Research Topics
| Scott G FillerSummaryAffiliation: University of California Country: USA Publications
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Publications
Relationship between Candida albicans virulence during experimental hematogenously disseminated infection and endothelial cell damage in vitroAngela A Sanchez
St. Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502, USA
Infect Immun 72:598-601. 2004..Therefore, the endothelial cell damage assay can be used as a screen to identify some virulence factors relevant to hematogenously disseminated candidiasis...- Insights from human studies into the host defense against candidiasisScott G Filler
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
Cytokine 58:129-32. 2012.... 
Tumor necrosis factor inhibition and invasive fungal infectionsScott G Filler
St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Clin Infect Dis 41:S208-12. 2005....- Candida-host cell receptor-ligand interactionsScott G Filler
St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Curr Opin Microbiol 9:333-9. 2006..A key difference between C. glabrata and C. albicans is that EPA expression in C. glabrata is governed by sub-telomeric silencing, whereas ALS expression in C. albicans is regulated by other mechanisms... - Pharmacokinetics of murine p75-Fc fusion protein and MP6-XT22 anti-murine TNF-alpha mAb in miceScott G Filler
Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
J Investig Dermatol Symp Proc 12:52-6. 2007.... - Fungal invasion of normally non-phagocytic host cellsScott G Filler
Division of Infectious Diseases at the Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
PLoS Pathog 2:e129. 2006..This review summarizes the mechanisms by which diverse fungal pathogens invade normally non-phagocytic host cells and discusses gaps in our knowledge that provide opportunities for future research... - Candida albicans Als3, a multifunctional adhesin and invasinYaoping Liu
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA, USA
Eukaryot Cell 10:168-73. 2011..This review will summarize the multiple functions of this interesting and multifunctional protein... - Functional and structural diversity in the Als protein family of Candida albicansDonald C Sheppard
St Johns Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, California 90502, USA
J Biol Chem 279:30480-9. 2004..albicans with an array of cell wall proteins capable of recognizing and interacting with a wide range of host constituents during infection... - Candida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasisLisa Y Chiang
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Cell Microbiol 9:233-45. 2007..Therefore, Cka2p governs the interactions of C. albicans with endothelial and oral epithelial cells in vitro and virulence during oropharyngeal candidiasis... - Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cellsQuynh T Phan
Department of Medicine, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, United States of America
PLoS Biol 5:e64. 2007..These results uncover the first known fungal invasin and provide evidence that C. albicans Als3 is a molecular mimic of human cadherins... - Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasisBrad J Spellberg
Department of Medicine, Los Angeles Biomedical Research Institute at Harbor University of California, Los Angeles UCLA Medical Center, Torrance, Torrance, CA 90502, USA
J Infect Dis 194:256-60. 2006..The rAls3p-N vaccine is a promising new vaccine candidate for further exploration to prevent systemic and mucosal candidal infections... - The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised miceBrad J Spellberg
Division of Infectious Diseases, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
Infect Immun 73:6191-3. 2005..We now report marked efficacy with subcutaneous rAls1p-N vaccination. Efficacy is retained in neutropenic and corticosteroid-treated mice. The rAls1p-N vaccine is a promising candidate for the prevention of invasive candidiasis... - Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary diseaseLisa Y Chiang
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
Infect Immun 76:3429-38. 2008..fumigatus could enhance the host defense against this organism by contributing to the recruitment of activated leukocytes to sites of angioinvasion... - The Aspergillus fumigatus transcription factor Ace2 governs pigment production, conidiation and virulenceDaniele E Ejzykowicz
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Mol Microbiol 72:155-69. 2009..Therefore, reduced expression of these genes likely contributes to the increased virulence of the Deltaace2 mutant... - Role of Aspergillus fumigatus DvrA in host cell interactions and virulenceDaniele E Ejzykowicz
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Eukaryot Cell 9:1432-40. 2010..These results indicate that DvrA influences A. fumigatus virulence as well as its capacity to damage host cells and stimulate a proinflammatory response... - EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infectionWeidong Zhu
Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, CA 90502, USA
Proc Natl Acad Sci U S A 109:14194-9. 2012..These results show the importance of EGFR and HER2 signaling in the pathogenesis of OPC and indicate the feasibility of treating candidal infections by targeting the host cell receptors with which the fungus interacts... - Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swineJames T Niemann
