D M Ferriero

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Neonatal encephalopathy in the term infant: neuroimaging and inflammatory cytokines
    Audrey Foster-Barber
    Neonatal Brain Disorders Laboratory, Department of Neurology, University of California at San Francisco, San Francisco, California 94143 0114, USA
    Ment Retard Dev Disabil Res Rev 8:20-4. 2002
  2. ncbi request reprint Timing is everything--delaying therapy for delayed cell death
    Donna M Ferriero
    Department of Neurology, University of California San Francisco, San Francisco, Calif 94143 0114, USA
    Dev Neurosci 24:349-51. 2002
  3. ncbi request reprint Oxidant mechanisms in neonatal hypoxia-ischemia
    D M Ferriero
    Department of Neurology, Division of Child Neurology, University of California, San Francisco, 94143 0114, USA
    Dev Neurosci 23:198-202. 2001
  4. ncbi request reprint Protecting neurons
    Donna M Ferriero
    University of California, San Francisco, Department of Neurology, San Francisco, California 94143 0663, USA
    Epilepsia 46:45-51. 2005
  5. ncbi request reprint Neonatal brain injury
    Donna M Ferriero
    Department of Neurolog, University of California at San Francisco, San Francisco, CA 94143 0663, USA
    N Engl J Med 351:1985-95. 2004
  6. ncbi request reprint Impact of addictive and harmful substances on fetal brain development
    D M Ferriero
    Department of Neurology, University of California San Francisco 94143 0114, USA
    Curr Opin Neurol 12:161-6. 1999
  7. doi request reprint Diffusion tensor imaging of the pyramidal tracts in infants with motor dysfunction
    N A Ludeman
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Neurology 71:1676-82. 2008
  8. pmc Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei
    S L Bonifacio
    Department of Pediatrics, Division of Neonatology, UCSF School of Medicine, 533 Parnassus Ave, Room U 585, Box 0748, San Francisco, CA 94143 0748, USA
    AJNR Am J Neuroradiol 33:2050-5. 2012
  9. ncbi request reprint Three-dimensional proton MR spectroscopic imaging of premature and term neonates
    D B Vigneron
    Department of Radiology, Magnetic Resonance Science Center, University of California, San Francisco, CA 94143, USA
    AJNR Am J Neuroradiol 22:1424-33. 2001
  10. ncbi request reprint Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments
    Ramadevi Pullela
    Department of Pediatrics, University of California, San Francisco, CA 94143 0520, USA
    Dev Neurosci 28:396-409. 2006

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Neonatal encephalopathy in the term infant: neuroimaging and inflammatory cytokines
    Audrey Foster-Barber
    Neonatal Brain Disorders Laboratory, Department of Neurology, University of California at San Francisco, San Francisco, California 94143 0114, USA
    Ment Retard Dev Disabil Res Rev 8:20-4. 2002
    ..This review discusses the interplay among inflammatory cytokines, neonatal encephalopathy, and neuroimaging parameters...
  2. ncbi request reprint Timing is everything--delaying therapy for delayed cell death
    Donna M Ferriero
    Department of Neurology, University of California San Francisco, San Francisco, Calif 94143 0114, USA
    Dev Neurosci 24:349-51. 2002
  3. ncbi request reprint Oxidant mechanisms in neonatal hypoxia-ischemia
    D M Ferriero
    Department of Neurology, Division of Child Neurology, University of California, San Francisco, 94143 0114, USA
    Dev Neurosci 23:198-202. 2001
    ..Understanding the molecular mechanisms of oxidative stress will lead to better therapies for neonatal hypoxia-ischemia...
  4. ncbi request reprint Protecting neurons
    Donna M Ferriero
    University of California, San Francisco, Department of Neurology, San Francisco, California 94143 0663, USA
    Epilepsia 46:45-51. 2005
    ..At this time, however, the postinjury enhancement of neurogenesis appears to offer the best hope for long-lasting functional recovery following brain injury...
  5. ncbi request reprint Neonatal brain injury
    Donna M Ferriero
    Department of Neurolog, University of California at San Francisco, San Francisco, CA 94143 0663, USA
    N Engl J Med 351:1985-95. 2004
  6. ncbi request reprint Impact of addictive and harmful substances on fetal brain development
    D M Ferriero
    Department of Neurology, University of California San Francisco 94143 0114, USA
    Curr Opin Neurol 12:161-6. 1999
    ..The extrapolation to effects on the human nervous system is confounded by the multiplicity of factors affecting central nervous system development...
