David Fink

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1
    Rachana Murthy
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System Neurology and GRECC, 5027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Mol Brain 6:30. 2013
  2. pmc Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Mol Pain 8:17. 2012
  3. pmc Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats
    Wenwen Zheng
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Pain 7:40. 2011
  4. pmc HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System, 1500 E, Medical Center Drive, Room 1914 TC, Ann Arbor, Michigan 48109 0316, USA
    Mol Pain 2:6. 2006
  5. pmc Gene therapy for pain: results of a phase I clinical trial
    David J Fink
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Ann Neurol 70:207-12. 2011
  6. pmc HSV gene transfer in the treatment of chronic pain
    David J Fink
    University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
    Sheng Li Xue Bao 60:610-6. 2008
  7. pmc Neuroprotective effect of herpes simplex virus-mediated gene transfer of erythropoietin in hyperglycemic dorsal root ganglion neurons
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Brain 132:879-88. 2009
  8. ncbi request reprint Cell and gene therapy in the treatment of pain
    David Fink
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Adv Drug Deliv Rev 55:1055-64. 2003
  9. pmc Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 0316, USA
    J Neurosci 28:6652-8. 2008
  10. pmc Gene transfer of glutamic acid decarboxylase reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System and Ann Arbor VA Healthcare System, Ann Arbor, MI 48109 0316, USA
    Ann Neurol 57:914-8. 2005

Research Grants

Collaborators

  • Joseph Glorioso
  • Shuanglin Hao
  • Munmun Chattopadhyay
  • James R Goss
  • Changfeng Tai
  • David Lacomis
  • Marina Mata
  • Darren Wolfe
  • William F Goins
  • Veljko Puskovic
  • Jun Liu
  • Jian Hu
  • Edward A Burton
  • Rahul Srinivasan
  • Shaohua Huang
  • Atsushi Natsume
  • Xiang min Peng
  • Rachana Murthy
  • Wenwen Zheng
  • David M Krisky
  • John Y K Lee
  • Xiao Ping Chen
  • David Krisky
  • J Mary Murphy
  • Roman J Giger
  • Xiankui Sun
  • Jeeyong Kim
  • Handong Ouyang
  • Xuexing Zheng
  • Shue Liu
  • James Wechuck
  • William C de Groat
  • Zhi Gang Zhou
  • Jeff Collins
  • Ed A Burton
  • James B Wechuck
  • Ali Ozuer
  • Michael E Epperly
  • Julie P Goff
  • Qing Bai
  • Joel S Greenberger
  • Gui Zhang
  • Frank P Barry
  • Ernst B Hunziker
  • Ramesh Ramakrishnan
  • Thomas Oligino
  • Darren P Wolfe
  • Peggy Marconi

