Scott G Filler

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Relationship between Candida albicans virulence during experimental hematogenously disseminated infection and endothelial cell damage in vitro
    Angela A Sanchez
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    Infect Immun 72:598-601. 2004
  2. pmc Divergent responses of different endothelial cell types to infection with Candida albicans and Staphylococcus aureus
    Kati Seidl
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS ONE 7:e39633. 2012
  3. pmc Mechanisms of Candida albicans trafficking to the brain
    Yaoping Liu
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Pathog 7:e1002305. 2011
  4. pmc Can host receptors for fungi be targeted for treatment of fungal infections?
    Scott G Filler
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    Trends Microbiol 21:389-96. 2013
  5. pmc Insights from human studies into the host defense against candidiasis
    Scott G Filler
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Cytokine 58:129-32. 2012
  6. pmc Fungal invasion of normally non-phagocytic host cells
    Scott G Filler
    Division of Infectious Diseases at the Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Pathog 2:e129. 2006
  7. ncbi request reprint Candida-host cell receptor-ligand interactions
    Scott G Filler
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Curr Opin Microbiol 9:333-9. 2006
  8. pmc Candida albicans Als3, a multifunctional adhesin and invasin
    Yaoping Liu
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA, USA
    Eukaryot Cell 10:168-73. 2011
  9. ncbi request reprint Tumor necrosis factor inhibition and invasive fungal infections
    Scott G Filler
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin Infect Dis 41:S208-12. 2005
  10. ncbi request reprint Pharmacokinetics of murine p75-Fc fusion protein and MP6-XT22 anti-murine TNF-alpha mAb in mice
    Scott G Filler
    Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Investig Dermatol Symp Proc 12:52-6. 2007

Detail Information

Publications72

  1. pmc Relationship between Candida albicans virulence during experimental hematogenously disseminated infection and endothelial cell damage in vitro
    Angela A Sanchez
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    Infect Immun 72:598-601. 2004
    ..Therefore, the endothelial cell damage assay can be used as a screen to identify some virulence factors relevant to hematogenously disseminated candidiasis...
  2. pmc Divergent responses of different endothelial cell types to infection with Candida albicans and Staphylococcus aureus
    Kati Seidl
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS ONE 7:e39633. 2012
    ..Thus, C. albicans and S. aureus interact with HMEC-1 cells in a substantially different manner than with HUVECs, and data obtained with one type of endothelial cell cannot necessarily be extrapolated to other types...
  3. pmc Mechanisms of Candida albicans trafficking to the brain
    Yaoping Liu
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Pathog 7:e1002305. 2011
    ..Therefore, during disseminated disease, C. albicans traffics to and infects the brain by binding to gp96, a unique receptor that is expressed specifically on the surface of brain endothelial cells...
  4. pmc Can host receptors for fungi be targeted for treatment of fungal infections?
    Scott G Filler
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    Trends Microbiol 21:389-96. 2013
    ..We summarize recent studies of the fungal receptors on normally non-phagocytic host cells and the therapeutic implications of blocking these receptors. ..
  5. pmc Insights from human studies into the host defense against candidiasis
    Scott G Filler
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Cytokine 58:129-32. 2012
    ....
  6. pmc Fungal invasion of normally non-phagocytic host cells
    Scott G Filler
    Division of Infectious Diseases at the Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Pathog 2:e129. 2006
    ..This review summarizes the mechanisms by which diverse fungal pathogens invade normally non-phagocytic host cells and discusses gaps in our knowledge that provide opportunities for future research...
  7. ncbi request reprint Candida-host cell receptor-ligand interactions
    Scott G Filler
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Curr Opin Microbiol 9:333-9. 2006
    ..A key difference between C. glabrata and C. albicans is that EPA expression in C. glabrata is governed by sub-telomeric silencing, whereas ALS expression in C. albicans is regulated by other mechanisms...
