Affiliation: University of Pennsylvania
Ferraro T, Golden G, Smith G, DeMuth D, Buono R, Berrettini W. Mouse strain variation in maximal electroshock seizure threshold. Brain Res. 2002;936:82-6 pubmed
..We conclude that MEST represents a useful tool for dissecting the multifactorial nature of seizure sensitivity in mice. ..
Ferraro T, Smith G, Schwebel C, Doyle G, Ruiz S, Oleynick J, et al
. Confirmation of multiple seizure susceptibility QTLs on chromosome 15 in C57BL/6J and DBA/2J inbred mice. Physiol Genomics. 2010;42A:1-7 pubmed publisher
..It harbors 83 genes in highly polymorphic areas, 310 genes in all. Complete dissection of these loci will lead to identification of genetic variants that influence SZS in mice and provide a better understanding of seizure biology. ..
Johnson H, Hanson L, Chen Y, Bieber A, Buono R, Ferraro T, et al
. Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption. BMC Genomics. 2013;14:678 pubmed publisher
..These genes encode for factors that may be potential targets for therapeutic approaches to treat disorders characterized by CD8 T cell-mediated BBB disruption. ..
Ferraro T, Golden G, Smith G, Martin J, Lohoff F, Gieringer T, et al
. Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene. Mamm Genome. 2004;15:239-51 pubmed
..The critical interval contains several candidate genes, one of which, Kcnj10, exhibits a potentially important polymorphism with regard to fundamental aspects of seizure susceptibility. ..
Ferraro T, Smith G, Schwebel C, Lohoff F, Furlong P, Berrettini W, et al
. Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains. Physiol Genomics. 2007;31:458-62 pubmed
Ferraro T, Golden G, Smith G, Martin J, Schwebel C, Doyle G, et al
. Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains. Neuropsychopharmacology. 2005;30:742-6 pubmed
..B6-Mop2 mice. Overall, these data confirm the existence of a gene(s) on chromosome 10 proximal to D10Mit124 that has a strong influence on the difference in morphine drinking behavior between B6 and D2 mice. ..