Research Topics
Genomes and GenesSpecies | Robert FinbergSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognitionJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 177:7114-21. 2006..A greater understanding of viral RNA-TLR7 activity relationships will promote rational approaches to interventional and vaccine strategies for important human viral pathogens...- Epstein-Barr virus-specific T cells for the management of Epstein-Barr virus lymphomasR W Finberg
University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Curr Opin Oncol 13:349-53. 2001..Current research involves optimizing methods to expand cells that recognize the EBV antigens expressed in the lymphoma cells... - Viruses and Toll-like receptorsRobert W Finberg
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 228, Worcester, MA 01605, USA
Microbes Infect 6:1356-60. 2004..Known roles for different TLRs and speculation as to their roles in viral pathogenesis and immunity are discussed in this review... - Toll like receptors and virusesRobert W Finberg
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Rev Med Virol 17:35-43. 2007..A greater understanding of relationships between viruses or viral products and TLRs should improve understanding of pathogenesis and lead to the development of new anti-viral therapies... - Cell activation by Toll-like receptors: role of LBP and CD14Robert W Finberg
Department of Medicine, University of Massachusetts Medical School, 264 Plantation Street, Worcester, Massachusetts 01605, USA
J Endotoxin Res 10:413-8. 2004..Here we report on the role of these proteins in the response to yeast zymosan. The requirements for this response (which unlike the response to LPS is a response to a particulate antigen) and the role of other serum proteins are defined... - The importance of bactericidal drugs: future directions in infectious diseaseRobert W Finberg
University of Massachusetts Medical Center, Worcester, MA 01655, USA
Clin Infect Dis 39:1314-20. 2004..Although a considerable amount of research has gone into the study of the role of bactericidal versus bacteriostatic antimicrobial agents in the treatment of different infectious diseases, there is no accepted standard of practice... - MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infectionShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, Worcester, USA
Eur J Immunol 35:822-30. 2005..We demonstrate that TLR-mediated responses are important in the innate immune response to LCMV and that MyD88 is essential for the control of the LCMV infection and the maturation/activation of virus-specific CD8(+) T cells... - Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activationAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Gastroenterology 127:1513-24. 2004..The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 proteins... 
Respiratory syncytial virus activates innate immunity through Toll-like receptor 2Matthew R Murawski
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, Massachusetts 01605, USA
J Virol 83:1492-500. 2009..Additionally, TLR2 interactions with RSV promoted neutrophil migration and dendritic cell activation within the lung. Collectively, these studies indicate that TLR2 is involved in RSV recognition and subsequent innate immune activation...- The role of toll-like receptors in herpes simplex infection in neonatesEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Infect Dis 191:746-8. 2005..This may explain the sepsis syndrome that is seen with HSV (and other virus infections) in neonates... - MyD88 intrinsically regulates CD4 T-cell responsesShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
J Virol 83:1625-34. 2009.... - Discovery of a novel TLR2 signaling inhibitor with anti-viral activityShenghua Zhou
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605 2216, USA
Antiviral Res 87:295-306. 2010..We also demonstrated that E567 inhibits cytokine responses in the mouse. Remarkably, E567 is also capable of inhibiting LCMV replication in mice. This is a new model for developing drugs for use in treating viral illnesses... 