  8. pmc Candida albicans Als3, a multifunctional adhesin and invasin
    Yaoping Liu
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA, USA
    Eukaryot Cell 10:168-73. 2011
    ..This review will summarize the multiple functions of this interesting and multifunctional protein...
  9. ncbi request reprint Tumor necrosis factor inhibition and invasive fungal infections
    Scott G Filler
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin Infect Dis 41:S208-12. 2005
    ....
  10. ncbi request reprint Pharmacokinetics of murine p75-Fc fusion protein and MP6-XT22 anti-murine TNF-alpha mAb in mice
    Scott G Filler
    Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Investig Dermatol Symp Proc 12:52-6. 2007
    ....
  11. ncbi request reprint Functional and structural diversity in the Als protein family of Candida albicans
    Donald C Sheppard
    St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    J Biol Chem 279:30480-9. 2004
    ..albicans with an array of cell wall proteins capable of recognizing and interacting with a wide range of host constituents during infection...
  12. pmc Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells
    Quynh T Phan
    Department of Medicine, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Biol 5:e64. 2007
    ..These results uncover the first known fungal invasin and provide evidence that C. albicans Als3 is a molecular mimic of human cadherins...
  13. ncbi request reprint Candida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasis
    Lisa Y Chiang
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Cell Microbiol 9:233-45. 2007
    ..Therefore, Cka2p governs the interactions of C. albicans with endothelial and oral epithelial cells in vitro and virulence during oropharyngeal candidiasis...
  14. pmc Investigation of the function of Candida albicans Als3 by heterologous expression in Candida glabrata
    Yue Fu
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Infect Immun 81:2528-35. 2013
    ..These results indicate that during disseminated infection, Als3 mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys...
  15. ncbi request reprint Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis
    Brad J Spellberg
    Department of Medicine, Los Angeles Biomedical Research Institute at Harbor University of California, Los Angeles UCLA Medical Center, Torrance, Torrance, CA 90502, USA
    J Infect Dis 194:256-60. 2006
    ..The rAls3p-N vaccine is a promising new vaccine candidate for further exploration to prevent systemic and mucosal candidal infections...
  16. pmc The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus
    Brad Spellberg
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, California 90502, USA
    Infect Immun 76:4574-80. 2008
    ..aureus and Candida, which collectively cause 200,000 bloodstream infections resulting in >/=40,000 to 50,000 deaths annually in the United States alone...
  17. pmc The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice
    Mingfu Liu
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Clin Invest 120:1914-24. 2010
    ..These results suggest a unique susceptibility of patients with DKA to mucormycosis and provide a foundation for the development of new therapeutic interventions for these deadly infections...
  18. pmc Efficacy of liposomal amphotericin B and posaconazole in intratracheal models of murine mucormycosis
    Guanpingsheng Luo
    Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles UCLA Medical Center, Torrance, California, USA
    Antimicrob Agents Chemother 57:3340-7. 2013
    ..These models can be used to study mechanisms of infection, develop immunotherapeutic strategies, and evaluate drug efficacies against life-threatening Mucorales infections...
  19. pmc Role of Aspergillus fumigatus DvrA in host cell interactions and virulence
    Daniele E Ejzykowicz
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Eukaryot Cell 9:1432-40. 2010
    ..These results indicate that DvrA influences A. fumigatus virulence as well as its capacity to damage host cells and stimulate a proinflammatory response...
  20. pmc The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice
    Brad J Spellberg
    Division of Infectious Diseases, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Infect Immun 73:6191-3. 2005
    ..We now report marked efficacy with subcutaneous rAls1p-N vaccination. Efficacy is retained in neutropenic and corticosteroid-treated mice. The rAls1p-N vaccine is a promising candidate for the prevention of invasive candidiasis...
  21. pmc Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary disease
    Lisa Y Chiang
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Infect Immun 76:3429-38. 2008
    ..fumigatus could enhance the host defense against this organism by contributing to the recruitment of activated leukocytes to sites of angioinvasion...