  7. doi request reprint Diffusion tensor imaging of the pyramidal tracts in infants with motor dysfunction
    N A Ludeman
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Neurology 71:1676-82. 2008
    ..To determine if diffusion tensor imaging (DTI) metrics of the pyramidal tracts correlate with motor outcome in infants presenting with motor dysfunction...
  8. pmc Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei
    S L Bonifacio
    Department of Pediatrics, Division of Neonatology, UCSF School of Medicine, 533 Parnassus Ave, Room U 585, Box 0748, San Francisco, CA 94143 0748, USA
    AJNR Am J Neuroradiol 33:2050-5. 2012
    ..However, its effects on brain microstructure and metabolism have not been fully characterized. We hypothesized that therapeutic hypothermia improves measures of brain microstructure and metabolism...
  9. ncbi request reprint Three-dimensional proton MR spectroscopic imaging of premature and term neonates
    D B Vigneron
    Department of Radiology, Magnetic Resonance Science Center, University of California, San Francisco, CA 94143, USA
    AJNR Am J Neuroradiol 22:1424-33. 2001
    ..This study also indicates the need for determining topologic and age-matched normative values before metabolic abnormalities in neonates can be accurately assessed by MR spectroscopy...
  10. ncbi request reprint Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments
    Ramadevi Pullela
    Department of Pediatrics, University of California, San Francisco, CA 94143 0520, USA
    Dev Neurosci 28:396-409. 2006
    ..Behavioral changes are a likely consequence of regional-specific neuronal degeneration...
  11. pmc Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain
    Matthew B Potts
    Brain and Spinal Injury Center and Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosci Res 87:1848-57. 2009
    ..087). Overall, these data demonstrate that traumatic injury to the injured immature brain impairs neurogenesis during maturation and suggest that GPx cannot rescue this reduced neurogenesis...
  12. ncbi request reprint Differential vulnerability of immature murine neurons to oxygen-glucose deprivation
    Xiangning Jiang
    Department of Neurology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0663, USA
    Exp Neurol 190:224-32. 2004
    ....
  13. ncbi request reprint Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons
    L M Almli
    Departments of Neurology and Pediatrics, University of California San Francisco, Box 0114, San Francisco, CA 94143-0114, USA
    Brain Res Dev Brain Res 132:121-9. 2001
    ..In the immature nervous system this neuronal injury can be attenuated by free radical scavengers and metal chelators...
  14. pmc Quantitative fiber tracking analysis of the optic radiation correlated with visual performance in premature newborns
    J I Berman
    Department of Radiology, University of California San Francisco, San Francisco, California, USA
    AJNR Am J Neuroradiol 30:120-4. 2009
    ..Many prematurely born neonates have abnormalities of vision or visual processing. This study tests the hypothesis that a correlation exists between the microstructure of the optic radiation and visual performance in premature neonates...
  15. ncbi request reprint Perinatal stroke in term infants with neonatal encephalopathy
    V Ramaswamy
    Department of Neurology, University of California San Francisco, CA 94143 0663, USA
    Neurology 62:2088-91. 2004
    ..These findings suggest that in newborns with encephalopathy, acute focal strokes are an uncommon but serious occurrence with substantial risk for abnormal neurodevelopmental outcome...
  16. ncbi request reprint Traumatic brain injury in the immature mouse brain: characterization of regional vulnerability
    Winnie Tong
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Exp Neurol 176:105-16. 2002
    ..These observations serve as an important baseline for studying human brain injury and optimizing therapies for the brain-injured child...
  17. ncbi request reprint MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy
    A J Barkovich
    Department of Radiology, University of California at San Francisco, San Francisco, Calif 94143 0628, USA
    AJNR Am J Neuroradiol 27:533-47. 2006
    ....
  18. ncbi request reprint Fructose-1,6-bisphosphate after hypoxic ischemic injury is protective to the neonatal rat brain
    A Sola
    Department of Pediatrics Neonatology, University of California, San Francisco 94143 0734, USA
    Brain Res 741:294-9. 1996
    ..These results indicate that FBP treatment administered systemically after hypoxia-ischemia reduces CNS injury in neonatal rats...
  19. pmc Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke
    Damjan Osredkar
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Neurobiol Dis 38:259-65. 2010
    ..These findings support the hypothesis that EPO not only prevents ischemia induced cell death but promotes neuronal cell fate commitment in in vitro models of neonatal stroke...
  20. ncbi request reprint Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model
    Dezhi Mu
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Neurobiol Dis 14:524-34. 2003
    ..The presence of HIF-1alpha and VEGF after moderate ischemia-reperfusion injury suggests potential avenues to exploit for neuroprotection...
