Robert L Ferris

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): a natural disease model provides insights into viral carcinogenesis
    Robert L Ferris
    UPCI Research Pavilion, The Hillman Cancer Center, 5117 Centre Avenue, Room 1 19d, Pittsburgh, PA 15213 1863, USA
    Eur J Cancer 41:807-15. 2005
  2. pmc TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR(+) head and neck cancer cells
    Chwee Ming Lim
    Department of Otolaryngology University of Pittsburgh Medical Center Pittsburgh, PA USA Department of Immunology University of Pittsburgh Cancer Center Pittsburgh, PA USA Department of Otolaryngology Head and Neck Surgery National University Health System Singapore
    Oncoimmunology 2:e24677. 2013
  3. doi Sentinel lymph node biopsy versus selective neck dissection for detection of metastatic oral squamous cell carcinoma
    Robert L Ferris
    Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
    Clin Exp Metastasis 29:693-8. 2012
  4. pmc Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread
    Robert L Ferris
    Hillman Cancer Center Research, Pavilion 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
    Clin Exp Metastasis 29:729-36. 2012
  5. ncbi Intraoperative qRT-PCR for detection of lymph node metastasis in head and neck cancer
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 17:1858-66. 2011
  6. ncbi NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 13:5663-4. 2007
  7. ncbi Diagnostic utility of positron emission tomography-computed tomography for predicting malignancy in cystic neck masses in adults
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Hillman Cancer Center Research Wing, Pittsburgh, Pennsylvania 15213, USA
    Laryngoscope 115:1979-82. 2005
  8. pmc Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape
    Robert L Ferris
    The Hillman Cancer Center Research Pavilion, 5117 Centre Ave, Room 2 26b, Pittsburgh, PA 15213, USA
    J Clin Oncol 28:4390-9. 2010
  9. ncbi Molecular biology of primary hyperparathyroidism
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh Eye and Ear Institute, 203 Lothrop Street, Suite 500, Pittsburgh, PA 15213, USA
    Otolaryngol Clin North Am 37:819-31, x. 2004
  10. doi Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck
    John A Vargo
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Head Neck 34:1153-61. 2012

Research Grants

Collaborators

Detail Information

Publications98

  1. ncbi Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): a natural disease model provides insights into viral carcinogenesis
    Robert L Ferris
    UPCI Research Pavilion, The Hillman Cancer Center, 5117 Centre Avenue, Room 1 19d, Pittsburgh, PA 15213 1863, USA
    Eur J Cancer 41:807-15. 2005
    ..The results of our studies are consistent with a causative role of HPV-16 in the pathogenesis of SCCHN...
  2. pmc TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR(+) head and neck cancer cells
    Chwee Ming Lim
    Department of Otolaryngology University of Pittsburgh Medical Center Pittsburgh, PA USA Department of Immunology University of Pittsburgh Cancer Center Pittsburgh, PA USA Department of Otolaryngology Head and Neck Surgery National University Health System Singapore
    Oncoimmunology 2:e24677. 2013
    ..These findings suggest that TLR3 agonists may provide a convenient means to improve the efficacy of mAb-based anticancer regimens...
  3. doi Sentinel lymph node biopsy versus selective neck dissection for detection of metastatic oral squamous cell carcinoma
    Robert L Ferris
    Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
    Clin Exp Metastasis 29:693-8. 2012
    ..We present novel immune targets in nodal metastases, the importance of the lymph node as a pre-metastatic niche, and immune-related proteins as biomarkers of metastasis...
  4. pmc Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread
    Robert L Ferris
    Hillman Cancer Center Research, Pavilion 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
    Clin Exp Metastasis 29:729-36. 2012
    ..We present novel immune targets in nodal metastases, the importance of the lymph node as a pre-metastatic niche, and immune-related proteins as biomarkers of metastasis...
  5. ncbi Intraoperative qRT-PCR for detection of lymph node metastasis in head and neck cancer
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 17:1858-66. 2011
    ..The purpose of this study was to develop a rapid, automated, and quantitative real-time PCR (qRT-PCR) assay that can match final pathology in an intraoperative time frame...
