Robert L Ferris

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsy
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 122:1020-30. 2012
  2. doi request reprint The benefit of early PET/CT surveillance in HPV-associated head and neck squamous cell carcinoma
    Irene Zhang
    Department of Otolaryngology, Eye and Ear Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Arch Otolaryngol Head Neck Surg 137:1106-11. 2011
  3. pmc PET-CT staging of the neck in cancers of the oropharynx: patterns of regional and retropharyngeal nodal metastasis
    Marcie Tauzin
    Department of Otolaryngology Head Neck Surgery, LSU Health Sciences Center, New Orleans, LA, USA
    World J Surg Oncol 8:70. 2010
  4. pmc EGFR-specific T cell frequencies correlate with EGFR expression in head and neck squamous cell carcinoma
    Patrick J Schuler
    Universitat Duisburg Essen, Hals Nasen Ohrenklinik Essen, Germany
    J Transl Med 9:168. 2011
  5. doi request reprint Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck
    John A Vargo
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Head Neck 34:1153-61. 2012
  6. doi request reprint Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial
    Dwight E Heron
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 75:1493-500. 2009
  7. doi request reprint Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy
    Trevor M Feinstein
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Head Neck 33:318-23. 2011
  8. pmc Quantitative expression and immunogenicity of MAGE-3 and -6 in upper aerodigestive tract cancer
    Pedro A Andrade Filho
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Int J Cancer 125:1912-20. 2009
  9. pmc Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and cross-presenting function
    Andres Lopez-Albaitero
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Immunother 32:465-73. 2009
  10. ncbi request reprint Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL
    Andres Lopez-Albaitero
    Departments of Otolaryngology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    J Immunol 176:3402-9. 2006

Collaborators

Detail Information

Publications86

  1. pmc Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsy
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 122:1020-30. 2012
    ....
  2. doi request reprint The benefit of early PET/CT surveillance in HPV-associated head and neck squamous cell carcinoma
    Irene Zhang
    Department of Otolaryngology, Eye and Ear Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Arch Otolaryngol Head Neck Surg 137:1106-11. 2011
    ..To evaluate the ability of posttreatment positron emission tomography and computed tomography (PET/CT) to predict ultimate disease status in patients with head and neck squamous cell carcinoma and known human papillomavirus (HPV) status...
  3. pmc PET-CT staging of the neck in cancers of the oropharynx: patterns of regional and retropharyngeal nodal metastasis
    Marcie Tauzin
    Department of Otolaryngology Head Neck Surgery, LSU Health Sciences Center, New Orleans, LA, USA
    World J Surg Oncol 8:70. 2010
    ..To study the retropharyngeal lymph node status (RPLN) by pretreatment PET-CT imaging in patients with squamous cell carcinomas of the oropharynx (OPSCC). Study Design: Retrospective...
  4. pmc EGFR-specific T cell frequencies correlate with EGFR expression in head and neck squamous cell carcinoma
    Patrick J Schuler
    Universitat Duisburg Essen, Hals Nasen Ohrenklinik Essen, Germany
    J Transl Med 9:168. 2011
    ..As the mechanisms responsible for cellular immune response to EGFR in vivo remain unclear, the frequency and function of EGFR-specific cytotoxic T cells (CTL) was determined in HNSCC patients...
  5. doi request reprint Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck
    John A Vargo
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Head Neck 34:1153-61. 2012
    ..Herein, we report the efficacy of SBRT in recurrent, nonsquamous cell cancers of the head and neck (NSCHNs)...
  6. doi request reprint Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial
    Dwight E Heron
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 75:1493-500. 2009
    ..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) in previously irradiated patients with squamous cell carcinoma of the head and neck (SCCHN)...
  7. doi request reprint Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy
    Trevor M Feinstein
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Head Neck 33:318-23. 2011
    ..This study was designed to identify the factors associated with the outcome after standard treatment with surgery and postoperative radiotherapy (RT) for locally advanced salivary gland cancers...