  21. ncbi request reprint Tone abnormalities are associated with maternal cigarette smoking during pregnancy in in utero cocaine-exposed infants
    D A Dempsey
    Department of Pediatrics, Department of Psychiatry, University of California, San Francisco, California 94143 0898, USA
    Pediatrics 106:79-85. 2000
    ..Our goal was to determine whether in utero cocaine exposure is associated with an abnormal neurologic examination in infants, while controlling for concomitant cigarette smoke exposure and other confounding variables...
  22. ncbi request reprint Delayed cell death in neonatal mouse hippocampus from hypoxia-ischemia is neither apoptotic nor necrotic
    R A Sheldon
    Neonatal Brain Disorders Laboratory, Department of Neurology, University of California San Francisco, San Francisco CA 94143-0114, USA
    Neurosci Lett 304:165-8. 2001
    ..While dying cells had an appearance consistent with apoptosis on light microscopy, cells were neither necrotic nor apoptotic at the ultrastructural level...
  23. ncbi request reprint Neonatal hypoxia-ischemia differentially upregulates MAGUKs and associated proteins in PSD-93-deficient mouse brain
    Xiangning Jiang
    Department of Neurology, University of California, San Francisco 94143 0663, USA
    Stroke 34:2958-63. 2003
    ..We investigated whether deletion of PSD-93 would dissociate the NMDAR from nNOS and be neuroprotective...
  24. ncbi request reprint Erythropoietin improves functional and histological outcome in neonatal stroke
    Yun Sil Chang
    Departments of Neurology and Pediatrics, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0663, USA
    Pediatr Res 58:106-11. 2005
    ..This functional improvement directly correlated with the amount of preserved hemispheric volume. These results suggest EPO may be a candidate in the treatment of neonatal stroke...
  25. pmc Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain
    Tomoko Yoneyama-Sarnecky
    Department of Neurosurgery, University of California, San Francisco, Calif, USA
    Dev Neurosci 32:81-90. 2010
    ..Together, these findings demonstrate that deficiency in HO-2 alters both the kinetics of secondary damage and fine motor recovery after TBI...
  26. ncbi request reprint Overexpression of glutathione peroxidase protects immature murine neurons from oxidative stress
    Claire W McLean
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA
    Dev Neurosci 27:169-75. 2005
    ..Increased GPx-1 expression in immature cortical neurons confers protection from oxidative stress, but availability of reducing equivalents determines susceptibility to oxidative cell death...
  27. ncbi request reprint Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke
    Dezhi Mu
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
    Exp Neurol 195:407-15. 2005
    ..These results suggest that DFO is protective when administered after neonatal ischemic stroke and that this protection may be like that afforded by preconditioning through the upregulation of similar downstream pathways...
  28. ncbi request reprint Human perinatal asphyxia: correlation of neonatal cytokines with MRI and outcome
    A Foster-Barber
    Laboratory of Neonatal Brain Disorders, Department of Neurology, San Francisco, Calif 94143-0114, USA
    Dev Neurosci 23:213-8. 2001
    ..Further analysis will include correlations of cytokine levels with injury on MRI spectroscopy, with neonatal clinical markers of encephalopathy, and with later neurodevelopmental outcome...
  29. ncbi request reprint Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report
    A J Barkovich
    Department of Neuroradiology, University of California, San Francisco 94143, USA
    AJNR Am J Neuroradiol 22:1786-94. 2001
    ..Further studies are ongoing in an attempt to expand upon this observation...
  30. ncbi request reprint Diffusion tensor MR imaging tractography of the pyramidal tracts correlates with clinical motor function in children with congenital hemiparesis
    O A Glenn
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 28:1796-802. 2007
    ..We hypothesized that the asymmetry correlates with the severity of hemiparesis and that diffusion metrics would be abnormal in the affected tracts and normal in the unaffected tracts...
  31. pmc Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia
    K B Nash
    Department of Neurology, University of California, San Francisco, USA
    Neurology 76:556-62. 2011
    ..Therapeutic hypothermia (TH) is becoming standard of care in newborns with hypoxic-ischemic encephalopathy (HIE). The prognostic value of the EEG and the incidence of seizures during TH are uncertain...
  32. doi request reprint Recurrent postnatal infections are associated with progressive white matter injury in premature infants
    Hannah C Glass
    Department of Neurology, University of California, San Francisco, USA
    Pediatrics 122:299-305. 2008
    ..Our objective was to identify clinical predictors of progressive white matter injury...
  33. ncbi request reprint Neonatal encephalopathy: association of cytokines with MR spectroscopy and outcome
    Agnes I Bartha
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Pediatr Res 56:960-6. 2004
    ..Understanding the link between elevated cytokines and outcome would inform novel strategies of cerebral protection...
