Robert Findling

Summary

Affiliation: University Hospitals Case Medical Center
Country: USA

Publications

  1. doi request reprint Respondent and item level patterns of response of aripiprazole in the acute treatment of pediatric bipolar I disorder
    Robert L Findling
    University Hospitals Case Medical Center Case Western Reserve University, Cleveland, OH, USA
    J Affect Disord 143:231-5. 2012
  2. doi request reprint Double-blind, randomized, placebo-controlled long-term maintenance study of aripiprazole in children with bipolar disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals, Case Medical Center, Cleveland, OH 44106, USA
    J Clin Psychiatry 73:57-63. 2012
  3. pmc The treatment of severe child aggression (TOSCA) study: Design challenges
    Cristan A Farmer
    Nisonger Center, Ohio State University, Columbus, USA
    Child Adolesc Psychiatry Ment Health 5:36. 2011
  4. doi request reprint Long-term tolerability of the methylphenidate transdermal system in pediatric attention-deficit/hyperactivity disorder: a multicenter, prospective, 12-month, open-label, uncontrolled, phase III extension of four clinical trials
    Robert L Findling
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Ther 31:1844-55. 2009
  5. doi request reprint An open-label study of aripiprazole: pharmacokinetics, tolerability, and effectiveness in children and adolescents with conduct disorder
    Robert L Findling
    University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Child Adolesc Psychopharmacol 19:431-9. 2009
  6. pmc The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio, USA
    Child Adolesc Psychiatry Ment Health 3:11. 2009
  7. doi request reprint A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarity
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 18:615-21. 2008
  8. doi request reprint A multiple-center, randomized, double-blind, placebo-controlled study of oral aripiprazole for treatment of adolescents with schizophrenia
    Robert L Findling
    Department of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
    Am J Psychiatry 165:1432-41. 2008
  9. doi request reprint Aripiprazole in children with attention-deficit/hyperactivity disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 18:347-54. 2008
  10. doi request reprint Tolerability and pharmacokinetics of aripiprazole in children and adolescents with psychiatric disorders: an open-label, dose-escalation study
    Robert L Findling
    Child and Adolescent Psychiatry, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH, USA
    J Clin Psychopharmacol 28:441-6. 2008

Research Grants

Detail Information

Publications101 found, 100 shown here

  1. doi request reprint Respondent and item level patterns of response of aripiprazole in the acute treatment of pediatric bipolar I disorder
    Robert L Findling
    University Hospitals Case Medical Center Case Western Reserve University, Cleveland, OH, USA
    J Affect Disord 143:231-5. 2012
    ..Few studies have evaluated the value of a parent- and subject-rated scale in detecting symptom change in response to pharmacologic treatment...
  2. doi request reprint Double-blind, randomized, placebo-controlled long-term maintenance study of aripiprazole in children with bipolar disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals, Case Medical Center, Cleveland, OH 44106, USA
    J Clin Psychiatry 73:57-63. 2012
    ..This study evaluates the long-term efficacy of aripiprazole compared to placebo in children with bipolar disorders...
  3. pmc The treatment of severe child aggression (TOSCA) study: Design challenges
    Cristan A Farmer
    Nisonger Center, Ohio State University, Columbus, USA
    Child Adolesc Psychiatry Ment Health 5:36. 2011
    ..abstract:..
  4. doi request reprint Long-term tolerability of the methylphenidate transdermal system in pediatric attention-deficit/hyperactivity disorder: a multicenter, prospective, 12-month, open-label, uncontrolled, phase III extension of four clinical trials
    Robert L Findling
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Ther 31:1844-55. 2009
    ..However, the effects of long-term use have not been systematically evaluated...
  5. doi request reprint An open-label study of aripiprazole: pharmacokinetics, tolerability, and effectiveness in children and adolescents with conduct disorder
    Robert L Findling
    University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Child Adolesc Psychopharmacol 19:431-9. 2009
    ..This study evaluated flexible-dose pharmacokinetics, safety, and effectiveness of aripiprazole in children and adolescents with conduct disorder (CD)...
  6. pmc The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio, USA
    Child Adolesc Psychiatry Ment Health 3:11. 2009
    ..CONCLUSION: Fluoxetine was not superior to placebo in alleviating depressive symptoms or in decreasing rates of positive drug screens in the acute treatment of adolescents with depression and a concomitant substance use disorder...