  8. pmc Quantitative expression and immunogenicity of MAGE-3 and -6 in upper aerodigestive tract cancer
    Pedro A Andrade Filho
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Int J Cancer 125:1912-20. 2009
    ..Demethylating agents could increase the number of patients amenable for targeting epigenetically modified tumor antigens in vaccine trials...
  9. pmc Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and cross-presenting function
    Andres Lopez-Albaitero
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Immunother 32:465-73. 2009
    ....
  10. ncbi request reprint Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL
    Andres Lopez-Albaitero
    Departments of Otolaryngology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    J Immunol 176:3402-9. 2006
    ....
  11. pmc Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients
    Raghvendra M Srivastava
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Cancer Res 19:1858-72. 2013
    ..However, the role of CD8(+) CTL and FcγR in initiating innate and adaptive immune responses in mAb-treated human patients with cancer is still emerging...
  12. doi request reprint Oncologic and functional outcomes of partial laryngeal surgery for intermediate-stage laryngeal cancer
    Emiro Caicedo-Granados
    Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Otolaryngol Head Neck Surg 148:235-42. 2013
    ..To evaluate the oncologic and functional outcomes of partial laryngeal surgery (PLS) using transoral laser microsurgery (TLM) and supracricoid laryngectomy (SCL) in patients with intermediate-stage laryngeal squamous cell carcinoma (LSCC)...
  13. pmc Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer
    Athanassios Argiris
    University of Pittsburgh Medical Center Cancer Pavilion, 5th Floor, Pittsburgh, PA 15232, USA
    J Clin Oncol 28:5294-300. 2010
    ..We incorporated cetuximab, a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR), into the induction therapy and subsequent chemoradiotherapy of head and neck cancer (HNC)...
  14. doi request reprint Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    J Natl Cancer Inst 100:502-12. 2008
    ..Constitutive prosurvival signaling by the phosphoinositide-3 kinase/Akt pathway has been observed in SCCHN cells independent of epidermal growth factor receptor (EGFR) signaling...
  15. pmc SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells
    Michael S Leibowitz
    Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Cancer Res 19:798-808. 2013
    ..We investigated whether an overexpressed phosphatase was responsible for basal suppression of pSTAT1 and subsequent APM component-mediated immune escape in HNC cells...
  16. pmc A retrospective, deformable registration analysis of the impact of PET-CT planning on patterns of failure in stereotactic body radiation therapy for recurrent head and neck cancer
    Kyle Wang
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Head Neck Oncol 4:12. 2012
    ..We analyzed the patterns of failure following SBRT for rSCCHN and assessed the impact of PET-CT treatment planning on these patterns of failure...
  17. ncbi request reprint Deferring planned neck dissection following chemoradiation for stage IV head and neck cancer: the utility of PET-CT
    Jayakar V Nayak
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Laryngoscope 117:2129-34. 2007
    ..To determine whether combined positron emission tomography and computed tomography (PET-CT) may be of value in deferring planned neck dissections for patients with advanced head and neck squamous cell carcinoma (HNSCC)...
  18. ncbi request reprint Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck
    Daisuke Ito
    Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 120:2618-24. 2007
    ....
  19. ncbi request reprint Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neck
    Robert L Ferris
    Department of Otolaryngology and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Res 65:2147-56. 2005
    ..These assays were completed (from tissue to result) in approximately 30 minutes, thus demonstrating the feasibility of intraoperative staging of SCCHN SLNs by QRT-PCR...
  20. ncbi request reprint Clinicopathologic features as stronger prognostic factors than histology or grade in risk stratification of primary parotid malignancies
    Rohan R Walvekar
    Department of Otolaryngology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania, USA
    Head Neck 33:225-31. 2011
    ....
  21. ncbi request reprint Head and neck cancer immunotherapy: clinical evaluation
    Michael S Leibowitz
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Suite 2 26, Pittsburgh, PA 15213, USA
    Curr Oncol Rep 10:162-9. 2008
    ..This article reviews immunotherapeutic strategies currently in clinical trials or under development for patients with SCCHN...