The David Geffen School of Medicine at UCLA, University of California Los Angeles, CA, USA
J Interferon Cytokine Res 29:749-58. 2009..TNF-alpha increases during recovery from cardiac arrest are associated with depression of left ventricle (LV) function. The effect of TNF-alpha can be attenuated by anti-TNF-alpha antibodies... - Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesisHong Liu
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Mol Microbiol 78:1038-54. 2010..Thus, AcuM represses SreA and thereby induces iron acquisition, a process that is essential for the maximal virulence of A. fumigatus... - Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasisHyunsook Park
Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA 90502, USA
Cell Microbiol 7:499-510. 2005..Interestingly, the efg1Delta/efg1Delta strain, but not the tpk2Delta/tpk2Delta had reduced virulence during HDC. Thus, Tpk2p may be more important for governing virulence during OPC than HDC... - The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureusBrad Spellberg
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, California 90502, USA
Infect Immun 76:4574-80. 2008..These data provide the foundation for cross-kingdom vaccine development against S. aureus and Candida, which collectively cause 200,000 bloodstream infections resulting in >/=40,000 to 50,000 deaths annually in the United States alone... - SSD1 is integral to host defense peptide resistance in Candida albicansKimberly D Gank
Division of Infectious Diseases, LAC Harbor UCLA Medical Center, Torrance, California 90509, USA
Eukaryot Cell 7:1318-27. 2008..Collectively, these results indicate that SSD1 is integral to C. albicans resistance to host defense peptides, a phenotype that appears to enhance the virulence of this organism in vivo... - The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic miceMingfu Liu
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
J Clin Invest 120:1914-24. 2010..These results suggest a unique susceptibility of patients with DKA to mucormycosis and provide a foundation for the development of new therapeutic interventions for these deadly infections... - Polarized response of endothelial cells to invasion by Aspergillus fumigatusYasuki Kamai
Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Cell Microbiol 11:170-82. 2009..fumigatus. These differences in the endothelial cell response to abluminal versus luminal infection may contribute to differences in the pathogenesis of invasive versus haematogenously disseminated aspergillosis... - Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasisBrad Spellberg
Department of Medicine, Research and Education Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA
Infect Immun 71:5756-64. 2003..Furthermore, the results provide in vivo confirmation that hyphal formation by C. albicans induces type 2 or IL-10-dominant host responses in tissues... - Transcriptional responses of candida albicans to epithelial and endothelial cellsHyunsook Park
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
Eukaryot Cell 8:1498-510. 2009.... - N-cadherin mediates endocytosis of Candida albicans by endothelial cellsQuynh T Phan
St. John's Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, California 90502, USA
J Biol Chem 280:10455-61. 2005..albicans hyphae. Therefore, a novel function of N-cadherin is that it serves as an endothelial cell receptor, which mediates the endocytosis of C. albicans... - An RNA transport system in Candida albicans regulates hyphal morphology and invasive growthSarah L Elson
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 5:e1000664. 2009..The differences in mRNA cargos likely reflect the distinct selective pressures acting on the two species... - Mechanisms of Candida albicans trafficking to the brainYaoping Liu
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
PLoS Pathog 7:e1002305. 2011..Therefore, during disseminated disease, C. albicans traffics to and infects the brain by binding to gp96, a unique receptor that is expressed specifically on the surface of brain endothelial cells... - Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunityAshraf S Ibrahim
Division of Infectious Diseases, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90502, USA
Infect Immun 73:999-1005. 2005..albicans and emphasize the potential for cell-mediated immune modulation as a prophylactic or therapeutic strategy against disseminated candidiasis... - Functional analysis of the Candida albicans ALS1 gene productLucio Loza
Division of Infectious Diseases, St. John's Cardiovascular Research Center, Harbor-UCLA Research and Education Institute, 1124 West Carson Street, Torrance, CA 90502, USA
Yeast 21:473-82. 2004.... - Divergent responses of different endothelial cell types to infection with Candida albicans and Staphylococcus aureusKati Seidl
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America
PLoS ONE 7:e39633. 2012..Thus, C. albicans and S. aureus interact with HMEC-1 cells in a substantially different manner than with HUVECs, and data obtained with one type of endothelial cell cannot necessarily be extrapolated to other types... 
