JOHN FIKE

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Irradiation induces neural precursor-cell dysfunction
    Michelle L Monje
    Department of Neurosurgery, Stanford University, Stanford, California, USA
    Nat Med 8:955-62. 2002
  2. pmc Neural precursor cells and central nervous system radiation sensitivity
    John R Fike
    Brain and Spinal Injury Center, University of California, San Francisco, CA 94110 0899, USA
    Semin Radiat Oncol 19:122-32. 2009
  3. ncbi request reprint Radiation response of neural precursor cells
    John R Fike
    Department of Neurological Surgery and Radiation Oncology, University of California, San Francisco, USA
    Neurosurg Clin N Am 18:115-27, x. 2007
  4. ncbi request reprint Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
  5. ncbi request reprint Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments
    Ramadevi Pullela
    Department of Pediatrics, University of California, San Francisco, CA 94143 0520, USA
    Dev Neurosci 28:396-409. 2006
  6. ncbi request reprint Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation
    Yang Fan
    Department of Neurological Surgery 112C, University of California at San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Eur J Neurosci 25:38-46. 2007
  7. ncbi request reprint Altered growth and radiosensitivity in neural precursor cells subjected to oxidative stress
    Charles L Limoli
    Department of Radiation Oncology, University of California, Medical Sciences I, Irvine, California 92697 2695, USA
    Int J Radiat Biol 82:640-7. 2006
  8. pmc Hippocampal neurogenesis and neuroinflammation after cranial irradiation with (56)Fe particles
    Radoslaw Rola
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94110, USA
    Radiat Res 169:626-32. 2008
  9. ncbi request reprint Alterations in hippocampal neurogenesis following traumatic brain injury in mice
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Exp Neurol 202:189-99. 2006
  10. ncbi request reprint The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception
    Jean Philippe Vit
    Department of Anatomy, University of California San Francisco, 94143 0452, USA
    Pain 120:188-201. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Irradiation induces neural precursor-cell dysfunction
    Michelle L Monje
    Department of Neurosurgery, Stanford University, Stanford, California, USA
    Nat Med 8:955-62. 2002
    ..These findings provide clear targets for future therapeutic interventions...
  2. pmc Neural precursor cells and central nervous system radiation sensitivity
    John R Fike
    Brain and Spinal Injury Center, University of California, San Francisco, CA 94110 0899, USA
    Semin Radiat Oncol 19:122-32. 2009
    ....
  3. ncbi request reprint Radiation response of neural precursor cells
    John R Fike
    Department of Neurological Surgery and Radiation Oncology, University of California, San Francisco, USA
    Neurosurg Clin N Am 18:115-27, x. 2007
    ..Understanding how neural precursor cells respond to noxious stimuli is likely to lead to new therapeutic approaches that should restore neurogenesis and perhaps improve cognitive performance...
  4. ncbi request reprint Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
    ..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits...
  5. ncbi request reprint Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments
    Ramadevi Pullela
    Department of Pediatrics, University of California, San Francisco, CA 94143 0520, USA
    Dev Neurosci 28:396-409. 2006
    ..Behavioral changes are a likely consequence of regional-specific neuronal degeneration...
  6. ncbi request reprint Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation
    Yang Fan
    Department of Neurological Surgery 112C, University of California at San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Eur J Neurosci 25:38-46. 2007
    ....
  7. ncbi request reprint Altered growth and radiosensitivity in neural precursor cells subjected to oxidative stress
    Charles L Limoli
    Department of Radiation Oncology, University of California, Medical Sciences I, Irvine, California 92697 2695, USA
    Int J Radiat Biol 82:640-7. 2006
    ..To determine whether changes in oxidative stress could enhance the sensitivity of neural precursor cells to ionizing radiation...
  8. pmc Hippocampal neurogenesis and neuroinflammation after cranial irradiation with (56)Fe particles
    Radoslaw Rola
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94110, USA
    Radiat Res 169:626-32. 2008
    ..Whether these changes will result in functional impairments or if/how they can be managed are topics for further investigation...
  9. ncbi request reprint Alterations in hippocampal neurogenesis following traumatic brain injury in mice
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Exp Neurol 202:189-99. 2006
    ..No differences were noted in oligodendrocytes (BrdU/NG2). Taken together, these data demonstrate that TBI alters both neurogenesis and gliogenesis. Such alterations may play a contributory role in TBI-induced cognitive impairment...
  10. ncbi request reprint The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception
    Jean Philippe Vit
    Department of Anatomy, University of California San Francisco, 94143 0452, USA
    Pain 120:188-201. 2006
    ..We conclude that the analgesic effect of low dose irradiation of bone cancer is associated with the alteration of nociceptive transmission in the central nervous system...
  11. pmc Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110 0899, and GRECC, VA Palo Alto Health Care System, USA
    Free Radic Biol Med 42:1133-45; discussion 1131-2. 2007
    ..This finding may have a major impact in developing strategies to reduce cognitive impairment after cranial irradiation...
  12. ncbi request reprint Radiation effects on neural precursor cells in the dentate gyrus
    Marta Andres-Mach
    Department of Neurological Surgery, San Francisco General Hospital, Bldg 1, 1001 Potrero Avenue, San Francisco, CA 94110 0899, USA
    Cell Tissue Res 331:251-62. 2008
    ....
  13. pmc Cell-density-dependent regulation of neural precursor cell function
    Charles L Limoli
    Departments of Radiation Oncology and Neurological Surgery, University of California, San Francisco, CA 94103
    Proc Natl Acad Sci U S A 101:16052-7. 2004
    ..These data showed that neural precursor cells were predisposed to microenvironmental cues that regulate redox-sensitive pathways to control cellular proliferation after CNS damage...
  14. pmc Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein)
    Susanna Rosi
    Brain and Spinal Injury Center, Department of Physical Therapy and Rehabilitation Sciences, University of California, San Francisco, San Francisco, California 94110, USA
    Cancer Res 68:9763-70. 2008
    ..These findings are the first to show that local brain irradiation initiates changes in hippocampal neurons that disrupt the activity patterns (Arc expression) associated with neuroplasticity and memory...
  15. pmc Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain
    Matthew B Potts
    Brain and Spinal Injury Center and Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosci Res 87:1848-57. 2009
    ..087). Overall, these data demonstrate that traumatic injury to the injured immature brain impairs neurogenesis during maturation and suggest that GPx cannot rescue this reduced neurogenesis...
  16. ncbi request reprint Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress
    Charles L Limoli
    Department of Radiation Oncology, University of California, San Francisco, California 94103 0806, USA
    Radiat Res 161:17-27. 2004
    ....
  17. ncbi request reprint Extreme sensitivity of adult neurogenesis to low doses of X-irradiation
    Shinichiro Mizumatsu
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    Cancer Res 63:4021-7. 2003
    ....
  18. pmc Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD
    Kelly Fishman
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94110 0899, USA
    Free Radic Biol Med 47:1459-67. 2009
    ..Overall, these data suggest that under conditions of SOD deficiency, there is a common pathway dictating how neurogenesis is affected by ionizing irradiation...
  19. pmc Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells
    Munjal M Acharya
    Department of Radiation Oncology, University of California, Irvine, CA 92697 2695, USA
    Proc Natl Acad Sci U S A 106:19150-5. 2009
    ..These results demonstrate the capability to ameliorate radiation-induced normal tissue injury using hESCs, and suggest that such strategies may provide useful interventions for reducing the adverse effects of irradiation on cognition...
  20. ncbi request reprint Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Nature 425:968-73. 2003
    ..These observations provide the first in vivo evidence for cell fusion of BMDCs with neurons and cardiomyocytes, raising the possibility that cell fusion may contribute to the development or maintenance of these key cell types...
  21. pmc Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity
    Jennifer Baure
    Department of Neurological Surgery, University of California, San Francisco, CA 94110, USA
    Mutagenesis 24:161-7. 2009
    ..The capability to induce significant gamma-H2AX formation under altered tonicity in the relative absence of DNA strand breaks suggests that this histone modification evolved in response to changes in chromatin structure...
  22. ncbi request reprint Depletion of neural precursor cells after local brain irradiation is due to radiation dose to the parenchyma, not the vasculature
    Shinji Otsuka
    Department of Neurological Surgery, University of California San Francisco, USA
    Radiat Res 165:582-91. 2006
    ..This information, and in particular the approach of selectively irradiating the vasculature, may be useful in developing radioprotective compounds for use during therapeutic irradiation...
  23. ncbi request reprint Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 159:812-34. 2003
    ..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public...
  24. ncbi request reprint Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits
    Jacob Raber
    Departments of Behavioral Neuroscience and Neurology, Oregon Health and Science University, Portland, OR, USA
    Ann Neurol 55:381-9. 2004
    ..These impairments after cerebral global ischemia under conditions of reduced neurogenesis support a role for the production of new cells in mediating functional recovery...
  25. ncbi request reprint Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
    Radiat Res 162:39-47. 2004
    ..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments...
  26. ncbi request reprint Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dose-dependent manner
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Radiat Res 162:442-6. 2004
    ..The present data provide the first evidence that high-LET radiation has deleterious effects on cells associated with hippocampal neurogenesis...
  27. ncbi request reprint Roles of the mammalian subventricular zone in cell replacement after brain injury
    Michael J Romanko
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Prog Neurobiol 74:77-99. 2004
    ..By reviewing, comparing and contrasting the responses of the SVZs to different injuries, our goal is to provide a foundation from which current and future studies on the potential of the SVZs for cell replacement can be evaluated...
  28. ncbi request reprint Efficient production of reactive oxygen species in neural precursor cells after exposure to 250 MeV protons
    Erich Giedzinski
    Department of Radiation Oncology, University of California, San Francisco, California 94103 0806, USA
    Radiat Res 164:540-4. 2005
    ..Our results corroborate earlier studies using X rays and provide further evidence that elevated ROS are integral to the radioresponse of neural precursor cells...
  29. ncbi request reprint High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesis
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Radiat Res 164:556-60. 2005
    ..These results indicate that high-LET radiation has a significant and long-lasting effect on the neurogenic population in the hippocampus that involves cell loss and changes in the microenvironment...
  30. ncbi request reprint Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003
    Helen B Stone
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 162:711-28. 2004
    ....

Research Grants11

  1. Radiation and Oxidative Stress: Effects on Neurogenesis
    JOHN FIKE; Fiscal Year: 2009
    ....
  2. Radiation and Oxidative Stress Effects on Neurogenesis
    JOHN FIKE; Fiscal Year: 2007
    ..abstract_text> ..
  3. NEUROGENESIS AND COGNITION IN IRRADIATED YOUNG MICE
    JOHN FIKE; Fiscal Year: 2002
    ..abstract_text> ..
  4. RADIATION RESPONSE OF THE NORMAL SUBEPENDYMA
    JOHN FIKE; Fiscal Year: 2001
    ..abstract_text> ..
  5. Radiation and Oxidative Stress: Effects on Neurogenesis
    John R Fike; Fiscal Year: 2010
    ....