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Genomes and Genes | Robert L FerrisSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spreadRobert L Ferris
Hillman Cancer Center Research, Pavilion 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
Clin Exp Metastasis 29:729-36. 2012..We present novel immune targets in nodal metastases, the importance of the lymph node as a pre-metastatic niche, and immune-related proteins as biomarkers of metastasis...
Sentinel lymph node biopsy versus selective neck dissection for detection of metastatic oral squamous cell carcinomaRobert L Ferris
Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
Clin Exp Metastasis 29:693-8. 2012..We present novel immune targets in nodal metastases, the importance of the lymph node as a pre-metastatic niche, and immune-related proteins as biomarkers of metastasis...
Molecular biology of primary hyperparathyroidismRobert L Ferris
Department of Otolaryngology, University of Pittsburgh Eye and Ear Institute, 203 Lothrop Street, Suite 500, Pittsburgh, PA 15213, USA
Otolaryngol Clin North Am 37:819-31, x. 2004..In addition,such an approach would facilitate more appropriate postoperative surveillance, as well as counseling and screening of family members who may be at high risk for HPT...- Intraoperative qRT-PCR for detection of lymph node metastasis in head and neck cancerRobert L Ferris
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 17:1858-66. 2011..The purpose of this study was to develop a rapid, automated, and quantitative real-time PCR (qRT-PCR) assay that can match final pathology in an intraoperative time frame... - Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescapeRobert L Ferris
The Hillman Cancer Center Research Pavilion, 5117 Centre Ave, Room 2 26b, Pittsburgh, PA 15213, USA
J Clin Oncol 28:4390-9. 2010..However, these results are only seen in a subset (20% to 30%) of patients. We discuss the immunologic mechanism(s) underlying these clinical findings and their potential role in the variability in patients' clinical response... - Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): a natural disease model provides insights into viral carcinogenesisRobert L Ferris
UPCI Research Pavilion, The Hillman Cancer Center, 5117 Centre Avenue, Room 1 19d, Pittsburgh, PA 15213 1863, USA
Eur J Cancer 41:807-15. 2005..The results of our studies are consistent with a causative role of HPV-16 in the pathogenesis of SCCHN... - NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinomaRobert L Ferris
Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 13:5663-4. 2007 - Diagnostic utility of positron emission tomography-computed tomography for predicting malignancy in cystic neck masses in adultsRobert L Ferris
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Hillman Cancer Center Research Wing, Pittsburgh, Pennsylvania 15213, USA
Laryngoscope 115:1979-82. 2005.... - Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neckJohn A Vargo
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Head Neck 34:1153-61. 2012..Herein, we report the efficacy of SBRT in recurrent, nonsquamous cell cancers of the head and neck (NSCHNs)... - Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trialDwight E Heron
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Int J Radiat Oncol Biol Phys 75:1493-500. 2009..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) in previously irradiated patients with squamous cell carcinoma of the head and neck (SCCHN)... - Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTLAndres Lopez-Albaitero
Departments of Otolaryngology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
J Immunol 176:3402-9. 2006.... - Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapyTrevor M Feinstein
Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Head Neck 33:318-23. 2011..This study was designed to identify the factors associated with the outcome after standard treatment with surgery and postoperative radiotherapy (RT) for locally advanced salivary gland cancers... - The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapyJean Claude M Rwigema
Departments of Radiation Oncology, University of Pittsburgh Cancer Institute, PA, USA
Am J Clin Oncol 34:372-9. 2011..To assess the effect of stereotactic body radiotherapy (SBRT) dose and tumor volume on outcomes in patients with recurrent, previously irradiated squamous cell carcinoma of the head and neck... - Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and cross-presenting functionAndres Lopez-Albaitero
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
J Immunother 32:465-73. 2009.... - Quantitative expression and immunogenicity of MAGE-3 and -6 in upper aerodigestive tract cancerPedro A Andrade Filho
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Int J Cancer 125:1912-20. 2009..Demethylating agents could increase the number of patients amenable for targeting epigenetically modified tumor antigens in vaccine trials... - Serum biomarkers as potential predictors of antitumor activity of cetuximab-containing therapy for locally advanced head and neck cancerAthanassios Argiris
Head and Neck Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States