Endothelial cell stimulation by Candida albicansQuynh T Phan
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Methods Mol Biol 470:313-26. 2009..albicans in vitro. We describe the use of real-time PCR and enzyme immunoassays to measure the effects of C. albicans on the endothelial cell production of E-selectin and tumor necrosis factor alpha in vitro...- Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosisLisa Y Chiang
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA
Antimicrob Agents Chemother 50:3464-6. 2006..KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents... - Current treatment strategies for disseminated candidiasisBrad J Spellberg
Division of Infectious Diseases, The Los Angeles Biomedical Institute, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
Clin Infect Dis 42:244-51. 2006..glabrata or C. krusei. Central venous catheters should be removed from all patients who have disseminated candidiasis, if feasible, and antifungal therapy should be administered to all patients who have candidemia or proven candidiasis... - Novel inhalational murine model of invasive pulmonary aspergillosisDonald C Sheppard
St. John's Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502, USA
Antimicrob Agents Chemother 48:1908-11. 2004..This procedure reproducibly delivered 1 x 10(3) to 3 x 10(3) conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B... - Interactions of Candida albicans with epithelial cellsWeidong Zhu
Divison of Infectious Disease, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Cell Microbiol 12:273-82. 2010..Future challenges include identifying the epithelial cell targets of adhesins and invasins, and determining the mechanisms by which C. albicans actively penetrates epithelial cells and induces epithelial cell damage... - Candida albicans stimulates local expression of leukocyte adhesion molecules and cytokines in vivoRebecca R M Cannom
Department of Medicine, Harbor-UCLA, Research and Education Institute, Torrance, California 90502, USA
J Infect Dis 186:389-96. 2002..Furthermore, leukocyte recruitment occurs relatively late in the infection, and this recruitment is likely amplified by proinflammatory mediators produced by the leukocytes themselves... - In vitro endothelial cell damage is positively correlated with enhanced virulence and poor vancomycin responsiveness in experimental endocarditis due to methicillin-resistant Staphylococcus aureusKati Seidl
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Cell Microbiol 13:1530-41. 2011.... - Mouse model of oropharyngeal candidiasisNorma V Solis
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Nat Protoc 7:637-42. 2012..This process results in a reproducible level of infection, the histopathology of which mimics that of pseudomembranous oropharyngeal candidiasis in humans. By using this model, data are obtained after 5-9 d of work... - Infliximab attenuates early myocardial dysfunction after resuscitation in a swine cardiac arrest modelJames T Niemann
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
Crit Care Med 38:1162-7. 2010..We hypothesized that blocking the effects of tumor necrosis factor-alpha with infliximab would prevent or minimize postresuscitation cardiac dysfunction... - Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of AmericaPeter G Pappas
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
Clin Infect Dis 48:503-35. 2009..This new information is incorporated into this revised document... - Interactions of Aspergillus fumigatus with endothelial cells: internalization, injury, and stimulation of tissue factor activityLeila M Lopes Bezerra
Department of Internal Medicine, Harbor-UCLA Research and Education Institute, 1124 W Carson St, Torrance, CA 90502, USA
Blood 103:2143-9. 2004..These results suggest that angioinvasion and thrombosis caused by A fumigatus hyphae in vivo may be due in part to endothelial cell invasion, induction of injury, and stimulation of tissue factor activity... - Guidelines for treatment of candidiasisPeter G Pappas
Division of Infectious Diseases, University of Alabama at Birmingham, Alabama 35294-0006, USA
Clin Infect Dis 38:161-89. 2004 - Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosisCaitlin Reed
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, CA, USA
Clin Infect Dis 47:364-71. 2008..g., caspofungin) are ineffective against mucormycosis. However, on the basis of preclinical data, we recently began treating rhino-orbital-cerebral mucormycosis (ROCM) with combination polyene-caspofungin therapy... - Endocytosis of Candida albicans by vascular endothelial cells is associated with tyrosine phosphorylation of specific host cell proteinsPaul H Belanger
St John's Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502, USA
Cell Microbiol 4:805-12. 2002..albicans. Therefore, C. albicans probably induces its own endocytosis by stimulating the tyrosine phosphorylation of two endothelial cell proteins... - A randomized study of the use of fluconazole in continuous versus episodic therapy in patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40Mitchell Goldman
