Research Topics
Genomes and Genes
Species | Thomas E FingerSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Differential localization of putative amino acid receptors in taste buds of the channel catfish, Ictalurus punctatusT E Finger
Department of Cellular and Structural Biology, Rocky Mountain Taste and Small Center, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Comp Neurol 373:129-38. 1996..In addition, PHA-E binds to the apices of solitary chemoreceptor cells in the epithelium, indicating that this independent chemoreceptor system may utilize some receptor sites similar to those in taste buds...
Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respirationThomas E Finger
Department of Cellular and Structural Biology, Rocky Mountain Taste and Smell Center, Neuroscience Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 100:8981-6. 2003..The trigeminal chemoreceptor cells are likely to be remnants of the phylogenetically ancient population of solitary chemoreceptor cells found in the epithelium of all anamniote aquatic vertebrates...- Sorting food from stones: the vagal taste system in Goldfish, Carassius auratusThomas E Finger
Department of Cell and Developmental Biology, University of Colorado at Denver and Health Sciences Center, Mail Stop 8108, PO Box 6511, Aurora, CO 80045 6511, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:135-43. 2008..The stereotyped, laminated structure of this system in goldfish has facilitated studies of the circuitry and neurotransmitter systems underlying the goldfish's ability to sort food from stones... - Cell types and lineages in taste budsThomas E Finger
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Health Sciences Center, Denver, CO 80262 USA
Chem Senses 30:i54-5. 2005 - Ascending spinal systems in the fish, Prionotus carolinusT E Finger
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Comp Neurol 422:106-22. 2000..Thus, although these fish use their spinal chemosense as other fishes use their external taste systems, the spinal chemosense apparently relies on the medial lemniscal system to guide this chemically driven feeding behavior... - Evolution of taste and solitary chemoreceptor cell systemsT E Finger
Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, USA
Brain Behav Evol 50:234-43. 1997..The lack of taste buds in hagfish and their presence in all vertebrates may indicate that the phylogenetic development of taste buds coincided with the elaboration of head structures at the craniate-vertebrate transition... - Evolution of gustatory reflex systems in the brainstems of fishesThomas E Finger
Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, CO, USA
Integr Zool 4:53-63. 2009..This suggests that evolutionary change in the central nervous system largely proceeds by rearrangement and elaboration of existing systems, rather than by addition of new structures or circuits... - Olfactory receptor neurons in fish: structural, molecular and functional correlatesAnne Hansen
Department of Cellular and Developmental Biology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
Chem Senses 30:i311. 2005 - Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signalsMarco Tizzano
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 107:3210-5. 2010.... - Calcium-fluxing glutamate receptors associated with primary gustatory afferent terminals in goldfish (Carassius auratus)Gema Huesa
Department of Cell and Developmental Biology, School of Medicine, University Colorado at Denver, Aurora, Colorado 80045, USA
J Comp Neurol 506:694-707. 2008..These results are consonant with the presence of Ca(2+)-fluxing glutamate receptors on the presynaptic terminals of primary gustatory terminals, providing an avenue for modulation of primary gustatory input... - Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: cellular organization and neurotransmittersTakanori Ikenaga
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
J Comp Neurol 516:213-25. 2009..Thus, the vagal gustatory portion of the viscerosensory complex is linked to branchiomotor neurons of the pharynx via a glutamatergic interneuronal system... - Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitroBrian D Gulbransen
Rocky Mountain Taste and Smell Center, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
J Neurophysiol 99:2929-37. 2008..Our results demonstrate that TRPM5- and gustducin-expressing nasal SCCs respond to the T2R agonist denatonium via a PLC-coupled transduction cascade typical of T2Rs in the taste system... - Expression of taste receptors in solitary chemosensory cells of rodent airwaysMarco Tizzano
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
BMC Pulm Med 11:3. 2011..The objective of this study is to map the distribution of SCCs within the airways and to determine the elements of the chemosensory transduction cascade expressed in these SCCs... - Solitary chemoreceptor cell survival is independent of intact trigeminal innervationBrian Gulbransen
Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, School of Medicine University of Colorado Denver, Aurora, Colorado 80045, USA
J Comp Neurol 508:62-71. 2008..Our results demonstrate that elimination of innervation at any of these times does not result in decreased SCC numbers. In conclusion, neither SCC development nor mature cell maintenance is dependent on intact trigeminal innervation... - Residual chemosensory capabilities in double P2X2/P2X3 purinergic receptor null mice: intraoral or postingestive detection?Robert M Hallock
Department of Cell and Developmental Biology, University of Colorado Denver, MS 8108, PO Box 6511, Aurora, CO 80045 6511, USA
Chem Senses 34:799-808. 2009..In contrast, in brief access tests, P2X2/P2X3(Dbl-/-) mice avoided citric acid and hydrochloric acid at the same concentrations as their wild-type counterparts, indicating that these weak acids activate oropharyngeal chemoreceptors... - The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouseShinji Kataoka
Department of Cell and Developmental Biology, University of Colorado at Denver and Health Science Center, Mail Stop 8108, P O Box 6511, Aurora, CO 80045, USA
Chem Senses 33:243-54. 2008..We suggest that Type III cells are necessary for transduction and/or transmission of information about "sour", but have little or no role in transmission of taste information of other taste qualities... - Expression of T1Rs and gustducin in palatal taste buds of miceLeslie M Stone
Rocky Mountain Taste and Smell Center, Aurora, CO 80045, USA
Chem Senses 32:255-62. 2007..T1R1-positive palate taste cells coexpress gustducin about half the time, suggesting that other G proteins may contribute to the transduction of umami stimuli in this taste field... - Differential distribution of olfactory receptor neurons in goldfish: structural and molecular correlatesAnne Hansen
Rocky Mountain Taste and Smell Center, Cell and Developmental Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Comp Neurol 477:347-59. 2004..V2R- and OR-type receptor molecules do not colocalize in one cell, and only crypt-type ORNs express more than one G-protein... - A2BR adenosine receptor modulates sweet taste in circumvallate taste budsShinji Kataoka
Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, Colorado, United States of America
PLoS ONE 7:e30032. 2012..Thus, our study identified a novel regulator of sweet taste, the A2BR, which functions to potentiate sweet responses in posterior lingual taste fields... - Expression of Galpha14 in sweet-transducing taste cells of the posterior tongueMarco Tizzano
Rocky Mountain Taste and Smell Center, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
BMC Neurosci 9:110. 2008..We utilized RT-PCR, immunocytochemistry and single-cell gene expression profiling to examine the expression of the Galphaq family (q, 11, 14) in mouse taste buds... - Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2epsilonWeiguo Feng
Department of Craniofacial Biology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
Mol Cell Neurosci 42:161-71. 2009..We also show that Cre recombinase expression directed by the AP-2epsilon locus can specifically target floxed genes within the olfactory bulb, extending the utility of this AK allele... - Group III metabotropic glutamate receptors (mGluRs) modulate transmission of gustatory inputs in the brain stemRobert M Hallock
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, Room L18 11403 G, RC 1, 12801 E 17th Ave, MS 8108, P O Box 6511, Aurora, CO 80045 6511, USA
J Neurophysiol 102:192-202. 2009..Collectively, these experiments indicate that mGluR4 and 8 are presynaptic at the primary gustatory afferent synapse and that their activation inhibits glutamatergic release... - Correlation between olfactory receptor cell type and function in the channel catfishAnne Hansen
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 23:9328-39. 2003..Finally, amino acid odorants activate both ciliated and microvillous ORNs but via different transduction pathways in the two types of cells... - ATP signaling is crucial for communication from taste buds to gustatory nervesThomas E Finger
Rocky Mountain Taste and Smell Center, Aurora CO 80045, USA
Science 310:1495-9. 2005..Finally, stimulation of taste buds in vitro evokes release of ATP. Thus, ATP fulfils the criteria for a neurotransmitter linking taste buds to the nervous system... - Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste budsDianna L Bartel
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045-6511, USA
J Comp Neurol 497:1-12. 2006..The presence of ecto-ATPase in taste buds likely reflects the importance of ATP as an intercellular signaling molecule in this system... 