  22. pmc The Aspergillus fumigatus transcription factor Ace2 governs pigment production, conidiation and virulence
    Daniele E Ejzykowicz
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Mol Microbiol 72:155-69. 2009
    ..Therefore, reduced expression of these genes likely contributes to the increased virulence of the Deltaace2 mutant...
  23. ncbi request reprint N-cadherin mediates endocytosis of Candida albicans by endothelial cells
    Quynh T Phan
    St John s Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, California 90502, USA
    J Biol Chem 280:10455-61. 2005
    ..albicans hyphae. Therefore, a novel function of N-cadherin is that it serves as an endothelial cell receptor, which mediates the endocytosis of C. albicans...
  24. pmc Role of endothelial cell septin 7 in the endocytosis of Candida albicans
    Quynh T Phan
    Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    MBio 4:e00542-13. 2013
    ..The key role of septin 7 in governing receptor-mediated endocytosis is likely relevant to host cell invasion by other microbial pathogens, in addition to C. albicans...
  25. pmc NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response
    Ashraf S Ibrahim
    The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles UCLA Medical Center and the St John s Cardiovascular Research Center, Torrance, CA, United States David Geffen School of Medicine at UCLA, Los Angeles, CA, United States Electronic address
    Vaccine 31:5549-56. 2013
    ..albicans by neutrophils primed with IFN-gamma. These data indicate that NDV-3 protects mice, from VVC by a mechanism that involves the concerted priming of both humoral and adaptive immune, responses. ..
  26. pmc EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection
    Weidong Zhu
    Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, CA 90502, USA
    Proc Natl Acad Sci U S A 109:14194-9. 2012
    ..These results show the importance of EGFR and HER2 signaling in the pathogenesis of OPC and indicate the feasibility of treating candidal infections by targeting the host cell receptors with which the fungus interacts...
  27. pmc SSD1 is integral to host defense peptide resistance in Candida albicans
    Kimberly D Gank
    Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, California 90509, USA
    Eukaryot Cell 7:1318-27. 2008
    ..Collectively, these results indicate that SSD1 is integral to C. albicans resistance to host defense peptides, a phenotype that appears to enhance the virulence of this organism in vivo...
  28. pmc Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swine
    James T Niemann
    The David Geffen School of Medicine at UCLA, University of California Los Angeles, CA, USA
    J Interferon Cytokine Res 29:749-58. 2009
    ..TNF-alpha increases during recovery from cardiac arrest are associated with depression of left ventricle (LV) function. The effect of TNF-alpha can be attenuated by anti-TNF-alpha antibodies...
  29. pmc Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis
    Hong Liu
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Mol Microbiol 78:1038-54. 2010
    ..Thus, AcuM represses SreA and thereby induces iron acquisition, a process that is essential for the maximal virulence of A. fumigatus...
  30. ncbi request reprint Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis
    Hyunsook Park
    Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Cell Microbiol 7:499-510. 2005
    ..Interestingly, the efg1Delta/efg1Delta strain, but not the tpk2Delta/tpk2Delta had reduced virulence during HDC. Thus, Tpk2p may be more important for governing virulence during OPC than HDC...
  31. pmc Transcriptional responses of candida albicans to epithelial and endothelial cells
    Hyunsook Park
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Eukaryot Cell 8:1498-510. 2009
    ....
  32. pmc Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis
    Brad Spellberg
    Department of Medicine, Research and Education Institute at Harbor UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90502, USA
    Infect Immun 71:5756-64. 2003
    ..Furthermore, the results provide in vivo confirmation that hyphal formation by C. albicans induces type 2 or IL-10-dominant host responses in tissues...
  33. pmc Polarized response of endothelial cells to invasion by Aspergillus fumigatus
    Yasuki Kamai
    Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Cell Microbiol 11:170-82. 2009
    ..fumigatus. These differences in the endothelial cell response to abluminal versus luminal infection may contribute to differences in the pathogenesis of invasive versus haematogenously disseminated aspergillosis...
  34. pmc An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth
    Sarah L Elson
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 5:e1000664. 2009
    ..The differences in mRNA cargos likely reflect the distinct selective pressures acting on the two species...