  7. doi request reprint A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarity
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 18:615-21. 2008
    ..As a result, future treatment studies in this population appear to be warranted, not only due to the putative impending risk of developing bipolar disorder, but also the manifest risk of current depressive episodes...
  8. doi request reprint A multiple-center, randomized, double-blind, placebo-controlled study of oral aripiprazole for treatment of adolescents with schizophrenia
    Robert L Findling
    Department of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
    Am J Psychiatry 165:1432-41. 2008
    ..This study was designed to examine the acute efficacy, safety, and tolerability of aripiprazole for adolescents with schizophrenia...
  9. doi request reprint Aripiprazole in children with attention-deficit/hyperactivity disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 18:347-54. 2008
    ..To examine the effectiveness and cognitive effects of aripiprazole (APZ) in children with a primary diagnosis of attention-deficit/hyperactivity disorder (ADHD)...
  10. doi request reprint Tolerability and pharmacokinetics of aripiprazole in children and adolescents with psychiatric disorders: an open-label, dose-escalation study
    Robert L Findling
    Child and Adolescent Psychiatry, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH, USA
    J Clin Psychopharmacol 28:441-6. 2008
    ..These data provided support for exploration of a 30-mg/d dose in child/adolescent schizophrenia and bipolar disorder...
  11. ncbi request reprint Long-term effectiveness and safety of lisdexamfetamine dimesylate in school-aged children with attention-deficit/hyperactivity disorder
    Robert L Findling
    Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    CNS Spectr 13:614-20. 2008
    ..In short-term studies, once-daily LDX provided efficacy throughout the day. This study presented here was conducted to assess the long-term safety, tolerability, and effectiveness of LDX in 6- to 12-year-olds with ADHD...
  12. doi request reprint Evolution of the treatment of attention-deficit/hyperactivity disorder in children: a review
    Robert L Findling
    Case Western Reserve University, Ohio, USA
    Clin Ther 30:942-57. 2008
    ..Stimulants such as methylphenidate (MPH) and amphetamines are the most widely used medications approved by the US Food and Drug Administration for the treatment of ADHDin children...
  13. ncbi request reprint A randomized, double-blind, placebo-controlled, parallel-group study of methylphenidate transdermal system in pediatric patients with attention-deficit/hyperactivity disorder
    Robert L Findling
    University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 69:149-59. 2008
    ..To evaluate the efficacy and safety of methylphenidate transdermal system compared with placebo, using osmotic-release oral system (OROS) methylphenidate as a reference therapy...
  14. ncbi request reprint Atypical antipsychotic treatment of disruptive behavior disorders in children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 69:9-14. 2008
    ....
  15. ncbi request reprint Methylphenidate in the treatment of children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106 5080, USA
    J Am Acad Child Adolesc Psychiatry 46:1445-53. 2007
    ..To examine the short-term efficacy of methylphenidate in the treatment of youths with bipolar disorder (BD) and comorbid attention deficit/hyperactivity disorder (ADHD)...
  16. doi request reprint Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled study
    Robert L Findling
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Psychiatry 70:1441-51. 2009
    ..To determine the efficacy and safety of aripiprazole for the treatment of pediatric bipolar I disorder, manic or mixed episode, with or without psychotic features...
  17. doi request reprint Effectiveness, safety, and tolerability of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: an open-label, dose-optimization study
    Robert L Findling
    University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 19:649-62. 2009
    ..The aim of this study was to assess the effectiveness and safety of lisdexamfetamine dimesylate (LDX) in children with attention-deficit/hyperactivity disorder (ADHD)...
  18. pmc Clinical characteristics of children receiving antipsychotic medication
    Robert L Findling
    University Hospitals Case Medical Center Case Western Reserve University, Cleveland, OH 44106, USA
    J Child Adolesc Psychopharmacol 21:311-9. 2011
    ..However, the only diagnoses associated with a greater likelihood of being treated with an antipsychotic were psychotic disorders or unmodified DSM-IV bipolar 1 disorder...
  19. pmc An open-label study of aripiprazole in children with a bipolar disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 21:345-51. 2011
    ..The purpose of this open-label study was to describe the effectiveness of aripiprazole (APZ) in the treatment of children with bipolar disorders suffering from manic symptomatology...
  20. pmc Dosing strategies for lithium monotherapy in children and adolescents with bipolar I disorder
    Robert L Findling
    Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 21:195-205. 2011
    ..The primary goal of this exploratory study was to obtain data that could lead to evidence-based dosing strategies for lithium in children and adolescents suffering from bipolar I disorder...