Second-order input to the medial amygdala from olfactory sensory neurons expressing the transduction channel TRPM5John A Thompson
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, Aurora, Colorado 80045, USA
J Comp Neurol 520:1819-30. 2012....- Solitary chemoreceptor cell proliferation in adult nasal epitheliumBrian D Gulbransen
Department of Cellular and Developmental Biology, Rocky Mountain Taste and Smell Center, Neuroscience Program, University of Colorado at Denver Health Sciences Center, Mail Stop 8108, P O Box 6511, Aurora, CO 80045, USA
J Neurocytol 34:117-22. 2005..No BrdU labeled cells were detected after 24 days suggesting relatively rapid replacement of the SCCs... - Co-occurrence of calcium-binding proteins and calcium-permeable glutamate receptors in the primary gustatory nucleus of goldfishTakanori Ikenaga
Department of Cell and Developmental Biology, University of Colorado Medical School, Aurora, Colorado 80045, USA
J Comp Neurol 499:90-105. 2006.... - Is TrpM5 a reliable marker for chemosensory cells? Multiple types of microvillous cells in the main olfactory epithelium of miceAnne Hansen
Rocky Mountain Taste and Smell Center, Dept of Cell and Developmental Biology, School of Medicine, University of Colorado Denver, Aurora, 80045, USA
BMC Neurosci 9:115. 2008..We asked whether the TrpM5-positive cells in the olfactory epithelium are microvillous and whether they belong to a chemosensory system, i.e. are olfactory neurons or trigeminally-innervated solitary chemosensory cells... - Brain-derived neurotrophic factor is present in adult mouse taste cells with synapsesCindy L Yee
Rocky Mountain Taste and Smell Center, Denver, Colorado 80262, USA
J Comp Neurol 459:15-24. 2003..The presence of SNAP-25 in BDNF-expressing cells suggests a role for BDNF in synaptic formation and transmission... - Effects of glossopharyngeal nerve section on the expression of neurotrophins and their receptors in lingual taste buds of adult miceCindy Yee
Rocky Mountain Taste and Smell Center, Department of Cellular and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045-6511, USA
J Comp Neurol 490:371-90. 2005..These results indicate that neurotrophin expression in taste buds is dependent on gustatory innervation, but expression in nerves is not dependent on contact with taste buds... - Neurotrophin-3 is expressed in a discrete subset of olfactory receptor neurons in the mouseAlison J Vigers
Rocky Mountain Taste and Smell Center, Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Comp Neurol 463:221-35. 2003..Thus, the timing and presence of beta-galactosidase in a subset of ORNs suggests that NT-3 plays a role in synaptogenesis and/or synapse function in a specific subset of ORNs within the olfactory bulb... - Variability of position of the P2 glomerulus within a map of the mouse olfactory bulbM L Schaefer
Department of Cellular and Structural Biology and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Comp Neurol 436:351-62. 2001..Furthermore, the data reported here demonstrate that the rostrocaudal position of small P2 glomeruli is three times more variable than that of large glomeruli... - Mature olfactory receptor neurons express connexin 43C Zhang
Department of Cellular and Structural Biology and the Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Comp Neurol 426:1-12. 2000..Our findings of connexin subunits in mature ORNs raise the novel possibility that gap junctions may play a fundamental role in information processing in the olfactory epithelium... - Excitatory amino acid neurotransmission in the primary gustatory nucleus of the goldfish Carassius auratusC A Smeraski
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262, USA
Ann N Y Acad Sci 855:442-9. 1998..These results indicate that excitatory amino acids are the neurotransmitter at the first relay in the taste pathway in the central nervous system... - Expression of sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouseJ M Hall
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262, USA
J Comp Neurol 406:143-55. 1999.... - "Type III" cells of rat taste buds: immunohistochemical and ultrastructural studies of neuron-specific enolase, protein gene product 9.5, and serotoninC L Yee
Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Comp Neurol 440:97-108. 2001..5, whereas others express PGP 9.5 but do not accumulate amines. Similarly, Type II taste cells come in at least two varieties: those immunoreactive for gustducin and those immunoreactive for PGP 9.5... - Distribution of cholecystokinin, calcitonin gene-related peptide, neuropeptide Y, and galanin in the primary gustatory nuclei of the goldfishWilliam J Farrell
Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Denver 80262, USA
J Comp Neurol 450:103-14. 2002.... - Differential distribution of hypocretin (orexin) and melanin-concentrating hormone in the goldfish brainGema Huesa
Department of Cell and Developmental Biology, University of Colorado at Denver, Health Sciences Center, Aurora, Colorado 80045, USA