  34. ncbi request reprint Acute hypoxia-ischemia results in hydrogen peroxide accumulation in neonatal but not adult mouse brain
    Michael J Lafemina
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
    Pediatr Res 59:680-3. 2006
    ....
  35. ncbi request reprint Copper/zinc superoxide dismutase transgenic brain in neonatal hypoxia-ischemia
    R Ann Sheldon
    Department of Neurology, University of California, San Francisco, California 94143, USA
    Methods Enzymol 353:389-97. 2002
  36. ncbi request reprint The injury response in the term newborn brain: can we neuroprotect?
    Shannon E G Hamrick
    Department of Pediatrics, Division of Child Neurology, University of California San Francisco, 521 Parnassus Avenue, C215 San Francisco, CA 94143 0663, USA
    Curr Opin Neurol 16:147-54. 2003
    ..The developing brain is uniquely vulnerable to hypoxic-ischemic injury, with a complex evolution of injury that affords opportunities for intervention, yet potentially jeopardizes normal maturational processes...
  37. ncbi request reprint The normal neonatal brain: MR imaging, diffusion tensor imaging, and 3D MR spectroscopy in healthy term neonates
    A I Bartha
    Department of Neurology, University of California at San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 28:1015-21. 2007
    ..We report quantitative values from a cohort of healthy term neonates to serve as baseline data for studies assessing brain development and injury...
  38. ncbi request reprint Molecular and biochemical mechanisms of perinatal brain injury
    Z S Vexler
    Department of Neurology, University California San Francisco, 521 Parnassus Ave, San Francisco, CA 94143-0114, USA
    Semin Neonatol 6:99-108. 2001
    ....
  39. ncbi request reprint Hypoxic preconditioning reverses protection after neonatal hypoxia-ischemia in glutathione peroxidase transgenic murine brain
    R Ann Sheldon
    Department of Neurology, University of California San Francisco, San Francisco, California 94143, USA
    Pediatr Res 61:666-70. 2007
    ..With PC, H2O2 remained low in hGPx-tg compared with Wt at 2 h, but at 24 h, there was no longer a difference between hGPx-tg and Wt cortices. Accumulation of H2O2 may be a mediator of injury, but may also induce protective mechanisms...
  40. pmc Perinatal events and early magnetic resonance imaging in therapeutic hypothermia
    Sonia L Bonifacio
    Division of Neonatology, University of California San Francisco, School of Medicine, 533 Parnassus Avenue, U585, Box 0748, San Francisco, CA 94143 0748, USA
    J Pediatr 158:360-5. 2011
    ..To compare the association between perinatal events and the pattern and extent of brain injury on early magnetic resonance imaging in newborn infants with and without therapeutic hypothermia for hypoxic-ischemic encephalopathy...
  41. pmc Magnetic resonance imaging and ultrasound injury in preterm infants with seizures
    Hannah C Glass
    Department of Neurology, University of California, San Francisco, California 94143, USA
    J Child Neurol 24:1105-11. 2009
    ..Magnetic resonance imaging may be the study of choice for evaluating preterm infants with seizures...
  42. ncbi request reprint Neuroimaging abnormalities in infants with congenital hemiparesis
    Yvonne W Wu
    Department of Neurology, University of California, San Francisco, California 94143 0137, USA
    Pediatr Neurol 35:191-6. 2006
    ..001). Neuroimaging studies provide useful diagnostic and prognostic information in infants with congenital hemiparesis...
  43. pmc Neurocritical care for neonates
    Hannah C Glass
    Department of Neurology, University of California, Box 0663, 521 Parnassus Avenue, C 215, San Francisco, CA 94143 0663, USA
    Neurocrit Care 12:421-9. 2010
    ..To describe the concept, implementation, patient characteristics, and preliminary outcomes of a Neonatal Neurocritical Care Service (NNCS) recently established at the University of California, San Francisco...
  44. ncbi request reprint Translational stroke research in the developing brain
    Zinaida S Vexler
    Department of Neurology, University of California San Francisco, San Francisco, California 94143 0663, USA
    Pediatr Neurol 34:459-63. 2006
    ..These issues need to be carefully addressed in designing future clinical trials...
  45. pmc Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke
    Janet Shimotake
    Department of Pediatrics, University of California, San Francisco, San Francisco Calif 94143 0663, USA
    Stroke 41:343-9. 2010
    ..Vascular endothelial growth factor is upregulated after a hypoxic insult and is involved in neuronal survival, angiogenesis, and neurogenesis during the recovery process...
  46. pmc Imaging selective vulnerability in the developing nervous system
    Donna M Ferriero
    Departments of Neurology and Pediatrics, Newborn Brain Research Institute, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0663, USA
    J Anat 217:429-35. 2010
    ..The injury response in the developing brain is a complex process that evolves over time and is amenable to repair...