  6. ncbi NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 13:5663-4. 2007
  7. ncbi Diagnostic utility of positron emission tomography-computed tomography for predicting malignancy in cystic neck masses in adults
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Hillman Cancer Center Research Wing, Pittsburgh, Pennsylvania 15213, USA
    Laryngoscope 115:1979-82. 2005
    ....
  8. pmc Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape
    Robert L Ferris
    The Hillman Cancer Center Research Pavilion, 5117 Centre Ave, Room 2 26b, Pittsburgh, PA 15213, USA
    J Clin Oncol 28:4390-9. 2010
    ..However, these results are only seen in a subset (20% to 30%) of patients. We discuss the immunologic mechanism(s) underlying these clinical findings and their potential role in the variability in patients' clinical response...
  9. ncbi Molecular biology of primary hyperparathyroidism
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh Eye and Ear Institute, 203 Lothrop Street, Suite 500, Pittsburgh, PA 15213, USA
    Otolaryngol Clin North Am 37:819-31, x. 2004
    ..In addition,such an approach would facilitate more appropriate postoperative surveillance, as well as counseling and screening of family members who may be at high risk for HPT...
  10. doi Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck
    John A Vargo
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Head Neck 34:1153-61. 2012
    ..Herein, we report the efficacy of SBRT in recurrent, nonsquamous cell cancers of the head and neck (NSCHNs)...
  11. doi Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial
    Dwight E Heron
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 75:1493-500. 2009
    ..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) in previously irradiated patients with squamous cell carcinoma of the head and neck (SCCHN)...
  12. doi Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy
    Trevor M Feinstein
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Head Neck 33:318-23. 2011
    ..This study was designed to identify the factors associated with the outcome after standard treatment with surgery and postoperative radiotherapy (RT) for locally advanced salivary gland cancers...
  13. ncbi Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL
    Andres Lopez-Albaitero
    Departments of Otolaryngology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    J Immunol 176:3402-9. 2006
    ....
  14. pmc Quantitative expression and immunogenicity of MAGE-3 and -6 in upper aerodigestive tract cancer
    Pedro A Andrade Filho
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Int J Cancer 125:1912-20. 2009
    ..Demethylating agents could increase the number of patients amenable for targeting epigenetically modified tumor antigens in vaccine trials...
  15. pmc Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and cross-presenting function
    Andres Lopez-Albaitero
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Immunother 32:465-73. 2009
    ....
  16. pmc The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy
    Jean Claude M Rwigema
    Departments of Radiation Oncology, University of Pittsburgh Cancer Institute, PA, USA
    Am J Clin Oncol 34:372-9. 2011
    ..To assess the effect of stereotactic body radiotherapy (SBRT) dose and tumor volume on outcomes in patients with recurrent, previously irradiated squamous cell carcinoma of the head and neck...
  17. pmc Serum biomarkers as potential predictors of antitumor activity of cetuximab-containing therapy for locally advanced head and neck cancer
    Athanassios Argiris
    Head and Neck Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States
    Oral Oncol 47:961-6. 2011
    ..Validation is warranted in future studies specifically designed to detect biomarker associations...
  18. pmc Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients
    Raghvendra M Srivastava
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Cancer Res 19:1858-72. 2013
    ..However, the role of CD8(+) CTL and FcγR in initiating innate and adaptive immune responses in mAb-treated human patients with cancer is still emerging...
  19. ncbi Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck
    Andreas Albers
    Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 65:11146-55. 2005
    ..These findings support further development of E7-specific immunotherapy and strategies for up-regulation of antigen-processing machinery components in HPV-associated SCCHN...
  20. doi Oncologic and functional outcomes of partial laryngeal surgery for intermediate-stage laryngeal cancer
    Emiro Caicedo-Granados
    Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Otolaryngol Head Neck Surg 148:235-42. 2013
    ..To evaluate the oncologic and functional outcomes of partial laryngeal surgery (PLS) using transoral laser microsurgery (TLM) and supracricoid laryngectomy (SCL) in patients with intermediate-stage laryngeal squamous cell carcinoma (LSCC)...