J Comp Neurol 488:476-91. 2005.... - A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neuronsMichael J Grybko
Department of Physiology and Biophysics, School of Medicine, University of Colorado, Aurora, CO, USA
Eur J Neurosci 33:1786-98. 2011..Fast nicotinic transmission might play a greater role in cholinergic signaling than previously assumed. We provide a model for the examination of synaptic properties of basal forebrain cholinergic innervation in the brain... - Central representation of postingestive chemosensory cues in mice that lack the ability to tasteJennifer M Stratford
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, USA
J Neurosci 31:9101-10. 2011..Together, these results suggest that P2X-dblKO mice can form preferences based on postingestive cues and that postingestive detection of MSG does not rely on the same purinergic signaling that is crucial for taste... - Trigeminal collaterals in the nasal epithelium and olfactory bulb: a potential route for direct modulation of olfactory information by trigeminal stimuliMichele L Schaefer
Department of Cellular and Structural Biology and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Comp Neurol 444:221-6. 2002..Furthermore, the collateral innervation of the epithelium and bulb may provide an avenue whereby nasal irritants could affect processing of coincident olfactory stimuli... - GABAergic modulation of primary gustatory afferent synaptic efficacyAndrew A Sharp
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurobiol 52:133-43. 2002..The mechanism of action of GABA(B) receptors suggests a presynaptic locus of action for that receptor... - Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillaeJoshua M H Hall
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Dev Biol 255:263-77. 2003.... - Chemosensors in the nose: guardians of the airwaysMarco Tizzano
Department of Cell and Developmental Biology, Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, Colorado, USA
Physiology (Bethesda) 28:51-60. 2013..Here, we describe the different cell types in the airways that utilize taste-receptor signaling to trigger protective epithelial and neural responses to potentially dangerous toxins and bacterial infection... - Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) miceTadahiro Ohkuri
Department of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Chem Senses 37:523-32. 2012..These results are consistent with the hypothesis that the residual avoidance of acidic solutions by P2X-dblKO mice may be attributable to the direct chemosensitivity of nerve fibers innervating the laryngeal epithelium and not to taste... - Kainate-activated cobalt uptake in the primary gustatory nucleus in goldfish: visualization of the morphology and distribution of cells expressing AMPA/kainate receptors in the vagal lobeC A Smeraski
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Comp Neurol 431:59-74. 2001..In the motor layer, cell bodies and proximal dendrites of small, multipolar neurons, and large motoneurons were regularly loaded with cobalt... - Analysis of cell lineage relationships in taste budsLeslie M Stone
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
J Neurosci 22:4522-9. 2002..Thus, at least some of the cell types in a taste bud represent distinct lineages of cells and are not merely phenotypic stages as a cell progresses from a young to a mature state... - TRPM5-expressing solitary chemosensory cells respond to odorous irritantsWeihong Lin
Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
J Neurophysiol 99:1451-60. 2008..Together, our data show that the TRPM5-expressing cells respond to a variety of chemicals at high exposure levels typical of irritants and are positioned in the nasal cavity appropriately to monitor inhaled air quality... - Glutamic acid decarboxylase 65, 67, and GABA-transaminase mRNA expression and total enzyme activity in the goldfish (Carassius auratus) brainChristopher J Martyniuk
Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, 20 Marie Curie, Ottawa, Ontario, Canada K1N 6N5
Brain Res 1147:154-66. 2007..Our results show that GAD65, GAD67, and GABA-T mRNAs are generally correlated with total GAD and GABA-T activity and all three transcripts have a largely overlapping mRNA distribution in the goldfish forebrain... - Beyond the olfactory bulb: an odotopic map in the forebrainAlexander A Nikonov
Department of Biological Sciences, Louisiana State University, Life Sciences Building, Room 202, Baton Rouge, LA 70803, USA
Proc Natl Acad Sci U S A 102:18688-93. 2005..For some units, distinctive response properties emerged, because the FB is the first center where odors subserving a common behavioral function (i.e., food function) converge...
Research Grants
- Trancellular Labeling from Defined Taste Receptor CellsThomas Finger; Fiscal Year: 2005..These mice also will be informative about the kinetics of protein handling, exocytosis and uptake by various cell types within the taste bud. ..