Detail Information

Publications51

  1. pmc Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1
    Rachana Murthy
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System Neurology and GRECC, 5027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Mol Brain 6:30. 2013
    ..Type B GABA receptors (GABA Rs) play a critical role in synaptic transmission. We carried out studies to determine whether neuronal cell surface expression of GABAB-Rs might be regulated by the Nogo receptor 1 (NgR1)...
  2. pmc Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Mol Pain 8:17. 2012
    ....
  3. pmc Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats
    Wenwen Zheng
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Pain 7:40. 2011
    ..Glia activation in the spinal cord has become an attractive target for attenuating chronic pain. This study will investigate the role of spinal TNFα released from glia in HIV-related neuropathic pain...
  4. pmc HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System, 1500 E, Medical Center Drive, Room 1914 TC, Ann Arbor, Michigan 48109 0316, USA
    Mol Pain 2:6. 2006
    ....
  5. pmc Gene therapy for pain: results of a phase I clinical trial
    David J Fink
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Ann Neurol 70:207-12. 2011
    ..This clinical trial was carried out to assess the safety and explore the potential efficacy of this approach in humans...
  6. pmc HSV gene transfer in the treatment of chronic pain
    David J Fink
    University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
    Sheng Li Xue Bao 60:610-6. 2008
    ..A phase 1 trial of this therapy in patients is set to begin soon...
  7. pmc Neuroprotective effect of herpes simplex virus-mediated gene transfer of erythropoietin in hyperglycemic dorsal root ganglion neurons
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Brain 132:879-88. 2009
    ..Herpes simplex virus-mediated transfer of erythropoietin to dorsal root ganglia may prove useful in treatment of diabetic neuropathy...
  8. ncbi request reprint Cell and gene therapy in the treatment of pain
    David Fink
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Adv Drug Deliv Rev 55:1055-64. 2003
    ..The data from animal models are reviewed, and the prospect for development of human therapies based on this approach is considered...
  9. pmc Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 0316, USA
    J Neurosci 28:6652-8. 2008
    ..7 in DRG through inhibition of PKC and p38. These results establish a novel interaction between the delta-opioid receptor and voltage-gated sodium channels...
  10. pmc Gene transfer of glutamic acid decarboxylase reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System and Ann Arbor VA Healthcare System, Ann Arbor, MI 48109 0316, USA
    Ann Neurol 57:914-8. 2005
    ..QHGAD67 inoculation also suppressed induction of c-Fos and phosphorylated extracellular signal-regulated kinase 1 and 2 in the spinal cord...
  11. ncbi request reprint Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain
    Jun Liu
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Ther 10:57-66. 2004
    ..These results suggest that HSV-mediated gene transfer to DRG could be used to treat below-level central neuropathic pain after incomplete SCI...
  12. ncbi request reprint Prolonged biologically active transgene expression driven by HSV LAP2 in brain in vivo
    Veljko Puskovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Mol Ther 10:67-75. 2004
    ....
  13. ncbi request reprint Replication-defective genomic HSV gene therapy vectors: design, production and CNS applications
    Edward A Burton
    University of Pittsburgh, Department of Neurology, E1246 Bioscience Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Curr Opin Mol Ther 7:326-36. 2005
    ..In this review, we summarize recent progress in the areas of vector development and vector production, and in developing gene transfer therapeutics to treat malignant glioma...
  14. ncbi request reprint Release of GABA from sensory neurons transduced with a GAD67-expressing vector occurs by non-vesicular mechanisms
    Jun Liu
    Department of Neurology, University of Michigan, 1500 E Medical Center Drive, Room 1914 TC, Ann Arbor, MI 48109 0316, USA
    Brain Res 1073:297-304. 2006
    ..We conclude that QHGAD67-mediated GABA release from dorsal root ganglion neurons is non-vesicular, independent of electrical depolarization, and that this efflux is mediated through reversal of the GABA transporter...
  15. ncbi request reprint Vector-mediated gene transfer to express inhibitory neurotransmitters in dorsal root ganglion reduces pain in a rodent model of lumbar radiculopathy
    John Y K Lee
    Penn Neurological Institute, PA Hospital, Philadelphia, PA, USA
    Spine (Phila Pa 1976) 31:1555-8. 2006
    ..A prospective in vivo animal study...
  16. ncbi request reprint Gene therapy for the treatment of sensory neuropathy
    Marina Mata
    Department of Neurology, University of Michigan Health System, Ann Arbor, MI 48109 0316, USA
    Expert Opin Biol Ther 6:499-507. 2006
    ..Evidence supporting the trial and the challenges facing this therapy are reviewed...
  17. ncbi request reprint Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury
    Xiang min Peng
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, 48109 0316, USA
    Ann Neurol 59:843-51. 2006
    ..Our objective was to elucidate the mechanisms responsible for below-level pain after partial spinal cord injury (SCI)...
  18. ncbi request reprint HSV vectors for gene therapy of chronic pain
    Rahul Srinivasan
    University of Pittsburgh School of Medicine, Department of Molecular Genetics and Biochemistry, Pittsburgh, PA 15261, USA
    Curr Opin Mol Ther 10:449-55. 2008
    ..Data from preclinical animal models as well as studies that support early phase clinical trials from 2002 to 2008 are described...
  19. ncbi request reprint Engineering an endomorphin-2 gene for use in neuropathic pain therapy
    Darren Wolfe
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1240 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Pain 133:29-38. 2007
    ....