  47. ncbi request reprint Models of cerebral palsy: which ones are best?
    Michael V Johnston
    Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Child Neurol 20:984-7. 2005
  48. ncbi request reprint Childhood status epilepticus and excitotoxic neuronal injury
    Tammy N Tsuchida
    Department of Neurology, University of California, San Francisco, San Francisco, California, USA
    Pediatr Neurol 36:253-7. 2007
    ..Review of the literature revealed 11 similar cases that support the hypothesis of excitotoxic neuronal cell death after status epilepticus...
  49. pmc Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons
    Shengjun Chang
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Neurosci Lett 441:134-8. 2008
    ..For both preconditioning paradigms, HIF-1alpha expression level declined to baseline at 72 h. Our results suggest that low levels of H(2)O(2) may up-regulate HIF-1alpha protein and thereby mediate H/I preconditioning protection...
  50. pmc Extreme premature birth is not associated with impaired development of brain microstructure
    Sonia L Bonifacio
    Department of Pediatrics, University of California, San Francisco, CA 94143 0748, USA
    J Pediatr 157:726-32.e1. 2010
    ..To assess whether birth at <26 weeks gestation is an important predictor of brain microstructure maturation as determined by using diffusion tensor imaging...
  51. pmc Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 years
    Kyle J Steinman
    MAS, University of California, Division of Child Neurology, 350 Parnassus Ave, Suite 609, San Francisco, CA 94117, USA
    Pediatrics 123:1025-30. 2009
    ....
  52. doi request reprint Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia
    Xiangning Jiang
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
    Ann Neurol 63:632-41. 2008
    ....
  53. pmc Cerebellar development in the preterm neonate: effect of supratentorial brain injury
    Emily W Y Tam
    Department of Neurology and Pediatrics, University of California San Francisco, 521 Parnassus Ave, San Francisco, CA 94143, USA
    Pediatr Res 66:102-6. 2009
    ..DTI studies may provide an early indicator for cerebellar injury and abnormal cerebellar development in preterm neonates...
  54. pmc Erythropoietin sustains cognitive function and brain volume after neonatal stroke
    Fernando F Gonzalez
    Department of Pediatrics, University of California, San Francisco, CA 94143 0663, USA
    Dev Neurosci 31:403-11. 2009
    ..These results suggest that additional, later doses of EPO may be required for cell repair, proliferation, and long-term incorporation into neural networks after neonatal brain injury...
  55. pmc MR spectroscopy of normative premature newborns
    Duan Xu
    Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA
    J Magn Reson Imaging 33:306-11. 2011
    ..To establish normative metabolite ratios throughout the newborn brain using three-dimensional (3D) MR spectroscopic imaging (MRSI)...
  56. ncbi request reprint Abnormal brain development in newborns with congenital heart disease
    Steven P Miller
    Department of Neurology, University of California at San Francisco, San Francisco, USA
    N Engl J Med 357:1928-38. 2007
    ..We characterized brain metabolism and microstructure, as measures of brain maturation, in newborns with congenital heart disease before they underwent heart surgery...
  57. pmc Genetic and pharmacologic manipulation of oxidative stress after neonatal hypoxia-ischemia
    R Ann Sheldon
    Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
    Int J Dev Neurosci 26:87-92. 2008
    ..Taken together, these results imply that H2O2 is a critical component of neonatal HI injury, and GPx1 plays an important role in the defense against this H2O2 and is thereby neuroprotective...
  58. ncbi request reprint Treatment of hypoxic-ischemic encephalopathy in newborns
    Hannah C Glass
    Donna M Ferriero, MD University of California San Francisco, Neonatal Brain Disorders Center, Box 0663, 521 Parnassus Avenue, C 215, San Francisco, CA 94143, USA
    Curr Treat Options Neurol 9:414-23. 2007
    ..Pilot clinical trials of newer anticonvulsants are ongoing and will provide critical information for care of neonatal seizures...
  59. pmc Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury
    Hannah C Glass
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
    J Pediatr 155:318-23. 2009
    ..To examine whether neonatal seizures are associated with neurodevelopmental outcomes in infants with hypoxia-ischemia independent of the presence and severity of brain injury seen on magnetic resonance imaging (MRI)...
  60. pmc HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia
    R Ann Sheldon
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Dev Neurosci 31:452-8. 2009
    ..05) and was more severe in the cortex. Genetic reduction of neuronal HIF-1 alpha results in a worsening of injury after neonatal HI, with a region-specific role for HIF-1 alpha in the setting of neonatal brain injury...