  21. ncbi Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck
    Daisuke Ito
    Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 120:2618-24. 2007
    ....
  22. doi Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    J Natl Cancer Inst 100:502-12. 2008
    ..Constitutive prosurvival signaling by the phosphoinositide-3 kinase/Akt pathway has been observed in SCCHN cells independent of epidermal growth factor receptor (EGFR) signaling...
  23. pmc Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer
    Athanassios Argiris
    University of Pittsburgh Medical Center Cancer Pavilion, 5th Floor, Pittsburgh, PA 15232, USA
    J Clin Oncol 28:5294-300. 2010
    ..We incorporated cetuximab, a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR), into the induction therapy and subsequent chemoradiotherapy of head and neck cancer (HNC)...
  24. pmc SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells
    Michael S Leibowitz
    Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Cancer Res 19:798-808. 2013
    ..We investigated whether an overexpressed phosphatase was responsible for basal suppression of pSTAT1 and subsequent APM component-mediated immune escape in HNC cells...
  25. ncbi Alterations in the T-cell receptor variable beta gene-restricted profile of CD8+ T lymphocytes in the peripheral circulation of patients with squamous cell carcinoma of the head and neck
    Andreas E Albers
    Division of Basic Research and Biostatistics, University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 12:2394-403. 2006
    ..We investigated whether T-cell receptor (TCR) variable beta chain (Vbeta)-restricted T cells were more sensitive to apoptosis than non-TCR Vbeta-restricted T cells...
  26. ncbi Clinicopathologic features as stronger prognostic factors than histology or grade in risk stratification of primary parotid malignancies
    Rohan R Walvekar
    Department of Otolaryngology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania, USA
    Head Neck 33:225-31. 2011
    ....
  27. ncbi Deferring planned neck dissection following chemoradiation for stage IV head and neck cancer: the utility of PET-CT
    Jayakar V Nayak
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Laryngoscope 117:2129-34. 2007
    ..To determine whether combined positron emission tomography and computed tomography (PET-CT) may be of value in deferring planned neck dissections for patients with advanced head and neck squamous cell carcinoma (HNSCC)...
  28. ncbi Head and neck cancer immunotherapy: clinical evaluation
    Michael S Leibowitz
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Suite 2 26, Pittsburgh, PA 15213, USA
    Curr Oncol Rep 10:162-9. 2008
    ..This article reviews immunotherapeutic strategies currently in clinical trials or under development for patients with SCCHN...
  29. ncbi CD8+ T cell recognition of polymorphic wild-type sequence p53(65-73) peptides in squamous cell carcinoma of the head and neck
    Pedro A Andrade Filho
    Department of Otolaryngology, University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, USA
    Cancer Immunol Immunother 59:1561-8. 2010
    ....
  30. pmc Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells
    Andres Lopez-Albaitero
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer Immunol Immunother 58:1853-64. 2009
    ..Cellular and secreted immune profiles and FcgammaR genotypes from patients' lymphocytes may provide clinically useful biomarkers of immune activation in cetuximab treated patients...
  31. ncbi Fractionated stereotactic body radiation therapy in the treatment of previously-irradiated recurrent head and neck carcinoma: updated report of the University of Pittsburgh experience
    Jean Claude Rwigema
    Department of Radiation Oncology, University Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Am J Clin Oncol 33:286-93. 2010
    ..The aim of this study was to assess the safety and outcome of stereotactic body radiotherapy (SBRT) in patients with recurrent previously irradiated squamous cell carcinoma of the head and neck (rSCCHN)...
  32. pmc Novel immunogenic HLA-A*0201-restricted epidermal growth factor receptor-specific T-cell epitope in head and neck cancer patients
    Pedro A Andrade Filho
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    J Immunother 33:83-91. 2010
    ..Thus, a novel, immunogenic EGFR-encoded CTL epitope may be incorporated into vaccines and would be useful for combinatorial immunotherapy with EGFR-specific mAbs in cancer patients...
