M Fiala

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients
    Laura Zhang
    Department of Medicine, Greater LA VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Alzheimers Dis 10:1-7. 2006
  2. pmc TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier
    M Fiala
    Department of Medicine, UCLA School of Medicine 90095 1769, USA
    Mol Med 3:553-64. 1997
  3. ncbi HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling
    Milan Fiala
    Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA 90095 1760, USA
    Cardiovasc Toxicol 4:97-107. 2004
  4. ncbi Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients
    Milan Fiala
    Department of Medicine, Greater LA VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Alzheimers Dis 7:221-32; discussion 255-62. 2005
  5. ncbi Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells
    Milan Fiala
    Department of Medicine, West Los Angeles VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Neurovirol 11:281-91. 2005
  6. ncbi Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier
    M Fiala
    Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095 1760, USA
    Eur J Clin Invest 32:360-71. 2002
  7. pmc Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model
    M Fiala
    Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Mol Med 4:480-9. 1998
  8. ncbi Essential role of HIV type 1-infected and cyclooxygenase 2-activated macrophages and T cells in HIV type 1 myocarditis
    Q N Liu
    Department of Medicine, West Los Angeles VA Medical Center and UCLA School of Medicine, Los Angeles, California 90095-1769, USA
    AIDS Res Hum Retroviruses 17:1423-33. 2001
  9. pmc HIV-1 penetrates coronary artery endothelial cells by transcytosis
    C Gujuluva
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    Mol Med 7:169-76. 2001
  10. ncbi HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis
    Milan Fiala
    Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA, USA
    Cardiovasc Toxicol 4:327-37. 2004

