tumor trials with HSV vectors, the stage is set for the use of HSV-based vectors to treat neurologic disease in humans in the near future... - Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animalsMunmun Chattopadhyay
Department of Neurology, University of Pittsburgh, USA
Eur J Neurosci 17:732-40. 2003.... - HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated miceVeljko Puskovic
Department of Neurology, University of Michigan Health System and VA Ann Arbor Healthcare System, Ann Arbor, MI 48109, USA
Mol Ther 14:710-5. 2006..These results demonstrate that vector-mediated EPO production may be used to reverse dopaminergic neurodegeneration in the face of continued toxic insult... - Viral vector-based gene transfer for treatment of chronic painShuanglin Hao
University of Michigan Health System--VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
Int Anesthesiol Clin 45:59-71. 2007 - Construction of replication-defective herpes simplex virus vectorsWilliam F Goins
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Curr Protoc Hum Genet . 2002..Three support protocols describe methods for preparing virus stocks, titering virus, and preparing viral DNA... - Gene delivery using herpes simplex virus vectorsEdward A Burton
Department of Clinical Neurology, University of Oxford, United Kingdom
DNA Cell Biol 21:915-36. 2002..Consequently, HSV vectors encoding appropriate transgenes to tackle these pathogenic processes are poised to enter clinical trials... - Herpes vector-mediated expression of proenkephalin reduces bone cancer painJames R Goss
Department of Neurology, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, PA 15213, USA
Ann Neurol 52:662-5. 2002..These results suggest that gene transfer with an enkephalin-expressing vector may be used to treat pain resulting from cancer in bone... - Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouseJames R Goss
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Diabetes 51:2227-32. 2002..3 microV). These results suggest that gene transfer with an NGF-producing herpes-based vector may prove useful in the treatment of diabetic neuropathy... - Development of replication-defective herpes simplex virus vectorsWilliam F Goins
Department of Molecular enetics and Biochemistry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Methods Mol Med 69:481-507. 2002 - Nifedipine potentiates the antinociceptive effect of endomorphin-1 microinjected into the periaqueductal gray in ratsShuanglin Hao
Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, Asahikawa, Japan
Anesth Analg 96:1065-71, table of contents. 2003..This suggests that calcium channel blockers may enhance the analgesia of opioids in patients with calcium channel blocker treatment... - Therapeutic gene transfer to the nervous system using viral vectorsJoseph C Glorioso
Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Neurovirol 9:165-72. 2003..The results of the first human gene therapy trials for neurologic disease, which are just now beginning, will be crucial in defining the next step in the development of this therapy... - Stem cell therapy in a caprine model of osteoarthritisJ Mary Murphy
Osiris Therapeutics, Baltimore, Maryland 21231, USA
Arthritis Rheum 48:3464-74. 2003..CONCLUSION: Local delivery of adult mesenchymal stem cells to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction normally seen in this model of OA... - Enhanced functional recovery after proximal nerve root injury by vector-mediated gene transferAtsushi Natsume
Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15217, USA
Exp Neurol 184:878-86. 2003..These results suggest an approach to root trauma that might be used to enhance functional recovery after injury... - Delivery using herpes simplex virus: an overviewWilliam F Goins
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Methods Mol Biol 246:257-99. 2004..These persistent genomes are devoid of lytic gene expression, but retain the ability to express latency-associated transcripts (LATs)... - Delivery of herpes simplex virus-based vectors to the nervous systemJames R Goss
Department of Neurology, University of Pittsburgh School of Medicine, and GRECC, VA Medical Center, Pittsburgh, PA, USA
Methods Mol Biol 246:309-22. 2004.... - Gene therapy for chronic painJoseph C Glorioso
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Curr Opin Mol Ther 5:483-8. 2003..A clinical trial is set to commence... - Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligationJian Hu
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Eur J Neurosci 20:1705-12. 2004..The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain... - Herpes vector-mediated gene transfer in treatment of diseases of the nervous systemJoseph C Glorioso
Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Annu Rev Microbiol 58:253-71. 2004..Human trials of nonreplicating HSV gene transfer by direct inoculation for treatment of glioblastoma and HSV gene transfer by subcutaneous inoculation for the treatment of chronic intractable pain should commence soon... - Long-term neuroprotection achieved with latency-associated promoter-driven herpes simplex virus gene transfer to the peripheral nervous systemMunmun Chattopadhyay
Department of Neurology, University of Michigan Health System and Neurology Service, VA Ann Arbor Healthcare System, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0316, USA
Mol Ther 12:307-13. 2005..These results indicate that expression of NGF or NT-3 driven by LAP2 is sufficient to prevent the development of neuropathy 6 months after vector inoculation in rats... - Delivery of herpes simplex virus-based vectors to stem cellsDarren Wolfe
Department of Pathobiology and Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, and Division of Neurology, Children's Hospital of Philadelphia, Philadelphia PA, USA
Methods Mol Biol 246:339-52. 2004..We have used therapeutic vectors to successfully treat human disease models in animals, including cancer, Parkinson's disease, and nerve damage (5-10)... - Use of laser capture microdissection together with in situ hybridization and real-time PCR to study distribution of latent herpes simplex virus genomes in mouse trigeminal gangliaXiao-Ping Chen
Department of Microbiology and Immunology, Tong-Ji University School of Medicine, Shanghai, China
Methods Mol Biol 293:285-93. 2005..The distribution of latent herpes simplex genomes at the individual cell level has been deteremined and the relationship of the number of latent genomes to the expression of latency-associated transcripts established... - Gene transfer to the nervous system: prospects for novel treatments directed at diseases of the aging nervous systemMarina Mata
Department of Neurology, University of Pittsburgh, Pennsylvania 15213, USA
J Gerontol A Biol Sci Med Sci 58:M1111-8. 2003..The full potential of this approach will not be established until the human trials are completed... - Bcl-2 and GDNF delivered by HSV-mediated gene transfer after spinal root avulsion provide a synergistic effectAtsushi Natsume
Department of Neurology, University of Pittsburgh School of Medicine, PA, USA
J Neurotrauma 19:61-8. 2002..Together, these findings suggest an approach to improving cell survival and regeneration following proximal root injury...
Research Grants
- GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHYDavid Fink; Fiscal Year: 1999
- GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHYDavid Fink; Fiscal Year: 2009..These studies are designed to develop novel agents that could be used to treat the disease effectively. ..
- Gene Therapy for PainDavid Fink; Fiscal Year: 2005..Specific Aim 5. To create and test novel HSV-based vectors in models of neuropathic, inflammatory, and cancer pain. ..
- GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHYDavid Fink; Fiscal Year: 2005..The studies in this proposal are designed to allow the development of an effective therapy appropriate for the treatment of patients. ..
- GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHYDavid J Fink; Fiscal Year: 2010..These studies are designed to develop novel agents that could be used to treat the disease effectively. ..