Robert Fettiplace

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Mechanisms of hair cell tuning
    R Fettiplace
    Department of Physiology, University of Wisconsin, Madison 53706, USA
    Annu Rev Physiol 61:809-34. 1999
  2. ncbi request reprint The sensory and motor roles of auditory hair cells
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Rev Neurosci 7:19-29. 2006
  3. ncbi request reprint Adaptation in auditory hair cells
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
    Curr Opin Neurobiol 13:446-51. 2003
  4. pmc Active hair bundle movements in auditory hair cells
    Robert Fettiplace
    185 Medical Sciences Building, 1300, University Avenue, Madison, WI 53706, USA
    J Physiol 576:29-36. 2006
  5. pmc Defining features of the hair cell mechanoelectrical transducer channel
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, WI 53706, USA
    Pflugers Arch 458:1115-23. 2009
  6. ncbi request reprint Clues to the cochlear amplifier from the turtle ear
    R Fettiplace
    Dept of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
    Trends Neurosci 24:169-75. 2001
  7. pmc Tonotopic variations of calcium signalling in turtle auditory hair cells
    A J Ricci
    Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Physiol 524:423-36. 2000
  8. ncbi request reprint Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms
    Helen J Kennedy
    Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Neurosci 26:2757-66. 2006
  9. ncbi request reprint Active hair bundle motion linked to fast transducer adaptation in auditory hair cells
    A J Ricci
    Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Neurosci 20:7131-42. 2000
  10. pmc Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins
    Kyunghee X Kim
    Department of Neuroscience, University of Wisconsin Madison, WI 53706, USA
    J Gen Physiol 141:141-8. 2013

Research Grants

  1. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2003
  2. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2007
  3. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2009
  4. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2010
  5. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 1993
  6. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2009

