Phoebe Fielding

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Sterol efflux to apolipoprotein A-I originates from caveolin-rich microdomains and potentiates PDGF-dependent protein kinase activity
    P E Fielding
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California 94143, USA
    Biochemistry 41:4929-37. 2002
  2. ncbi request reprint Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80
    Phoebe E Fielding
    Cardiovascular Research Institute and Departments of Medicine, University of California, San Francisco, California 94143, USA
    Biochemistry 43:2578-86. 2004
  3. ncbi request reprint Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex
    Jarkko Huuskonen
    Cardiovascular Research Institute, University of California San Francisco, CA 94143, USA
    Arterioscler Thromb Vasc Biol 25:1180-5. 2005
  4. ncbi request reprint Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferase
    Yasushi Nakamura
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Biochemistry 43:14811-20. 2004
  5. ncbi request reprint Benzophenone-containing cholesterol surrogates: synthesis and biological evaluation
    Thomas A Spencer
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    J Lipid Res 45:1510-8. 2004
  6. ncbi request reprint Regulation of ATP-binding cassette transporter A1 transcription by thyroid hormone receptor
    Jarkko Huuskonen
    Cardiovascular Research Institute, San Francisco, California 94143 0130, USA
    Biochemistry 43:1626-32. 2004
  7. ncbi request reprint Role of p160 coactivator complex in the activation of liver X receptor
    Jarkko Huuskonen
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Arterioscler Thromb Vasc Biol 24:703-8. 2004
  8. ncbi request reprint Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts
    Jarkko Huuskonen
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Biochem Biophys Res Commun 306:463-8. 2003
  9. ncbi request reprint Relationship between cholesterol trafficking and signaling in rafts and caveolae
    Christopher J Fielding
    Cardiovascular Research Institute and Department of Physiology, University of California, San Francisco, CA 94143 0130, USA
    Biochim Biophys Acta 1610:219-28. 2003
  10. ncbi request reprint Preparation and biochemical evaluation of fluorenone-containing lipid analogs
    Thomas A Spencer
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    Bioorg Med Chem Lett 16:3000-4. 2006

Research Grants

  1. NEW PATHWAY LIMITS CELLULAR CHOLESTEROL CONTENT
    Phoebe Fielding; Fiscal Year: 2000
  2. NEW PATHWAY LIMITS CELLULAR CHOLESTEROL CONTENT
    Phoebe Fielding; Fiscal Year: 2004

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Sterol efflux to apolipoprotein A-I originates from caveolin-rich microdomains and potentiates PDGF-dependent protein kinase activity
    P E Fielding
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California 94143, USA
    Biochemistry 41:4929-37. 2002
    ..These results suggest that sterols within caveolae are mobile and selectively transferred to apo A-I. They also suggest a novel role for sterol efflux in amplifying PDGF-mediated signal transduction...
  2. ncbi request reprint Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80
    Phoebe E Fielding
    Cardiovascular Research Institute and Departments of Medicine, University of California, San Francisco, California 94143, USA
    Biochemistry 43:2578-86. 2004
    ....
  3. ncbi request reprint Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex
    Jarkko Huuskonen
    Cardiovascular Research Institute, University of California San Francisco, CA 94143, USA
    Arterioscler Thromb Vasc Biol 25:1180-5. 2005
    ..In this study, we investigated the activation of ABCA1 by brahma-related gene 1 (BRG-1) and brahma, members of the SWI/SNF (mating type switching/sucrose nonfermenting) chromatin remodeling complex...
  4. ncbi request reprint Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferase
    Yasushi Nakamura
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Biochemistry 43:14811-20. 2004
    ..The cholesteryl ester produced in pre-beta(1)-HDL in turn became the preferred substrate of CETP. Selective LCAT-mediated reactivity with pre-beta(1)-HDL represents a novel mechanism increasing the efficiency of RCT...
  5. ncbi request reprint Benzophenone-containing cholesterol surrogates: synthesis and biological evaluation
    Thomas A Spencer
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    J Lipid Res 45:1510-8. 2004
    ..The results suggest an unexpected tolerance of biological membranes regarding the incorporation of sterols of differing chemical structure...
  6. ncbi request reprint Regulation of ATP-binding cassette transporter A1 transcription by thyroid hormone receptor
    Jarkko Huuskonen
    Cardiovascular Research Institute, San Francisco, California 94143 0130, USA
    Biochemistry 43:1626-32. 2004
    ..These data identify a novel regulatory mechanism for ABCA1 and suggest new strategies to modify its expression...
  7. ncbi request reprint Role of p160 coactivator complex in the activation of liver X receptor
    Jarkko Huuskonen
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Arterioscler Thromb Vasc Biol 24:703-8. 2004
    ..In this study, we have investigated the role of p160 coactivator complex in the regulation of ATP-binding transporter A1 (ABCA1), a clinically important gene transcriptionally upregulated by LXR/RXR (retinoid X receptor) heterodimer...
  8. ncbi request reprint Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts
    Jarkko Huuskonen
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Biochem Biophys Res Commun 306:463-8. 2003
    ..In both cell lines class 3 transcript levels were minimal and unchanged. It is shown here for the first time that the regulation of ABCA1 mRNA levels exploits the use of alternative transcription start sites...
  9. ncbi request reprint Relationship between cholesterol trafficking and signaling in rafts and caveolae
    Christopher J Fielding
    Cardiovascular Research Institute and Department of Physiology, University of California, San Francisco, CA 94143 0130, USA
    Biochim Biophys Acta 1610:219-28. 2003
    ..A role in the uptake of microorganisms by cells ascribed to caveolae now seems more likely to be mediated by cell surface rafts...
  10. ncbi request reprint Preparation and biochemical evaluation of fluorenone-containing lipid analogs
    Thomas A Spencer
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    Bioorg Med Chem Lett 16:3000-4. 2006
    ....
  11. ncbi request reprint Mechanism of prebeta-HDL formation and activation
    Phuonglan Chau
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Biochemistry 45:3981-7. 2006
    ..Product but not precursor apo A1 promoted reverse cholesterol transport (RCT) from human aortic smooth muscle cells. These studies suggest an important contribution of secreted lipid-free apo A1 to HDL formation...
  12. ncbi request reprint Bone morphogenetic protein-1 (BMP-1) cleaves human proapolipoprotein A1 and regulates its activation for lipid binding
    Phuonglan Chau
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
    Biochemistry 46:8445-50. 2007
    ..The decrease in circulating apo A1 levels that is characteristic of the response to inflammation and infection may be mediated, at least in part, via BMP-1 by this novel mechanism...

Research Grants8

  1. NEW PATHWAY LIMITS CELLULAR CHOLESTEROL CONTENT
    Phoebe Fielding; Fiscal Year: 2000
    ..These studies will provide novel basic information on the biology of cellular cholesterol homeostasis. They will also identify new targets for intervention in promoting the unloading of cholesterol-filled cells. ..
  2. NEW PATHWAY LIMITS CELLULAR CHOLESTEROL CONTENT
    Phoebe Fielding; Fiscal Year: 2004
    ..Each of these studies has significant relevance to the basis of FC accumulation in atherosclerosis. ..