  33. ncbi Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis
    Jeong Whun Kim
    Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA
    Clin Cancer Res 11:7901-10. 2005
    ..The absence of CCR7 expression on the majority of CD8(+) T cells in the peripheral circulation of patients with squamous cell carcinoma of the head and neck contributes to apoptosis and a rapid turnover of these effector cells...
  34. doi Extracapsular spread in head and neck carcinoma: impact of site and human papillomavirus status
    Jessica H Maxwell
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    Cancer 119:3302-8. 2013
    ..The prognostic value of ECS was evaluated for patients with oropharyngeal SCC (OPC; with known p16/human papillomavirus [HPV] status) and for patients with SCC of the oral cavity (OCC)...
  35. doi Accuracy of computed tomography in the prediction of extracapsular spread of lymph node metastases in squamous cell carcinoma of the head and neck
    Raymond L Chai
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    JAMA Otolaryngol Head Neck Surg 139:1187-94. 2013
    ..However, few studies have specifically assessed the diagnostic accuracy of computed tomography for determining the presence or absence of extracapsular spread (ECS)...
  36. ncbi Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neck
    Nicky Sirianni
    Department of Otolaryngology and Immunology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 10:6929-37. 2004
    ..The criterion of p53 overexpression would exclude these individuals from wt p53-based immunotherapy...
  37. pmc A retrospective, deformable registration analysis of the impact of PET-CT planning on patterns of failure in stereotactic body radiation therapy for recurrent head and neck cancer
    Kyle Wang
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Head Neck Oncol 4:12. 2012
    ..We analyzed the patterns of failure following SBRT for rSCCHN and assessed the impact of PET-CT treatment planning on these patterns of failure...
  38. pmc Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: a pilot randomized trial in head and neck cancer
    Howard S Moskowitz
    Department of Otolaryngology, Johns Hopkins Hospital, Baltimore, MD, USA
    Oral Oncol 48:1136-45. 2012
    ..Co-targeting of the G-protein-coupled receptor cyclooxygenase (COX) with EGFR inhibitors has shown promise in preclinical models and early phase clinical studies...
  39. doi Prospective evaluation of patient-reported quality-of-life outcomes following SBRT ± cetuximab for locally-recurrent, previously-irradiated head and neck cancer
    John A Vargo
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Radiother Oncol 104:91-5. 2012
    ..Here-in, we report the first prospective evaluation of patient-reported quality-of-life (PR-QoL) following re-irradiation with SBRT±cetuximab for rSCCHN...
  40. ncbi Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx
    Rohan R Walvekar
    Department of Otolaryngology, Head Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Laryngoscope 118:2129-34. 2008
    ..To define the role of surgical staging in limited (T1-2, N0-1) oropharyngeal squamous cell cancers...
  41. doi Concurrent cetuximab with stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: a single institution matched case-control study
    Dwight E Heron
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Am J Clin Oncol 34:165-72. 2011
    ....
  42. ncbi Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy
    Elmer R Cano
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Head Neck 31:1431-8. 2009
    ..We report a program consisting of concurrent chemoradiation followed by brachytherapy for these patients...
  43. ncbi Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients
    Bridget Hathaway
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Laryngoscope 115:522-7. 2005
    ..Furthermore, we hypothesized that persistent immune dysregulation in patients cured of their disease may be reflected in altered cytokine profiles in the systemic circulation...
  44. ncbi Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neck
    Robert L Ferris
    Department of Otolaryngology and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Res 65:2147-56. 2005
    ..These assays were completed (from tissue to result) in approximately 30 minutes, thus demonstrating the feasibility of intraoperative staging of SCCHN SLNs by QRT-PCR...
