A A Ferrando

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi Alterations in protein metabolism during space flight and inactivity
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, and the Metabolism Unit, Shriners Hospital for Children, Galveston, Texas 77550, USA
    Nutrition 18:837-41. 2002
  2. ncbi Differential anabolic effects of testosterone and amino acid feeding in older men
    Arny A Ferrando
    Departments of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 88:358-62. 2003
  3. ncbi Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
    Arny A Ferrando
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 282:E601-7. 2002
  4. ncbi Amino acid control of muscle protein turnover in renal disease
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    J Ren Nutr 15:34-8. 2005
  5. ncbi Effects of inactivity and hormonal mediators on skeletal muscle during recovery from trauma
    A A Ferrando
    Department of Metabolism, Shriner s Burns Institute, Galveston, Texas 77550, USA
    Curr Opin Clin Nutr Metab Care 3:171-5. 2000
  6. ncbi Bed rest and myopathies
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, Shrine Hospital for Children, Galveston, Texas 77550, USA
    Curr Opin Clin Nutr Metab Care 9:410-5. 2006
  7. ncbi Short-term oxandrolone administration stimulates net muscle protein synthesis in young men
    M Sheffield-Moore
    Department of Surgery, University of Texas Medical Branch, and Shriners Burn Hospital for Children, Galveston 77550, USA
    J Clin Endocrinol Metab 84:2705-11. 1999
  8. ncbi Combined effects of hyperaminoacidemia and oxandrolone on skeletal muscle protein synthesis
    M Sheffield-Moore
    Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA
    Am J Physiol Endocrinol Metab 278:E273-9. 2000
  9. ncbi Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids
    Douglas Paddon-Jones
    Department of Surgery, University of Texas Medical Branch and Metabolism Unit, Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 284:E946-53. 2003
  10. ncbi Testosterone administration in severe burns ameliorates muscle catabolism
    A A Ferrando
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 29:1936-42. 2001

Detail Information

Publications31

  1. ncbi Alterations in protein metabolism during space flight and inactivity
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, and the Metabolism Unit, Shriners Hospital for Children, Galveston, Texas 77550, USA
    Nutrition 18:837-41. 2002
    ....
  2. ncbi Differential anabolic effects of testosterone and amino acid feeding in older men
    Arny A Ferrando
    Departments of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 88:358-62. 2003
    ..Taken together, however, these diverse stimulatory effects can increase lean body mass and muscle strength over time...
  3. ncbi Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
    Arny A Ferrando
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 282:E601-7. 2002
    ..We conclude that physiological and near-physiological increases of testosterone in older men will increase muscle protein anabolism and muscle strength...
  4. ncbi Amino acid control of muscle protein turnover in renal disease
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    J Ren Nutr 15:34-8. 2005
    ..Despite the substantial evidence of ICAA regulation, its physiologic significance is not evident. However, the regulation of ICAAs represents a method by which skeletal muscle ensures its capacity for anabolism...
  5. ncbi Effects of inactivity and hormonal mediators on skeletal muscle during recovery from trauma
    A A Ferrando
    Department of Metabolism, Shriner s Burns Institute, Galveston, Texas 77550, USA
    Curr Opin Clin Nutr Metab Care 3:171-5. 2000
    ..The safe and effective normalization of testosterone concentrations after severe injury attenuates the loss of muscle protein. The retention of lean body mass will positively affect clinical and rehabilitative outcomes...
  6. ncbi Bed rest and myopathies
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, Shrine Hospital for Children, Galveston, Texas 77550, USA
    Curr Opin Clin Nutr Metab Care 9:410-5. 2006
    ..Changes in protein metabolism with bed rest alone and during physiological stress are discussed. Nutritional and hormonal interventions that ameliorate the loss of skeletal muscle are highlighted...
  7. ncbi Short-term oxandrolone administration stimulates net muscle protein synthesis in young men
    M Sheffield-Moore
    Department of Surgery, University of Texas Medical Branch, and Shriners Burn Hospital for Children, Galveston 77550, USA
    J Clin Endocrinol Metab 84:2705-11. 1999
    ..The mechanism for this stimulation may be related to an OX-induced increase in AR expression in skeletal muscle...
