Caleb Finch

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Progesterone antagonism of neurite outgrowth depends on microglial activation via Pgrmc1/S2R
    N Bali
    Molecular Biology Program, University of Southern California, Los Angeles, CA 90089, USA
    Endocrinology 154:2468-80. 2013
  2. pmc Age increase of estrogen receptor-α (ERα) in cortical astrocytes impairs neurotrophic support in male and female rats
    Jason M Arimoto
    Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191, USA
    Endocrinology 154:2101-13. 2013
  3. pmc Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging
    Caleb E Finch
    Ethel Percy Andrus Gerontology Center, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089 0191
    Age (Dordr) 34:1075-91. 2012
  4. ncbi request reprint History and prospects: symposium on organisms with slow aging
    C E Finch
    Ethel Percy Andrus Gerontology Center, University of Southern California, 3715 McClintock, Los Angeles, CA 90089 0191, USA
    Exp Gerontol 36:593-7. 2001
  5. ncbi request reprint Developmental origins of aging in brain and blood vessels: an overview
    Caleb E Finch
    Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
    Neurobiol Aging 26:281-91. 2005
  6. ncbi request reprint Inflammatory exposure and historical changes in human life-spans
    Caleb E Finch
    Andrus Gerontology Center and Departments of Biological Sciencesand of Sociology, University of Southern California, Los Angeles, CA 90089, USA
    Science 305:1736-9. 2004
  7. ncbi request reprint Meat-adaptive genes and the evolution of slower aging in humans
    Caleb E Finch
    Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Q Rev Biol 79:3-50. 2004
  8. ncbi request reprint Synapses everlasting: the passion of Carl Cotman
    Caleb E Finch
    Andrus Gerontology Center and Department of Biological Science, University of Southern California, Los Angeles California, USA
    Neurochem Res 28:1615-6. 2003
  9. ncbi request reprint Neurons, glia, and plasticity in normal brain aging
    Caleb E Finch
    Department of Biological Sciences, Ethel Percy Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Neurobiol Aging 24:S123-7; discussion S131. 2003
  10. ncbi request reprint Third Annual Leonard Berg Symposium: final thoughts and future directions
    Caleb E Finch
    Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 17:S72. 2003

Detail Information

Publications70

  1. pmc Progesterone antagonism of neurite outgrowth depends on microglial activation via Pgrmc1/S2R
    N Bali
    Molecular Biology Program, University of Southern California, Los Angeles, CA 90089, USA
    Endocrinology 154:2468-80. 2013
    ..We suggest that microglial activation may influence brain responses to exogenous P4, which is a prospective therapy in traumatic brain injury. ..
  2. pmc Age increase of estrogen receptor-α (ERα) in cortical astrocytes impairs neurotrophic support in male and female rats
    Jason M Arimoto
    Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191, USA
    Endocrinology 154:2101-13. 2013
    ..These findings suggest that increased astrocyte ERα expression during aging contributes to the E2 desensitization of the neuronal responses in both sexes...
  3. pmc Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging
    Caleb E Finch
    Ethel Percy Andrus Gerontology Center, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089 0191
    Age (Dordr) 34:1075-91. 2012
    ....
  4. ncbi request reprint History and prospects: symposium on organisms with slow aging
    C E Finch
    Ethel Percy Andrus Gerontology Center, University of Southern California, 3715 McClintock, Los Angeles, CA 90089 0191, USA
    Exp Gerontol 36:593-7. 2001
    ..We also introduce some of the species discussed in subsequent chapters which are unfamiliar models to most biomedical researchers...
  5. ncbi request reprint Developmental origins of aging in brain and blood vessels: an overview
    Caleb E Finch
    Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
    Neurobiol Aging 26:281-91. 2005
    ..These findings give a basis for considering inflammatory processes early in life which can lead to fully fired pathogenesis of cardiovascular disease and possibly for Alzheimer disease...
  6. ncbi request reprint Inflammatory exposure and historical changes in human life-spans
    Caleb E Finch
    Andrus Gerontology Center and Departments of Biological Sciencesand of Sociology, University of Southern California, Los Angeles, CA 90089, USA
    Science 305:1736-9. 2004
    ..We propose that a "cohort morbidity phenotype" represents inflammatory processes that persist from early age into adult life...