  35. pmc In vitro endothelial cell damage is positively correlated with enhanced virulence and poor vancomycin responsiveness in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Kati Seidl
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Cell Microbiol 13:1530-41. 2011
    ....
  36. ncbi request reprint Functional analysis of the Candida albicans ALS1 gene product
    Lucio Loza
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, 1124 West Carson Street, Torrance, CA 90502, USA
    Yeast 21:473-82. 2004
    ....
  37. pmc Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity
    Ashraf S Ibrahim
    Division of Infectious Diseases, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90502, USA
    Infect Immun 73:999-1005. 2005
    ..albicans and emphasize the potential for cell-mediated immune modulation as a prophylactic or therapeutic strategy against disseminated candidiasis...
  38. pmc Novel inhalational murine model of invasive pulmonary aspergillosis
    Donald C Sheppard
    St John s Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    Antimicrob Agents Chemother 48:1908-11. 2004
    ..This procedure reproducibly delivered 1 x 10(3) to 3 x 10(3) conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B...
  39. pmc Endothelial cell stimulation by Candida albicans
    Quynh T Phan
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Methods Mol Biol 470:313-26. 2009
    ..albicans in vitro. We describe the use of real-time PCR and enzyme immunoassays to measure the effects of C. albicans on the endothelial cell production of E-selectin and tumor necrosis factor alpha in vitro...
  40. pmc Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis
    Lisa Y Chiang
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 50:3464-6. 2006
    ..KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents...
  41. ncbi request reprint Current treatment strategies for disseminated candidiasis
    Brad J Spellberg
    Division of Infectious Diseases, The Los Angeles Biomedical Institute, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
    Clin Infect Dis 42:244-51. 2006
    ..glabrata or C. krusei. Central venous catheters should be removed from all patients who have disseminated candidiasis, if feasible, and antifungal therapy should be administered to all patients who have candidemia or proven candidiasis...
  42. pmc Interactions of Candida albicans with epithelial cells
    Weidong Zhu
    Divison of Infectious Disease, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Cell Microbiol 12:273-82. 2010
    ..Future challenges include identifying the epithelial cell targets of adhesins and invasins, and determining the mechanisms by which C. albicans actively penetrates epithelial cells and induces epithelial cell damage...
  43. ncbi request reprint Candida albicans stimulates local expression of leukocyte adhesion molecules and cytokines in vivo
    Rebecca R M Cannom
    Department of Medicine, Harbor UCLA, Research and Education Institute, Torrance, California 90502, USA
    J Infect Dis 186:389-96. 2002
    ..Furthermore, leukocyte recruitment occurs relatively late in the infection, and this recruitment is likely amplified by proinflammatory mediators produced by the leukocytes themselves...
  44. pmc Role of Retrograde Trafficking in Stress Response, Host Cell Interactions, and Virulence of Candida albicans
    Yaoping Liu
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Eukaryot Cell 13:279-87. 2014
    ..Aberrant retrograde trafficking stimulates the calcineurin signaling pathway, leading to the increased expression of Chr11 and Utr2, which enables C. albicans to withstand environmental stress. ..
  45. pmc Mouse model of oropharyngeal candidiasis
    Norma V Solis
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Nat Protoc 7:637-42. 2012
    ..This process results in a reproducible level of infection, the histopathology of which mimics that of pseudomembranous oropharyngeal candidiasis in humans. By using this model, data are obtained after 5-9 d of work...
  46. ncbi request reprint Guidelines for treatment of candidiasis
    Peter G Pappas
    Division of Infectious Diseases, University of Alabama at Birmingham, Alabama 35294 0006, USA
    Clin Infect Dis 38:161-89. 2004
  47. doi request reprint Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America
    Peter G Pappas
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Clin Infect Dis 48:503-35. 2009
    ..This new information is incorporated into this revised document...