  8. ncbi Combined effects of hyperaminoacidemia and oxandrolone on skeletal muscle protein synthesis
    M Sheffield-Moore
    Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA
    Am J Physiol Endocrinol Metab 278:E273-9. 2000
    ..C+AA; P = 0.01) and 53% (BOx vs. Ox+AA; P < 0.01), respectively. We conclude that the normal anabolic effects of acute hyperaminoacidemia are maintained in skeletal muscle undergoing oxandrolone-induced anabolism...
  9. ncbi Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids
    Douglas Paddon-Jones
    Department of Surgery, University of Texas Medical Branch and Metabolism Unit, Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 284:E946-53. 2003
    ..180 min) in the C + AA group. Thus, although differences in protein metabolism were evident, EAA ingestion improved muscle protein anabolism during acute hypercortisolemia and may help minimize muscle loss following debilitating injury...
  10. ncbi Testosterone administration in severe burns ameliorates muscle catabolism
    A A Ferrando
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 29:1936-42. 2001
    ..0001). Amino acid supplementation at either time point provided no additional effects. CONCLUSIONS: Restoration of blood testosterone can ameliorate the muscle catabolism of severe burn injury with normal feedings...
  11. pmc Anabolic effects of oxandrolone after severe burn
    D W Hart
    Department of Surgery, The University of Texas Medical Branch and The Shriners Hospitals for Children, Galveston, Texas, USA
    Ann Surg 233:556-64. 2001
    ..These findings suggest the efficacy of oxandrolone in impeding muscle protein catabolism in cachectic, critically injured children...
  12. ncbi Inactivity amplifies the catabolic response of skeletal muscle to cortisol
    A A Ferrando
    Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA
    J Clin Endocrinol Metab 84:3515-21. 1999
    ..05). Thus, inactivity sensitizes skeletal muscle to the catabolic effects of hypercortisolemia. Furthermore, these effects on healthy volunteers are analogous to those seen after severe injury...
  13. pmc Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity
    T B Symons
    The Univ of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol 107:34-8. 2009
    ....
  14. ncbi The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn
    S J Thomas
    Department of Surgery, University of Texas Medical Branch, and the Shriners Burns Hospital, Galveston 77550, USA
    Surgery 132:341-7. 2002
    ..Our aim was to determine the effect of euglycemic hyperinsulinemia over the entire hospitalization on muscle anabolism by investigating lean body mass (LBM) as the primary endpoint...
  15. ncbi Anabolic hormones in critically ill patients
    A A Ferrando
    Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA
    Curr Opin Clin Nutr Metab Care 2:171-5. 1999
    ..Emerging technologies and conservative administration regimens hold promise for the development of the clinical ability to restore anabolic influence, while minimizing undesirable side effects...
  16. ncbi Immune responses and latent herpesvirus reactivation in spaceflight
    R P Stowe
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0609, USA
    Aviat Space Environ Med 72:884-91. 2001
    ..In addition, adrenocortical and immune responses of an elderly astronaut (payload specialist-2, PS2; age 77) who flew on this mission were compared with that of younger crewmembers...
  17. ncbi Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4: protein in muscle from patients with acanthosis nigricans and severe insulin resistance
    C A Stuart
    Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA
    Metabolism 50:771-7. 2001
    ..These data suggest that glucose transporter gene expression and their basal distribution in human muscle are related to insulin resistance and could be determinants of whole body insulin responsiveness...
  18. doi Improving muscle mass: response of muscle metabolism to exercise, nutrition and anabolic agents
    Kevin D Tipton
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Essays Biochem 44:85-98. 2008
    ..Results from acute metabolic studies provide useful information for estimation of the efficacy of anabolic agents...
  19. pmc Effect of amino acid supplementation on muscle mass, strength and physical function in elderly
    Elisabet Børsheim
    Department of Surgery, University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Clin Nutr 27:189-95. 2008
    ..The aim of this study was to determine if regular intake of a nutritional supplement containing essential amino acids (EAA)+arginine could reverse these responses in elderly subjects...