  7. ncbi request reprint Meat-adaptive genes and the evolution of slower aging in humans
    Caleb E Finch
    Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Q Rev Biol 79:3-50. 2004
    ..Other evolved genes mediate lipid metabolism and host defense. The timing of the evolution of apoE and other candidates for meat-adaptive genes is discussed in relation to key events in human evolution...
  8. ncbi request reprint Synapses everlasting: the passion of Carl Cotman
    Caleb E Finch
    Andrus Gerontology Center and Department of Biological Science, University of Southern California, Los Angeles California, USA
    Neurochem Res 28:1615-6. 2003
  9. ncbi request reprint Neurons, glia, and plasticity in normal brain aging
    Caleb E Finch
    Department of Biological Sciences, Ethel Percy Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Neurobiol Aging 24:S123-7; discussion S131. 2003
    ..Lastly, it is discussed how developmental variations in the numbers of Purkinje cells and ovarian oocytes can be factors in outcomes of aging that are not under strict genetic control...
  10. ncbi request reprint Third Annual Leonard Berg Symposium: final thoughts and future directions
    Caleb E Finch
    Andrus Gerontology Center, University of Southern California, Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 17:S72. 2003
  11. ncbi request reprint The biology of aging in model organisms
    Caleb E Finch
    Andrus Gerontology Center and Department of Biological Sciences, University of Souther California, Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 17:S39-41. 2003
  12. pmc The neurotoxicology of hard foraging and fat-melts
    Caleb E Finch
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 101:17887-8. 2004
  13. ncbi request reprint The genetics of aging
    C E Finch
    Andrus Gerontology Center and Department Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
    Annu Rev Genomics Hum Genet 2:435-62. 2001
    ..Thus, genetic approaches may identify a set of circuits that was established in ancestral metazoans to regulate their longevity...
  14. ncbi request reprint Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper
    Caleb E Finch
    Davis School of Gerontology and USC College, Dept Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Curr Alzheimer Res 4:185-9. 2007
    ..As human lifespan lengthened and cognitive and cardiovascular health became more important, the apoE3 allele spread, while the E4 allele was maintained in all populations by balancing selection...
  15. pmc Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis
    Namrata Bali
    University of Southern California Dornsife College of Letters, Arts and Sciences, Los Angeles, California 90089 0191, USA
    Endocrinology 153:759-69. 2012
    ..The differential regulation of hippocampal Pgrmc1 and Pgr by E2 and P4 may guide drug development in hormonal therapy for support of neurogenesis and synaptic regeneration...
  16. doi request reprint Atherosclerosis is an old disease: Summary of the Ruffer Centenary Symposium, The Paleocardiology of Ancient Egypt, a meeting report of the Horus Study team
    Caleb E Finch
    Andrus Gerontology Center and Dept of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States
    Exp Gerontol 46:843-6. 2011
    ..Further research is needed to develop an epidemiological context for estimating population level prevalence of vascular disease and its risk factors in ancient Egyptian societies...
  17. ncbi request reprint Environmental influences that may precede fertilization: a first examination of the prezygotic hypothesis from maternal age influences on twins
    C E Finch
    Andrus Gerontology Center, University of Southern California, Los Angeles 90089 0191, USA
    Behav Genet 28:101-6. 1998
    ..While no differences between MZ and DZ pairs were found that would indicate a major effect of the prezygotic environment, suggestions are made for further experimental studies of this unexplored question in human development...
  18. pmc Cell resilience in species life spans: a link to inflammation?
    Caleb E Finch
    University of Southern California, Los Angeles, CA 90089 0191, USA
    Aging Cell 9:519-26. 2010
    ..We suggest expanding the battery of stressors and markers used for comparative studies to additional cell types and additional parameters relevant to host defense and to their ecological specificities...
  19. doi request reprint Update on slow aging and negligible senescence--a mini-review
    Caleb E Finch
    Department of Biological Sciences, Davis School of Gerontology and the USC College, University of Southern California, Los Angeles, Calif 90089 0191, USA
    Gerontology 55:307-13. 2009
    ..However, centenarians certainly do not show negligible senescence...
  20. ncbi request reprint Neurons, glia, and plasticity in normal brain aging
    C E Finch
    Andrus Gerontology Center, Dept Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Adv Gerontol 10:35-9. 2002
    ..Lastly, I discuss how developmental variations in the numbers of Purkinje cells and ovarian oocytes can be factors in outcomes of aging that are not under strict genetic control...