  48. ncbi request reprint Interactions of Aspergillus fumigatus with endothelial cells: internalization, injury, and stimulation of tissue factor activity
    Leila M Lopes Bezerra
    Department of Internal Medicine, Harbor UCLA Research and Education Institute, 1124 W Carson St, Torrance, CA 90502, USA
    Blood 103:2143-9. 2004
    ..These results suggest that angioinvasion and thrombosis caused by A fumigatus hyphae in vivo may be due in part to endothelial cell invasion, induction of injury, and stimulation of tissue factor activity...
  49. pmc Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis
    Caitlin Reed
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, CA, USA
    Clin Infect Dis 47:364-71. 2008
    ..g., caspofungin) are ineffective against mucormycosis. However, on the basis of preclinical data, we recently began treating rhino-orbital-cerebral mucormycosis (ROCM) with combination polyene-caspofungin therapy...
  50. pmc Infliximab attenuates early myocardial dysfunction after resuscitation in a swine cardiac arrest model
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Crit Care Med 38:1162-7. 2010
    ..We hypothesized that blocking the effects of tumor necrosis factor-alpha with infliximab would prevent or minimize postresuscitation cardiac dysfunction...
  51. pmc Genetic basis for differential activities of fluconazole and voriconazole against Candida krusei
    Takashi Fukuoka
    Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    Antimicrob Agents Chemother 47:1213-9. 2003
    ....
  52. ncbi request reprint Endocytosis of Candida albicans by vascular endothelial cells is associated with tyrosine phosphorylation of specific host cell proteins
    Paul H Belanger
    St John s Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
    Cell Microbiol 4:805-12. 2002
    ..albicans. Therefore, C. albicans probably induces its own endocytosis by stimulating the tyrosine phosphorylation of two endothelial cell proteins...
  53. ncbi request reprint Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway
    Yue Fu
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, Bldg RB2, 1124 West Carson St, Torrance, CA 90502, USA
    Mol Microbiol 44:61-72. 2002
    ..cerevisiae Flo11p. Consistent with our in vitro results, Als1p was required for both normal filamentation and virulence in the mouse model of haematogenously disseminated candidiasis...
  54. ncbi request reprint A randomized study of the use of fluconazole in continuous versus episodic therapy in patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40
    Mitchell Goldman
    Indiana University School of Medicine, Division of Infectious Diseases, Wishard Memorial Hospital, Indianapolis, IN 46202, USA
    Clin Infect Dis 41:1473-80. 2005
    ..However, concerns exist with regard to the use of fluconazole prophylaxis and the risk of development of fluconazole treatment-refractory infections...
  55. pmc Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cells
    Raquel Martinez-Lopez
    Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
    Eukaryot Cell 5:140-7. 2006
    ..Collectively, these results suggest that Ecm33p is required for normal cell wall architecture as well as normal function and expression of cell surface proteins in C. albicans...
  56. pmc Requirement for Candida albicans Sun41 in biofilm formation and virulence
    Carmelle T Norice
    Department of Microbiology, Columbia University, New York, NY, USA
    Eukaryot Cell 6:2046-55. 2007
    ..We suggest that the sun41Delta/sun41Delta cell wall defect is the primary cause of its attenuated virulence. As a small fungal surface protein with predicted glucosidase activity, Sun41 represents a promising therapeutic target...
  57. pmc Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis
    Dana A Davis
    Department of Microbiology and Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University, New York, New York 10032, USA
    Genetics 162:1573-81. 2002
    ..Epistasis tests show that Mds3p contributes to virulence and alkaline pH responses independently of the well-characterized Rim101p pH-response pathway...
  58. pmc Calcineurin is essential for Candida albicans survival in serum and virulence
    Jill R Blankenship
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eukaryot Cell 2:422-30. 2003
    ..Our studies illustrate that calcineurin has evolved to control aspects of the virulence of two divergent fungal pathogens via distinct mechanisms that can be targeted to achieve broad-spectrum antifungal action...
