Research Topics
| JOHN FIKESummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Irradiation induces neural precursor-cell dysfunctionMichelle L Monje
Department of Neurosurgery, Stanford University, Stanford, California, USA
Nat Med 8:955-62. 2002..These findings provide clear targets for future therapeutic interventions...
Neural precursor cells and central nervous system radiation sensitivityJohn R Fike
Brain and Spinal Injury Center, University of California, San Francisco, CA 94110 0899, USA
Semin Radiat Oncol 19:122-32. 2009....- Radiation response of neural precursor cellsJohn R Fike
Department of Neurological Surgery and Radiation Oncology, University of California, San Francisco, USA
Neurosurg Clin N Am 18:115-27, x. 2007..Understanding how neural precursor cells respond to noxious stimuli is likely to lead to new therapeutic approaches that should restore neurogenesis and perhaps improve cognitive performance... - Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young miceRadoslaw Rola
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
Exp Neurol 188:316-30. 2004..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits... - Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairmentsRamadevi Pullela
Department of Pediatrics, University of California, San Francisco, CA 94143-0520, USA
Dev Neurosci 28:396-409. 2006..Behavioral changes are a likely consequence of regional-specific neuronal degeneration... - Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiationYang Fan
Department of Neurological Surgery 112C, University of California at San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Eur J Neurosci 25:38-46. 2007.... - Altered growth and radiosensitivity in neural precursor cells subjected to oxidative stressCharles L Limoli
Department of Radiation Oncology, University of California, Medical Sciences I, Irvine, California 92697 2695, USA
Int J Radiat Biol 82:640-7. 2006..To determine whether changes in oxidative stress could enhance the sensitivity of neural precursor cells to ionizing radiation... - Hippocampal neurogenesis and neuroinflammation after cranial irradiation with (56)Fe particlesRadoslaw Rola
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94110, USA
Radiat Res 169:626-32. 2008..Whether these changes will result in functional impairments or if/how they can be managed are topics for further investigation... - Alterations in hippocampal neurogenesis following traumatic brain injury in miceRadoslaw Rola
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Exp Neurol 202:189-99. 2006..No differences were noted in oligodendrocytes (BrdU/NG2). Taken together, these data demonstrate that TBI alters both neurogenesis and gliogenesis. Such alterations may play a contributory role in TBI-induced cognitive impairment... - The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociceptionJean Philippe Vit
Department of Anatomy, University of California San Francisco, 94143 0452, USA
Pain 120:188-201. 2006..We conclude that the analgesic effect of low dose irradiation of bone cancer is associated with the alteration of nociceptive transmission in the central nervous system... - Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesisRadoslaw Rola
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110 0899, and GRECC, VA Palo Alto Health Care System, USA
Free Radic Biol Med 42:1133-45; discussion 1131-2. 2007..This finding may have a major impact in developing strategies to reduce cognitive impairment after cranial irradiation... - Radiation effects on neural precursor cells in the dentate gyrusMarta Andres-Mach
Department of Neurological Surgery, San Francisco General Hospital, Bldg 1, 1001 Potrero Avenue, San Francisco, CA 94110 0899, USA
Cell Tissue Res 331:251-62. 2008.... - Cell-density-dependent regulation of neural precursor cell functionCharles L Limoli
Departments of Radiation Oncology and Neurological Surgery, University of California, San Francisco, CA 94103
Proc Natl Acad Sci U S A 101:16052-7. 2004..These data showed that neural precursor cells were predisposed to microenvironmental cues that regulate redox-sensitive pathways to control cellular proliferation after CNS damage... - Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein)Susanna Rosi
Brain and Spinal Injury Center, Department of Physical Therapy and Rehabilitation Sciences, University of California, San Francisco, San Francisco, California 94110, USA
Cancer Res 68:9763-70. 2008..These findings are the first to show that local brain irradiation initiates changes in hippocampal neurons that disrupt the activity patterns (Arc expression) associated with neuroplasticity and memory... - Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brainMatthew B Potts
Brain and Spinal Injury Center and Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosci Res 87:1848-57. 2009..087). Overall, these data demonstrate that traumatic injury to the injured immature brain impairs neurogenesis during maturation and suggest that GPx cannot rescue this reduced neurogenesis... - Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stressCharles L Limoli