Collaborators

Detail Information

Publications25

  1. ncbi Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients
    Laura Zhang
    Department of Medicine, Greater LA VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Alzheimers Dis 10:1-7. 2006
    ..Immunomodulation of the innate immune system by curcuminoids might be a safe approach to immune clearance of amyloidosis in AD brain...
  2. pmc TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier
    M Fiala
    Department of Medicine, UCLA School of Medicine 90095 1769, USA
    Mol Med 3:553-64. 1997
    ..High-level plasma viremia is a likely source of brain infection. To understand the invasion route, we investigated virus penetration across in vitro models with contrasting paracellular permeability subjected to TNF-alpha...
  3. ncbi HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling
    Milan Fiala
    Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA 90095 1760, USA
    Cardiovasc Toxicol 4:97-107. 2004
    ....
  4. ncbi Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients
    Milan Fiala
    Department of Medicine, Greater LA VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Alzheimers Dis 7:221-32; discussion 255-62. 2005
    ..Thus Abeta clearance is not restricted to brain microglia and involves systemic innate immune responses. In AD, however, macrophage phagocytosis is defective, which may elicit compensatory response by the adaptive immune system...
  5. ncbi Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells
    Milan Fiala
    Department of Medicine, West Los Angeles VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Neurovirol 11:281-91. 2005
    ..The toxicity of cocaine for the blood-brain barrier may lead to increased virus neuroinvasion and neurovascular complications of cocaine abuse...
  6. ncbi Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier
    M Fiala
    Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095 1760, USA
    Eur J Clin Invest 32:360-71. 2002
    ..Monocyte/macrophages are known to infiltrate the brain of patients with HIV-1 encephalitis (HIVE). In Alzheimer's disease brain, the origin of activated microglia has not been determined...
  7. pmc Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model
    M Fiala
    Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Mol Med 4:480-9. 1998
    ....
  8. ncbi Essential role of HIV type 1-infected and cyclooxygenase 2-activated macrophages and T cells in HIV type 1 myocarditis
    Q N Liu
    Department of Medicine, West Los Angeles VA Medical Center and UCLA School of Medicine, Los Angeles, California 90095-1769, USA
    AIDS Res Hum Retroviruses 17:1423-33. 2001
    ..These data suggest that COX-2-activated and HIV-1-infected monocyte-macrophages and T cells play a crucial role in the progression of HIV-1 myocarditis to HIV-1 cardiomyopathy...
  9. pmc HIV-1 penetrates coronary artery endothelial cells by transcytosis
    C Gujuluva
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    Mol Med 7:169-76. 2001
    ..CONCLUSIONS: The endothelium is not an impenetrable barrier to HIV-1. The virus opens a transcellular route across coronary and brain endothelia in cytoplasmic vacuoles...
  10. ncbi HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis
    Milan Fiala
    Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA, USA
    Cardiovasc Toxicol 4:327-37. 2004
    ..In conclusion, HIV-1 and gp120 induce toxicity through induction of cardiomyocyte and endothelial cell apoptosis. HAART drugs disrupt endothelial cell junctions and mitochondria and could cause vascular damage...
  11. pmc CXC and CC chemokine receptors on coronary and brain endothelia
    O Berger
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Mol Med 5:795-805. 1999
    ..Chemokine receptors on leukocytes play a key role in inflammation and HIV-1 infection. Chemokine receptors on endothelia may serve an important role in HIV-1 tissue invasion and angiogenesis...
  12. doi Immune blood biomarkers of Alzheimer disease patients
    Hripsime Avagyan
    Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States
    J Neuroimmunol 210:67-72. 2009
    ..The significance of abnormal results in aged persons should be investigated by prospective studies to determine the risk of AD...
  13. ncbi Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease
    Milan Fiala
    Department of Medicine, UCLA VA School of Medicine, Los Angeles, CA, USA
    J Alzheimers Dis 11:457-63. 2007
    ..Finally, peripheral blood leukocytes are a superior model system for investigation of innate immune dysfunction in Alzheimer's disease...
  14. doi Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy
    Justin Zaghi
    Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital Research Center, Los Angeles, CA 90095 7358, USA
    Acta Neuropathol 117:111-24. 2009
    ..In conclusion, in patients with AD, macrophages appear to shuttle Abeta from neurons to vessels where their apoptosis may release fibrillar Abeta, contributing to cerebral amyloid angiopathy...
  15. doi 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients
    Ava Masoumi
    Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095 7358, USA
    J Alzheimers Dis 17:703-17. 2009
    ..Human macrophages are a new paradigm for testing immune therapies for AD...
  16. pmc Biomarkers of inflammation and amyloid-beta phagocytosis in patients at risk of Alzheimer disease
    Milan Fiala
    Departments of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Exp Gerontol 45:57-63. 2010
    ..Thus novel diagnostic tests may provide biomarkers for pre-clinical detection, clarification of progression from MCI to AD, and follow-up of patients in clinical trials of immunostimulating therapies...
  17. ncbi Re-balancing of inflammation and abeta immunity as a therapeutic for Alzheimer's disease-view from the bedside
    Milan Fiala
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    CNS Neurol Disord Drug Targets 9:192-6. 2010
    ..Increased inflammation may represent the "first hit", and defective transcription of immune genes the "second hit" in the pathogenesis of AD...
  18. pmc Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin
    Milan Fiala
    Department of Medicine, Greater Los Angeles Veterans Affairs Medical Center, and School of Medicine, University of California Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:12849-54. 2007
    ..Thus, bisdemethoxycurcumin may correct immune defects of AD patients and provide a previously uncharacterized approach to AD immunotherapy...
  19. ncbi Neuro-immunity in stress-related oral ulcerations: a fractal analysis
    Francesco Chiappelli
    Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90095 1668, USA
    Front Biosci 10:3034-41. 2005
    ..Our findings also open new frontiers of fundamental, clinical and translational biosciences of OLP...
  20. pmc IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
    Milan Fiala
    Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 650 Charles E, Young Dr, South, Los Angeles, CA 90095 1735, USA
    J Neuroinflammation 7:76. 2010
    ..Immune modulation of chronic inflammation may be a new approach to sALS...
  21. pmc Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways
    Cheryl Twu
    Department of Medicine, Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, CA 90073, USA
    Proc Natl Acad Sci U S A 99:14386-91. 2002
    ..In conclusion, in patients with HIVCM, cardiomyocytes die through both mitochondrion- and death receptor-controlled apoptotic pathways...
  22. pmc Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway
    Nancy Q Liu
    Department of Medicine, Greater Los Angeles VA Medical Center, 675 Young Drive South, Los Angeles, CA 90073, USA
    J Virol 76:6689-700. 2002
    ..Therefore, HIV-1 penetrates BMVECs in ICAM-1-lined macropinosomes by a mechanism involving lipid rafts, MAPK signaling, and glycosylaminoglycans, while CD4 and chemokine receptors play limited roles in this process...
  23. ncbi Neuroendocrine-immune surveillance of osteosarcoma: emerging hypothesis
    P Prolo
    Division of Oral Biology and Medicine, CHS 63 090, School of Dentistry, and Dental Research Institute, UCLA, Los Angeles, CA 90095 1668, USA
    J Dent Res 82:417-21. 2003
    ..This paper discusses the mechanisms by which apoptosis of osteosarcoma cells is modulated by the neuroendocrine-immune system, and potential physiological implications...
  24. ncbi Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells
    Michael C Graves
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1668, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:213-9. 2004
    ..Our data suggest that inflammation in ALS spinal cord and cortex is based on innate immune responses by macrophages and mast cells and adaptive immune responses by T cells...
  25. pmc Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion
    Michael D Bobardt
    Department of Immunology, IMM 9, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 78:6567-84. 2004
    ....