  59. ncbi request reprint In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion
    Sascha Thewes
    Division Mycology, Robert Koch Institute, Berlin, Germany
    Mol Microbiol 63:1606-28. 2007
    ..One of the genes identified as associated with liver invasion was DFG16, a gene crucial for pH-dependent hyphal formation, correct pH sensing, invasion at physiological pH and systemic infection...
  60. pmc Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, USA
    PLoS Pathog 2:e63. 2006
    ..Known adhesins Als1 and Hwp1 also contribute to biofilm formation, as does the novel protein Ece1...
  61. pmc In vivo analysis of Aspergillus fumigatus developmental gene expression determined by real-time reverse transcription-PCR
    Fabrice N Gravelat
    Department of Microbiology and Immunology, McGill University, Duff Medical Building, Room 502, Montreal, Quebec H3A 2B4, Canada
    Infect Immun 76:3632-9. 2008
    ..These results highlight the importance of the evaluation of putative virulence factors expressed by competent hyphae and analysis of gene expression levels during invasive infection rather than in vitro alone...
  62. pmc Complementary adhesin function in C. albicans biofilm formation
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York 10032, USA
    Curr Biol 18:1017-24. 2008
    ..Here, we focus on an adherence mechanism that permits biofilm formation by Candida albicans, the major invasive fungal pathogen of humans...
  63. pmc Contribution of Candida albicans ALS1 to the pathogenesis of experimental oropharyngeal candidiasis
    Yasuki Kamai
    Biological Research Laboratory, Sankyo Co, Ltd, Shinagawa ku, Tokyo 140 8710, Japan
    Infect Immun 70:5256-8. 2002
    ..Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection...
  64. pmc A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans
    Eric S Bensen
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Eukaryot Cell 1:787-98. 2002
    ..In addition, cells lacking Fkh2p were unable to damage human epithelial or endothelial cells in vitro, suggesting that Fkh2p contributes to C. albicans virulence...
  65. ncbi request reprint Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates
    Shahrzad Dilmaghanian
    Division of Clinical Pharmacology and Toxicology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Chirality 16:79-85. 2004
    ..Overall, levo-KTZ was 2-4-fold more active than dextro-KTZ. Therefore, levo-KTZ is a more potent inhibitor of CYP3A4 and has stronger in vitro antifungal activity. Chirality 16:79-85, 2004...
  66. pmc The Aspergillus fumigatus StuA protein governs the up-regulation of a discrete transcriptional program during the acquisition of developmental competence
    Donald C Sheppard
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada
    Mol Biol Cell 16:5866-79. 2005
    ..Additionally, hyphae of the DeltastuA mutant displayed reduced expression of the catalase gene CAT1 and were hypersusceptible to hydrogen peroxide...
  67. pmc The Yak1 kinase is involved in the initiation and maintenance of hyphal growth in Candida albicans
    Sophie Goyard
    Unité Biologie et Pathogénicité Fongiques, Institut National de la Recherche Agronomique USC2019, Paris, France
    Mol Biol Cell 19:2251-66. 2008
    ....
  68. ncbi request reprint Mice with disseminated candidiasis die of progressive sepsis
    Brad Spellberg
    Los Angeles Biomedical Research Institute, Division of Infectious Diseases at Harbor University of California at Los Angeles Medical Center, Torrance 90502, USA
    J Infect Dis 192:336-43. 2005
    ..However, despite decades of use, little is known about the physiological characteristics of the host in this model, and the cause of death remains unclear...
  69. doi request reprint Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence
    Sara Spikes
    Division of Pathology and Laboratory Medicine, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Infect Dis 197:479-86. 2008
    ..These activities have led to the proposal that gliotoxin contributes to pathogenesis during invasive aspergillosis. We tested this hypothesis by creating isogenic strains of gliotoxin-producing and nonproducing strains...
  70. pmc Standardization of an experimental murine model of invasive pulmonary aspergillosis
    Donald C Sheppard
    McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada
    Antimicrob Agents Chemother 50:3501-3. 2006
    ....