  22. pmc Novel immunogenic HLA-A*0201-restricted epidermal growth factor receptor-specific T-cell epitope in head and neck cancer patients
    Pedro A Andrade Filho
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    J Immunother 33:83-91. 2010
    ..Thus, a novel, immunogenic EGFR-encoded CTL epitope may be incorporated into vaccines and would be useful for combinatorial immunotherapy with EGFR-specific mAbs in cancer patients...
  23. ncbi request reprint Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck
    Andreas Albers
    Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 65:11146-55. 2005
    ..These findings support further development of E7-specific immunotherapy and strategies for up-regulation of antigen-processing machinery components in HPV-associated SCCHN...
  24. doi request reprint CD8+ T cell recognition of polymorphic wild-type sequence p53(65-73) peptides in squamous cell carcinoma of the head and neck
    Pedro A Andrade Filho
    Department of Otolaryngology, University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, USA
    Cancer Immunol Immunother 59:1561-8. 2010
    ....
  25. pmc Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells
    Andres Lopez-Albaitero
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer Immunol Immunother 58:1853-64. 2009
    ..Cellular and secreted immune profiles and FcgammaR genotypes from patients' lymphocytes may provide clinically useful biomarkers of immune activation in cetuximab treated patients...
  26. pmc Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: a pilot randomized trial in head and neck cancer
    Howard S Moskowitz
    Department of Otolaryngology, Johns Hopkins Hospital, Baltimore, MD, USA
    Oral Oncol 48:1136-45. 2012
    ..Co-targeting of the G-protein-coupled receptor cyclooxygenase (COX) with EGFR inhibitors has shown promise in preclinical models and early phase clinical studies...
  27. doi request reprint Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx
    Rohan R Walvekar
    Department of Otolaryngology, Head Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Laryngoscope 118:2129-34. 2008
    ..To define the role of surgical staging in limited (T1-2, N0-1) oropharyngeal squamous cell cancers...
  28. doi request reprint Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy
    Elmer R Cano
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Head Neck 31:1431-8. 2009
    ..We report a program consisting of concurrent chemoradiation followed by brachytherapy for these patients...
  29. ncbi request reprint Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis
    Jeong Whun Kim
    Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA
    Clin Cancer Res 11:7901-10. 2005
    ..The absence of CCR7 expression on the majority of CD8(+) T cells in the peripheral circulation of patients with squamous cell carcinoma of the head and neck contributes to apoptosis and a rapid turnover of these effector cells...
  30. ncbi request reprint Antiviral activity of Cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck (SCCHN) cell line improves radiation sensitivity
    Nicky Sirianni
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Oral Oncol 41:423-8. 2005
    ..Future therapies for HPV-associated tumors may include intralesional antiviral therapy in combination with radiation therapy, but optimization for clinical utility is needed...
  31. pmc Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes
    Michael S Leibowitz
    Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer Immunol Immunother 60:525-35. 2011
    ..These findings demonstrate that APM component downregulation is regulated primarily by an IFN-γ-pSTAT1-mediated signaling pathway, independent of oncogenic STAT3 overexpression in SCCHN cells...
  32. ncbi request reprint NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 13:5663-4. 2007
  33. ncbi request reprint Alterations in the T-cell receptor variable beta gene-restricted profile of CD8+ T lymphocytes in the peripheral circulation of patients with squamous cell carcinoma of the head and neck
    Andreas E Albers
    Division of Basic Research and Biostatistics, University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 12:2394-403. 2006
    ..We investigated whether T-cell receptor (TCR) variable beta chain (Vbeta)-restricted T cells were more sensitive to apoptosis than non-TCR Vbeta-restricted T cells...
  34. doi request reprint Intraoperative qRT-PCR for detection of lymph node metastasis in head and neck cancer
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 17:1858-66. 2011
    ..The purpose of this study was to develop a rapid, automated, and quantitative real-time PCR (qRT-PCR) assay that can match final pathology in an intraoperative time frame...