  61. ncbi request reprint Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke
    Fernando F Gonzalez
    Department of Pediatrics, University of California, San Francisco, Calif 94143 0663, USA
    Dev Neurosci 29:321-30. 2007
    ..These results suggest that EPO may neuroprotect and direct cell fate toward neurogenesis and away from gliogenesis in neonatal stroke...
  62. ncbi request reprint Candidate gene polymorphisms do not differ between newborns with stroke and normal controls
    Steven P Miller
    Department of Neurology, University of California, San Francisco, California, USA
    Stroke 37:2678-83. 2006
    ..Pathways involved in the pathophysiology of neonatal stroke are diverse and may include thrombosis and thrombolysis, vascular reactivity, and inflammation...
  63. ncbi request reprint Comparing microstructural and macrostructural development of the cerebral cortex in premature newborns: diffusion tensor imaging versus cortical gyration
    Amy R Deipolyi
    Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94143, USA
    Neuroimage 27:579-86. 2005
    ..0001) but not in the tangential diffusivities (P > 0.05)...
  64. ncbi request reprint Comparing the diagnosis of white matter injury in premature newborns with serial MR imaging and transfontanel ultrasonography findings
    Steven P Miller
    Department of Neurology, University of California San Francisco, San Francisco, CA, USA
    AJNR Am J Neuroradiol 24:1661-9. 2003
    ..The objective of this study was to compare the diagnosis of white matter injury detected by serial MR imaging and ultrasonography of a contemporary cohort of premature neonates...
  65. ncbi request reprint Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress
    Zinaida S Vexler
    Department of Neurology, University of California San Francisco, Box 0114, 521 Parnassus Ave, San Francisco, CA, USA
    Brain Res 960:90-8. 2003
    ..The efficacy of FBP depended on duration of hypoxia and was associated with higher intracellular GSH concentration, an effect partly mediated via increased glutathione reductase activity...
  66. ncbi request reprint Serial quantitative diffusion tensor MRI of the premature brain: development in newborns with and without injury
    Steven P Miller
    Department of Neurology, University of California, San Francisco, California, USA
    J Magn Reson Imaging 16:621-32. 2002
    ..To determine the change over time of the apparent diffusion coefficient (ADC) and relative anisotropy of cerebral water in a cohort of premature newborns serially studied near birth and again near term...
  67. ncbi request reprint Intraventricular hemorrhage in term neonates caused by sinovenous thrombosis
    Yvonne W Wu
    Department of Neurology, University of California, San Francisco, CA 94143 0136, USA
    Ann Neurol 54:123-6. 2003
    ..03). Term neonates with intraventricular hemorrhage should undergo neuroimaging to evaluate the presence of sinovenous thrombosis. Ann Neurol 2003..
  68. ncbi request reprint Manipulation of antioxidant pathways in neonatal murine brain
    R Ann Sheldon
    Department of Neurology, University of California San Francisco, San Francisco, California 94143
    Pediatr Res 56:656-62. 2004
    ..008). These findings support the hypothesis that the immature brain has limited GPX activity and is more susceptible to oxidative damage and may explain the paradoxical effect seen in ischemic neonatal brain when SOD1 is overexpressed...
  69. ncbi request reprint Selective vulnerability of subplate neurons after early neonatal hypoxia-ischemia
    Patrick S McQuillen
    Department of Pediatrics, University of California San Francisco Medical Center, San Francisco, California 94143 0106, USA
    J Neurosci 23:3308-15. 2003
    ..However, deficits in motor function still occur, as in babies with PVL. Subplate neuron cell death in PVL provides another mechanism for abnormal neurodevelopment after neonatal hypoxia-ischemia...
  70. ncbi request reprint Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants
    Jeffrey I Berman
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuroimage 27:862-71. 2005
    ..In summary, deterministic and probabilistic DTI fiber tracking methods were used to quantify the developmental changes of motor and somatosensory pathways in premature infants...
  71. ncbi request reprint Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns
    Savannah C Partridge
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuroimage 22:1302-14. 2004
    ..This work contributes to the understanding of normal white matter development in the preterm neonatal brain, an important step toward the use of DTI for the improved evaluation and treatment of white matter injury of prematurity...
  72. ncbi request reprint Preoperative brain injury in newborns with transposition of the great arteries
    Steven P Miller
    Department of Pediatrics, University of California, San Francisco, CA 94143 0663, USA
    Ann Thorac Surg 77:1698-706. 2004
    ....
  73. ncbi request reprint Perinatal subplate neuron injury: implications for cortical development and plasticity
    P S McQuillen
    Department of Pediatrics, Box 0106, University of California San Francisco Medical Center, San Francisco, CA 94143 0106, USA
    Brain Pathol 15:250-60. 2005
    ..We suggest that subplate neuron injury may be a central component of perinatal brain injury resulting in specific neurodevelopmental consequences...