  71. doi request reprint Transcriptome profile of the vascular endothelial cell response to Candida albicans
    Katherine S Barker
    Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, University of Memphis, Tennessee, USA
    J Infect Dis 198:193-202. 2008
    ..During hematogenously disseminated candidiasis, bloodborne Candida albicans interacts with vascular endothelial cells (ECs), which have the capacity to influence the local inflammatory response to this organism...

Research Grants24

  1. Candida Invasion of Endothelium and Virulence
    Scott Filler; Fiscal Year: 2009
    ..Furthermore, this information may be used to develop new diagnostic or therapeutic strategies against this frequently fatal disease. ..
  2. Candida albicans Epithelial Cell Interactions and Oropharyngeal Disease
    Scott G Filler; Fiscal Year: 2010
    ..Furthermore, this information may be used to develop new therapeutic strategies against this highly prevalent disease. ..
  3. Candida Invasion of Endothelium and Virulence
    Scott G Filler; Fiscal Year: 2010
    ..Furthermore, this information may be used to develop new diagnostic or therapeutic strategies against this frequently fatal disease. ..
  4. Transcriptional regulation of A. fumigatus virulence
    Scott Filler; Fiscal Year: 2007
    ..Collectively, these results will form the foundation for the future development of new therapeutic strategies for invasive aspergillosis. ..
  5. Transcriptional regulation of A. fumigatus virulence
    Scott Filler; Fiscal Year: 2009
    ..Collectively, these results will form the foundation for the future development of new therapeutic strategies for invasive aspergillosis. ..
  6. Candida Invasion of Endothelium and Virulence
    Scott Filler; Fiscal Year: 2007
    ..albicans genes that promote endothelial cell damage in vitro and virulence. ..
  7. C. albicans-Epithelial Interactions & Oropharyngeal Disease
    Scott Filler; Fiscal Year: 2009
    ..4) The functional relationships among C. albicans virulence genes will be elucidated by transcriptional profiling and epistasis analysis using both newly created and existing C. albicans mutants. ..
  8. Aspergillus Angioinvasion and Dissemination
    Scott Filler; Fiscal Year: 2006
    ..These studies are designed to lay the essential foundation for a comprehensive research program aimed at elucidating the molecular mechanisms by which A. fumigatus invades blood vessels and hematogenously disseminates. ..
  9. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2001
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
  10. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2002
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
  11. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2003
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
  12. Candida Invasion of Endothelium and Virulence
    Scott Filler; Fiscal Year: 2004
    ..albicans genes that promote endothelial cell damage in vitro and virulence. ..
  13. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2004
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
  14. Candida Invasion of Endothelium and Virulence
    Scott Filler; Fiscal Year: 2005
    ..albicans genes that promote endothelial cell damage in vitro and virulence. ..
  15. Candida Invasion of Endothelium and Virulence
    Scott Filler; Fiscal Year: 2006
    ..albicans genes that promote endothelial cell damage in vitro and virulence. ..
  16. C. albicans-Epithelial Interactions & Oropharyngeal Disease
    Scott Filler; Fiscal Year: 2005
    ..4) The functional relationships among C. albicans virulence genes will be elucidated by transcriptional profiling and epistasis analysis using both newly created and existing C. albicans mutants. ..
  17. Transcriptional regulation of A. fumigatus virulence
    Scott G Filler; Fiscal Year: 2010
    ..Collectively, these results will form the foundation for the future development of new therapeutic strategies for invasive aspergillosis. ..
  18. C. albicans-Epithelial Interactions & Oropharyngeal Disease
    Scott Filler; Fiscal Year: 2007
    ..4) The functional relationships among C. albicans virulence genes will be elucidated by transcriptional profiling and epistasis analysis using both newly created and existing C. albicans mutants. ..
  19. C. albicans-Epithelial Interactions & Oropharyngeal Disease
    Scott Filler; Fiscal Year: 2006
    ..4) The functional relationships among C. albicans virulence genes will be elucidated by transcriptional profiling and epistasis analysis using both newly created and existing C. albicans mutants. ..
  20. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2000
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..