Oral Oncol 47:961-6. 2011..Validation is warranted in future studies specifically designed to detect biomarker associations... - Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neckDaisuke Ito
Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Int J Cancer 120:2618-24. 2007.... - Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapyJun Wang
Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
J Natl Cancer Inst 100:502-12. 2008..Constitutive prosurvival signaling by the phosphoinositide-3 kinase/Akt pathway has been observed in SCCHN cells independent of epidermal growth factor receptor (EGFR) signaling... - Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancerAthanassios Argiris
University of Pittsburgh Medical Center Cancer Pavilion, 5th Floor, Pittsburgh, PA 15232, USA
J Clin Oncol 28:5294-300. 2010..We incorporated cetuximab, a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR), into the induction therapy and subsequent chemoradiotherapy of head and neck cancer (HNC)... - Alterations in the T-cell receptor variable beta gene-restricted profile of CD8+ T lymphocytes in the peripheral circulation of patients with squamous cell carcinoma of the head and neckAndreas E Albers
Division of Basic Research and Biostatistics, University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 12:2394-403. 2006..This may reflect increased apoptosis of expanded or contracted CD8(+) T cells, which define the TCR Vbeta profile of antigen-responsive T-cell populations in patients with cancer... - Fractionated stereotactic body radiation therapy in the treatment of previously-irradiated recurrent head and neck carcinoma: updated report of the University of Pittsburgh experienceJean Claude Rwigema
Department of Radiation Oncology, University Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
Am J Clin Oncol 33:286-93. 2010..The aim of this study was to assess the safety and outcome of stereotactic body radiotherapy (SBRT) in patients with recurrent previously irradiated squamous cell carcinoma of the head and neck (rSCCHN)... - Deferring planned neck dissection following chemoradiation for stage IV head and neck cancer: the utility of PET-CTJayakar V Nayak
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Laryngoscope 117:2129-34. 2007..To determine whether combined positron emission tomography and computed tomography (PET-CT) may be of value in deferring planned neck dissections for patients with advanced head and neck squamous cell carcinoma (HNSCC)... - Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cellsAndres Lopez-Albaitero
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
Cancer Immunol Immunother 58:1853-64. 2009..Cellular and secreted immune profiles and FcgammaR genotypes from patients' lymphocytes may provide clinically useful biomarkers of immune activation in cetuximab treated patients... - Novel immunogenic HLA-A*0201-restricted epidermal growth factor receptor-specific T-cell epitope in head and neck cancer patientsPedro A Andrade Filho
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
J Immunother 33:83-91. 2010..Thus, a novel, immunogenic EGFR-encoded CTL epitope may be incorporated into vaccines and would be useful for combinatorial immunotherapy with EGFR-specific mAbs in cancer patients... - CD8+ T cell recognition of polymorphic wild-type sequence p53(65-73) peptides in squamous cell carcinoma of the head and neckPedro A Andrade Filho
Department of Otolaryngology, University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, USA
Cancer Immunol Immunother 59:1561-8. 2010.... - Head and neck cancer immunotherapy: clinical evaluationMichael S Leibowitz
Department of Otolaryngology, University of Pittsburgh School of Medicine, Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Suite 2 26, Pittsburgh, PA 15213, USA
Curr Oncol Rep 10:162-9. 2008..This article reviews immunotherapeutic strategies currently in clinical trials or under development for patients with SCCHN... - Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neckAndreas Albers
Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 65:11146-55. 2005..These findings support further development of E7-specific immunotherapy and strategies for up-regulation of antigen-processing machinery components in HPV-associated SCCHN... - Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosisJeong Whun Kim
Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA
Clin Cancer Res 11:7901-10. 2005..The absence of CCR7 expression on the majority of CD8(+) T cells in the peripheral circulation of patients with squamous cell carcinoma of the head and neck contributes to apoptosis and a rapid turnover of these effector cells... - Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neckNicky Sirianni
Department of Otolaryngology and Immunology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 10:6929-37. 2004..p53 peptides may be useful tumor antigens for squamous cell carcinoma of the head and neck immunotherapy in addition to viral gene products... - Clinicopathologic features as stronger prognostic factors than histology or grade in risk stratification of primary parotid malignanciesRohan R Walvekar