  21. doi request reprint Efficacy and safety of lisdexamfetamine dimesylate in adolescents with attention-deficit/hyperactivity disorder
    Robert L Findling
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Am Acad Child Adolesc Psychiatry 50:395-405. 2011
    ..To examine lisdexamfetamine dimesylate (LDX) efficacy and safety versus placebo in adolescents with attention-deficit/hyperactivity disorder (ADHD)...
  22. pmc Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) study
    Robert L Findling
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 71:1664-72. 2010
    ..This article describes the initial demographic information, diagnostic and symptom prevalence, and medication exposure for the LAMS cohort that will be followed longitudinally...
  23. doi request reprint A 6-month, open-label, extension study of the tolerability and effectiveness of the methylphenidate transdermal system in adolescents diagnosed with attention-deficit/hyperactivity disorder
    Robert L Findling
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 20:365-75. 2010
    ..The aim of this study was to evaluate the tolerability and effectiveness of the methylphenidate transdermal system (MTS) over 6 months in adolescents with attention-deficit/hyperactivity disorder (ADHD)...
  24. pmc Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study
    Robert L Findling
    Case Western Reserve University
    J Am Acad Child Adolesc Psychiatry 49:583-94; quiz 632. 2010
    ..To examine the long-term safety and efficacy of three antipsychotics in early-onset schizophrenia spectrum disorders...
  25. pmc Medical and substance use comorbidity in bipolar disorder
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Affect Disord 116:64-9. 2009
    ....
  26. pmc A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Clin Psychiatry 70:113-21. 2009
    ....
  27. ncbi request reprint Atypical antipsychotics in the treatment of children and adolescents: clinical applications
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 65:30-44. 2004
    ..Evidence on the use of atypical antipsychotics in children and adolescents is summarized in this review...
  28. doi request reprint Pharmacological treatment of pathologic aggression in children
    Drew H Barzman
    Division of Child and Adolescent Psychiatry, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Int Rev Psychiatry 20:151-7. 2008
    ..Future research is needed to evaluate whether the long-term risks associated with the pharmacological treatment of PA outweigh the potential benefits to the child...
  29. doi request reprint Family conflict moderates response to pharmacological intervention in pediatric bipolar disorder
    Lisa D Townsend
    Case Western Reserve University, Cleveland, 11400 Euclid Avenue, OH 44106, USA
    J Child Adolesc Psychopharmacol 17:843-52. 2007
    ..Family conflict affects the expression of psychopathology in youth. This study investigated whether family conflict moderates response to medication in youth with bipolar disorder...
  30. ncbi request reprint Double-blind 18-month trial of lithium versus divalproex maintenance treatment in pediatric bipolar disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, USA
    J Am Acad Child Adolesc Psychiatry 44:409-17. 2005
    ....
  31. ncbi request reprint A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder
    Joseph R Calabrese
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Am J Psychiatry 162:2152-61. 2005
    ..The authors tested the hypothesis that divalproex would be more effective than lithium in the long-term management of patients with recently stabilized rapid-cycling bipolar disorder...
  32. doi request reprint Guns, adolescents, and mental illness
    Nora K McNamara
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106 5080, USA
    Am J Psychiatry 165:190-4. 2008
  33. ncbi request reprint Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry, New York University School of Medicine, 530 First Ave 7D, New York, NY 10016, USA
    J Clin Psychiatry 69:1364-73. 2008
    ..To evaluate the efficacy and safety of 30, 50, and 70 mg/day lisdexamfetamine dimesylate compared with placebo in adults with attention-deficit/hyperactivity disorder (ADHD)...
  34. ncbi request reprint A 26-week open-label study of quetiapine in children with conduct disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 17:1-9. 2007
    ..The aim of this study was to describe the long-term safety and effectiveness of quetiapine in conduct disorder (CD)...
  35. pmc Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia
    Sanjiv Kumra
    Division of Child and Adolescent Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55454, USA
    Schizophr Bull 34:60-71. 2008
    ..Such a substantial risk points to the urgent need to develop therapeutic strategies to prevent and/or mitigate weight gain and diabetes early in the course of treatment in this population...
  36. pmc Initiation of stimulant and antidepressant medication and clinical presentation in juvenile bipolar I disorder
    Maria E Pagano
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
    Bipolar Disord 10:334-41. 2008
    ..Another aim was to investigate differences in clinical presentation between youths prescribed stimulant or antidepressant medication before and after the onset of juvenile BP I disorder...