  20. ncbi request reprint Protective effect of herpes simplex virus-mediated neurotrophin gene transfer in cisplatin neuropathy
    Munmun Chattopadhyay
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain 127:929-39. 2004
    ..Iatrogenic neuropathy caused by administration of chemotherapeutic drugs represents an excellent target for a human trial to assess the potential of gene therapy to prevent neuropathy...
  21. ncbi request reprint HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain
    Shuanglin Hao
    Department of Neurology, Pittsburgh, Pennsylvania 15213, USA
    Mol Ther 8:367-75. 2003
    ..Gene transfer to produce a trophic factor offers a novel approach to the treatment of neuropathic pain that may be appropriate for human therapy...
  22. ncbi request reprint In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3
    Munmun Chattopadhyay
    Department of Neurology, University of Pittsburgh, PA, USA
    Ann Neurol 51:19-27. 2002
    ..In vivo gene transfer using herpes simplex virus vectors provides a unique option for treatment of diseases of the sensory peripheral nervous system...
  23. ncbi request reprint Therapeutic gene transfer with herpes-based vectors: studies in Parkinson's disease and motor nerve regeneration
    David J Fink
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Exp Neurol 184:S19-24. 2003
    ..Gene transfer may be useful in the treatment of neurologic disorders in which neuronal cell death occurs in a restricted anatomic distribution...
  24. ncbi request reprint Development of HSV-mediated gene transfer for the treatment of chronic pain
    Marina Mata
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Exp Neurol 184:S25-9. 2003
    ..We have demonstrated that an HSV-based vector expressing proenkephalin reduces pain-related responses in rodent models of inflammatory pain, neuropathic pain, and pain resulting from cancer in bone. A human trial has been proposed...
  25. ncbi request reprint Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pain 102:135-42. 2003
    ..The pharmacologic analysis demonstrates that transgene-mediated expression and local release of opioid peptides produce some effects that are distinct from peptide analogues delivered pharmacologically...
  26. ncbi request reprint Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals
    Munmun Chattopadhyay
    Department of Neurology, University of Pittsburgh, USA
    Eur J Neurosci 17:732-40. 2003
    ....
  27. ncbi request reprint Targeted gene delivery to the nervous system using herpes simplex virus vectors
    Marina Mata
    Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Physiol Behav 77:483-8. 2002
    ..Targeted gene delivery using HSV-based vectors offers a means to utilize short-lived peptides to produce specific effects in the nervous system...
  28. ncbi request reprint Exploiting the neurotherapeutic potential of peptides: targeted delivery using HSV vectors
    Joseph C Glorioso
    Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Expert Opin Biol Ther 3:1233-9. 2003
    ..The first human trial of HSV-mediated gene transfer to DRG is about to commence. HSV-mediated gene transfer may allow the therapeutic potential of these peptides for the treatment of neurologic disease to be realised...
  29. ncbi request reprint Gene therapy: novel treatments for polyneuropathy and chronic pain
    Marina Mata
    Department of Neurology, University of Pittsburgh, S 520 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Neurol Neurosci Rep 4:1-2. 2004
  30. ncbi request reprint Use of HSV vectors to modify the nervous system
    Joseph C Glorioso
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, VA Medical Center, Pittsburgh, PA 15213, USA
    Curr Opin Drug Discov Devel 5:289-95. 2002
    ..With these applications and the clinical experience in human tumor trials with HSV vectors, the stage is set for the use of HSV-based vectors to treat neurologic disease in humans in the near future...
  31. ncbi request reprint HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated mice
    Veljko Puskovic
    Department of Neurology, University of Michigan Health System and VA Ann Arbor Healthcare System, Ann Arbor, MI 48109, USA
    Mol Ther 14:710-5. 2006
    ..These results demonstrate that vector-mediated EPO production may be used to reverse dopaminergic neurodegeneration in the face of continued toxic insult...
  32. ncbi request reprint Development of replication-defective herpes simplex virus vectors
    William F Goins
    Department of Molecular enetics and Biochemistry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Methods Mol Med 69:481-507. 2002
  33. ncbi request reprint Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Diabetes 51:2227-32. 2002
    ..3 microV). These results suggest that gene transfer with an NGF-producing herpes-based vector may prove useful in the treatment of diabetic neuropathy...
  34. pmc Viral vector-based gene transfer for treatment of chronic pain
    Shuanglin Hao
    University of Michigan Health System VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
    Int Anesthesiol Clin 45:59-71. 2007
  35. doi request reprint Construction of replication-defective herpes simplex virus vectors
    William F Goins
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Protoc Hum Genet . 2002
    ..Three support protocols describe methods for preparing virus stocks, titering virus, and preparing viral DNA...
  36. ncbi request reprint Herpes vector-mediated expression of proenkephalin reduces bone cancer pain
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Ann Neurol 52:662-5. 2002
    ..These results suggest that gene transfer with an enkephalin-expressing vector may be used to treat pain resulting from cancer in bone...
  37. ncbi request reprint Gene delivery using herpes simplex virus vectors
    Edward A Burton
    Department of Clinical Neurology, University of Oxford, United Kingdom
    DNA Cell Biol 21:915-36. 2002
    ..Consequently, HSV vectors encoding appropriate transgenes to tackle these pathogenic processes are poised to enter clinical trials...
  38. ncbi request reprint Nifedipine potentiates the antinociceptive effect of endomorphin-1 microinjected into the periaqueductal gray in rats