  21. ncbi request reprint A perspective on sporadic inclusion-body myositis: the role of aging and inflammatory processes
    Caleb E Finch
    Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Neurology 66:S1-6. 2006
    ....
  22. ncbi request reprint Variations in senescence and longevity include the possibility of negligible senescence
    C E Finch
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Gerontol A Biol Sci Med Sci 53:B235-9. 1998
    ..A tissue bank is urgently needed to provide specimens of long-lived organisms for study of possible antiaging mechanisms that permit achievement of great ages...
  23. ncbi request reprint Infrastructure for research on aging rodents: need for regional facilities to support transgenic studies on aging
    C E Finch
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles 90089 0191, USA
    Neurobiol Aging 20:213-5. 1999
    ..A national system of regional facilities with Core labs for characterizing genetics, hormones, and pathology would greatly accelerate progress...
  24. ncbi request reprint The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms
    C E Finch
    Neurogerontology Division, Andrus Gerontology Center and University of Southern California, Los Angeles 90089 0191, USA
    Neurobiol Aging 20:407-28. 1999
    ..In discussing theses possibilities, we review the diverse bioactivities of apoE, which include involvement in hormone systems. The evolution of menopause is also considered in relation to the protective effect of estrogen on AD...
  25. ncbi request reprint Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro
    Z Xie
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, 90089, USA
    J Neurochem 93:1038-46. 2005
    ..As a functional measure, apoJ-activated microglia secreted neurotoxic agents in a microglia-neuron co-culture model. We hypothesize that ApoJ contributes to chronic inflammation and neurotoxicity through direct effects on microglia...
  26. ncbi request reprint Variations of synaptotagmin I, synaptotagmin IV, and synaptophysin mRNA levels in rat hippocampus during the estrous cycle
    M Crispino
    Neuroscience Program, University of Southern California, Los Angeles, California, 90089 2520, USA
    Exp Neurol 159:574-83. 1999
    ....
  27. ncbi request reprint Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro
    I Rozovsky
    Neurogerontology Division, Andrus Gerontology Center, Los Angeles, CA
    Neuroscience 62:741-58. 1994
    ..These increased messenger RNAs were associated with immunoreactive deposits that differed by cell type and intra- versus extracellular locations. These results suggest that the complement system is involved in brain responses to injury...
  28. ncbi request reprint Transforming growth factor-beta1 induces transforming growth factor-beta1 and transforming growth factor-beta receptor messenger RNAs and reduces complement C1qB messenger RNA in rat brain microglia
    T E Morgan
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Neuroscience 101:313-21. 2000
    ..The auto-induction of the transforming growth factor-beta1 system has implications for transgenic mice that overexpress transforming growth factor-beta1 in brain cells and for its potential role in amyloidogenesis...
  29. ncbi request reprint Anti-inflammatory mechanisms of dietary restriction in slowing aging processes
    T E Morgan
    Leonard Davis School of Gerontology and USC College, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA
    Interdiscip Top Gerontol 35:83-97. 2007
    ..Increasing evidence suggests that common pathways are emerging that link many normal aging inflammatory processes with age-related diseases such as Alzheimer, cancer, diabetes and cardiovascular disease...
  30. ncbi request reprint Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines
    V D Longo
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurochem 75:1977-85. 2000
    ..Abeta neurotoxicity was partially blocked by the iron chelator deferoxamine. These data suggest that increased superoxide generation and the release of iron from 4Fe-4S clusters are early events in Abeta1-42 neurotoxicity...
  31. ncbi request reprint Bidirectional transcription regulation of glial fibrillary acidic protein by estradiol in vivo and in vitro
    D J Stone
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles 90089 0191, USA
    Endocrinology 139:3202-9. 1998
    ..We conclude that estrogen may act directly upon astrocytes by estrogen receptor binding, and that the direction of the transcriptional response is influenced by astrocyte-neuron interactions...
  32. ncbi request reprint C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis
    R P Grewal
    Department of Neurology, School of Medicine, University of Southern California, Los Angeles 90089 1340, USA
    Neurosci Lett 271:65-7. 1999
    ..By in situ hybridization, SALS spinal cords showed increased C1qB and clusterin mRNA in areas undergoing neurodegeneration. This evidence implicates inflammatory mechanisms during neurodegenerative processes in SALS...