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Mechanisms of hair cell tuning
    R Fettiplace
    Department of Physiology, University of Wisconsin, Madison 53706, USA
    Annu Rev Physiol 61:809-34. 1999
    ..Calcium-dependent feedback onto transduction channels may underlie active hair bundle mechanics. The relative contributions of electrical and mechanical feedback to active tuning of hair cells may vary as a function of sound frequency...
  2. ncbi request reprint The sensory and motor roles of auditory hair cells
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Rev Neurosci 7:19-29. 2006
    ..Both motor mechanisms are probably needed to provide the high sensitivity and frequency discrimination of the mammalian cochlea...
  3. ncbi request reprint Adaptation in auditory hair cells
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
    Curr Opin Neurobiol 13:446-51. 2003
    ..The tuning information conveyed in transduction may combine with the somatic motility of outer hair cells to produce an active process that supplies amplification and augments frequency selectivity in the mammalian cochlea...
  4. pmc Active hair bundle movements in auditory hair cells
    Robert Fettiplace
    185 Medical Sciences Building, 1300, University Avenue, Madison, WI 53706, USA
    J Physiol 576:29-36. 2006
    ..This review summarizes evidence for active hair bundle motion and its connection to MT channel adaptation. Key factors for the hair bundle motor to play a role in the mammalian cochlea include the size and speed of force production...
  5. pmc Defining features of the hair cell mechanoelectrical transducer channel
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, WI 53706, USA
    Pflugers Arch 458:1115-23. 2009
    ..The strengths and weaknesses of a TRP channel contender are discussed...
  6. ncbi request reprint Clues to the cochlear amplifier from the turtle ear
    R Fettiplace
    Dept of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
    Trends Neurosci 24:169-75. 2001
    ..Furthermore, their speed depends on the frequency to which the hair cell is most sensitive, suggesting that such movements could be important in cochlear amplification and frequency discrimination...
  7. pmc Tonotopic variations of calcium signalling in turtle auditory hair cells
    A J Ricci
    Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Physiol 524:423-36. 2000
    ....
  8. ncbi request reprint Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms
    Helen J Kennedy
    Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Neurosci 26:2757-66. 2006
    ..It is conceivable that the two processes can interact, a signal from the MET channels being capable of modulating the activity of the prestin motor...
  9. ncbi request reprint Active hair bundle motion linked to fast transducer adaptation in auditory hair cells
    A J Ricci
    Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Neurosci 20:7131-42. 2000
    ..This force generator may permit stimulus amplification during transduction in auditory hair cells...
  10. pmc Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins
    Kyunghee X Kim
    Department of Neuroscience, University of Wisconsin Madison, WI 53706, USA
    J Gen Physiol 141:141-8. 2013
    ..Changes in P(Ca) with maturation are consistent with a developmental decrease in abundance of Tmc2 in OHCs but not in IHCs...
  11. pmc The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells
    Qingguo Chen
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Eur J Neurosci 36:2302-10. 2012
    ..The limited ability of PMCA2 to extrude the Ca(2+) load through MT channels may constitute a major cause of OHC vulnerability and high-frequency hearing loss...
  12. pmc The resting transducer current drives spontaneous activity in prehearing mammalian cochlear inner hair cells
    Stuart L Johnson
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom
    J Neurosci 32:10479-83. 2012
    ..We propose that, in vivo, spontaneous Ca(2+) action potentials are intrinsically generated by IHCs up to the onset of hearing and that they are likely to influence the final sensory-independent refinement of the developing cochlea...
  13. ncbi request reprint Force generation by mammalian hair bundles supports a role in cochlear amplification
    H J Kennedy
    Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Nature 433:880-3. 2005
    ..Our results show the existence of another force generator in outer hair cells that may participate in cochlear amplification...
  14. ncbi request reprint The transduction channel filter in auditory hair cells
    Anthony J Ricci
    Center for Neuroscience, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:7831-9. 2005
    ....
  15. ncbi request reprint The distribution of calcium buffering proteins in the turtle cochlea
    Carole M Hackney
    MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
    J Neurosci 23:4577-89. 2003
    ..Parvalbumin-beta was also found in both inner and outer hair cells of the guinea pig cochlea...
  16. pmc The actions of calcium on hair bundle mechanics in mammalian cochlear hair cells
    Maryline Beurg
    INSERM U587, Universite Victor Segalen Bordeaux, Hopital Pellegrin, Bordeaux, France
    Biophys J 94:2639-53. 2008
    ..The significance of these results for cochlear transduction and amplification are discussed...
  17. ncbi request reprint A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells
    Maryline Beurg
    Equipe Associée 3665 Université Victor Segalen Bordeaux 2, Institut National de la Sante et de la Recherche Medicale, Unité 587, Hopital Pellegrin, 33076 Bordeaux, France
    J Neurosci 26:10992-1000. 2006
    ..The results imply that the MT channel has properties possessed by few known candidates, and its diversity suggests expression of multiple isoforms...
  18. ncbi request reprint Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells
    Helen J Kennedy
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Nat Neurosci 6:832-6. 2003
    ..It is argued that sub-millisecond transducer adaptation can operate in outer hair cells under the ionic, driving force and temperature conditions that prevail in the intact mammalian cochlea...
  19. ncbi request reprint Tonotopic variation in the conductance of the hair cell mechanotransducer channel
    Anthony J Ricci
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Neuron 40:983-90. 2003
    ..It suggests diversity of transducer channel structure or environment along the cochlea that may be an important element of its tonotopic organization...
  20. pmc The dimensions and composition of stereociliary rootlets in mammalian cochlear hair cells: comparison between high- and low-frequency cells and evidence for a connection to the lateral membrane
    David N Furness
    Institute of Science and Technology in Medicine, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
    J Neurosci 28:6342-53. 2008
    ....
  21. ncbi request reprint The concentrations of calcium buffering proteins in mammalian cochlear hair cells
    Carole M Hackney
    MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
    J Neurosci 25:7867-75. 2005
    ..The high concentration of calcium buffer in outer hair cells, similar only to skeletal muscle, may protect against deleterious consequences of Ca2+ loading after acoustic overstimulation...

Research Grants20

  1. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2003
    ..Since the mechanotransducer channel may be the target of many diseases, acquired and genetic, exploring its mechanisms in situ could provide a rational approach to such clinical problems. ..
  2. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2007
    ..The work will address reasons for the differential sensitivity by mapping number and properties of transducer channels with cochlear location. ..
  3. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2009
    ..We hypothesize that calcium overloading leading to mitochondrial dysfunction is a major route to cell damage. ..
  4. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2010
    ..We hypothesize that calcium overloading leading to mitochondrial dysfunction is a major route to cell damage. ..
  5. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 1993
    ....
  6. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2009
    ..We hypothesize that calcium overloading leading to mitochondrial dysfunction is a major route to cell damage. ..