    Shuanglin Hao
    Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, Asahikawa, Japan
    Anesth Analg 96:1065-71, table of contents. 2003
    ..This result shows that the potent antinociceptive effect of endomorphin-1 microinjected into the vPAG is mediated through the mu-opioid receptor and is potentiated by concomitant administration of nifedipine...
  39. ncbi request reprint Therapeutic gene transfer to the nervous system using viral vectors
    Joseph C Glorioso
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurovirol 9:165-72. 2003
    ..The results of the first human gene therapy trials for neurologic disease, which are just now beginning, will be crucial in defining the next step in the development of this therapy...
  40. ncbi request reprint Enhanced functional recovery after proximal nerve root injury by vector-mediated gene transfer
    Atsushi Natsume
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15217, USA
    Exp Neurol 184:878-86. 2003
    ..These results suggest an approach to root trauma that might be used to enhance functional recovery after injury...
  41. ncbi request reprint Delivery using herpes simplex virus: an overview
    William F Goins
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Methods Mol Biol 246:257-99. 2004
    ..These persistent genomes are devoid of lytic gene expression, but retain the ability to express latency-associated transcripts (LATs)...
  42. ncbi request reprint Delivery of herpes simplex virus-based vectors to the nervous system
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, and GRECC, VA Medical Center, Pittsburgh, PA, USA
    Methods Mol Biol 246:309-22. 2004
    ....
  43. ncbi request reprint Stem cell therapy in a caprine model of osteoarthritis
    J Mary Murphy
    Osiris Therapeutics, Baltimore, Maryland 21231, USA
    Arthritis Rheum 48:3464-74. 2003
    ....
  44. ncbi request reprint Gene therapy for chronic pain
    Joseph C Glorioso
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Opin Mol Ther 5:483-8. 2003
    ..A clinical trial is set to commence...
  45. ncbi request reprint Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation
    Jian Hu
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Eur J Neurosci 20:1705-12. 2004
    ..The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain...
  46. ncbi request reprint Herpes vector-mediated gene transfer in treatment of diseases of the nervous system
    Joseph C Glorioso
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Microbiol 58:253-71. 2004
    ..Human trials of nonreplicating HSV gene transfer by direct inoculation for treatment of glioblastoma and HSV gene transfer by subcutaneous inoculation for the treatment of chronic intractable pain should commence soon...
  47. ncbi request reprint Long-term neuroprotection achieved with latency-associated promoter-driven herpes simplex virus gene transfer to the peripheral nervous system
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan Health System and Neurology Service, VA Ann Arbor Healthcare System, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0316, USA
    Mol Ther 12:307-13. 2005
    ..These results indicate that expression of NGF or NT-3 driven by LAP2 is sufficient to prevent the development of neuropathy 6 months after vector inoculation in rats...
  48. ncbi request reprint Delivery of herpes simplex virus-based vectors to stem cells
    Darren Wolfe
    Department of Pathobiology and Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, and Division of Neurology, Children s Hospital of Philadelphia, Philadelphia PA, USA
    Methods Mol Biol 246:339-52. 2004
    ..We have used therapeutic vectors to successfully treat human disease models in animals, including cancer, Parkinson's disease, and nerve damage (5-10)...
  49. ncbi request reprint Use of laser capture microdissection together with in situ hybridization and real-time PCR to study distribution of latent herpes simplex virus genomes in mouse trigeminal ganglia
    Xiao Ping Chen
    Department of Microbiology and Immunology, Tong Ji University School of Medicine, Shanghai, China
    Methods Mol Biol 293:285-93. 2005
    ..The distribution of latent herpes simplex genomes at the individual cell level has been deteremined and the relationship of the number of latent genomes to the expression of latency-associated transcripts established...
  50. ncbi request reprint Gene transfer to the nervous system: prospects for novel treatments directed at diseases of the aging nervous system
    Marina Mata
    Department of Neurology, University of Pittsburgh, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 58:M1111-8. 2003
    ..The full potential of this approach will not be established until the human trials are completed...
  51. ncbi request reprint Bcl-2 and GDNF delivered by HSV-mediated gene transfer after spinal root avulsion provide a synergistic effect
    Atsushi Natsume
    Department of Neurology, University of Pittsburgh School of Medicine, PA, USA
    J Neurotrauma 19:61-8. 2002
    ..Together, these findings suggest an approach to improving cell survival and regeneration following proximal root injury...

Research Grants13

  1. GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHY
    David Fink; Fiscal Year: 1999
  2. GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHY
    David Fink; Fiscal Year: 2009
    ..These studies are designed to develop novel agents that could be used to treat the disease effectively. ..
  3. Gene Therapy for Pain
    David Fink; Fiscal Year: 2005
    ..Specific Aim 5. To create and test novel HSV-based vectors in models of neuropathic, inflammatory, and cancer pain. ..
  4. GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHY
    David Fink; Fiscal Year: 2005
    ..The studies in this proposal are designed to allow the development of an effective therapy appropriate for the treatment of patients. ..
  5. GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHY
    David J Fink; Fiscal Year: 2010
    ..These studies are designed to develop novel agents that could be used to treat the disease effectively. ..