  37. ncbi request reprint Psychopharmacology of pediatric bipolar disorder: a review
    Sylvester Smarty
    Child and Adolescent Psychiatry, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Psychopharmacology (Berl) 191:39-54. 2007
    ..For these reasons, there is a need for effective treatment for PBD...
  38. ncbi request reprint Long-term, open-label study of risperidone in children with severe disruptive behaviors and below-average IQ
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospital of Cleveland, OH 44106, USA
    Am J Psychiatry 161:677-84. 2004
    ..This study determined the long-term safety and effectiveness of risperidone in treating severe disruptive behavior in children with subaverage intelligence...
  39. ncbi request reprint Combination lithium and divalproex sodium in pediatric bipolarity
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University School of Medicine, USA
    J Am Acad Child Adolesc Psychiatry 42:895-901. 2003
    ..Many youths with bipolar disorder do not respond to DVPX or Li monotherapy. An open-label study was conducted to examine the effectiveness of combination DVPX and Li therapy with youths diagnosed with bipolar disorder...
  40. ncbi request reprint Early symptoms of mania and the role of parental risk
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 7:623-34. 2005
    ....
  41. ncbi request reprint Prolactin levels during long-term risperidone treatment in children and adolescents
    Robert L Findling
    University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 64:1362-9. 2003
    ..This analysis was designed to investigate prolactin levels in children and adolescents on long-term risperidone treatment and explore any relationship with side effects hypothetically attributable to prolactin (SHAP)...
  42. pmc Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder
    Mani N Pavuluri
    Department of Psychiatry, Institute for Juvenile Research, University of Illinois at Chicago, USA
    Bipolar Disord 12:593-605. 2010
    ..To determine the relative effects of risperidone and divalproex in pediatric mania...
  43. ncbi request reprint Use of antipsychotics in children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 66:29-40. 2005
    ....
  44. doi request reprint Child and adolescent psychopharmacology update
    Molly McVoy
    Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Walker Building, Cleveland, Ohio 44106, USA
    Psychiatr Clin North Am 32:111-33. 2009
    ..This article is an effort to summarize the recent advances in medication therapy of the pediatric population and bring the general psychiatrist up to date on the evidence-based psychopharmacologic treatment of children and adolescents...
  45. ncbi request reprint Use of quetiapine in children and adolescents
    Robert L Findling
    Division of Child and Adolescent Psychiatry, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 63:27-31. 2002
    ..Methodologically rigorous studies with substantive numbers of subjects are needed to confirm or refute these preliminary impressions...
  46. ncbi request reprint Update on the treatment of bipolar disorder in children and adolescents
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    Eur Psychiatry 20:87-91. 2005
    ....
  47. ncbi request reprint Gender differences in criminality: bipolar disorder with co-occurring substance abuse
    Susan Hatters Friedman
    Department of Psychiatry, University Hospitals of Cleveland, Hanna Pavilion, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Am Acad Psychiatry Law 33:188-95. 2005
    ..Implications from this pilot study include the need for earlier identification of bipolar disorder and for the increased availability of psychiatric and substance abuse services within correctional facilities...
  48. doi request reprint A linguistic analysis of in-office dialogue among psychiatrists, parents, and child and adolescent patients with ADHD
    Robert L Findling
    Case Western Reserve University, USA
    J Atten Disord 13:78-86. 2009
    ..The aim was to evaluate in-office discussions of ADHD and psychiatric comorbidities...
  49. ncbi request reprint Short- and long-term cardiovascular effects of mixed amphetamine salts extended release in children
    Robert L Findling
    University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Pediatr 147:348-54. 2005
    ....
  50. ncbi request reprint Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, OH 44106 5080, USA
    Neuropsychopharmacology 31:1274-85. 2006
    ..Certain gastrointestinal and behavioral activation events (aggressive reaction and nervousness) were reported more frequently in the youngest age group...
  51. pmc Current research in child and adolescent bipolar disorder
    Christine A Demeter
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    Dialogues Clin Neurosci 10:215-28. 2008
    ..This paper will review what is currently known and what still is left to learn about clinically salient topics that pertain to bipolar disorder in children and adolescents...
  52. ncbi request reprint Comparing diagnostic checklists for pediatric bipolar disorder in academic and community mental health settings
    Eric Youngstrom
    Department of Psychology, Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 7:507-17. 2005
    ....
  53. doi request reprint Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, 10524 Euclid Avenue, Cleveland, OH 44106, USA
    Bipolar Disord 10:907-15. 2008
    ..To study treatment-emergent mania/hypomania (TEM) associated with second-generation antidepressant monotherapy in patients with rapid cycling bipolar disorder (RCBD)...