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signalingFrantisek Sandor
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605 2324, USA
J Cell Biol 162:1099-110. 2003..The domains from each receptor did not need to be contained within a single contiguous protein. Chimeric TLR analysis further defined the toll/IL-1R domains as the area of crucial intracellular TLR1-TLR2 interaction...- Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infectionShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
J Immunol 178:5173-81. 2007..We believe that these results explain how the route of infection, probably by virtue of activating different cell populations, can lead to entirely different outcomes of infection based on the underlying genetics of the host... - Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivoEva Szomolanyi-Tsuda
Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
J Virol 80:4286-91. 2006..Our studies suggest that in addition to the reported involvement of TLR9 and TLR3, TLR2 is also involved in innate immune responses to MCMV infection... - Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responsesShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
J Neuroimmunol 194:70-82. 2008..These results define a functional role for TLR signaling in viral infection-induced activation of CNS glial cells as well as for the immunopathology in the CNS... - Toll-like receptor-mediated activation of neutrophils by influenza A virusJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Blood 112:2028-34. 2008..These studies demonstrate neutrophil activation by influenza virus and highlight the importance of TLR7 and TLR8 in that response... - MDA5 and MAVS mediate type I interferon responses to coxsackie B virusJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Virol 84:254-60. 2010..These data highlight the importance of type I interferon in host defense and provide insight on the mechanisms of innate immune responses following coxsackievirus infection... - Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virusShenghua Zhou
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Virol 84:9452-62. 2010..These virus-host interactions may play important roles in the pathogeneses of LCMV and other human arenavirus diseases... - Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteinsLori W McGinnes
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Room S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
J Virol 85:366-77. 2011..These results suggest that these VLPs are effective RSV vaccines in mice, in contrast to other nonreplicating RSV vaccine candidates... - Herpes simplex virus and toll-like receptorsRobert W Finberg
Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Viral Immunol 18:457-65. 2005..This review focuses on the interaction between Toll-like receptors, a critical component of the innate immune system of mammals, and their role in herpes simplex pathogenesis and immunity... - Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophilsEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
Blood 100:1860-8. 2002..Thus, our studies demonstrate that GM-CSF dramatically enhances the functional response of neutrophils to TLR2 ligands, including LPS-associated lipopeptides... - Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitisEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 101:1315-20. 2004..Thus, these studies suggest the TLR2-mediated cytokine response to HSV-1 is detrimental to the host... - Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificityEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building Room 226, Worcester, Massachusetts 01605, USA
J Endotoxin Res 10:419-24. 2004..MEF cultures are homogenous and amenable to biochemical analysis and should allow rigorous studies of the contribution of individual TLRs to the innate immune response... - Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNAJennifer P Wang
Department of Medicine, University of Massachusetts, 364 Plantation, Worcester, MA 01605, USA
J Immunol 178:3363-7. 2007..These data define a pathway by which intracellular TLR7 senses viral RNA and indicate a role for TLRs in association with Abs in sustaining virus-specific responses... - Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2Jennifer P Wang
Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
J Virol 79:12658-66. 2005..Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection... - Innate immunity to respiratory virusesJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Cell Microbiol 9:1641-6. 2007..We also provide an overview of the current knowledge of regulation of type I interferons and inflammatory cytokines in viral infection... - R753Q single-nucleotide polymorphism impairs toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteinsRobert A Brown
Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Transplantation 89:811-5. 2010..Individuals with the R753Q single-nucleotide polymorphism (SNP) in the TLR2 gene have increased the risk of allograft failure after liver transplantation for chronic hepatitis C... 
Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particlesChristine A St Pierre
Department of Medicine, University of Massachusetts Medical School, Lazare Research Building, Room 228, 364 Plantation Street, Worcester, Massachusetts 01605, USA
J Orthop Res 28:1418-24. 2010..Efficacy of IL-1Ra treatment introduces the potential for antagonist-based therapies for implant osteolysis...- Newcastle disease virus-like particles containing respiratory syncytial virus G protein induced protection in BALB/c mice, with no evidence of immunopathologyMatthew R Murawski
Department of Molecular Genetics, University of Massachusetts Medical School, Rm S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
J Virol 84:1110-23. 2010..These data support further development of virus-like particle vaccine candidates for protection against RSV... - CD14: chaperone or matchmaker?Robert W Finberg
University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Immunity 24:127-9. 2006..In this issue of Immunity, describe a physical and functional relationship between Toll-like receptor 3 (TLR3) and the pattern recognition protein CD14. In the presence of CD14, TLR3-mediated signal transduction events are amplified... - Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytesJessy J Alexander
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Immunol 185:3759-67. 2010..These findings illustrate the complexities of complement-dependent IC processing by blood cells and in the glomerulus, and the importance of CFH as a plasma complement regulator... - The erythrocyte viral trap: transgenic expression of viral receptor on erythrocytes attenuates coxsackievirus B infectionDamon R Asher
Department of Medicine, University of Massachusetts Medical School, 227 Lazare Research Building, 364 Plantation Street, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 102:12897-902. 2005..Erythrocytes also may be coated with a variety of receptors by nontransgenic methods, making this a very flexible model for the treatment of infectious diseases in humans... - Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in miceThomas C Greenough
Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 02130, USA
J Infect Dis 191:507-14. 2005..Antibodies to both epitopes protected mice against SARS-CoV challenge. Clinical trials are planned to test MAb 201, a fully human MAb specific for the epitope within the receptor-binding region... - Coxsackievirus and adenovirus receptor is essential for cardiomyocyte developmentDamon R Asher
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Genesis 42:77-85. 2005..5 dpc. These findings are consistent with the view that CAR provides positive survival signals to cardiomyocytes that are essential for normal heart development... - Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2Teresa Compton
McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, Madison, Wisconsin 53706, USA
J Virol 77:4588-96. 2003..Since many of the pathological processes associated with CMV disease are facilitated or directly mediated by inflammatory cytokines, identification of the host membrane detection machinery may ultimately lead to improved therapeutics... - Inhibition of TLR-4/MD-2 signaling by RP105/MD-1Senad Divanovic
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Endotoxin Res 11:363-8. 2005.... - Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105Senad Divanovic
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nat Immunol 6:571-8. 2005..Finally, RP105 regulated TLR4 signaling in dendritic cells as well as endotoxin responses in vivo. Thus, our results identify RP105 as a physiological negative regulator of TLR4 responses... - Tolls: you pay them on the way in and on the way out!Robert W Finberg
J Infect Dis 196:497-8. 2007 - CD109 represents a novel branch of the alpha2-macroglobulin/complement gene familyKeith R Solomon
Department of Orthopaedic Surgery, Children s Hospital, Boston, MA 02115, USA
Gene 327:171-83. 2004..elegans (ZK337.1) and E. coli homologs, we propose CD109 represents a novel and independent branch of the alpha2-macroglobulin/complement gene family (AMCOM) and may be its oldest member... - Structure and chromosomal localization of the murine coxsackievirus and adenovirus receptor geneJin Wen Chen
Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
DNA Cell Biol 22:253-9. 2003..RT-PCR analysis of the mCAR RNA 5'-terminus suggests that transcription may begin 141-161 nucleotides upstream of the ATG translational start site...
Research Grants
- Pathogenesis of myocarditisRobert Finberg; Fiscal Year: 2007..At the same time we will define the roles of CD14, and several TLRs (especially TLR2, TLR4 and TLR7) in the response to CBS and its regulation in the development of myocarditis. ..
- Innate Immunity and Herpes Simplex PathogenesisRobert Finberg; Fiscal Year: 2007..abstract_text> ..
- TLRs in Innate Immunity to Viral InfectionRobert Finberg; Fiscal Year: 2006..These studies should enable us to better understand the pathophysiology of viral infections. ..
- CD14 Signaling and Activation of Innate Immune ResponseRobert Finberg; Fiscal Year: 2003..These studies will help to define how host invasion by microbes leads to septic shock and may provide novel targets for the design of therapeutic interventions against the life-threatening conditions associated with bacterial sepsis. ..
- CAR PROTEIN AND AUTO IMMUNITYRobert Finberg; Fiscal Year: 2002..We plan to define the role of this protein in the induction of auto-immune disease and use transgenic and knock-out mice to define the mechanisms by which viruses stimulate autoimmune responses. ..
- Innate Immunity and Herpes Simplex PathogensisRobert Finberg; Fiscal Year: 2009..abstract_text> ..