  74. pmc Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain
    C Manabat
    Department of Neurology, University of California at San Francisco, 94143 0114, USA
    Stroke 34:207-13. 2003
    ..This study was designed to determine the role of caspase-dependent injury in the pathophysiology of pure focal cerebral ischemia in the immature brain...
  75. ncbi request reprint Seizure-associated brain injury in term newborns with perinatal asphyxia
    S P Miller
    Department of Neurology, University of California, San Francisco 94143 0628, USA
    Neurology 58:542-8. 2002
    ..There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage the developing brain...
  76. ncbi request reprint Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy
    Steven P Miller
    Department of Neurology, University of California at San Francisco, San Francisco, 94110, USA
    Am J Obstet Gynecol 190:93-9. 2004
    ..This study was undertaken to determine the value of a neonatal encephalopathy score (ES) and the presence of seizures for predicting 30-month neurodevelopmental outcome...
  77. ncbi request reprint Neonatal seizures: multicenter variability in current treatment practices
    Agnes I Bartha
    Department of Pediatrics, University of California at San Francisco, San Francisco, California 94143 0663, and Legacy Emanuel Children s Hospital, Portland, OR, USA
    Pediatr Neurol 37:85-90. 2007
    ..Trials of anticonvulsants with long-term neurodevelopmental follow-up are needed to develop evidence-based treatment guidelines...
  78. ncbi request reprint Encephalopathy as a predictor of magnetic resonance imaging abnormalities in asphyxiated newborns
    Seth A Kaufman
    School of Medicine, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0114, USA
    Pediatr Neurol 28:342-6. 2003
    ..However, standard clinical criteria do not alter the prior risk of abnormal basal ganglia magnetic resonance imaging results for newborns with moderate encephalopathy...
  79. ncbi request reprint Predictors of 30-month outcome after perinatal depression: role of proton MRS and socioeconomic factors
    Steven P Miller
    Department of Neurology, University of California San Francisco, San Francisco, California 94143, USA
    Pediatr Res 52:71-7. 2002
    ....
  80. ncbi request reprint Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome
    Steven P Miller
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    J Pediatr 147:609-16. 2005
    ..To determine the neurodevelopmental outcome of prematurely born newborns with magnetic resonance imaging (MRI) abnormalities...
  81. ncbi request reprint Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70
    Yasuhiko Matsumori
    Department of Neurological Surgery, University of California, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Stroke 37:507-12. 2006
    ....
  82. ncbi request reprint Selective vulnerability in the developing central nervous system
    Patrick S McQuillen
    Department of Pediatrics, University of California San Francisco Medical Center, San Francisco, California 94143 0106, USA
    Pediatr Neurol 30:227-35. 2004
    ..The unique roles of particular mechanisms including oxidative stress, glutamatergic neurotransmission, and programmed cell death are discussed in the context of this selective vulnerability...
  83. pmc Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke
    M Dzietko
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA
    Transl Stroke Res 4:189-200. 2013
    ..These results suggest that VEGF has a neuroprotective effect, in part by enhancing endogenous angiogenesis. These data contribute to a better understanding of neonatal stroke. ..
  84. ncbi request reprint Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
    M Bergeron
    Department of Neurology, University of Cincinnati, OH 45267 0536, USA
    Ann Neurol 48:285-96. 2000
    ..Thus, HIF-1 activation could contribute to protective brain preconditioning, which could be used in high-risk deliveries and other clinical situations...
  85. ncbi request reprint Neurodevelopmental outcome after endovascular treatment of vein of Galen malformations
    H J Fullerton
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 61:1386-90. 2003
    ..To assess neurodevelopmental outcome after endovascular treatment of vein of Galen malformations (VOGM)...
  86. ncbi request reprint Ontogeny of excitotoxic injury to nicotinamide adenine dinucleotide phosphate diaphorase reactive neurons in the neonatal rat striatum
    D M Ferriero
    Department of Neurology, University of California, San Francisco 94110
    Neuroscience 36:417-24. 1990
    ....
  87. ncbi request reprint Hypoxia increases calcium flux through cortical neuron glutamate receptors via protein kinase C
    P E Bickler
    Departments of Anesthesia Neurology, University of California at San Francisco, San Francisco, California 94143 0542, USA
    J Neurochem 88:878-84. 2004
    ....
  88. doi request reprint Therapeutics for neonatal brain injury
    Fernando F Gonzalez
    Department of Pediatrics, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143, USA
    Pharmacol Ther 120:43-53. 2008
    ..In this review, we summarize recent findings in neuroprotection and neurogenesis for the immature brain, including combination therapy to optimize repair...