  45. ncbi Antiviral activity of Cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck (SCCHN) cell line improves radiation sensitivity
    Nicky Sirianni
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Oral Oncol 41:423-8. 2005
    ..Future therapies for HPV-associated tumors may include intralesional antiviral therapy in combination with radiation therapy, but optimization for clinical utility is needed...
  46. ncbi Immunotherapy of head and neck cancer using tumor antigen-specific monoclonal antibodies
    Steve C Lee
    The Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
    Curr Oncol Rep 11:156-62. 2009
    ....
  47. ncbi Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype
    Jun Wang
    Department of Otolaryngology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 64:1861-6. 2004
    ..Thus, CCR6, CCR7, and their ligands, normally important in controlling immune cell trafficking in response to inflammatory stimuli, may have an important role in determining the metastasis of SCCHN cells in vivo...
  48. pmc Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes
    Michael S Leibowitz
    Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer Immunol Immunother 60:525-35. 2011
    ..These findings demonstrate that APM component downregulation is regulated primarily by an IFN-γ-pSTAT1-mediated signaling pathway, independent of oncogenic STAT3 overexpression in SCCHN cells...
  49. pmc A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinoma
    Leo A Niemeier
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer 118:2069-77. 2012
    ..The objective of the study was to evaluate whether the combination of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation and specific histopathologic features allows risk stratification of TPMC...
  50. pmc Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN)
    Yvonne K Mburu
    Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 287:3581-90. 2012
    ..As such, CCR7, NF-κB, and AP1 could be potentially useful therapeutic targets in controlling the progression and metastasis of SCCHN tumors...
  51. ncbi Primary lymphoma of the larynx: new diagnostic and therapeutic approaches
    Jayakar V Nayak
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    ORL J Otorhinolaryngol Relat Spec 65:321-6. 2003
    ..The presence of nonsquamous laryngeal tumors reinforces the dictum to obtain a reliable tissue diagnosis before initiating definitive therapy...
  52. doi Positron emission tomography-computed tomography adds to the management of salivary gland malignancies
    Ali Razfar
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 120:734-8. 2010
    ..To evaluate the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying salivary gland malignancies and to examine the role of PET-CT in the management of these patients...
  53. pmc Evaluation of a thyroid nodule
    Steven R Bomeli
    Division of Head and Neck Surgery, Department of Otolaryngology, University of Pittsburgh, PA, USA
    Otolaryngol Clin North Am 43:229-38, vii. 2010
    ..Detecting malignancy preoperatively allows total thyroidectomy in a single operation without the need for frozen section or a second operation for completion of a thyroidectomy if malignancy is found during the initial thyroid lobectomy...
  54. pmc Sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancer
    Lisheng Ge
    Departments of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    Cancer Epidemiol Biomarkers Prev 18:2913-22. 2009
    ..These data show that increased TACE activity in cancer is biologically and clinically relevant, and indicate that TACE activity could be a significant biomarker of cancer prognosis...
  55. pmc HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
    Lynn M Knowles
    Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 15:3740-50. 2009
    ....
  56. ncbi Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh School of Medicine, PA 15213, USA
    Oncogene 24:5897-904. 2005
    ..The CCR7-mediated pathway in metastatic SCCHN cells functions independently of EGFR signal transduction and therefore may represent an additional target for therapeutic intervention to prevent tumor progression and metastasis...
  57. ncbi Adjuvant stereotactic body radiotherapy ± cetuximab following salvage surgery in previously irradiated head and neck cancer
    John A Vargo
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, U S A
    Laryngoscope 124:1579-84. 2014
    ..We aimed to identify if stereotactic body radiotherapy (SBRT) ± cetuximab improves tumor control while reducing treatment-related toxicity following salvage surgery...
  58. doi RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers
    Nikhil Gupta
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 98:E914-22. 2013
    ..RAS mutations are common in thyroid tumors and confer a high risk of cancer when detected in fine-needle aspiration (FNA) specimens. Specific characteristics of RAS-positive thyroid cancers are not well described...
