J D Fernstrom

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Effects of dietary polyunsaturated fatty acids on neuronal function
    J D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Lipids 34:161-9. 1999
  2. ncbi request reprint Nutritional aspects of glutamate
    John D Fernstrom
    UPMC Health System Weight Management Center, University of Pittsburgh School of Medicine, PA 15213, USA
    Forum Nutr 56:80-1. 2003
  3. doi request reprint Meal ingestion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates
    SuJean Choi
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA 15213, United States
    Physiol Behav 98:156-62. 2009
  4. ncbi request reprint Monoamines and protein intake: are control mechanisms designed to monitor a threshold intake or a set point?
    J D Fernstrom
    Department of Psychiatry, UPMC Health System Weight Management Center, University of Pittsburgh School of Medicine, UPMC Western Psychiatric Institute and Clinic, PA 15213, USA
    Nutr Rev 59:S60-5; discussion S66-8. 2001
  5. ncbi request reprint The development of tolerance to drugs that suppress food intake
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Pharmacol Ther 117:105-22. 2008
  6. ncbi request reprint Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Nutr 137:1539S-1547S; discussion 1548S. 2007
  7. ncbi request reprint The 5th workshop on the assessment of adequate intake of dietary amino acids: general discussion 1
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
    J Nutr 136:1711S-1715S. 2006
  8. ncbi request reprint Long-term changes in blood pressure in extremely obese patients who have undergone bariatric surgery
    John D Fernstrom
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Surg 141:276-83. 2006
  9. ncbi request reprint Exercise, serum free tryptophan, and central fatigue
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA 15213, USA
    J Nutr 136:553S-559S. 2006
  10. ncbi request reprint Introduction to symposium on branched-chain amino acids in exercise
    John D Fernstrom
    University of Pittsburgh School of Medicine, and Metabolism Unit, Shriners Burns Hospital, Galveston, TX
    J Nutr 136:524S. 2006