  54. doi request reprint Controlled clinical trial of zolpidem for the treatment of insomnia associated with attention-deficit/ hyperactivity disorder in children 6 to 17 years of age
    Jeffrey L Blumer
    Pediatric Pharmacology Critical Care, Rainbow Babies and Children s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Pediatrics 123:e770-6. 2009
    ..25 mg/kg per day (maximum of 10 mg/day), compared with placebo, in children 6 through 17 years of age who were experiencing insomnia associated with attention-deficit/hyperactivity disorder...
  55. pmc Correlates of historical suicide attempt in rapid-cycling bipolar disorder: a cross-sectional assessment
    Keming Gao
    Department of Psychiatry, Case Western University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Clin Psychiatry 70:1032-40. 2009
    ..A rapid-cycling course in bipolar disorder has previously been identified as a risk factor for attempted suicide. This study investigated factors associated with suicide attempts in patients with rapid-cycling bipolar I or II disorder...
  56. ncbi request reprint Discriminative validity of the general behavior inventory using youth report
    Carla Kmett Danielson
    Department of Psychology, Case Western Reserve University, Cleveland, Ohio 44106 7123, USA
    J Abnorm Child Psychol 31:29-39. 2003
    ....
  57. ncbi request reprint Who are the comorbid adolescents? Agreement between psychiatric diagnosis, youth, parent, and teacher report
    Eric A Youngstrom
    Department of Psychology, Case Western Reserve University, Cleveland, Ohio 44106 7123, USA
    J Abnorm Child Psychol 31:231-45. 2003
    ..14-.40). Results also indicate that single DSM-IV disorders, such as bipolar disorder, can manifest "comorbid" patterns of behavior problems on checklists...
  58. doi request reprint Review of pharmacotherapy options for the treatment of attention-deficit/hyperactivity disorder (ADHD) and ADHD-like symptoms in children and adolescents with developmental disorders
    Brieana M Rowles
    Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    Dev Disabil Res Rev 16:273-82. 2010
    ..This article reviews what is known about the efficacy and tolerability of pharmacological interventions for the treatment of children and adolescents suffering from developmental disorders and comorbid ADHD/ADHD-like symptoms...
  59. ncbi request reprint Employing parent, teacher, and youth self-report checklists in identifying pediatric bipolar spectrum disorders: an examination of diagnostic accuracy and clinical utility
    Shoshana Y Kahana
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 13:471-88. 2003
    ..Results indicate that the Child Behavior Checklist has limited utility when attempting to derive clinically meaningful information about the presentation of juvenile BPSD...
  60. ncbi request reprint Evaluation of risks associated with short- and long-term psychostimulant therapy for treatment of ADHD in children
    Todd Kociancic
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Expert Opin Drug Saf 3:93-100. 2004
    ..Until more extensive, methodologically rigorous data are available, it appears that judicious psychostimulant pharmacotherapy of ADHD in children may be justified...
  61. pmc Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Bipolar Disord 12:404-13. 2010
    ..It was hypothesized that illnesses of the endocrine/metabolic system would be associated with greater psychiatric symptom burden and would impact the response to treatment with lithium and valproate...
  62. pmc First-dose pharmacokinetics of lithium carbonate in children and adolescents
    Robert L Findling
    University Hospitals, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Psychopharmacol 30:404-10. 2010
    ..The developed population pharmacokinetic model may be used to predict other dosage regimens, support scaling from adult to pediatric pharmacokinetics, and support the design of future clinical trials...
  63. ncbi request reprint Prevention of postpartum depression: a pilot randomized clinical trial
    Katherine L Wisner
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    Am J Psychiatry 161:1290-2. 2004
    ..The authors attempted to reduce the rate of postpartum depression in high-risk women and to increase the time to recurrence...
  64. ncbi request reprint Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trials
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 69:1057-63. 2008
    ..To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD)...
  65. pmc Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Affect Disord 110:167-73. 2008
    ..Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions...
  66. pmc Independent predictors for lifetime and recent substance use disorders in patients with rapid-cycling bipolar disorder: focus on anxiety disorders
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Am J Addict 19:440-9. 2010
    ....
  67. ncbi request reprint Venlafaxine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 17:433-45. 2007
    ..The objectives of this pilot study were to explore the changes in symptom severity, tolerability, and the pharmacodynamics of venlafaxine treatment in youths with attention-deficit/hyperactivity disorder (ADHD)...