  33. ncbi request reprint Can estrogens prevent neurodegeneration?
    L S Schneider
    University of Southern California, School of Medicine, Los Angeles, USA
    Drugs Aging 11:87-95. 1997
    ..Although basic research will progress, there is currently sufficient knowledge to promote active clinical research on the possible disease-modifying or neuroprotective effects of estrogens in the elderly...
  34. ncbi request reprint Alzheimer's disease and some speculations about the evolution of its modifiers
    R M Sapolsky
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Ann N Y Acad Sci 924:99-103. 2000
    ..We analyze this in the context of the altricial nature of new-born primates, their long period of dependency on competent maternal care, and the requirement of cognitive intactness for such competency...
  35. ncbi request reprint The glucocorticoid paradox of caloric restriction in slowing brain aging
    N V Patel
    Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA
    Neurobiol Aging 23:707-17. 2002
    ....
  36. ncbi request reprint Messenger RNA for glial fibrillary acidic protein is decreased in rat brain following acute and chronic corticosterone treatment
    N R Nichols
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 0191
    Brain Res Mol Brain Res 7:1-7. 1990
    ....
  37. pmc Inflammation and infection do not promote arterial aging and cardiovascular disease risk factors among lean horticulturalists
    Michael Gurven
    Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA
    PLoS ONE 4:e6590. 2009
    ..In contrast, moderate to vigorous daily activity, minimal obesity, and low fat intake predict minimal CVD risk among older Tsimane...
  38. ncbi request reprint Expression of complement C1qB and C4 mRNAs during rat brain development
    S A Johnson
    Neurogerontology Division, Andrus Gerontology Center, University of Southern California, Los Angeles 90089 0191
    Brain Res Dev Brain Res 80:163-74. 1994
    ..We suggest that C1q and C4 components have novel roles during brain development that may be unrelated to normal cytotoxic actions of the activated classical C cascade...
  39. ncbi request reprint Complement activation in very early Alzheimer disease
    H Zanjani
    Andrus Gerontology Center and Department of Biological Science, University of Southern California Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 19:55-66. 2005
    ..However, C-system regulators CD59, CR1, DAF, and MCP were not detected on plaques or tangles at any stage, indicating that C-activation related to AD is incompletely controlled...
  40. ncbi request reprint Learning induces a CDC2-related protein kinase, KKIAMRE
    H Gomi
    Neuroscience Program, University of Southern California, Los Angeles, California 90089 2520, USA
    J Neurosci 19:9530-7. 1999
    ..These results suggest that there is a new category of cdc2-related kinases in the brain whose function may be important in learning and memory...
  41. ncbi request reprint Chronic lesions differentially decrease tyrosine hydroxylase messenger RNA in dopaminergic neurons of the substantia nigra
    G M Pasinetti
    Andrus Gerontology Center, University of Southern California, Los Angeles 90089 0191
    Brain Res Mol Brain Res 5:203-9. 1989
    ..We propose that chronic lesions have long-term effects on gene expression because of damage sustained during compensatory hyperactivity after the lesion, or because of decreased trophic support from other neurons...
  42. ncbi request reprint Progressive changes in regulation of apolipoproteins E and J in glial cultures during postnatal development and aging
    Nilay V Patel
    Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
    Neurosci Lett 371:199-204. 2004
    ..These differences may contribute to age-related neuroinflammatory processes, and are pertinent to the general use of neonatal-derived primary glia in models for neurodegenerative disease...
  43. ncbi request reprint Equine estrogens induce apolipoprotein E and glial fibrillary acidic protein in mixed glial cultures
    Irina Rozovsky
    Neurogerontology Division, Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintoch Avenue, Los Angeles, CA 90089 0191, USA
    Neurosci Lett 323:191-4. 2002
    ....
  44. ncbi request reprint Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia
    Zhong Xie
    Division of Biogerontology, Andrus Gerontology Center, and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurosci 22:3484-92. 2002
    ..These results implicate peroxynitrite as a mediator of the toxicity of activated microglia, which may play a major role in Abeta1-42 neurotoxicity and Alzheimer's disease...
  45. ncbi request reprint A proposal to sequence genomes of unique interest for research on aging
    João Pedro de Magalhães
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Gerontol A Biol Sci Med Sci 62:583-4. 2007
  46. pmc Progesterone receptors: form and function in brain
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Front Neuroendocrinol 29:313-39. 2008
    ....