  35. ncbi request reprint Immunotherapy of head and neck cancer using tumor antigen-specific monoclonal antibodies
    Steve C Lee
    The Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Room 2 26b, Pittsburgh, PA 15213, USA
    Curr Oncol Rep 11:156-62. 2009
    ....
  36. ncbi request reprint Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): a natural disease model provides insights into viral carcinogenesis
    Robert L Ferris
    UPCI Research Pavilion, The Hillman Cancer Center, 5117 Centre Avenue, Room 1 19d, Pittsburgh, PA 15213 1863, USA
    Eur J Cancer 41:807-15. 2005
    ..The results of our studies are consistent with a causative role of HPV-16 in the pathogenesis of SCCHN...
  37. ncbi request reprint Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neck
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburgh, PA 15213, USA
    Adv Otorhinolaryngol 62:121-33. 2005
    ..Our data indicate that inhibition of CCR signaling may provide a targeted molecular therapy to prevent HNSCC metastasis...
  38. doi request reprint Prospective evaluation of patient-reported quality-of-life outcomes following SBRT ± cetuximab for locally-recurrent, previously-irradiated head and neck cancer
    John A Vargo
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Radiother Oncol 104:91-5. 2012
    ..Here-in, we report the first prospective evaluation of patient-reported quality-of-life (PR-QoL) following re-irradiation with SBRT±cetuximab for rSCCHN...
  39. pmc A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinoma
    Leo A Niemeier
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer 118:2069-77. 2012
    ..The objective of the study was to evaluate whether the combination of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation and specific histopathologic features allows risk stratification of TPMC...
  40. pmc Evaluation of a thyroid nodule
    Steven R Bomeli
    Division of Head and Neck Surgery, Department of Otolaryngology, University of Pittsburgh, PA, USA
    Otolaryngol Clin North Am 43:229-38, vii. 2010
    ..Detecting malignancy preoperatively allows total thyroidectomy in a single operation without the need for frozen section or a second operation for completion of a thyroidectomy if malignancy is found during the initial thyroid lobectomy...
  41. ncbi request reprint Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients
    Bridget Hathaway
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Laryngoscope 115:522-7. 2005
    ..Furthermore, we hypothesized that persistent immune dysregulation in patients cured of their disease may be reflected in altered cytokine profiles in the systemic circulation...
  42. pmc Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN)
    Yvonne K Mburu
    Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 287:3581-90. 2012
    ..As such, CCR7, NF-κB, and AP1 could be potentially useful therapeutic targets in controlling the progression and metastasis of SCCHN tumors...
  43. doi request reprint Fractionated stereotactic body radiation therapy in the treatment of previously-irradiated recurrent head and neck carcinoma: updated report of the University of Pittsburgh experience
    Jean Claude Rwigema
    Department of Radiation Oncology, University Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Am J Clin Oncol 33:286-93. 2010
    ..The aim of this study was to assess the safety and outcome of stereotactic body radiotherapy (SBRT) in patients with recurrent previously irradiated squamous cell carcinoma of the head and neck (rSCCHN)...
  44. ncbi request reprint Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh School of Medicine, PA 15213, USA
    Oncogene 24:5897-904. 2005
    ..The CCR7-mediated pathway in metastatic SCCHN cells functions independently of EGFR signal transduction and therefore may represent an additional target for therapeutic intervention to prevent tumor progression and metastasis...
  45. doi request reprint Positron emission tomography-computed tomography adds to the management of salivary gland malignancies
    Ali Razfar
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 120:734-8. 2010
    ..To evaluate the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying salivary gland malignancies and to examine the role of PET-CT in the management of these patients...
  46. doi request reprint Concurrent cetuximab with stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: a single institution matched case-control study
    Dwight E Heron
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Am J Clin Oncol 34:165-72. 2011
    ....
  47. pmc Sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancer
    Lisheng Ge
    Departments of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    Cancer Epidemiol Biomarkers Prev 18:2913-22. 2009
    ..These data show that increased TACE activity in cancer is biologically and clinically relevant, and indicate that TACE activity could be a significant biomarker of cancer prognosis...