Department of Radiation Oncology, University of California, San Francisco, California 94103 0806, USA
Radiat Res 161:17-27. 2004.... - Extreme sensitivity of adult neurogenesis to low doses of X-irradiationShinichiro Mizumatsu
Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
Cancer Res 63:4021-7. 2003.... - Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSODKelly Fishman
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94110 0899, USA
Free Radic Biol Med 47:1459-67. 2009..Overall, these data suggest that under conditions of SOD deficiency, there is a common pathway dictating how neurogenesis is affected by ionizing irradiation... - Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cellsMunjal M Acharya
Department of Radiation Oncology, University of California, Irvine, CA 92697 2695, USA
Proc Natl Acad Sci U S A 106:19150-5. 2009..These results demonstrate the capability to ameliorate radiation-induced normal tissue injury using hESCs, and suggest that such strategies may provide useful interventions for reducing the adverse effects of irradiation on cognition... - Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytesManuel Alvarez-Dolado
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143-0520, USA
Nature 425:968-73. 2003..These observations provide the first in vivo evidence for cell fusion of BMDCs with neurons and cardiomyocytes, raising the possibility that cell fusion may contribute to the development or maintenance of these key cell types... - Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarityJennifer Baure
Department of Neurological Surgery, University of California, San Francisco, CA 94110, USA
Mutagenesis 24:161-7. 2009..The capability to induce significant gamma-H2AX formation under altered tonicity in the relative absence of DNA strand breaks suggests that this histone modification evolved in response to changes in chromatin structure... - Depletion of neural precursor cells after local brain irradiation is due to radiation dose to the parenchyma, not the vasculatureShinji Otsuka
Department of Neurological Surgery, University of California San Francisco, USA
Radiat Res 165:582-91. 2006..This information, and in particular the approach of selectively irradiating the vasculature, may be useful in developing radioprotective compounds for use during therapeutic irradiation... - Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001C Norman Coleman
Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Radiat Res 159:812-34. 2003..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public... - Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficitsJacob Raber
Departments of Behavioral Neuroscience and Neurology, Oregon Health and Science University, Portland, OR, USA
Ann Neurol 55:381-9. 2004..These impairments after cerebral global ischemia under conditions of reduced neurogenesis support a role for the production of new cells in mediating functional recovery... - Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesisJacob Raber
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
Radiat Res 162:39-47. 2004..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments... - Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dose-dependent mannerRadoslaw Rola
U CA, San Francisco
Radiat Res 162:442-6. 2004..The present data provide the first evidence that high-LET radiation has deleterious effects on cells associated with hippocampal neurogenesis... - Roles of the mammalian subventricular zone in cell replacement after brain injuryMichael J Romanko
Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Prog Neurobiol 74:77-99. 2004..By reviewing, comparing and contrasting the responses of the SVZs to different injuries, our goal is to provide a foundation from which current and future studies on the potential of the SVZs for cell replacement can be evaluated... - Efficient production of reactive oxygen species in neural precursor cells after exposure to 250 MeV protonsErich Giedzinski
U CA, San Francisco
Radiat Res 164:540-4. 2005..Our results corroborate earlier studies using X rays and provide further evidence that elevated ROS are integral to the radioresponse of neural precursor cells... - High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesisRadoslaw Rola
Loma Linda U, CA
Radiat Res 164:556-60. 2005..These results indicate that high-LET radiation has a significant and long-lasting effect on the neurogenic population in the hippocampus that involves cell loss and changes in the microenvironment... - Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003Helen B Stone
National Cancer Institute, Bethesda, Maryland 20892, USA
Radiat Res 162:711-28. 2004....
Research Grants
- Radiation and Oxidative Stress: Effects on NeurogenesisJOHN FIKE; Fiscal Year: 2009....
- Radiation and Oxidative Stress Effects on NeurogenesisJOHN FIKE; Fiscal Year: 2007..abstract_text> ..
- NEUROGENESIS AND COGNITION IN IRRADIATED YOUNG MICEJOHN FIKE; Fiscal Year: 2002..abstract_text> ..
- RADIATION RESPONSE OF THE NORMAL SUBEPENDYMAJOHN FIKE; Fiscal Year: 2001..abstract_text> ..
- Radiation and Oxidative Stress: Effects on NeurogenesisJohn R Fike; Fiscal Year: 2010....