  20. ncbi Restoration of hormonal action and muscle protein
    Arny A Ferrando
    Center for Translational Research on Aging and Longevity, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Crit Care Med 35:S630-4. 2007
    ..To restore hormonal influence, clinicians should consider reestablishing anabolic stimuli and reducing catabolic stimuli...
  21. ncbi Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia
    Peter N Uchakin
    Department of Internal Medicine, Mercer University School of Medicine, 1550 College Street, Macon, GA, USA
    Aviat Space Environ Med 78:608-12. 2007
    ..Hypokinesia is associated with spaceflight and prolonged illnesses and may lead to secondary immune deficiency...
  22. ncbi Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 91:4836-41. 2006
    ..We recently demonstrated that 28-d bed rest in healthy volunteers results in a moderate loss of lean leg mass and strength...
  23. ncbi Aerobic exercise training increases skeletal muscle protein turnover in healthy adults at rest
    Matthew A Pikosky
    Department Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    J Nutr 136:379-83. 2006
    ..072 +/- 0.012%/h, P < 0.05); FBR tended to increase (0.105+/- 0.014 vs. 0.143+/- 0.018%/h; P=0.06) after training. Findings show that aerobic training for 4 wk increases skeletal muscle protein turnover in previously unfit subjects...
  24. ncbi Amino acid supplementation for reversing bed rest and steroid myopathies
    Douglas Paddon-Jones
    Department of Surgery, University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, TX, USA
    J Nutr 135:1809S-1812S. 2005
    ..It may be necessary to concomitantly reduce the catabolic influence of cortisol or provide another anabolic stimulus...
  25. ncbi The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementation
    Douglas Paddon-Jones
    Metabolism Unit, 815 Market Street, Galveston, Texas
    J Clin Endocrinol Metab 90:1453-9. 2005
    ..04%.h(-1)) and post-BR (EXP, 0.111 +/- 0.015, and CON, 0.05 +/- 0.002%.h(-1)). Unlike a typical clinical meal, AA/CHO supplementation stimulated net muscle protein synthesis despite acute hypercortisolemia and prolonged inactivity...
  26. ncbi Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 288:E761-7. 2005
    ..2 +/- 8.5 nmol x min(-1) x 100 ml leg volume(-1). These data indicate that CAA supplementation produces a greater anabolic effect than ingestion of intact protein but does not interfere with the normal metabolic response to a meal...
  27. ncbi Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    Douglas Paddon-Jones
    Metabolism Unit, 815 Market Street, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 89:4351-8. 2004
    ..8 +/- 1.4 kg; CON, -17.8 +/- 4.4 kg). Essential amino acid and carbohydrate supplementation may represent a viable intervention for individuals at risk of sarcopenia due to immobility or prolonged bedrest...
  28. ncbi Amino acid ingestion improves muscle protein synthesis in the young and elderly
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 286:E321-8. 2004
    ..Despite differences in the time course of plasma phenylalanine kinetics and a greater residual IC phenylalanine concentration, amino acid supplementation acutely stimulated muscle protein synthesis in both young and elderly individuals...
  29. pmc Gene expression patterns in skeletal muscle of thermally injured children treated with oxandrolone
    Robert E Barrow
    Shriners Hospitals for Children, Department of Surgery, The University of Texas Medical Branch, Galveston 77550, USA
    Ann Surg 237:422-8. 2003
    ..To analyze gene expression patterns in skeletal muscle from burned children...
  30. pmc Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burned
    Steven E Wolf
    Department of Surgery, Shriners Burns Hospital, University of Texas Medical Branch, 815 Market, Galveston, TX 77550, USA
    Ann Surg 237:801-10; discussion 810-1. 2003
    ..To determine the effects of the anabolic agent oxandrolone on muscle protein and gene expression in severely burned children...
  31. ncbi Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Am J Physiol Endocrinol Metab 291:E1067-73. 2006
    ..Immunofluorescent studies demonstrated that GLUT4 and GLUT12 were predominantly expressed in type I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers...