Genomes and Genes
Affiliation: University of California
- ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairmentMilan Fiala
Department of Surgery and Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA and Department of Biostatistics, University of California, Los Angeles, School of Public Health, Los Angeles, California, USA
FASEB J 29:2681-9. 2015..Our study is the first to show significant immune and biochemical effects of ω-3 fatty acids with antioxidants in patients with MCI. Cognitive benefits of ω-3 supplementation in patients with MCI should be tested in a clinical trial...
- Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but curcumin inhibits interferon-γ production: benefits of omega-3 with curcumin against cancerMilan Fiala
Department of Surgery, School of Medicine, University of California, Los Angeles, CA 90095, USA
Molecules 20:3020-6. 2015..The combined use of curcuminoids and omega-3 in cancer immunotherapy will require deeper understanding of their in vivo interactions with the immune system. ..
- HIV-1 Antigens in Neurons of Cocaine-Abusing PatientsMilan Fiala
Departments of Medicine, UCLA School of Medicine, Los Angeles, California, USA
Open Virol J 2:24-31. 2008..Cocaine effects may be important in vivo since the neurons of drug abusing patients with HIV-1 associated dementia displayed gp120, p24 and Nef...
- Immune defects in Alzheimer's disease: new medications developmentJohn R Cashman
Human BioMolecular Research Institute, San Diego, CA 92121, USA
BMC Neurosci 9:S13. 2008..Bisdemethoxycurcumin appears to enhance immune function in mononuclear cells of AD patients and may provide a novel approach to AD immunotherapy...
- Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's diseaseMilan Fiala
Department of Medicine, UCLA VA School of Medicine, Los Angeles, CA, USA
J Alzheimers Dis 11:457-63. 2007..Finally, peripheral blood leukocytes are a superior model system for investigation of innate immune dysfunction in Alzheimer's disease...
- Biomarkers of inflammation and amyloid-beta phagocytosis in patients at risk of Alzheimer diseaseMilan Fiala
Departments of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
Exp Gerontol 45:57-63. 2010..Thus novel diagnostic tests may provide biomarkers for pre-clinical detection, clarification of progression from MCI to AD, and follow-up of patients in clinical trials of immunostimulating therapies...
- Re-balancing of inflammation and abeta immunity as a therapeutic for Alzheimer's disease-view from the bedsideMilan Fiala
Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
CNS Neurol Disord Drug Targets 9:192-6. 2010..More invasive immune approaches involve Abeta vaccine and cytokine antagonists. Increased inflammation may represent the "first hit", and defective transcription of immune genes the "second hit" in the pathogenesis of AD...
- IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patientsMilan Fiala
Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 650 Charles E, Young Dr, South, Los Angeles, CA 90095 1735, USA
J Neuroinflammation 7:76. 2010..Immune modulation of chronic inflammation may be a new approach to sALS...
- MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimer's disease by vitamin D and curcuminoidsMilan Fiala
Department of Medicine, Greater Los Angeles VA Medical Center and UCLA School of Medicine, Los Angeles, CA, USA
J Alzheimers Dis 25:135-44. 2011..In vitro results suggest that vitamin D3 supplementation might be beneficial in both Type I and II patients, whereas curcuminoids only in Type I. These results must be investigated in a large prospective study...
- Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcuminMilan Fiala
Department of Medicine, Greater Los Angeles Veterans Affairs Medical Center, and School of Medicine, University of California Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:12849-54. 2007..Thus, bisdemethoxycurcumin may correct immune defects of AD patients and provide a previously uncharacterized approach to AD immunotherapy...
- 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patientsMathew T Mizwicki
Department of Surgery, David Geffen School of Medicine at UCLA, University of California Los Angeles, CA 90095, USA
J Alzheimers Dis 34:155-70. 2013....
- Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patientsLaura Zhang
Department of Medicine, Greater LA VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
J Alzheimers Dis 10:1-7. 2006..Immunomodulation of the innate immune system by curcuminoids might be a safe approach to immune clearance of amyloidosis in AD brain...
- 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patientsAva Masoumi
Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095 7358, USA
J Alzheimers Dis 17:703-17. 2009..Human macrophages are a new paradigm for testing immune therapies for AD...
- Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathyJustin Zaghi
Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital Research Center, Los Angeles, CA 90095 7358, USA
Acta Neuropathol 117:111-24. 2009..In conclusion, in patients with AD, macrophages appear to shuttle Abeta from neurons to vessels where their apoptosis may release fibrillar Abeta, contributing to cerebral amyloid angiopathy...
- Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patientsMilan Fiala
Department of Medicine, Greater LA VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
J Alzheimers Dis 7:221-32; discussion 255-62. 2005..Thus Abeta clearance is not restricted to brain microglia and involves systemic innate immune responses. In AD, however, macrophage phagocytosis is defective, which may elicit compensatory response by the adaptive immune system...
- Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord: inhibition of inflammation by resolvin D1Guanghao Liu
Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 650 Charles E Young Dr South, Los Angeles, CA 90095 1735, USA
Am J Neurodegener Dis 1:60-74. 2012..RvD1 strongly inhibits in ALS macrophages and PBMCs cytokine transcription and production. Resolvins offer a new approach to suppression of inflammatory activation in ALS...
- Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cellsMilan Fiala
Department of Medicine, West Los Angeles VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
J Neurovirol 11:281-91. 2005..The toxicity of cocaine for the blood-brain barrier may lead to increased virus neuroinvasion and neurovascular complications of cocaine abuse...
- Immune blood biomarkers of Alzheimer disease patientsHripsime Avagyan
Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States
J Neuroimmunol 210:67-72. 2009..The significance of abnormal results in aged persons should be investigated by prospective studies to determine the risk of AD...
- HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosisMilan Fiala
Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA, USA
Cardiovasc Toxicol 4:327-37. 2004..In conclusion, HIV-1 and gp120 induce toxicity through induction of cardiomyocyte and endothelial cell apoptosis. HAART drugs disrupt endothelial cell junctions and mitochondria and could cause vascular damage...
- HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signalingMilan Fiala
Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA 90095 1760, USA
Cardiovasc Toxicol 4:97-107. 2004....
- Genomic and nongenomic signaling induced by 1α,25(OH)2-vitamin D3 promotes the recovery of amyloid-β phagocytosis by Alzheimer's disease macrophagesMathew T Mizwicki
Department of Biochemistry, University of California, Riverside, CA 90095 3517, USA
J Alzheimers Dis 29:51-62. 2012..The structure-function results provide evidence that 1,25D3 activation of VDR-dependent genomic and nongenomic signaling, work in concert to recover dysregulated innate immune function in AD...
- Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cellsMichael C Graves
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1668, USA
Amyotroph Lateral Scler Other Motor Neuron Disord 5:213-9. 2004..Our data suggest that inflammation in ALS spinal cord and cortex is based on innate immune responses by macrophages and mast cells and adaptive immune responses by T cells...
- Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsyMilan Fiala
Department of Medicine, Greater LA VA Medical Center, Los Angeles, CA 90073, United States UCLA School of Medicine, Los Angeles, CA 90095, United States
Pathophysiology 20:59-69. 2013..The results have implications for the development of new medical and surgical therapies based on inhibition of chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy...
- Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signalingMathew T Mizwicki
Department of Surgery, David Geffen School of Medicine at UCLA 650 Charles E Young Dr South, Los Angeles, CA 90095 1735, USA
Am J Neurodegener Dis 1:305-15. 2012..This pilot study demonstrates that in vitro tocilizumab suppresses many factors that drive inflammation in sALS patients, with possible increased efficacy in Group 1 ALS patients...
- Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathwayNancy Q Liu
Department of Medicine, Greater Los Angeles VA Medical Center, 675 Young Drive South, Los Angeles, CA 90073, USA
J Virol 76:6689-700. 2002..Therefore, HIV-1 penetrates BMVECs in ICAM-1-lined macropinosomes by a mechanism involving lipid rafts, MAPK signaling, and glycosylaminoglycans, while CD4 and chemokine receptors play limited roles in this process...
- Curcuminoids and ω-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon γ productionRamesh C Halder
Department of Surgery, University of California, Los Angeles, School of Medicine Los Angeles, CA, USA
Front Physiol 6:129. 2015..The effects of curcuminoids with ω-3 fatty acids and anti-oxidants on pancreatic cancer will be investigated in a mouse model with humanized immune system...
- Neuro-immunity in stress-related oral ulcerations: a fractal analysisFrancesco Chiappelli
Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90095 1668, USA
Front Biosci 10:3034-41. 2005..Our findings also open new frontiers of fundamental, clinical and translational biosciences of OLP...
- Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathwaysCheryl Twu
Department of Medicine, Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, CA 90073, USA
Proc Natl Acad Sci U S A 99:14386-91. 2002..In conclusion, in patients with HIVCM, cardiomyocytes die through both mitochondrion- and death receptor-controlled apoptotic pathways...
- Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasionMichael D Bobardt
Department of Immunology, IMM 9, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
J Virol 78:6567-84. 2004....
- CARDIOMYOPATHY, HIV1 AND CHEMOKINESMilan Fiala; Fiscal Year: 2001..The results of this research could lead to development of new strategies for preventing or ameliorating the effects of HIV infection on the heart. ..
- COCAINE AND HIV1 IN CORONARY ENDOTHELIUMMilan Fiala; Fiscal Year: 2002..abstract_text> ..