  59. doi A new paradigm for the diagnosis and management of unknown primary tumors of the head and neck: a role for transoral robotic surgery
    Vikas Mehta
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center, Eye and Ear Institute, Pittsburgh, PA 15213, USA
    Laryngoscope 123:146-51. 2013
    ..With improved visualization and freedom of motion, transoral robotic surgery (TORS) is an innovative surgical modality that allows resection of oropharyngeal subsites with minimal morbidity...
  60. doi Posttreatment quality-of-life assessment in patients with head and neck cancer treated with intensity-modulated radiation therapy
    Michael O'Neill
    University of Pittsburgh School of Medicine, PA, USA
    Am J Clin Oncol 34:478-82. 2011
    ....
  61. pmc Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsy
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 122:1020-30. 2012
    ....
  62. doi Clinical usefulness of positron emission tomography-computed tomography in recurrent thyroid carcinoma
    Ali Razfar
    Department of Otolaryngology, University of Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 136:120-5. 2010
    ..To determine the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying recurrent thyroid cancer and to elucidate its role in the clinical management of thyroid carcinoma...
  63. ncbi Immune activation by epidermal growth factor receptor specific monoclonal antibody therapy for head and neck cancer
    Andres Lopez-Albaitero
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 133:1277-81. 2007
    ..To determine if the epidermal growth factor receptor (EGFR)-specific monoclonal antibodies (mAbs) cetuximab or panitumumab mediate in vitro immune activation against squamous cell carcinoma of the head and neck (SCCHN) cell lines...
  64. ncbi CCR7 mediates inflammation-associated tumor progression
    Yvonne K Mburu
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunol Res 36:61-72. 2006
    ..While extending these observations to metastatic SCCHN tumor cells, our studies highlight the importance of downstream NF-kappaB mediated CCR7 signals in the progression of SCCHN malignancy...
  65. pmc Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas
    Ivan Martinez
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Room East 1240, 200 Lothrop Street, Pittsburgh, PA 15208, USA
    Eur J Cancer 43:415-32. 2007
    ..Our results reveal specific gene expression patterns in HPV-positive and HPV-negative oropharyngeal squamous carcinomas that may serve as potential biomarkers for the development of SCCHN...
  66. ncbi Recent thymic emigrants and subsets of naive and memory T cells in the circulation of patients with head and neck cancer
    Iris Kuss
    University of Pittsburgh Cancer Institute, PA 15213 1863, USA
    Clin Immunol 116:27-36. 2005
    ..The defect persists long after curative treatments and may contribute to immune cell dysregulation in patients with cancer...
  67. doi Reconstruction of the through-and-through anterior mandibulectomy defect: indications and limitations of the double-skin paddle fibular free flap
    Frederic W B Deleyiannis
    Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 118:1329-34. 2008
    ....
  68. ncbi Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neck
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburgh, PA 15213, USA
    Adv Otorhinolaryngol 62:121-33. 2005
    ..Our data indicate that inhibition of CCR signaling may provide a targeted molecular therapy to prevent HNSCC metastasis...
  69. ncbi Head and neck squamous cell carcinoma cell lines: established models and rationale for selection
    Charles J Lin
    Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Head Neck 29:163-88. 2007
    ..An easily accessible guide that organizes important characteristics of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for in vitro or in vivo studies...
  70. ncbi Elective neck dissection and survival in patients with squamous cell carcinoma of the oral cavity and oropharynx
    Umamaheswar Duvvuri
    Department of Otolaryngology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, USA
    Laryngoscope 114:2228-34. 2004
    ..The study addressed the question of whether elective neck dissection improves regional control and survival in patients with squamous cell carcinoma of the oral cavity and oropharynx presenting with T1/T2 node-negative disease...
  71. ncbi Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling
    Faina Linkov
    Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Epidemiol Biomarkers Prev 16:102-7. 2007
    ..The data presented show that simultaneous testing using a multiplexed panel of serum biomarkers may present a promising new approach for the early detection of head and neck cancer...