Department of Otolaryngology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania, USA
Head Neck 33:225-31. 2011.... - A retrospective, deformable registration analysis of the impact of PET-CT planning on patterns of failure in stereotactic body radiation therapy for recurrent head and neck cancerKyle Wang
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Head Neck Oncol 4:12. 2012..We analyzed the patterns of failure following SBRT for rSCCHN and assessed the impact of PET-CT treatment planning on these patterns of failure... - Prospective evaluation of patient-reported quality-of-life outcomes following SBRT ± cetuximab for locally-recurrent, previously-irradiated head and neck cancerJohn A Vargo
University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Radiother Oncol 104:91-5. 2012..Here-in, we report the first prospective evaluation of patient-reported quality-of-life (PR-QoL) following re-irradiation with SBRT±cetuximab for rSCCHN... - Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapyElmer R Cano
Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Head Neck 31:1431-8. 2009..We report a program consisting of concurrent chemoradiation followed by brachytherapy for these patients... - Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotypeJun Wang
Department of Otolaryngology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 64:1861-6. 2004..Thus, CCR6, CCR7, and their ligands, normally important in controlling immune cell trafficking in response to inflammatory stimuli, may have an important role in determining the metastasis of SCCHN cells in vivo... - Role of surgery in limited (T1-2, N0-1) cancers of the oropharynxRohan R Walvekar
Department of Otolaryngology, Head Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Laryngoscope 118:2129-34. 2008..To define the role of surgical staging in limited (T1-2, N0-1) oropharyngeal squamous cell cancers... - Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patientsBridget Hathaway
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Laryngoscope 115:522-7. 2005..CONCLUSION: Multiplexed serum cytokine profiles may be applicable to early detection, for screening those at high risk for SCCHN, and as clinically predictive biomarkers of disease status in successfully treated patients... - Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytesMichael S Leibowitz
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
Cancer Immunol Immunother 60:525-35. 2011..These findings demonstrate that APM component downregulation is regulated primarily by an IFN-γ-pSTAT1-mediated signaling pathway, independent of oncogenic STAT3 overexpression in SCCHN cells... - Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neckRobert L Ferris
Department of Otolaryngology and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer Res 65:2147-56. 2005..These assays were completed (from tissue to result) in approximately 30 minutes, thus demonstrating the feasibility of intraoperative staging of SCCHN SLNs by QRT-PCR... - Antiviral activity of Cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck (SCCHN) cell line improves radiation sensitivityNicky Sirianni
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Oral Oncol 41:423-8. 2005..Future therapies for HPV-associated tumors may include intralesional antiviral therapy in combination with radiation therapy, but optimization for clinical utility is needed... - Concurrent cetuximab with stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: a single institution matched case-control studyDwight E Heron
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Am J Clin Oncol 34:165-72. 2011.... - Immunotherapy of head and neck cancer using tumor antigen-specific monoclonal antibodiesSteve C Lee
The Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
Curr Oncol Rep 11:156-62. 2009.... - A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinomaLeo A Niemeier
Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Cancer 118:2069-77. 2012..The objective of the study was to evaluate whether the combination of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation and specific histopathologic features allows risk stratification of TPMC... - Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN)Yvonne K Mburu
Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 287:3581-90. 2012..As such, CCR7, NF-κB, and AP1 could be potentially useful therapeutic targets in controlling the progression and metastasis of SCCHN tumors... - Positron emission tomography-computed tomography adds to the management of salivary gland malignanciesAli Razfar
Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Laryngoscope 120:734-8. 2010..To evaluate the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying salivary gland malignancies and to examine the role of PET-CT in the management of these patients... - Sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancerLisheng Ge
Departments of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