  68. doi request reprint Evaluation and comparison of psychometric instruments for pediatric bipolar spectrum disorders in four age groups
    Thomas W Frazier
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Child Adolesc Psychopharmacol 17:853-66. 2007
    ..The CDRS-R may be better conceptualized as a two-factor measure in older adolescents. The semistructured K-SADS interview can be used to generate reliable diagnoses across a broad age range...
  69. ncbi request reprint Sex differences in pediatric bipolar disorder
    Jeanne M Duax
    Department of Psychology, Case Western Reserve University, Cleveland, OH 44106 7123, USA
    J Clin Psychiatry 68:1565-73. 2007
    ..To explore sex differences in pediatric bipolar disorder in terms of subtype and severity of depressive and manic symptomatology...
  70. ncbi request reprint Adherence to pharmacological treatment for juvenile bipolar disorder
    Dennis Drotar
    Department of Psychiatry, Case Western Reserve University, USA
    J Am Acad Child Adolesc Psychiatry 46:831-9. 2007
    ..The objective of this study was to describe the prevalence and correlates of adherence to divalproex sodium (DVPX) and lithium carbonate (Li) combination treatment during the initial stabilization treatment phase...
  71. doi request reprint Psychopharmacology of pediatric bipolar disorders in children and adolescents
    Tiffany Thomas
    Division of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Cleveland, OH 44106 5080, USA
    Pediatr Clin North Am 58:173-87, xii. 2011
    ..Despite these new advances, further placebo-controlled trials investigating the efficacy and safety of pharmacologic treatment strategies for young people with bipolar disorder are still needed...
  72. ncbi request reprint Mood state at study entry as predictor of the polarity of relapse in bipolar disorder
    Joseph R Calabrese
    Case University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Biol Psychiatry 56:957-63. 2004
    ..We conclude that putative mood stabilizers must be tested in recently manic and recently depressed patients to determine their spectrum of prophylactic efficacy...
  73. ncbi request reprint Observed clinical and health services outcomes in pediatric inpatients treated with atypical antipsychotics: 1999-2003
    Scott C Flanders
    Ortho McNeil Janssen Scientific Affairs, L L C, Titusville, New Jersey, USA
    J Child Adolesc Psychopharmacol 17:312-27. 2007
    ..The aim of this study was to compare clinical and health services outcomes in pediatric inpatients prescribed an atypical antipsychotic (AA) to those not prescribed an AA at discharge...
  74. ncbi request reprint A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77755, USA
    Am J Psychiatry 161:1079-83. 2004
    ..The current study investigated the efficacy and safety of citalopram compared with placebo in the treatment of pediatric patients with major depression...
  75. ncbi request reprint A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/hyperactivity disorder
    Laurence L Greenhill
    New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 109:E39. 2002
    ..To compare the efficacy, safety, and tolerability of once-daily administration of modified-release methylphenidate (MPH MR) with placebo in children with attention-deficit/hyperactivity disorder (ADHD)...
  76. ncbi request reprint Double-blind, placebo-controlled trial of divalproex monotherapy in the treatment of symptomatic youth at high risk for developing bipolar disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, and the University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 68:781-8. 2007
    ..To determine if divalproex sodium was superior to placebo in the treatment of symptomatic youths who suffer from a bipolar spectrum disorder and who also have a parent with a diagnosis of a bipolar illness...
  77. ncbi request reprint A prospective study of stimulant response in preschool children: insights from ROC analyses
    Elizabeth J Short
    Department of Psychology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Am Acad Child Adolesc Psychiatry 43:251-9. 2004
    ..The purpose of this study was to examine the efficacy of psychostimulant medication in a naturalistic sample of preschoolers. Benefits and side effects for methylphenidate and mixed amphetamine salts (Adderall) were examined...
  78. ncbi request reprint Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: a drug-placebo and drug-drug response curve analysis of a naturalistic study
    Stephen V Faraone
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 5:121-9. 2002
    ..The analyses also highlight an important subgroup of placebo responders, which suggests that future research should focus on how to predict robust placebo response in ADHD patients...
  79. ncbi request reprint Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics
    Jean A Frazier
    Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
    J Am Acad Child Adolesc Psychiatry 46:979-88. 2007
    ..We examined baseline demographic and clinical profiles of youths enrolled from 2001 to 2006 in the publicly funded multicenter, randomized controlled trial Treatment of Early-Onset Schizophrenia Spectrum Disorders...