  72. ncbi Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck
    Iris Kuss
    University of Pittsburgh Cancer Institute and Departments of Pathology and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 10:3755-62. 2004
    ..Clin Cancer Res 2002;8:2553-62)] suggested a possibility of lymphocyte imbalance. Therefore, absolute numbers and percentages of lymphocyte subsets were examined in the peripheral blood of SCCHN patients and controls...
  73. doi Management of patients treated with chemoradiotherapy for head and neck cancer without prophylactic feeding tubes: the University of Pittsburgh experience
    Brian T McLaughlin
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Laryngoscope 120:71-5. 2010
    ..Mucositis and dysphagia are common complications of chemoradiotherapy (CRT) for head and neck cancer that may necessitate nutritional support with a gastrostomy tube (G-tube)...
  74. ncbi Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma
    Stephen Y Lai
    Department of Otolaryngology Head and Neck Surgery, The Eye and Ear Institute, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Oncogene 24:4442-9. 2005
    ..Increased levels of EPO and EPOR in lymph node metastases as compared to primary tumors from HNSCC patients further support the role of EPO/EPOR in HNSCC disease progression and metastasis...
  75. doi Immunotherapy for head and neck cancer
    H Carter Davidson
    Department of Otolaryngology, University of Pittsburgh, Hillman Cancer Center Research Pavilion, PA 15213, United States
    Oral Oncol 45:747-51. 2009
    ..This article reviews immunotherapeutic strategies currently in clinical trials or under development for patients with SCCHN...
  76. ncbi Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?
    Michael R Shurin
    Department of Pathology, University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, PA 15213, USA
    Cancer Metastasis Rev 25:333-56. 2006
    ..This review is limited to discussing the role of intratumoral cytokine network in the understanding immunobiology of tumor-associated dendritic cells, which seems to possess different regulatory functions at the tumor site...
  77. pmc Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8⁺ T cells
    Carmen Visus
    Division of Basic Research, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 17:6174-84. 2011
    ..The ALDH1A1 isoform was previously identified as a tumor antigen recognized by CD8(+) T cells. This study examines the ability of ALDH1A1-specific CD8(+) T cells to eliminate ALDH(bright) cells and control tumor growth and metastases...
  78. ncbi Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers
    Regiane S Andrade
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 65:1315-22. 2006
    ....
  79. ncbi Immune responses to p53 in patients with cancer: enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites
    Andreas E Albers
    University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Immunol Immunother 54:1072-81. 2005
    ..Also, the localization of "regulatory" T cells (Treg) to tumor sites in HNC has not been investigated to date...
  80. ncbi Immune escape associated with functional defects in antigen-processing machinery in head and neck cancer
    Robert L Ferris
    University of Pittsburgh Cancer Institute and Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 12:3890-5. 2006
    ....
  81. pmc Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 96:3390-7. 2011
    ..Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate management...
  82. pmc Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity
    Steve C Lee
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Immunol Res 50:248-54. 2011
    ..These events likely contribute to clinical activity, as well as provide a potential biomarker of response to mAb therapy...
  83. pmc Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck
    Mark E Sharafinski
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Head Neck 32:1412-21. 2010
    ....
  84. doi Ocular outcomes after gold weight placement and facial nerve resection
    Ali Razfar
    Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Otolaryngol Head Neck Surg 140:82-5. 2009
    ..To assess the effectiveness of acute gold weight placement after facial nerve resection and to determine the role of concomitant lower eyelid procedures...
  85. ncbi Progress in head and neck cancer immunotherapy: can tolerance and immune suppression be reversed?
    Robert L Ferris
    Department of Otolaryngology, Hillman Cancer Center Research Pavilion, Pittsburgh, PA 15213, USA
    ORL J Otorhinolaryngol Relat Spec 66:332-40. 2004
    ..This article reviews adjuvant immunotherapeutic strategies currently in trials or under development for SCCHN patients, including vaccination or cytokine immunostimulation...
