Genomes and Genes
Brian T Fife
Affiliation: University of Minnesota
- Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signalBrian T Fife
UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, California, USA
Nat Immunol 10:1185-92. 2009..Blockade of the immunomodulatory receptor CTLA-4 did not alter T cell motility or abrogate tolerance. Thus, PD-1-PD-L1 interactions maintain peripheral tolerance by mechanisms fundamentally distinct from those of CTLA-4...
- Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathwayBrian T Fife
UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, and Transplantation Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
J Exp Med 203:2737-47. 2006....
- Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD miceCraig Meagher
Diabetes Center, University of California, San Francisco, CA 94143, USA
J Immunol 180:7793-803. 2008..CD28KO mice provides an excellent model for the study of disease pathogenesis and development of new therapies for human autoimmune pancreatitis...
- PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetesKristen E Pauken
Department of Medicine, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Diabetes 62:2859-69. 2013..These data support a model by which PD-1 regulates islet-reactive CD4(+) T cells in a cell intrinsic manner by suppressing proliferation, inhibiting infiltration of the pancreas, and limiting diabetes. ..
- Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic miceQizhi Tang
Diabetes Center, Department of Medicine, University of California, San Francisco 94143, USA
Nat Immunol 7:83-92. 2006..Such persistent T(reg) cell-dendritic cell contacts preceded the inhibition of T(H) cell activation by dendritic cells, supporting the idea that dendritic cells are central to T(reg) cell function in vivo...
- Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonistBrian T Fife
UCSF Diabetes Center, Department of Medicine, UCSF, San Francisco, California 94143, and Department of Internal Medicine, Division of Nephrology, Mayo Clinic, Rochester, Minnesota, USA
J Clin Invest 116:2252-61. 2006....
- Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathwaysBrian T Fife
Department of Medicine, UCSF Diabetes Center, University of California, San Francisco, CA 94113, USA
Immunol Rev 224:166-82. 2008....
- Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunityXuyu Zhou
Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 205:1983-91. 2008..These results support a central role for miRNAs in maintaining the stability of differentiated T reg cell function in vivo and homeostasis of the adaptive immune system...
- Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in miceAndrew C Melton
Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
J Clin Invest 120:4436-44. 2010..Our results therefore suggest that the integrin αvβ8 pathway is biologically important and that αvβ8 expression on DCs could be a therapeutic target for the treatment of Th17-driven autoimmune disease...
- The role of the PD-1 pathway in autoimmunity and peripheral toleranceBrian T Fife
Department of Medicine, Division of Rheumatic and Autoimmune Diseases, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Ann N Y Acad Sci 1217:45-59. 2011..Finally, we discuss the potential to selectively target the PD-1 pathway therapeutically to alter T cell function during autoimmunity...