Research Topics
| Robert FettiplaceSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Mechanisms of hair cell tuningR Fettiplace
Department of Physiology, University of Wisconsin, Madison 53706, USA
Annu Rev Physiol 61:809-34. 1999..Calcium-dependent feedback onto transduction channels may underlie active hair bundle mechanics. The relative contributions of electrical and mechanical feedback to active tuning of hair cells may vary as a function of sound frequency...
Active hair bundle movements in auditory hair cellsRobert Fettiplace
185 Medical Sciences Building, 1300, University Avenue, Madison, WI 53706, USA
J Physiol 576:29-36. 2006..This review summarizes evidence for active hair bundle motion and its connection to MT channel adaptation. Key factors for the hair bundle motor to play a role in the mammalian cochlea include the size and speed of force production...- Adaptation in auditory hair cellsRobert Fettiplace
Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
Curr Opin Neurobiol 13:446-51. 2003..The tuning information conveyed in transduction may combine with the somatic motility of outer hair cells to produce an active process that supplies amplification and augments frequency selectivity in the mammalian cochlea... - Defining features of the hair cell mechanoelectrical transducer channelRobert Fettiplace
Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, WI 53706, USA
Pflugers Arch 458:1115-23. 2009..The strengths and weaknesses of a TRP channel contender are discussed... - Clues to the cochlear amplifier from the turtle earR Fettiplace
Dept of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
Trends Neurosci 24:169-75. 2001..Furthermore, their speed depends on the frequency to which the hair cell is most sensitive, suggesting that such movements could be important in cochlear amplification and frequency discrimination... - Tonotopic variations of calcium signalling in turtle auditory hair cellsA J Ricci
Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
J Physiol 524:423-36. 2000.... - The sensory and motor roles of auditory hair cellsRobert Fettiplace
Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, Wisconsin 53706, USA
Nat Rev Neurosci 7:19-29. 2006..Both motor mechanisms are probably needed to provide the high sensitivity and frequency discrimination of the mammalian cochlea... - Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanismsHelen J Kennedy
Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
J Neurosci 26:2757-66. 2006..It is conceivable that the two processes can interact, a signal from the MET channels being capable of modulating the activity of the prestin motor... - Active hair bundle motion linked to fast transducer adaptation in auditory hair cellsA J Ricci
Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
J Neurosci 20:7131-42. 2000..This force generator may permit stimulus amplification during transduction in auditory hair cells... - The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cellsQingguo Chen
Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Eur J Neurosci 36:2302-10. 2012..The limited ability of PMCA2 to extrude the Ca(2+) load through MT channels may constitute a major cause of OHC vulnerability and high-frequency hearing loss... - The resting transducer current drives spontaneous activity in prehearing mammalian cochlear inner hair cellsStuart L Johnson
Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom
J Neurosci 32:10479-83. 2012..We propose that, in vivo, spontaneous Ca(2+) action potentials are intrinsically generated by IHCs up to the onset of hearing and that they are likely to influence the final sensory-independent refinement of the developing cochlea... - Force generation by mammalian hair bundles supports a role in cochlear amplificationH J Kennedy
Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
Nature 433:880-3. 2005..Our results show the existence of another force generator in outer hair cells that may participate in cochlear amplification... - The transduction channel filter in auditory hair cellsAnthony J Ricci
Center for Neuroscience, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
J Neurosci 25:7831-9. 2005.... - Tonotopic variation in the conductance of the hair cell mechanotransducer channelAnthony J Ricci
Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Neuron 40:983-90. 2003..It suggests diversity of transducer channel structure or environment along the cochlea that may be an important element of its tonotopic organization... - A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cellsMaryline Beurg
, , , , 33076 Bordeaux, France
J Neurosci 26:10992-1000. 2006..The results imply that the MT channel has properties possessed by few known candidates, and its diversity suggests expression of multiple isoforms... - The actions of calcium on hair bundle mechanics in mammalian cochlear hair cellsMaryline Beurg
INSERM U587, Universite Victor Segalen Bordeaux, Hopital Pellegrin, Bordeaux, France
Biophys J 94:2639-53. 2008..The significance of these results for cochlear transduction and amplification are discussed... - Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cellsHelen J Kennedy
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Nat Neurosci 6:832-6. 2003..It is argued that sub-millisecond transducer adaptation can operate in outer hair cells under the ionic, driving force and temperature conditions that prevail in the intact mammalian cochlea... - The distribution of calcium buffering proteins in the turtle cochleaCarole M Hackney
MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
J Neurosci 23:4577-89. 2003..Parvalbumin-beta was also found in both inner and outer hair cells of the guinea pig cochlea... - The dimensions and composition of stereociliary rootlets in mammalian cochlear hair cells: comparison between high- and low-frequency cells and evidence for a connection to the lateral membraneDavid N Furness
Institute of Science and Technology in Medicine, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
J Neurosci 28:6342-53. 2008.... - The concentrations of calcium buffering proteins in mammalian cochlear hair cellsCarole M Hackney
MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
J Neurosci 25:7867-75. 2005..The high concentration of calcium buffer in outer hair cells, similar only to skeletal muscle, may protect against deleterious consequences of Ca2+ loading after acoustic overstimulation...
Research Grants
- INTRACELLULAR CALCIUM IN HAIR CELLSRobert Fettiplace; Fiscal Year: 2003..Since the mechanotransducer channel may be the target of many diseases, acquired and genetic, exploring its mechanisms in situ could provide a rational approach to such clinical problems. ..
- INTRACELLULAR CALCIUM IN HAIR CELLSRobert Fettiplace; Fiscal Year: 2007..The work will address reasons for the differential sensitivity by mapping number and properties of transducer channels with cochlear location. ..
- INTRACELLULAR CALCIUM IN HAIR CELLSRobert Fettiplace; Fiscal Year: 2009..We hypothesize that calcium overloading leading to mitochondrial dysfunction is a major route to cell damage. ..
- INTRACELLULAR CALCIUM IN HAIR CELLSRobert Fettiplace; Fiscal Year: 2010..We hypothesize that calcium overloading leading to mitochondrial dysfunction is a major route to cell damage. ..
- INTRACELLULAR CALCIUM IN HAIR CELLSRobert Fettiplace; Fiscal Year: 1993....
- INTRACELLULAR CALCIUM IN HAIR CELLSRobert Fettiplace; Fiscal Year: 2009..We hypothesize that calcium overloading leading to mitochondrial dysfunction is a major route to cell damage. ..