  80. ncbi request reprint Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods
    Jon McClellan
    University of Washington, Seattle, USA
    J Am Acad Child Adolesc Psychiatry 46:969-78. 2007
    ..The rationale, design, and methods of the Treatment of Early Onset Schizophrenia Spectrum Disorders Study are described...
  81. ncbi request reprint Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence
    Michael G Aman
    Nisonger Center UAP, Ohio State University, Columbus 43210 1257, USA
    Am J Psychiatry 159:1337-46. 2002
    ..The short-term efficacy and safety of risperidone in the treatment of disruptive behaviors was examined in a well-characterized cohort of children with subaverage intelligence...
  82. ncbi request reprint Toward an integration of parent and clinician report on the Young Mania Rating Scale
    Eric A Youngstrom
    Department of Psychiatry at Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA
    J Affect Disord 77:179-90. 2003
    ..The Young Mania Rating Scale (YMRS) has validity in the assessment of mania in adults. The purpose of this study was to examine how the YMRS might optimally be used in the assessment of youths...
  83. ncbi request reprint Efficacy and tolerability of lisdexamfetamine dimesylate (NRP-104) in children with attention-deficit/hyperactivity disorder: a phase III, multicenter, randomized, double-blind, forced-dose, parallel-group study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Ther 29:450-63. 2007
    ..Following ingestion, the pharmacologically active d-amphetamine molecule is gradually released by rate-limited hydrolysis...
  84. ncbi request reprint Comparing the diagnostic accuracy of six potential screening instruments for bipolar disorder in youths aged 5 to 17 years
    Eric A Youngstrom
    Department of Psychology, Case Western Reserve University, University Hospitals of Cleveland, Ohia 44106 7123, USA
    J Am Acad Child Adolesc Psychiatry 43:847-58. 2004
    ..To compare the diagnostic efficiency of six index tests as predictors of juvenile bipolar disorder in two large outpatient samples, aged 5 to 10 and 11 to 17 years, gathered from 1997 to 2002...
  85. ncbi request reprint Pharmacotherapy of aggression in a 9-year-old with ADHD
    Robert L Findling
    Department of Psychiatry, University Hospital of Cleveland Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Am Acad Child Adolesc Psychiatry 46:653-8. 2007
  86. ncbi request reprint Juvenile maladaptive aggression: a review of prevention, treatment, and service configuration and a proposed research agenda
    Daniel F Connor
    Department of Psychiatry MC1410, University of Connecticut Health Center, Farmington 06030 1410, USA
    J Clin Psychiatry 67:808-20. 2006
    ..To propose a research agenda for disorders of aggression in child and adolescent psychiatry...
  87. ncbi request reprint Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
    J Clin Psychiatry 67:827-30. 2006
    ....
  88. ncbi request reprint Risperidone in the management of disruptive behavior disorders
    Gahan J Pandina
    Medical Affairs Division, Janssen Pharmaceutica Products, L P, Titusville, New Jersey, USA
    J Child Adolesc Psychopharmacol 16:379-92. 2006
    ..As with all antipsychotics, practitioners should monitor young patients' growth, weight, sexual maturation, and metabolic parameters...
  89. ncbi request reprint Comparing the effects of sampling designs on the diagnostic accuracy of eight promising screening algorithms for pediatric bipolar disorder
    Eric Youngstrom
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    Biol Psychiatry 60:1013-9. 2006
    ..The present investigation compared eight screening algorithms in the same sample but under two different design strategies...
  90. ncbi request reprint A pilot evaluation of the safety, tolerability, pharmacokinetics, and effectiveness of memantine in pediatric patients with attention-deficit/hyperactivity disorder combined type
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University and Division of Child and Adolescent Psychiatry, University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 17:19-33. 2007
    ..Disturbances in N-methyl-D-aspartate (NMDA) receptor activity may play a role in attention-deficit/hyperactivity disorder (ADHD)...
  91. doi request reprint Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study
    Linmarie Sikich
    University of North Carolina at Chapel Hill, NC 27514, USA
    Am J Psychiatry 165:1420-31. 2008
    ....
  92. ncbi request reprint Venlafaxine ER for the treatment of pediatric subjects with depression: results of two placebo-controlled trials
    Graham J Emslie
    University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    J Am Acad Child Adolesc Psychiatry 46:479-88. 2007
    ....
  93. ncbi request reprint A pilot controlled trial of topiramate for mania in children and adolescents with bipolar disorder
    Melissa P DelBello
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Am Acad Child Adolesc Psychiatry 44:539-47. 2005
    ..To assess the efficacy of topiramate monotherapy for acute mania in children and adolescents with bipolar disorder type I...
