F Field

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo-2 cells: effect on cholesterol efflux to high-density lipoprotein
    Shubha Murthy
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochem J 377:545-52. 2004
  2. ncbi Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells
    F J Field
    Department of Internal Medicine, 4 522 JCP, 200 Hawkins Drive, and Veterans Administration, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Lipid Res 42:1687-98. 2001
  3. ncbi Origins of intestinal ABCA1-mediated HDL-cholesterol
    F Jeffrey Field
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 49:2605-19. 2008
  4. ncbi Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport
    F Jeffrey Field
    Department of Veterans Affairs, Iowa City, IA 52242, USA
    Biochem J 368:855-64. 2002
  5. ncbi Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression
    F Jeffrey Field
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 44:1199-208. 2003
  6. ncbi LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells
    F Jeffrey Field
    Department of Veterans Affairs, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 45:905-13. 2004
  7. ncbi Ezetimibe interferes with cholesterol trafficking from the plasma membrane to the endoplasmic reticulum in CaCo-2 cells
    F Jeffrey Field
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 48:1735-45. 2007
  8. ncbi Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression
    F Jeffrey Field
    Department of Veterans Affairs, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 45:2252-9. 2004
  9. ncbi Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid
    Satya N Mathur
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 48:395-404. 2007
  10. ncbi TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2
    F Jeffrey Field
    Department of Internal, Medicine University of Iowa, Iowa City, IA 52242, USA f jeffrey fi
    J Lipid Res 51:1407-15. 2010

Research Grants

  1. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2007
  2. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009

Collaborators

Detail Information

Publications12

  1. ncbi Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo-2 cells: effect on cholesterol efflux to high-density lipoprotein
    Shubha Murthy
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochem J 377:545-52. 2004
    ....
  2. ncbi Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells
    F J Field
    Department of Internal Medicine, 4 522 JCP, 200 Hawkins Drive, and Veterans Administration, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Lipid Res 42:1687-98. 2001
    ..In contrast, 25-hydroxycholesterol influx or cholesterol depletion alters the amount of mature SREBP, leading to the regulation of sterol-responsive gene expression...
  3. ncbi Origins of intestinal ABCA1-mediated HDL-cholesterol
    F Jeffrey Field
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 49:2605-19. 2008
    ..NPC1 may have a role in this process...
  4. ncbi Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport
    F Jeffrey Field
    Department of Veterans Affairs, Iowa City, IA 52242, USA
    Biochem J 368:855-64. 2002
    ..Since all fatty acids decreased fatty acid synthesis, mechanisms other than changes in SREBP-1c expression must be entertained. Increased endogenous fatty acid synthesis does not promote triacylglycerol-rich lipoprotein secretion...
  5. ncbi Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression
    F Jeffrey Field
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 44:1199-208. 2003
    ..Fatty acid influx decreases intestinal fatty acid synthesis by a posttranscriptional mechanism independent of the SREBP pathway...
  6. ncbi LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells
    F Jeffrey Field
    Department of Veterans Affairs, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 45:905-13. 2004
    ..ABCA1, however, may play a role in beta-sitosterol absorption...
  7. ncbi Ezetimibe interferes with cholesterol trafficking from the plasma membrane to the endoplasmic reticulum in CaCo-2 cells
    F Jeffrey Field
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 48:1735-45. 2007
    ..Interfering with its function will profoundly decrease the amount of cholesterol transported into lymph...
  8. ncbi Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression
    F Jeffrey Field
    Department of Veterans Affairs, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 45:2252-9. 2004
    ..Cholesterol flux regulates ABC expression but not NPC1L1. The different localization of ABCA1 suggests a different function for this protein than for ABCG1, ABCG5, ABCG8, and NPC1L1...
  9. ncbi Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid
    Satya N Mathur
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 48:395-404. 2007
    ..Moreover, a diet enriched in n-3 fatty acids decreases the gene expression of NPC1L1 in duodenum and jejunum of hamster...
  10. ncbi TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2
    F Jeffrey Field
    Department of Internal, Medicine University of Iowa, Iowa City, IA 52242, USA f jeffrey fi
    J Lipid Res 51:1407-15. 2010
    ..The results suggest that TNF-alpha, the major cytokine implicated in the inflammation of Crohn's disease, decreases HDL cholesterol levels by attenuating the expression of intestinal ABCA1 and cholesterol efflux to apoA1...
  11. ncbi LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells
    Shubha Murthy
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 43:1054-64. 2002
    ..Thus, in CaCo-2 cells, LXR/RXR activation increases gene expression of ABCA1 and ABCG1 and the basolateral efflux of cholesterol, suggesting that ABCA1 plays an important role in intestinal HDL production and cholesterol absorption...
  12. ncbi Oxysterols trigger ABCA1-mediated basolateral surfactant efflux
    Marianna Agassandian
    Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Am J Respir Cell Mol Biol 31:227-33. 2004
    ..The results indicate the existence of an oxysterol-activated basolateral exit pathway for surfactant that might impact the availability of phospholipid destined for apical secretion...

Research Grants6

  1. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2007
    ..The results of this proposal will provide new and novel information on the roles of the ABC transporters, NPC1L1, and lipid rafts in intestinal sterol metabolism ..
  2. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009
    ..The results of this proposal will provide new and novel information on the roles of the ABC transporters, NPC1L1, and lipid rafts in intestinal sterol metabolism ..