  47. ncbi request reprint Evolutionary medicine: from dwarf model systems to healthy centenarians?
    Valter D Longo
    Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Science 299:1342-6. 2003
    ..This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects...
  48. pmc Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    Yuesong Gong
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 100:10417-22. 2003
    ..Current results confirm the prediction that soluble oligomeric A beta ligands are intrinsic to AD pathology, and validate their use in new approaches to therapeutic AD drugs and vaccines...
  49. ncbi request reprint Aging and increased hypothalamic glial fibrillary acid protein (GFAP) mRNA in F344 female rats. Dissociation of GFAP inducibility from the luteinizing hormone surge
    Christopher P Anderson
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, Calif, USA
    Neuroendocrinology 76:121-30. 2002
    ..The aging rats also showed higher levels of GFAP mRNA in the arcuate nucleus and ventromedial nucleus, consistent with the general trend for elevated GFAP mRNA during aging in other brain regions and in both sexes...
  50. ncbi request reprint Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity
    Zhong Xie
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Exp Neurol 182:135-41. 2003
    ..Thus, glial activation during aging shows regional selectivity in cytokine expression, with opposite effects of aging on the increased inducibility of IL-1 and IL-6 vs the decreased production of nitric oxide...
  51. ncbi request reprint Ageing: the old worm turns more slowly
    Thomas B L Kirkwood
    Nature 419:794-5. 2002
  52. ncbi request reprint Differential patterns of age-related mortality increase in middle age and old age
    Shiro Horiuchi
    Laboratory of Populations, Rockefeller University, New York, NY 10021, USA
    J Gerontol A Biol Sci Med Sci 58:495-507. 2003
    ....
  53. ncbi request reprint Cytokines and cognition--the case for a head-to-toe inflammatory paradigm
    Craig J Wilson
    St Vincent Institute on Aging, St Vincent Hospitals and Health Services, Indianapolis, Indiana 46260, USA
    J Am Geriatr Soc 50:2041-56. 2002
    ..Given the multiple levels at which cytokines are capable of influencing cognition it is plausible that peripheral cytokine dysregulation with advancing age interacts with cognitive aging...
  54. ncbi request reprint Commentary: do older men and women gain equally from improving childhood conditions?
    Eileen M Crimmins
    Andrus Gerontology Center, and USC College, Department of Biological Sciences and Sociology, University of Southern California, Los Angeles, CA 90089 0191, USA
    Int J Epidemiol 35:1270-1. 2006
  55. pmc Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase
    Mohammad Ali Faghihi
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, Florida 33458, USA
    Nat Med 14:723-30. 2008
    ..In summary, we report that a long noncoding RNA is directly implicated in the increased abundance of Abeta 1-42 in Alzheimer's disease...
  56. ncbi request reprint Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
    ..Results suggest the hypothesis that targeting and functional disruption of particular synapses by Abeta oligomers may provide a molecular basis for the specific loss of memory function in early AD...
  57. ncbi request reprint Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin
    Irina Rozovsky
    Neurogerontology Division, Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089 0191, USA
    Endocrinology 143:636-46. 2002
    ....
  58. ncbi request reprint Caliban's heritance and the genetics of neuronal aging
    Bruce Teter
    Department of Medicine, University of California Los Angeles, 16111 Plummer Street, Sepulveda, CA 91343, USA
    Trends Neurosci 27:627-32. 2004
    ....
  59. ncbi request reprint Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP
    Irina Rozovsky
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089 0191, USA
    Neurobiol Aging 26:705-15. 2005
    ..These results implicate increased astrocytic GFAP expression as a proximal cause of neuron atrophy during normal aging...
  60. ncbi request reprint Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models
    Nilay V Patel
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Neurobiol Aging 26:995-1000. 2005
    ....
  61. ncbi request reprint The aging factor in health and disease: the promise of basic research on aging
    Robert N Butler
    International Longevity Center USA, Alliance for Health and the Future, and Department of Geriatrics, Mount Sinai Medical Center, New York, NY 10028, USA
    Aging Clin Exp Res 16:104-11; discussion 111-2. 2004
  62. ncbi request reprint What is aging? What is its role in Alzheimer's disease? What can we do about it?
