Research Topics
Genomes and Genes | THOMAS FERRAROSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Genotyping microsatellite polymorphisms by agarose gel electrophoresis with ethidium bromide staining: application to quantitative trait loci analysis of seizure susceptibility in miceT N Ferraro
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia 19104, USA
Psychiatr Genet 8:227-33. 1998..Overall, these results demonstrate that AGE/EBS can be useful for rapid screening of genomic regions of special interest in QTL mapping studies...
Confirmation of multiple seizure susceptibility QTLs on chromosome 15 in C57BL/6J and DBA/2J inbred miceT N Ferraro
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
Physiol Genomics 42:1-7. 2010..It harbors 83 genes in highly polymorphic areas, 310 genes in all. Complete dissection of these loci will lead to identification of genetic variants that influence SZS in mice and provide a better understanding of seizure biology...- Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strainsThomas N Ferraro
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3404, USA
Physiol Genomics 31:458-62. 2007.... - Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transferThomas N Ferraro
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3404, USA
Epilepsia 48:1667-77. 2007.... - Role of genetics in the diagnosis and treatment of epilepsyThomas N Ferraro
University of Pennsylvania, Department of Psychiatry, 125 S 31 Street, Room 2209 TRL, Philadelphia, PA 19104 3403, USA
Expert Rev Neurother 6:1789-800. 2006..Further elucidation of the relationship between gene mutations and channel function will add value to genetic testing in the future, as will better characterization of the association between gene mutations and clinical phenotypes... 
Quantitative trait loci for electrical seizure threshold mapped in C57BLKS/J and C57BL/10SnJ miceT N Ferraro
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
Genes Brain Behav 10:309-15. 2011....- The relationship between the pharmacology of antiepileptic drugs and human gene variation: an overviewThomas N Ferraro
Departments of Psychiatry and Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Epilepsy Behav 7:18-36. 2005..Delineation of these effects in the coming years will promote enhanced success in the treatment of epilepsy... - Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative geneThomas N Ferraro
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Mamm Genome 15:239-51. 2004..The critical interval contains several candidate genes, one of which, Kcnj10, exhibits a potentially important polymorphism with regard to fundamental aspects of seizure susceptibility... - Quantitative genetic study of maximal electroshock seizure threshold in mice: evidence for a major seizure susceptibility locus on distal chromosome 1T N Ferraro
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Genomics 75:35-42. 2001..These results support the hypothesis that the distal portion of chromosome 1 harbors a gene(s) that has a fundamental role in regulating seizure susceptibility... - Mouse strain variation in maximal electroshock seizure thresholdThomas N Ferraro
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
Brain Res 936:82-6. 2002..We conclude that MEST represents a useful tool for dissecting the multifactorial nature of seizure sensitivity in mice... - Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strainsThomas N Ferraro
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
Neuropsychopharmacology 30:742-6. 2005..B6-Mop2 mice. Overall, these data confirm the existence of a gene(s) on chromosome 10 proximal to D10Mit124 that has a strong influence on the difference in morphine drinking behavior between B6 and D2 mice... - Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exonGlenn A Doyle
The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
Gene 388:135-47. 2007..In summary, we have identified three brain expressed, alternatively spliced mouse MOR splice variants containing a novel exon and encoding new putative MOR isoforms, MOR-1V and MOR-1W... - Identification and functional significance of polymorphisms in the mu-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 miceGlenn A Doyle
The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
Neurosci Res 55:244-54. 2006..No significant differences in construct activity were found between untreated and morphine-treated BE(2)-C or Neuro-2a cells, suggesting that morphine does not regulate transcription of Oprm... - Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependenceJohn P Dahl
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
Addict Biol 11:76-83. 2006..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects... - Challenges and opportunities in the application of pharmacogenetics to antiepileptic drug therapyThomas N Ferraro
University of Pennsylvania, Center for Neurobiology and Behavior, Room 2209, Translational Research Laboratories, and The Children s Hospital of Philadelphia, Department of Pediatrics, Philadelphia, PA 19104, USA
Pharmacogenomics 7:89-103. 2006..Further development of these critical factors will optimize chances for overcoming current challenges posed by AED pharmacogenetic research and ultimately allow the realization of improved, more rational therapeutic strategies... - Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strainsGlenn A Doyle
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 33:2801-9. 2008..10 (which harbors Oprm1) between the acromere and Stxbp5, as well as on distal Chr. 6 between marker D6Mit10 and the telomere... - Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorderFalk W Lohoff
Department of Psychiatry, Translational Research Laboratory, Center for Neurobiology and Behavior, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 USA
Psychiatr Genet 18:53-8. 2008..Animal models of PACAP mutations show remarkable behavioral defects, including hyperactivity and increased exploratory behavior... - Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophreniaFalk W Lohoff
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychobiology 57:55-60. 2008..Further studies are necessary to confirm this effect, and to elucidate the role of VMAT1 in central nervous system physiology and possible involvement in the genetic origins of SZ... - Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependenceFalk W Lohoff
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neurosci Lett 440:280-3. 2008.... - Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorderFalk W Lohoff
Department of Psychiatry, Translational Research Laboratories, University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
J Neural Transm 115:1339-45. 2008..Additional studies are necessary to confirm and elucidate the role of VAPA as a susceptibility gene for BPD on chromosome 18p... - Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependenceFalk W Lohoff
Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuropsychopharmacology 33:3078-84. 2008..Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders... - Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependenceFalk W Lohoff
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Neurosci Lett 453:199-203. 2009..However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence... - Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorderFalk W Lohoff
Translational Research Laboratory, Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
Am J Med Genet B Neuropsychiatr Genet 153:830-6. 2010..Our results provide evidence of an association between a polymorphism in the MPPE1 gene and BPD. Additional studies are necessary to confirm and elucidate the role of MPPE1 as a susceptibility gene for BPD on chromosome 18p... - Pharmacogenetic considerations in the treatment of psychiatric disordersFalk W Lohoff
University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, Department of Psychiatry, Translational Research Laboratories, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
Expert Opin Pharmacother 11:423-39. 2010..In addition to clinical heterogeneity, diagnostic uncertainty, environmental, social factors, and genetic factors have been identified as playing an important role in the interindividual differences in therapeutic and toxic drug effects... - Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependenceFalk W Lohoff
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Neurosci Lett 473:87-91. 2010..However, additional studies using larger sample sizes and clinically homogenous populations are necessary before confidently excluding these variants as contributing genetic risk factors for CD... - Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependenceJohn P Dahl
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Psychiatr Res 39:475-9. 2005..The results of this study suggest that polymorphisms in the CRHR 1 gene are not major risk factors for the development of alcohol dependence in persons of European ancestry... - Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traitsFalk W Lohoff
Center for Neurobiology and Behavior, University of Pennsylvania, USA
Neurosci Lett 434:41-5. 2008..408, p=0.0004; STAI trait: Thr/Ile vs. Ile/Ile: T=3.074, p=0.009) but not in the male group. Our findings support the hypothesis that anxiety-related personality traits are associated with variation in the VMAT1/SLC18A1 gene... - No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsyFalk W Lohoff
Department of Psychiatry, University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, 3535 Market Street, 2nd Floor, R2070, Philadelphia, PA 19104, USA
Neurosci Lett 382:33-8. 2005..Linkage disequilibrium was demonstrated throughout the gene. Results suggest that the polymorphisms we studied in the ATP1A2 gene do not represent major susceptibility factors for common forms of IGE... - Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American populationJohn P Dahl
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, 19104, USA
Psychiatr Genet 15:277-83. 2005..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population... - Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorderFalk W Lohoff
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 31:2739-47. 2006..Additional studies are necessary to confirm this effect and to elucidate the role of VMAT1 in central nervous system physiology... - No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependenceAndrew E Weller
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Psychiatr Genet 16:193-6. 2006..The aim of this study is to investigate whether polymorphisms in the human Par-4 gene contribute to the etiology of cocaine dependence... - Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependenceJohn P Dahl
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104, USA
Am J Med Genet B Neuropsychiatr Genet 139:106-8. 2005.... - Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exonGlenn A Doyle
The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
Gene 395:98-107. 2007..These exon 19-containing splice variants add to the growing complexity of the mouse Oprm1 gene... - Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsyFalk W Lohoff
Department of Psychiatry, Center for Neurobiology and Behaviour, University of Pennsylvania School of Medicine, 3535 Market Street, 2nd Floor, R2070, Philadelphia, PA 19104, USA
Epilepsy Res 66:59-62. 2005..Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry... - No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorderFalk W Lohoff
School of Medicine Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Clinical Research Building, Room 135a, 415 Curie Boulevard, Philadelphia, PA 19104 6140, USA
Psychiatry Res 135:171-7. 2005..Our results suggest that common variations in the CHRNA2 gene are unlikely to confer susceptibility to BPD in this sample. Further studies are required to elucidate the susceptibility locus for BPD on chromosome 8p21-22... - Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorderAndrew E Weller
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Psychiatr Genet 16:3-8. 2006..The purpose of this study is to investigate whether polymorphisms in the human NAPG gene contribute to the etiology of bipolar disorder... - Polygenic epilepsyThomas N Ferraro
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Adv Neurol 97:389-98. 2006.... - Novel de novo mutation of a conserved SCN1A amino-acid residue (R1596)Dennis J Dlugos
Department of Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Pediatr Neurol 37:303-5. 2007..In this case, the wild type of residue (R1596) is well-conserved across evolution from bacteria to humans, providing support for the hypothesis that this mutation causes epilepsy... - Recruitment rates and fear of phlebotomy in pediatric patients in a genetic study of epilepsyDennis J Dlugos
Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Epilepsy Behav 6:444-6. 2005..Further analysis of the factors influencing decisions to decline study enrollment is warranted. These data will help in the design of future genetic studies and may increase future participation rates... - Chemoconvulsant-induced seizure susceptibility: toward a common genetic basis?Yohan Chaix
Laboratoire de Neurobiologie, Equipe Génétique des Epilepsies, Universite d Orleans, France
Epilepsia 48:48-52. 2007..One is located on the distal part of Chromosome 1, a region implicated in a number of other studies. Here, we address the general importance of this chromosomal fragment for influencing seizure susceptibility...
Research Grants
- QUANTITATIVE GENETIC STUDY OF SEIZURESTHOMAS FERRARO; Fiscal Year: 2007..abstract_text> ..
- PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPYTHOMAS FERRARO; Fiscal Year: 2003....
- QUANTITATIVE GENETIC STUDY OF SEIZURESTHOMAS FERRARO; Fiscal Year: 2002..Hopefully, these findings will lead as well to new and important information regarding the pathogenesis of human epilepsy. ..
- QUANTITATIVE GENETIC STUDY OF SEIZURESThomas N Ferraro; Fiscal Year: 2010....