Cancer Epidemiol Biomarkers Prev 18:2913-22. 2009..These data show that increased TACE activity in cancer is biologically and clinically relevant, and indicate that TACE activity could be a significant biomarker of cancer prognosis... - Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFRJun Wang
Department of Otolaryngology, University of Pittsburgh School of Medicine, PA 15213, USA
Oncogene 24:5897-904. 2005..The CCR7-mediated pathway in metastatic SCCHN cells functions independently of EGFR signal transduction and therefore may represent an additional target for therapeutic intervention to prevent tumor progression and metastasis... - Primary lymphoma of the larynx: new diagnostic and therapeutic approachesJayakar V Nayak
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
ORL J Otorhinolaryngol Relat Spec 65:321-6. 2003..The presence of nonsquamous laryngeal tumors reinforces the dictum to obtain a reliable tissue diagnosis before initiating definitive therapy... - HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancerLynn M Knowles
Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 15:3740-50. 2009.... - Evaluation of a thyroid noduleSteven R Bomeli
Division of Head and Neck Surgery, Department of Otolaryngology, University of Pittsburgh, PA, USA
Otolaryngol Clin North Am 43:229-38, vii. 2010..Detecting malignancy preoperatively allows total thyroidectomy in a single operation without the need for frozen section or a second operation for completion of a thyroidectomy if malignancy is found during the initial thyroid lobectomy... - Posttreatment quality-of-life assessment in patients with head and neck cancer treated with intensity-modulated radiation therapyMichael O'Neill
University of Pittsburgh School of Medicine, PA, USA
Am J Clin Oncol 34:478-82. 2011.... - Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsyRobert L Ferris
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Laryngoscope 122:1020-30. 2012.... - Clinical usefulness of positron emission tomography-computed tomography in recurrent thyroid carcinomaAli Razfar
Department of Otolaryngology, University of Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 136:120-5. 2010..To determine the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying recurrent thyroid cancer and to elucidate its role in the clinical management of thyroid carcinoma... - Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomasIvan Martinez
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Room East 1240, 200 Lothrop Street, Pittsburgh, PA 15208, USA
Eur J Cancer 43:415-32. 2007..Our results reveal specific gene expression patterns in HPV-positive and HPV-negative oropharyngeal squamous carcinomas that may serve as potential biomarkers for the development of SCCHN... - Head and neck squamous cell carcinoma cell lines: established models and rationale for selectionCharles J Lin
Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Head Neck 29:163-88. 2007..An easily accessible guide that organizes important characteristics of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for in vitro or in vivo studies... - CCR7 mediates inflammation-associated tumor progressionYvonne K Mburu
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Immunol Res 36:61-72. 2006..While extending these observations to metastatic SCCHN tumor cells, our studies highlight the importance of downstream NF-kappaB mediated CCR7 signals in the progression of SCCHN malignancy... - Immune activation by epidermal growth factor receptor specific monoclonal antibody therapy for head and neck cancerAndres Lopez Albaitero
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 133:1277-81. 2007..To determine if the epidermal growth factor receptor (EGFR)-specific monoclonal antibodies (mAbs) cetuximab or panitumumab mediate in vitro immune activation against squamous cell carcinoma of the head and neck (SCCHN) cell lines... - Reconstruction of the through-and-through anterior mandibulectomy defect: indications and limitations of the double-skin paddle fibular free flapFrederic W B Deleyiannis
Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Laryngoscope 118:1329-34. 2008.... - Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neckJun Wang
Department of Otolaryngology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburgh, PA 15213, USA
Adv Otorhinolaryngol 62:121-33. 2005..Our data indicate that inhibition of CCR signaling may provide a targeted molecular therapy to prevent HNSCC metastasis... - Recent thymic emigrants and subsets of naive and memory T cells in the circulation of patients with head and neck cancerIris Kuss
University of Pittsburgh Cancer Institute, PA 15213-1863, USA
Clin Immunol 116:27-36. 2005..The defect persists long after curative treatments and may contribute to immune cell dysregulation in patients with cancer... - Elective neck dissection and survival in patients with squamous cell carcinoma of the oral cavity and oropharynxUmamaheswar Duvvuri
Department of Otolaryngology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, USA
Laryngoscope 114:2228-34. 2004..The study addressed the question of whether elective neck dissection improves regional control and survival in patients with squamous cell carcinoma of the oral cavity and oropharynx presenting with T1/T2 node-negative disease... - SHP2 Is Overexpressed and Inhibits pSTAT1-Mediated APM Component Expression, T-cell Attracting Chemokine Secretion, and CTL Recognition in Head and Neck Cancer CellsMichael S Leibowitz
