Research Topics
Genomes and Genes | R FeyereisenSummaryAffiliation: University of Arizona Country: USA Publications
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Publications
Insect P450 enzymesR Feyereisen
Department of Entomology, University of Arizona, Tucson 85721, USA
Annu Rev Entomol 44:507-33. 1999..Polymorphisms in induction or constitutive expression allow insects to scan their P450 gene repertoire for the appropriate response to chemical insults, and these evolutionary pressures in turn maintain P450 diversity...
Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domainM B Murataliev
Department of Entomology, University of Arizona, Tucson 85721, USA
Biochemistry 35:15029-37. 1996..Cytochrome c reductase and hydroxylase activities of P450BM3 involve different sites of interaction with the flavoprotein domain, different catalytic intermediates, and different rate-limiting steps...
Functional interactions in cytochrome P450BM3: flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domainM B Murataliev
Department of Entomology and Center for Toxicology, University of Arizona, Tucson, Arizona 85721 0036, USA
Biochemistry 36:8401-12. 1997..We also propose that an interaction of bound NADP+ with anionic FAD semiquinone is essential for splitting a pair of electrons that are then transferred in two one-electron transfer steps to the heme catalytic site...
Mechanism of cytochrome P450 reductase from the house fly: evidence for an FMN semiquinone as electron donorM B Murataliev
Department of Entomology and Center for Toxicology, University of Arizona, Tucson 85721 0036, USA
FEBS Lett 453:201-4. 1999..The results show that the reduction state of the house fly P450 reductase during catalysis cycles in a 0-2-1-0 sequence...
Interaction of NADP(H) with oxidized and reduced P450 reductase during catalysis. Studies with nucleotide analoguesM B Murataliev
Department of Entomology and Center for Toxicology, University of Arizona, Tucson, Arizona 85721 0036, USA
Biochemistry 39:5066-74. 2000....
The Drosophila cytochrome P450 gene Cyp6a2: structure, localization, heterologous expression, and induction by phenobarbitalB C Dunkov
Department of Entomology, University of Arizona, Tucson 85721 0036, USA
DNA Cell Biol 16:1345-56. 1997..The Cyp6a2 gene appears to be a suitable model for a genetic analysis of the phenobarbital induction process...
Overproduction of a P450 that metabolizes diazinon is linked to a loss-of-function in the chromosome 2 ali-esterase (MdalphaE7) gene in resistant house fliesC Sabourault
Department of Entomology, University of Arizona, Tucson, AZ, USA
Insect Mol Biol 10:609-18. 2001....
The cytochrome P450 gene superfamily in Drosophila melanogaster: annotation, intron-exon organization and phylogenyN Tijet
Department of Entomology, Forbes 410, P O Box 210036, The University of Arizona, Tucson 85721, USA
Gene 262:189-98. 2001..melanogaster, CYP6A2, has been functionally characterized. Gene organization appears to be a useful tool in the study of the regulation, the physiological role and the function of these P450s...
Juvenile hormone resistance: ! no PASaran !R Feyereisen
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 95:2725-6. 1998
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allataC Helvig
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 101:4024-9. 2004..Heterologously expressed CYP15A1 from D. punctata or its ortholog from economically important species may be useful in the design and screening of selective insect control agents...
Molecular cloning, overexpression in Escherichia coli, structural and functional characterization of house fly cytochrome b5V M Guzov
Department of Entomology, University of Arizona, Tucson, Arizona 85721, USA
J Biol Chem 271:26637-45. 1996..The results indicate that cytochrome b5 stimulates a step following the first electron transfer during cytochrome P450 6A1 turnover...
Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA libraryD J Fraser
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
J Pharmacol Exp Ther 283:1425-32. 1997..These findings also suggest that 3A26 and 3A12 may be an interesting model system for the investigation of structure-function relationships involved in steroid metabolism catalyzed by members of the cytochrome P450 3A subfamily...
Functional interactions in cytochrome P450BM3. Evidence that NADP(H) binding controls redox potentials of the flavin cofactorsM B Murataliev
Department of Entomology and Center for Toxicology, University of Arizona, Tucson, Arizona 85721, USA
Biochemistry 39:12699-707. 2000..The values obtained differ from those calculated from equilibrium redox potentials by as much as 2 orders of magnitude. The differences result from the enzyme's interaction with NADP(H)...
Allatostatin-like-immunoreactive neurons of the tobacco hornworm, Manduca sexta, and isolation and identification of a new neuropeptide related to cockroach allatostatinsN T Davis
Division of Neurobiology, University of Arizona, Tucson 85721, USA
J Comp Neurol 385:265-84. 1997..The YXFGLamide-immunoreactive neurons in the terminal abdominal ganglion were found to innervate the hindgut, indicating that YXFGLamides may be involved in the control of the rate of myogenic contractions of the larval hindgut...
A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with pyrethroid resistance in Heliothis virescens FY Park
Interdisciplinary Program in Insect Science, University of Arizona, Tucson 85721, USA
Biochem Biophys Res Commun 239:688-91. 1997..Implications of this finding in the evolution and mechanisms of pyrethroid resistance are discussed...
Identification of three allatostatins and their cDNA from the mosquito Aedes aegyptiJ A Veenstra
Department of Entomology, University of Arizona, Tucson 85721, USA
Peptides 18:937-42. 1997..Identification of a partial prepro-allatostatin cDNA from a midgut cDNA library shows that the same gene is also expressed in the mosquito midgut...
Cytochrome P450 gene clusters in Drosophila melanogasterB C Dunkov
Department of Entomology, University of Arizona, Tucson 85721, USA
Mol Gen Genet 251:290-7. 1996..The identification of these genes and alleles will allow us to clarify the involvement of P450s in xenobiotic metabolism and will facilitate a genetic analysis of P450 functions in insects...