Indiana University School of Medicine, Division of Infectious Diseases, Wishard Memorial Hospital, Indianapolis, IN 46202, USA
Clin Infect Dis 41:1473-80. 2005..However, concerns exist with regard to the use of fluconazole prophylaxis and the risk of development of fluconazole treatment-refractory infections... - Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathwayYue Fu
Division of Infectious Diseases, St John s Cardiovascular Research Center, Harbor UCLA Research and Education Institute, Bldg RB2, 1124 West Carson St, Torrance, CA 90502, USA
Mol Microbiol 44:61-72. 2002..cerevisiae Flo11p. Consistent with our in vitro results, Als1p was required for both normal filamentation and virulence in the mouse model of haematogenously disseminated candidiasis... - Genetic basis for differential activities of fluconazole and voriconazole against Candida kruseiTakashi Fukuoka
Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502, USA
Antimicrob Agents Chemother 47:1213-9. 2003.... - Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivoClarissa J Nobile
Department of Microbiology, Columbia University, New York, New York, USA
PLoS Pathog 2:e63. 2006..Known adhesins Als1 and Hwp1 also contribute to biofilm formation, as does the novel protein Ece1... - In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasionSascha Thewes
Division Mycology, Robert Koch Institute, Berlin, Germany
Mol Microbiol 63:1606-28. 2007..One of the genes identified as associated with liver invasion was DFG16, a gene crucial for pH-dependent hyphal formation, correct pH sensing, invasion at physiological pH and systemic infection... - Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cellsRaquel Martinez-Lopez
, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
Eukaryot Cell 5:140-7. 2006..Collectively, these results suggest that Ecm33p is required for normal cell wall architecture as well as normal function and expression of cell surface proteins in C. albicans... - Requirement for Candida albicans Sun41 in biofilm formation and virulenceCarmelle T Norice
Department of Microbiology, Columbia University, New York, NY, USA
Eukaryot Cell 6:2046-55. 2007..We suggest that the sun41Delta/sun41Delta cell wall defect is the primary cause of its attenuated virulence. As a small fungal surface protein with predicted glucosidase activity, Sun41 represents a promising therapeutic target... - Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesisDana A Davis
Department of Microbiology and Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University, New York, New York 10032, USA
Genetics 162:1573-81. 2002..Epistasis tests show that Mds3p contributes to virulence and alkaline pH responses independently of the well-characterized Rim101p pH-response pathway... - Calcineurin is essential for Candida albicans survival in serum and virulenceJill R Blankenship
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Eukaryot Cell 2:422-30. 2003..Our studies illustrate that calcineurin has evolved to control aspects of the virulence of two divergent fungal pathogens via distinct mechanisms that can be targeted to achieve broad-spectrum antifungal action... - The Yak1 kinase is involved in the initiation and maintenance of hyphal growth in Candida albicansSophie Goyard
Unité Biologie et Pathogénicité Fongiques, Institut National de la Recherche Agronomique USC2019, Paris, France
Mol Biol Cell 19:2251-66. 2008.... - The Aspergillus fumigatus StuA protein governs the up-regulation of a discrete transcriptional program during the acquisition of developmental competenceDonald C Sheppard
Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada
Mol Biol Cell 16:5866-79. 2005..Additionally, hyphae of the DeltastuA mutant displayed reduced expression of the catalase gene CAT1 and were hypersusceptible to hydrogen peroxide... - Mice with disseminated candidiasis die of progressive sepsisBrad Spellberg
Los Angeles Biomedical Research Institute, Division of Infectious Diseases at Harbor University of California at Los Angeles Medical Center, Torrance 90502, USA
J Infect Dis 192:336-43. 2005..However, despite decades of use, little is known about the physiological characteristics of the host in this model, and the cause of death remains unclear... - Transcriptome profile of the vascular endothelial cell response to Candida albicansKatherine S Barker
Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, University of Memphis, Tennessee, USA
J Infect Dis 198:193-202. 2008..During hematogenously disseminated candidiasis, bloodborne Candida albicans interacts with vascular endothelial cells (ECs), which have the capacity to influence the local inflammatory response to this organism... - Standardization of an experimental murine model of invasive pulmonary aspergillosisDonald C Sheppard
McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada
Antimicrob Agents Chemother 50:3501-3. 2006.... - Complementary adhesin function in C. albicans biofilm formationClarissa J Nobile
Department of Microbiology, Columbia University, New York, New York 10032, USA
Curr Biol 18:1017-24. 2008..Here, we focus on an adherence mechanism that permits biofilm formation by Candida albicans, the major invasive fungal pathogen of humans... - In vivo analysis of Aspergillus fumigatus developmental gene expression determined by real-time reverse transcription-PCRFabrice N Gravelat
Department of Microbiology and Immunology, McGill University, Duff Medical Building, Room 502, Montreal, Quebec H3A 2B4, Canada
Infect Immun 76:3632-9. 2008..These results highlight the importance of the evaluation of putative virulence factors expressed by competent hyphae and analysis of gene expression levels during invasive infection rather than in vitro alone... - Contribution of Candida albicans ALS1 to the pathogenesis of experimental oropharyngeal candidiasisYasuki Kamai
Biological Research Laboratory, Sankyo Co, Ltd, Shinagawa ku, Tokyo 140 8710, Japan
Infect Immun 70:5256-8. 2002..Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection... - Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substratesShahrzad Dilmaghanian
Division of Clinical Pharmacology and Toxicology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Chirality 16:79-85. 2004..Overall, levo-KTZ was 2-4-fold more active than dextro-KTZ. Therefore, levo-KTZ is a more potent inhibitor of CYP3A4 and has stronger in vitro antifungal activity. Chirality 16:79-85, 2004... - Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulenceSara Spikes
Division of Pathology and Laboratory Medicine, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
J Infect Dis 197:479-86. 2008..These activities have led to the proposal that gliotoxin contributes to pathogenesis during invasive aspergillosis. We tested this hypothesis by creating isogenic strains of gliotoxin-producing and nonproducing strains... - A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicansEric S Bensen
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Eukaryot Cell 1:787-98. 2002..In addition, cells lacking Fkh2p were unable to damage human epithelial or endothelial cells in vitro, suggesting that Fkh2p contributes to C. albicans virulence...
Research Grants
- Candida Invasion of Endothelium and VirulenceScott Filler; Fiscal Year: 2009..Furthermore, this information may be used to develop new diagnostic or therapeutic strategies against this frequently fatal disease. ..
- Transcriptional regulation of A. fumigatus virulenceScott Filler; Fiscal Year: 2007..Collectively, these results will form the foundation for the future development of new therapeutic strategies for invasive aspergillosis. ..
- Transcriptional regulation of A. fumigatus virulenceScott Filler; Fiscal Year: 2009..Collectively, these results will form the foundation for the future development of new therapeutic strategies for invasive aspergillosis. ..
- C. albicans-Epithelial Interactions & Oropharyngeal DiseaseScott Filler; Fiscal Year: 2009..4) The functional relationships among C. albicans virulence genes will be elucidated by transcriptional profiling and epistasis analysis using both newly created and existing C. albicans mutants. ..
- Candida Invasion of Endothelium and VirulenceScott G Filler; Fiscal Year: 2010..Furthermore, this information may be used to develop new diagnostic or therapeutic strategies against this frequently fatal disease. ..
- Transcriptional regulation of A. fumigatus virulenceScott G Filler; Fiscal Year: 2010..Collectively, these results will form the foundation for the future development of new therapeutic strategies for invasive aspergillosis. ..
- C. albicans-Epithelial Interactions & Oropharyngeal DiseaseScott Filler; Fiscal Year: 2007..4) The functional relationships among C. albicans virulence genes will be elucidated by transcriptional profiling and epistasis analysis using both newly created and existing C. albicans mutants. ..
- Candida Invasion of Endothelium and VirulenceScott Filler; Fiscal Year: 2007..albicans genes that promote endothelial cell damage in vitro and virulence. ..
- PATHOGENESIS OF OROPHARYNGEAL CANDIDIASISScott Filler; Fiscal Year: 2004..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
- Aspergillus Angioinvasion and DisseminationScott Filler; Fiscal Year: 2006..These studies are designed to lay the essential foundation for a comprehensive research program aimed at elucidating the molecular mechanisms by which A. fumigatus invades blood vessels and hematogenously disseminates. ..
- Candida albicans Epithelial Cell Interactions and Oropharyngeal DiseaseScott G Filler; Fiscal Year: 2010..Furthermore, this information may be used to develop new therapeutic strategies against this highly prevalent disease. ..