  86. doi Head and neck cancer
    Athanassios Argiris
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15232, USA
    Lancet 371:1695-709. 2008
    ..We review the epidemiology, molecular pathogenesis, diagnosis and staging, and the latest multimodal management of squamous cell carcinoma of the head and neck...
  87. ncbi Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo
    Galina V Shurin
    Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 174:5490-8. 2005
    ..Activation of DC with recombinant human CXCL14 was accompanied by up-regulation of NF-kappaB activity. These data suggest that CXCL14 is a potent chemoattractant and activator of DC and might be involved in DC homing in vivo...
  88. ncbi Human leukocyte antigen (HLA) class I defects in head and neck cancer: molecular mechanisms and clinical significance
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 1523, USA
    Immunol Res 33:113-33. 2005
    ....
  89. pmc Human β-defensin 3 promotes NF-κB-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck
    Yvonne K Mburu
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Carcinogenesis 32:168-74. 2011
    ..Our findings suggest that hBD3 represents a novel NF-κB-regulated mediator of CCR7 expression and anti-apoptotic pathways, which may be exploited by developing SCCHN tumors to enhance their survival and metastasis...
  90. ncbi Steroid psychosis after head and neck surgery: case report and review of the literature
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Otolaryngol Head Neck Surg 129:591-2. 2003
  91. ncbi Prognosis as a determinant of free flap utilization for reconstruction of the lateral mandibular defect
    Frederic W B Deleyiannis
    University of Pittsburgh, Division of Plastic and Reconstructive Surgery, Suite 6B Scaife Hall, 3550 Terrace Ave, Pittsburgh, PA 15261, USA
    Head Neck 28:1061-8. 2006
    ....
  92. ncbi Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck
    Thomas K Hoffmann
    Department of Pathology, Cancer Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Clin Cancer Res 8:1787-93. 2002
    ..An overall decrease in the myeloid-derived subset of DC could contribute to the failure of SCCHN patients to develop effective antitumor immune responses...
  93. ncbi Diagnostic assessment of laryngeal cancer
    Apurva A Thekdi
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Eye and Ear Institute, 200 Lothrop Street, Suite 521, Pittsburgh, PA 15213, USA
    Otolaryngol Clin North Am 35:953-69, v. 2002
    ..Newer methods of assessment and follow-up are being scientifically validated and will likely enhance the diagnostic efforts of the head and neck surgical oncologist...
  94. ncbi Radiology quiz case 2. Parapharyngeal second branchial cleft cyst
    Seshu Gadiparthi
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 130:1121, 1124-5. 2004
  95. ncbi Correlation of protease-activated receptor-1 with differentiation markers in squamous cell carcinoma of the head and neck and its implication in lymph node metastasis
    Xin Zhang
    Department of Hematology Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia 30322, USA
    Clin Cancer Res 10:8451-9. 2004
    ..Although the functions of PAR-1 in many normal cells, such as platelets and astrocytes, have been well studied, its roles in cancer progression and metastasis have not been fully elucidated, and studies to date appear contradictory...
  96. ncbi Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes
    Huashan Peng
    The Center for Hearing Sciences, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, JHOC 6241, 601 N Caroline Street, Baltimore, MD 21287, USA
    Life Sci 76:263-80. 2004
    ..However, a lack of demonstrated response to applied acetylcholine using standard single-cell recording techniques suggests a physiology different than that seen in hair cells of the inner ear...
  97. ncbi Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer
    Marion E Couch
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina, G0412 Neurosciences Hospital, Chapel Hill, North Carolina, USA
    Clin Cancer Res 13:7199-206. 2007
    ....
  98. doi Recurrence in head and neck squamous cell carcinoma. Editorial
    Michael S Leibowitz
    Cancer 113:671-3. 2008

Research Grants2

  1. Chemokine Signals in Head and Neck Cancer Progression
    Robert Ferris; Fiscal Year: 2007
    ..Overall these studies are designed to identify the EGFR-independent, CCR7-mediated pathways relevant to invasion and survival of SCCHN and to use this information to facilitate the development of CCR7 targeted therapeutic strategies. ..