  94. ncbi request reprint Risperidone in children with disruptive behavior disorders and subaverage intelligence: a 1-year, open-label study of 504 patients
    Jan Croonenberghs
    University Center of Child and Adolescent Psychiatry, University of Antwerp, Belgium
    J Am Acad Child Adolesc Psychiatry 44:64-72. 2005
    ..To determine the long-term safety and effectiveness of risperidone for severe disruptive behaviors in children...
  95. ncbi request reprint Fluoxetine treatment for prevention of relapse of depression in children and adolescents: a double-blind, placebo-controlled study
    Graham J Emslie
    University of Texas Southwestern Medical Center at Dallas, Texas, USA
    J Am Acad Child Adolesc Psychiatry 43:1397-405. 2004
    ....
  96. ncbi request reprint Update on pediatric bipolar disorder
    Lisa D Townsend
    Child and Adolescent Psychiatry, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    Curr Psychiatry Rep 9:529-34. 2007
    ....
  97. ncbi request reprint Comparison of the clinical efficacy of twice-daily Ritalin and once-daily Equasym XL with placebo in children with Attention Deficit/Hyperactivity Disorder
    Robert L Findling
    Discovery and Wellness Center for Children, Dept of Psychiatry, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    Eur Child Adolesc Psychiatry 15:450-9. 2006
    ....
  98. pmc Pediatric bipolar disorder: validity, phenomenology, and recommendations for diagnosis
    Eric A Youngstrom
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Bipolar Disord 10:194-214. 2008
    ..To find, review, and critically evaluate evidence pertaining to the phenomenology of pediatric bipolar disorder and its validity as a diagnosis...
  99. ncbi request reprint Quetiapine in nine youths with autistic disorder
    Robert L Findling
    Departments of Psychiatry and Pediatrics, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    J Child Adolesc Psychopharmacol 14:287-94. 2004
    ..The aim of this study was to examine the effectiveness of quetiapine in adolescents suffering from autistic disorder (AD)...
  100. ncbi request reprint Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD
    Robert M Post
    J Clin Psychiatry 65:898-902. 2004
  101. ncbi request reprint A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77755 0188, USA
    Am J Psychiatry 163:1179-86. 2006
    ..This multicenter trial examined the efficacy and safety of oxcarbazepine in the treatment of bipolar disorder in children and adolescents...

Research Grants14

  1. 3/4-Stimulant and Risperidone for Youth with Severe Physical Aggression
    Robert Findling; Fiscal Year: 2009
    ..Given the increasing rates and severity of violence in our society, this investigation will help to determine if drug therapy, combined with parent-provided behavior therapy, can reduce child aggression. ..
  2. 3/4-Stimulant and Risperidone for Youth with Severe Physical Aggression
    Robert L Findling; Fiscal Year: 2010
    ..Given the increasing rates and severity of violence in our society, this investigation will help to determine if drug therapy, combined with parent-provided behavior therapy, can reduce child aggression. ..
  3. 3/4-Stimulant and Risperidone for Youth with Severe Physical Aggression
    Robert Findling; Fiscal Year: 2009
    ..Given the increasing rates and severity of violence in our society, this investigation will help to determine if drug therapy, combined with parent-provided behavior therapy, can reduce child aggression. ..
  4. Longitudinal Assessment of Manic Symptoms
    Robert Findling; Fiscal Year: 2009
    ..The proposed research will also lend clarification to current controversies regarding the differential diagnosis between bipolar spectrum disorders and ADHD in children. ..
  5. Longitudinal Assessment of Manic Symptoms
    Robert Findling; Fiscal Year: 2007
    ..The proposed research will also lend clarification to current controversies regarding the differential diagnosis between bipolar spectrum disorders and ADHD in children. ..
  6. Longitudinal Assessment of Manic Symptoms
    Robert Findling; Fiscal Year: 2006
    ..The proposed research will also lend clarification to current controversies regarding the differential diagnosis between bipolar spectrum disorders and ADHD in children. ..
  7. PEDIATRIC BIPOLAR COLLABORATIVE MOOD STABILZER TRAIL
    Robert Findling; Fiscal Year: 2003
    ..Lastly, this trial will provide descriptive information on the stability of acute phase response to monotherapy over a 16 week continuation phase. ..
  8. Longitudinal Assessment of Manic Symptoms
    Robert L Findling; Fiscal Year: 2010
    ....