Authors Affiliations Departments of Immunology and Otolaryngology, University of Pittsburgh and Departments of Pathology and Surgery and Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Clin Cancer Res 19:798-808. 2013..We investigated whether an overexpressed phosphatase was responsible for basal suppression of pSTAT1 and subsequent APM component-mediated immune escape in HNC cells... - Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinomaStephen Y Lai
Department of Otolaryngology Head and Neck Surgery, The Eye and Ear Institute, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Oncogene 24:4442-9. 2005..Increased levels of EPO and EPOR in lymph node metastases as compared to primary tumors from HNSCC patients further support the role of EPO/EPOR in HNSCC disease progression and metastasis... - Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?Michael R Shurin
Department of Pathology, University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, PA 15213, USA
Cancer Metastasis Rev 25:333-56. 2006..This review is limited to discussing the role of intratumoral cytokine network in the understanding immunobiology of tumor-associated dendritic cells, which seems to possess different regulatory functions at the tumor site... - Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profilingFaina Linkov
Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Cancer Epidemiol Biomarkers Prev 16:102-7. 2007..The data presented show that simultaneous testing using a multiplexed panel of serum biomarkers may present a promising new approach for the early detection of head and neck cancer... - Immunotherapy for head and neck cancerH Carter Davidson
Department of Otolaryngology, University of Pittsburgh, Hillman Cancer Center Research Pavilion, PA 15213, United States
Oral Oncol 45:747-51. 2009..This article reviews immunotherapeutic strategies currently in clinical trials or under development for patients with SCCHN... - Management of patients treated with chemoradiotherapy for head and neck cancer without prophylactic feeding tubes: the University of Pittsburgh experienceBrian T McLaughlin
Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
Laryngoscope 120:71-5. 2010..Mucositis and dysphagia are common complications of chemoradiotherapy (CRT) for head and neck cancer that may necessitate nutritional support with a gastrostomy tube (G-tube)... - Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neckIris Kuss
University of Pittsburgh Cancer Institute and Departments of Pathology and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 10:3755-62. 2004..Patients with recurrent disease at the time of blood draw tended to have the lowest CD4+ T-cell counts. CONCLUSIONS: Patients with SCCHN have altered lymphocyte homeostasis, which persists for months or years after curative therapies... - Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8⁺ T cellsCarmen Visus
Division of Basic Research, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 17:6174-84. 2011..The ALDH1A1 isoform was previously identified as a tumor antigen recognized by CD8(+) T cells. This study examines the ability of ALDH1A1-specific CD8(+) T cells to eliminate ALDH(bright) cells and control tumor growth and metastases... - Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancersRegiane S Andrade
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
Int J Radiat Oncol Biol Phys 65:1315-22. 2006..These results support a potential clinical role of FDG-PET/CT in the early assessment of therapy response after definitive radiation therapy... - Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samplesYuri E Nikiforov
Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Clin Endocrinol Metab 96:3390-7. 2011..Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate management... - Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunitySteve C Lee
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
Immunol Res 50:248-54. 2011..These events likely contribute to clinical activity, as well as provide a potential biomarker of response to mAb therapy... - Immune escape associated with functional defects in antigen-processing machinery in head and neck cancerRobert L Ferris
University of Pittsburgh Cancer Institute and Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 12:3890-5. 2006.... - Immune responses to p53 in patients with cancer: enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sitesAndreas E Albers
University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Cancer Immunol Immunother 54:1072-81. 2005..However, despite enrichment in tumor peptide-specific T cells, the effector cell population (CD3+CD8+) in TIL or PBMC was unresponsive to activation in the tumor microenvironment enriched in Treg... - Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neckMark E Sharafinski
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA
Head Neck 32:1412-21. 2010.... - Ocular outcomes after gold weight placement and facial nerve resectionAli Razfar
Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Otolaryngol Head Neck Surg 140:82-5. 2009..To assess the effectiveness of acute gold weight placement after facial nerve resection and to determine the role of concomitant lower eyelid procedures... - Head and neck cancerAthanassios Argiris
Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15232, USA
Lancet 371:1695-709. 2008..We review the epidemiology, molecular pathogenesis, diagnosis and staging, and the latest multimodal management of squamous cell carcinoma of the head and neck... - Progress in head and neck cancer immunotherapy: can tolerance and immune suppression be reversed?Robert L Ferris
Department of Otolaryngology, Hillman Cancer Center Research Pavilion, Pittsburgh, PA 15213, USA
ORL J Otorhinolaryngol Relat Spec 66:332-40. 2004..This article reviews adjuvant immunotherapeutic strategies currently in trials or under development for SCCHN patients, including vaccination or cytokine immunostimulation... - Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivoGalina V Shurin
Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
J Immunol 174:5490-8. 2005..Activation of DC with recombinant human CXCL14 was accompanied by up-regulation of NF-kappaB activity. These data suggest that CXCL14 is a potent chemoattractant and activator of DC and might be involved in DC homing in vivo... - Human β-defensin 3 promotes NF-κB-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neckYvonne K Mburu
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Carcinogenesis 32:168-74. 2011..Our findings suggest that hBD3 represents a novel NF-κB-regulated mediator of CCR7 expression and anti-apoptotic pathways, which may be exploited by developing SCCHN tumors to enhance their survival and metastasis... - Human leukocyte antigen (HLA) class I defects in head and neck cancer: molecular mechanisms and clinical significanceRobert L Ferris
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 1523, USA
Immunol Res 33:113-33. 2005.... - Steroid psychosis after head and neck surgery: case report and review of the literatureRobert L Ferris
Department of Otolaryngology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Otolaryngol Head Neck Surg 129:591-2. 2003 - Prognosis as a determinant of free flap utilization for reconstruction of the lateral mandibular defectFrederic W B Deleyiannis
University of Pittsburgh, Division of Plastic and Reconstructive Surgery, Suite 6B Scaife Hall, 3550 Terrace Ave, Pittsburgh, PA 15261, USA
Head Neck 28:1061-8. 2006.... - Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neckThomas K Hoffmann
Department of Pathology, Cancer Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Clin Cancer Res 8:1787-93. 2002..An overall decrease in the myeloid-derived subset of DC could contribute to the failure of SCCHN patients to develop effective antitumor immune responses... - Diagnostic assessment of laryngeal cancerApurva A Thekdi
Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Eye and Ear Institute, 200 Lothrop Street, Suite 521, Pittsburgh, PA 15213, USA
Otolaryngol Clin North Am 35:953-69, v. 2002..Newer methods of assessment and follow-up are being scientifically validated and will likely enhance the diagnostic efforts of the head and neck surgical oncologist... - Radiology quiz case 2. Parapharyngeal second branchial cleft cystSeshu Gadiparthi
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 130:1121, 1124-5. 2004 - Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytesHuashan Peng
The Center for Hearing Sciences, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, JHOC 6241, 601 N Caroline Street, Baltimore, MD 21287, USA
Life Sci 76:263-80. 2004..However, a lack of demonstrated response to applied acetylcholine using standard single-cell recording techniques suggests a physiology different than that seen in hair cells of the inner ear... - Recurrence in head and neck squamous cell carcinoma. EditorialMichael S Leibowitz
Cancer 113:671-3. 2008 - Correlation of protease-activated receptor-1 with differentiation markers in squamous cell carcinoma of the head and neck and its implication in lymph node metastasisXin Zhang
Department of Hematology Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia 30322, USA
Clin Cancer Res 10:8451-9. 2004..Although the functions of PAR-1 in many normal cells, such as platelets and astrocytes, have been well studied, its roles in cancer progression and metastasis have not been fully elucidated, and studies to date appear contradictory... - Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancerMarion E Couch
Department of Otolaryngology Head and Neck Surgery, University of North Carolina, G0412 Neurosciences Hospital, Chapel Hill, North Carolina, USA
Clin Cancer Res 13:7199-206. 2007....
Research Grants
- Chemokine Signals in Head and Neck Cancer ProgressionRobert Ferris; Fiscal Year: 2007..Overall these studies are designed to identify the EGFR-independent, CCR7-mediated pathways relevant to invasion and survival of SCCHN and to use this information to facilitate the development of CCR7 targeted therapeutic strategies. ..