  48. pmc The immune signature of CD8(+)CCR7(+) T cells in the peripheral circulation associates with disease recurrence in patients with HNSCC
    Malgorzata Czystowska
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Cancer Res 19:889-99. 2013
    ..The functional and clinical significance of this imbalance was investigated using peripheral blood of patients with squamous cell carcinoma of the head and neck (HNSCC)...
  49. doi request reprint Molecular and histopathologic characteristics of multifocal papillary thyroid carcinoma
    Mona Bansal
    Departments of Pathology and Laboratory Medicine Otolaryngology, Head Neck Surgery Division of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Am J Surg Pathol 37:1586-91. 2013
    ..Histopathologically, MSPTs are typically located in different lobes, have distinct growth patterns, and do not show microscopic peritumoral dissemination. ..
  50. doi request reprint RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers
    Nikhil Gupta
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 98:E914-22. 2013
    ..RAS mutations are common in thyroid tumors and confer a high risk of cancer when detected in fine-needle aspiration (FNA) specimens. Specific characteristics of RAS-positive thyroid cancers are not well described...
  51. doi request reprint A new paradigm for the diagnosis and management of unknown primary tumors of the head and neck: a role for transoral robotic surgery
    Vikas Mehta
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center, Eye and Ear Institute, Pittsburgh, PA 15213, USA
    Laryngoscope 123:146-51. 2013
    ..With improved visualization and freedom of motion, transoral robotic surgery (TORS) is an innovative surgical modality that allows resection of oropharyngeal subsites with minimal morbidity...
  52. ncbi request reprint Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling
    Faina Linkov
    Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Epidemiol Biomarkers Prev 16:102-7. 2007
    ..The data presented show that simultaneous testing using a multiplexed panel of serum biomarkers may present a promising new approach for the early detection of head and neck cancer...
  53. doi request reprint Posttreatment quality-of-life assessment in patients with head and neck cancer treated with intensity-modulated radiation therapy
    Michael O'Neill
    University of Pittsburgh School of Medicine, PA, USA
    Am J Clin Oncol 34:478-82. 2011
    ....
  54. doi request reprint Clinical usefulness of positron emission tomography-computed tomography in recurrent thyroid carcinoma
    Ali Razfar
    Department of Otolaryngology, University of Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 136:120-5. 2010
    ..To determine the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying recurrent thyroid cancer and to elucidate its role in the clinical management of thyroid carcinoma...
  55. ncbi request reprint Head and neck squamous cell carcinoma cell lines: established models and rationale for selection
    Charles J Lin
    Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Head Neck 29:163-88. 2007
    ..An easily accessible guide that organizes important characteristics of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for in vitro or in vivo studies...
  56. pmc Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas
    Ivan Martinez
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Room East 1240, 200 Lothrop Street, Pittsburgh, PA 15208, USA
    Eur J Cancer 43:415-32. 2007
    ..Our results reveal specific gene expression patterns in HPV-positive and HPV-negative oropharyngeal squamous carcinomas that may serve as potential biomarkers for the development of SCCHN...
  57. pmc HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
    Lynn M Knowles
    Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 15:3740-50. 2009
    ....
  58. doi request reprint Correlation of tumor marker expression with nodal disease burden in metastatic head and neck cancer
    Sumita Trivedi
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Otolaryngol Head Neck Surg 149:261-8. 2013
    ..In addition, we investigated whether the level of expression of these 3 markers was associated with clinical outcomes for patients with HNSCC...
  59. doi request reprint Reconstruction of the through-and-through anterior mandibulectomy defect: indications and limitations of the double-skin paddle fibular free flap
    Frederic W B Deleyiannis
    Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 118:1329-34. 2008
    ....