    J Wesson Ashford
    Stanford VA Alzheimer Center, Palo Alto, CA 94304 1207, USA
    J Alzheimers Dis 7:247-53; discussion 255-62. 2005
  63. ncbi request reprint Macrosialin increases during normal brain aging are attenuated by caloric restriction
    Angela M Wong
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Neurosci Lett 390:76-80. 2005
    ..Thus, the previously documented increase in oxidized lipoproteins, inflammation, and microglial activation during normal aging may contribute to the age-related increase in macrosialin expression...
  64. pmc Infection, inflammation, height, and longevity
    Eileen M Crimmins
    Andrus Gerontology Center, College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Proc Natl Acad Sci U S A 103:498-503. 2006
    ..Thus, early growth and cardiovascular diseases of old age may share infectious and inflammatory causes rooted in the external environment...
  65. ncbi request reprint Ovarian aging in two species of long-lived rockfish, Sebastes aleutianus and S. alutus
    Jan Peter de Bruin
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Biol Reprod 71:1036-42. 2004
    ..These species represent an iteroparous extreme in the spectrum of life history strategies and merit investigation to determine the mechanisms for such an extended reproductive life span...
  66. ncbi request reprint Bernard Strehler--inspiration for basic research into the mechanisms of aging
    Caleb E Finch
    Ethel Percy Andrus Gerontology Center and the Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, 90089 0191, Los Angeles, CA, USA
    Mech Ageing Dev 123:827-9. 2002
  67. ncbi request reprint What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Mech Ageing Dev 126:439-43. 2005
    ..In this article we review what is currently understood about the factors underlying the variability of life span and consider the implications for research that aims to improve the predictability of health in old age...
  68. pmc Gene Aging Nexus: a web database and data mining platform for microarray data on aging
    Fei Pan
    Department of Biological Sciences, University of Southern California Los Angeles, CA 90089, USA
    Nucleic Acids Res 35:D756-9. 2007
    ..By providing the possibility of integrative microarray analysis, GAN should be useful in building the systems-biology understanding of aging. GAN is accessible at http://gan.usc.edu...
  69. ncbi request reprint Genetics of aging and diseases: from rare mutations and model systems to disease prevention
    Valter D Longo
    Arch Neurol 59:1706-8. 2002
  70. ncbi request reprint Self-assembly of Abeta(1-42) into globular neurotoxins
    Brett A Chromy
    Biodefense Division, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L 446, Livermore, California 94551, USA
    Biochemistry 42:12749-60. 2003
    ..The observed neurotoxicity, structure, and stability of synthetic Abeta(1-42) globular assemblies support the hypothesis that Abeta(1-42) oligomers play a role in triggering nerve cell dysfunction and death in Alzheimer's disease...

Research Grants15

  1. CRP, inflammation, and neurodegeneration during aging
    Caleb Finch; Fiscal Year: 2006
    ..F1 hybrids will be made with APPswe/ind and the existing systemic huCRPtg (Y1) and with the neuron-specific huCRPtg (when available). The F1 hybrids will be examined for changes in deposits of Abeta-amyloid. ..
  2. ApoJ (Clusterin) in Alzheimer's Disease and Aging
    Caleb Finch; Fiscal Year: 2006
    ..In vitro studies with primary glial cultures from wildtype and apoJ-deficient mice will examine mechanisms of apoJ in microglial activation and in the sensitivity of neurons to AB. ..
  3. 'Training in Endocrinology and Neurobiology of Aging'
    Caleb Finch; Fiscal Year: 2006
    ..Opportunities for human studies on aging, including ethnic differences in aging processes, are provided through the Alzheimer Disease Research Center and the Diabetes Research Center. ..
  4. SYMPOSIUM ON ORGANISMS WITH SLOW AGING
    Caleb Finch; Fiscal Year: 2002
    ..A volunteer poster session will expand the range of organisms on the formal program and support the development of further interests by students and by researchers not so far identified with this new area. ..
  5. APOJ (CLUSTERIN) IN ALZHEIMER DISEASE AND AGING
    Caleb Finch; Fiscal Year: 2000
    ....
  6. 'Training in Endocrinology and Neurobiology of Aging'
    Caleb Finch; Fiscal Year: 2007
    ..Opportunities for human studies on aging, including ethnic differences in aging processes, are provided through the Alzheimer Disease Research Center and the Diabetes Research Center. ..