  89. ncbi request reprint Multiple risk factors in neonatal sinovenous thrombosis
    Yvonne W Wu
    Department of Neurology, University of California San Francisco, 500 Parnassus Avenue, Rm 412, San Francisco, CA 94143 0136, USA
    Neurology 59:438-40. 2002
    ..Eighteen neonates had multiple maternal, neonatal, perinatal, or prothrombotic complications. Sinovenous thrombosis was often accompanied by infarction (50%) or intraventricular hemorrhage (33%)...
  90. ncbi request reprint Widening spectrum of congenital hemiplegia: Periventricular venous infarction in term neonates
    J Takanashi
    Neuroradiology Section, Department of Radiology, University of California San Francisco, USA
    Neurology 61:531-3. 2003
    ..Some cases of congenital hemiplegia in term neonates may be due to clinically silent periventricular venous infarction that occurred in utero...
  91. ncbi request reprint Developmental expression of heme oxygenase-1 (HSP32) in rat brain: an immunocytochemical study
    M Bergeron
    Department of Neurology, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain Res Dev Brain Res 105:181-94. 1998
    ..These results show that HO-1 protein expression is regulated in different cell types of specific regions of the rat brain during development...
  92. ncbi request reprint The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain
    D P Sarco
    Neonatal Brain Disorders Laboratory, Departments of Neurology, University of California San Francisco, San Francisco, USA
    Neurosci Lett 282:113-6. 2000
    ..Deferoxamine may protect the neonatal brain by a number of anti-oxidant mechanisms including iron chelation, enhancement of stress gene expression, or induction of other factors responsible for neuroprotection...
  93. ncbi request reprint Can we define the pathogenesis of human periventricular white-matter injury using animal models?
    Donna M Ferriero
    J Child Neurol 21:580-1. 2006
  94. ncbi request reprint Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 52:802-13. 2002
    ..Moreover, neuroblasts in the injured neostriatum appear to differentiate into a region-appropriate phenotype, which suggests that the mature brain is capable of replacing some neurons lost after ischemic injury...
  95. ncbi request reprint Potential for protection and repair following injury to the developing brain: a role for erythropoietin?
    Augusto Sola
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Res 57:110R-117R. 2005
    ..In addition we review several potential neuroprotective strategies specific to the developing nervous system, with a focus on erythropoietin (Epo) because of its potential role in protection as well as repair...
  96. ncbi request reprint Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury
    Ernest M Graham
    Department of Gyn Ob, Division of Maternal Fetal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurobiol Dis 17:89-98. 2004
    ..Basal levels of endogenous decoy proteins may modulate the response to Fas death receptor signaling and provide a novel approach to understanding mechanisms of neonatal brain injury...
  97. pmc Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion
    Christine Fox
    Department of Neurology, University of California, San Francisco, California 94143 0663, USA
    J Cereb Blood Flow Metab 25:1138-49. 2005
    ..Therefore, minocycline provides early but transient protection, which is largely independent of microglial activation or activation of the MAPK p38 pathway...
  98. ncbi request reprint Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns
    Savannah C Partridge
    Department of Radiology, University of California San Francisco, San Francisco, California 94143 2512, USA
    J Magn Reson Imaging 22:467-74. 2005
    ..To evaluate the feasibility of performing diffusion tensor tractography (DTT) to map and quantify the pyramidal white matter tracts of premature newborns...
  99. ncbi request reprint Induction of haem oxygenase-1 causes cortical non-haem iron increase in experimental pneumococcal meningitis: evidence that concomitant ferritin up-regulation prevents iron-induced oxidative damage
    Hao Ren
    Institute for Infectious Diseases, University of Berne, Berne, Switzerland
    J Neurochem 100:532-44. 2007
    ..Cortical damage does not appear to be a direct consequence of increased iron, therefore...
  100. ncbi request reprint Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury
    Yasuhiko Matsumori
    Department of Neurological Surgery, University of California at San Francisco 94121, USA
    J Cereb Blood Flow Metab 25:899-910. 2005
    ..Our results suggest that interaction between Hsp70 and AIF might have reduced downstream events leading to cell death, including the reduction of nuclear AIF translocation in the neonatal brains of Hsp70 Tg mice after H/I...
  101. ncbi request reprint Trends in severe brain injury and neurodevelopmental outcome in premature newborn infants: the role of cystic periventricular leukomalacia
    Shannon E G Hamrick
    Department of Pediatrics, University of California San Francisco, CA 94143 0663, USA
    J Pediatr 145:593-9. 2004
    ....