  60. pmc Human beta-defensin 3 induces maturation of human langerhans cell-like dendritic cells: an antimicrobial peptide that functions as an endogenous adjuvant
    Laura K Ferris
    Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Invest Dermatol 133:460-8. 2013
    ..Thus, hBD3 contributes to the integration of innate and adaptive immune responses in the skin, and may be a useful adjuvant for skin immunization and an important factor in the pathophysiology of inflammatory skin diseases...
  61. pmc First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy
    Malabika Sen
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Discov 2:694-705. 2012
    ..These results provide the first demonstration of a successful strategy to inhibit tumor STAT3 signaling via systemic administration of a selective STAT3 inhibitor, thereby paving the way for broad clinical development...
  62. ncbi request reprint Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers
    Regiane S Andrade
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 65:1315-22. 2006
    ....
  63. ncbi request reprint Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype
    Jun Wang
    Department of Otolaryngology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 64:1861-6. 2004
    ..Thus, CCR6, CCR7, and their ligands, normally important in controlling immune cell trafficking in response to inflammatory stimuli, may have an important role in determining the metastasis of SCCHN cells in vivo...
  64. ncbi request reprint Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck
    Iris Kuss
    University of Pittsburgh Cancer Institute and Departments of Pathology and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 10:3755-62. 2004
    ..Clin Cancer Res 2002;8:2553-62)] suggested a possibility of lymphocyte imbalance. Therefore, absolute numbers and percentages of lymphocyte subsets were examined in the peripheral blood of SCCHN patients and controls...
  65. ncbi request reprint Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neck
    Nicky Sirianni
    Department of Otolaryngology and Immunology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 10:6929-37. 2004
    ..The criterion of p53 overexpression would exclude these individuals from wt p53-based immunotherapy...
  66. ncbi request reprint Immune activation by epidermal growth factor receptor specific monoclonal antibody therapy for head and neck cancer
    Andres Lopez-Albaitero
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 133:1277-81. 2007
    ..To determine if the epidermal growth factor receptor (EGFR)-specific monoclonal antibodies (mAbs) cetuximab or panitumumab mediate in vitro immune activation against squamous cell carcinoma of the head and neck (SCCHN) cell lines...
  67. doi request reprint Management of patients treated with chemoradiotherapy for head and neck cancer without prophylactic feeding tubes: the University of Pittsburgh experience
    Brian T McLaughlin
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Laryngoscope 120:71-5. 2010
    ..Mucositis and dysphagia are common complications of chemoradiotherapy (CRT) for head and neck cancer that may necessitate nutritional support with a gastrostomy tube (G-tube)...
  68. ncbi request reprint Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma
    Stephen Y Lai
    Department of Otolaryngology Head and Neck Surgery, The Eye and Ear Institute, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Oncogene 24:4442-9. 2005
    ..Increased levels of EPO and EPOR in lymph node metastases as compared to primary tumors from HNSCC patients further support the role of EPO/EPOR in HNSCC disease progression and metastasis...
  69. doi request reprint Immunotherapy for head and neck cancer
    H Carter Davidson
    Department of Otolaryngology, University of Pittsburgh, Hillman Cancer Center Research Pavilion, PA 15213, United States
    Oral Oncol 45:747-51. 2009
    ..This article reviews immunotherapeutic strategies currently in clinical trials or under development for patients with SCCHN...
  70. ncbi request reprint Diagnostic utility of positron emission tomography-computed tomography for predicting malignancy in cystic neck masses in adults
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Hillman Cancer Center Research Wing, Pittsburgh, Pennsylvania 15213, USA
    Laryngoscope 115:1979-82. 2005
    ....
  71. ncbi request reprint Immune responses to p53 in patients with cancer: enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites
    Andreas E Albers
    University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Immunol Immunother 54:1072-81. 2005
    ..Also, the localization of "regulatory" T cells (Treg) to tumor sites in HNC has not been investigated to date...
  72. pmc Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 96:3390-7. 2011
    ..Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate management...
  73. pmc Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8⁺ T cells
    Carmen Visus
    Division of Basic Research, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 17:6174-84. 2011
    ..The ALDH1A1 isoform was previously identified as a tumor antigen recognized by CD8(+) T cells. This study examines the ability of ALDH1A1-specific CD8(+) T cells to eliminate ALDH(bright) cells and control tumor growth and metastases...
  74. ncbi request reprint Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?
    Michael R Shurin
    Department of Pathology, University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, PA 15213, USA
    Cancer Metastasis Rev 25:333-56. 2006
    ..This review is limited to discussing the role of intratumoral cytokine network in the understanding immunobiology of tumor-associated dendritic cells, which seems to possess different regulatory functions at the tumor site...
  75. ncbi request reprint Immune escape associated with functional defects in antigen-processing machinery in head and neck cancer
    Robert L Ferris
    University of Pittsburgh Cancer Institute and Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 12:3890-5. 2006
    ....
  76. ncbi request reprint CCR7 mediates inflammation-associated tumor progression
    Yvonne K Mburu
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunol Res 36:61-72. 2006
    ..While extending these observations to metastatic SCCHN tumor cells, our studies highlight the importance of downstream NF-kappaB mediated CCR7 signals in the progression of SCCHN malignancy...
  77. pmc Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck
    Mark E Sharafinski
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Head Neck 32:1412-21. 2010
    ....
  78. pmc Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity
    Steve C Lee
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Immunol Res 50:248-54. 2011
    ..These events likely contribute to clinical activity, as well as provide a potential biomarker of response to mAb therapy...
  79. pmc Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape
    Robert L Ferris
    The Hillman Cancer Center Research Pavilion, 5117 Centre Ave, Room 2 26b, Pittsburgh, PA 15213, USA
    J Clin Oncol 28:4390-9. 2010
    ..However, these results are only seen in a subset (20% to 30%) of patients. We discuss the immunologic mechanism(s) underlying these clinical findings and their potential role in the variability in patients' clinical response...
  80. pmc Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus
    Abigail I Wald
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Head Neck 33:504-12. 2011
    ..Differences in microRNA (miRNA) expression may affect their clinical outcomes...
  81. pmc Defective NF-κB signaling in metastatic head and neck cancer cells leads to enhanced apoptosis by double-stranded RNA
    Naoki Umemura
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 72:45-55. 2012
    ..By elucidating how TLR3 ligands trigger apoptosis in metastatic cells, our findings suggest insights into how to improve their clinical use...
  82. pmc Human β-defensin 3 promotes NF-κB-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck
    Yvonne K Mburu
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Carcinogenesis 32:168-74. 2011
    ..Our findings suggest that hBD3 represents a novel NF-κB-regulated mediator of CCR7 expression and anti-apoptotic pathways, which may be exploited by developing SCCHN tumors to enhance their survival and metastasis...
  83. ncbi request reprint Human leukocyte antigen (HLA) class I defects in head and neck cancer: molecular mechanisms and clinical significance
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 1523, USA
    Immunol Res 33:113-33. 2005
    ....
  84. ncbi request reprint Progress in head and neck cancer immunotherapy: can tolerance and immune suppression be reversed?
    Robert L Ferris
    Department of Otolaryngology, Hillman Cancer Center Research Pavilion, Pittsburgh, PA 15213, USA
    ORL J Otorhinolaryngol Relat Spec 66:332-40. 2004
    ..This article reviews adjuvant immunotherapeutic strategies currently in trials or under development for SCCHN patients, including vaccination or cytokine immunostimulation...
  85. pmc Minimally invasive video-assisted thyroidectomy: expanded indications and oncologic completeness
    Stephen Y Lai
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Head Neck 30:1403-7. 2008
    ..Minimally invasive video-assisted thyroidectomy (MIVAT) has received increasing attention as a technique applicable for a subset of thyroid nodules...
  86. pmc The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation
    Hyun Jin Kwun
    Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Virology 412:357-65. 2011
    ..Although LANA1 and EBV EBNA1 are functionally similar, they appear to use different mechanisms to evade host cytotoxic T lymphocyte surveillance...