Research Grants

Detail Information

Publications24

  1. ncbi request reprint Effects of dietary polyunsaturated fatty acids on neuronal function
    J D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Lipids 34:161-9. 1999
    ....
  2. ncbi request reprint Nutritional aspects of glutamate
    John D Fernstrom
    UPMC Health System Weight Management Center, University of Pittsburgh School of Medicine, PA 15213, USA
    Forum Nutr 56:80-1. 2003
  3. doi request reprint Meal ingestion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates
    SuJean Choi
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA 15213, United States
    Physiol Behav 98:156-62. 2009
    ..Conceivably, this relationship might inform the brain about the nutritional quality of the protein ingested...
  4. ncbi request reprint Monoamines and protein intake: are control mechanisms designed to monitor a threshold intake or a set point?
    J D Fernstrom
    Department of Psychiatry, UPMC Health System Weight Management Center, University of Pittsburgh School of Medicine, UPMC Western Psychiatric Institute and Clinic, PA 15213, USA
    Nutr Rev 59:S60-5; discussion S66-8. 2001
    ....
  5. ncbi request reprint The development of tolerance to drugs that suppress food intake
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Pharmacol Ther 117:105-22. 2008
    ..If appetite suppressants are to become a more important tool in obesity treatment, agents that do not lose efficacy when administered for extended periods of time must be identified...
  6. ncbi request reprint Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Nutr 137:1539S-1547S; discussion 1548S. 2007
    ..An attractive candidate is the passive monitoring of protein intake to influence protein-seeking behavior...
  7. ncbi request reprint The 5th workshop on the assessment of adequate intake of dietary amino acids: general discussion 1
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
    J Nutr 136:1711S-1715S. 2006
  8. ncbi request reprint Long-term changes in blood pressure in extremely obese patients who have undergone bariatric surgery
    John D Fernstrom
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Surg 141:276-83. 2006
    ..Systolic and diastolic pressure and the incidence of hypertension in very obese patients decline after bariatric surgery and do not rebound...
  9. ncbi request reprint Exercise, serum free tryptophan, and central fatigue
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA 15213, USA
    J Nutr 136:553S-559S. 2006
    ..g., respiration), the current understanding of 5HT neuronal function in central fatigue might benefit from the study of specific 5HT pathways during exercise...
  10. ncbi request reprint Introduction to symposium on branched-chain amino acids in exercise
    John D Fernstrom
    University of Pittsburgh School of Medicine, and Metabolism Unit, Shriners Burns Hospital, Galveston, TX
    J Nutr 136:524S. 2006
  11. ncbi request reprint Branched-chain amino acids and brain function
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Nutr 135:1539S-46S. 2005
    ....
  12. ncbi request reprint Application of branched-chain amino acids in human pathological states: discussion of session 4
    John D Fernstrom
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Nutr 136:331S-2S. 2006
  13. ncbi request reprint Intermittent, chronic fenfluramine administration to rats repeatedly suppresses food intake despite substantial brain serotonin reductions
    SuJean Choi
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Res 928:30-9. 2002
    ..Several possible interpretations of these findings are considered, based on the multiple mechanisms through which this drug has been proposed to modify synaptic serotonin transmission...
  14. ncbi request reprint Can nutrient supplements modify brain function?
    J D Fernstrom
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 71:1669S-75S. 2000
    ....
  15. doi request reprint Cerebrospinal fluid concentrations of large neutral and basic amino acids in Macaca mulatta: diurnal variations and responses to chronic changes in dietary protein intake
    Michael A Grimes
    Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Metabolism 58:129-40. 2009
    ..Based on observations in rats, the variations in the CSF concentrations of the LNAAs in monkeys may be large enough to influence metabolic and signaling pathways in brain to which they have been linked...
  16. doi request reprint Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children
    Kumaravel Rajakumar
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:90-5. 2008
    ..Serum 25-hydroxyvitamin D (25(OH)D) is low in obese adults...
  17. ncbi request reprint Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression
    SuJean Choi
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Brain Res 1087:83-6. 2006
    ..No changes occurred in POMC mRNA. Thus, only the NPY mRNA response to dl-FEN correlated with changes in food intake over time in a manner consistent with the known effects of NPY on food intake...
  18. ncbi request reprint 5,7-Dihydroxytryptamine: regional brain concentrations following intraventricular administration to rats
    S J Choi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Neurochem Res 26:1145-9. 2001
    ..At 24 hours, hypothalamus and brainstem 5HT levels had declined >70% and cerebral cortex approximately 50% below control values. The relevance of these findings to the protective action of monoamine reuptake blockers is discussed...
  19. ncbi request reprint Diet, monoamine neurotransmitters and appetite control
    J D Fernstrom
    UPMC Health System Weight Management Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 5:117-31; discussion 131-3. 2001
    ....
  20. ncbi request reprint Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass
    Penelope S Coates
    Osteoporosis Prevention and Treatment Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 89:1061-5. 2004
    ..In summary, within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term...
  21. ncbi request reprint Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats
    SuJean Choi
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA 15213, United States
    Life Sci 81:1024-30. 2007
    ..The rat thus appears to be an inadequate model of weight gain produced by some antipsychotics in humans...
  22. ncbi request reprint Serotonin reuptake inhibitors do not prevent 5,7-dihydroxytryptamine-induced depletion of serotonin in rat brain
    SuJean Choi
    Department of Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Res 1007:19-28. 2004
    ....
  23. ncbi request reprint Twenty-four-hour plasma tryptophan concentrations and ratios are below normal in obese subjects and are not normalized by substantial weight reduction
    Leif Breum
    Department of Internal Medicine and Endocrinology, HS Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Am J Clin Nutr 77:1112-8. 2003
    ..Plasma tryptophan concentrations and ratios have been measured only at single time points in obese subjects; it is not known whether low values for these 2 variables persist throughout a 24-h period...
  24. ncbi request reprint Biochemical responses of healthy subjects during dietary supplementation with L-arginine
    Rhobert W Evans
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Nutr Biochem 15:534-9. 2004
    ..However, subjects varied widely in their responses, indicating that L-arginine supplementation needs to be tailored to individuals...

Research Grants13

  1. DIET, AROMATIC AMINO ACIDS, AND CNS NEUROTRANSMITTERS
    John Fernstrom; Fiscal Year: 2001
    ..Our data will also add important new information on the relative roles of TYR and PHE as substrates in CAM synthesis, and the impact of diet on CAM synthesis, acting via changes it produces in the neuronal pools of each substrate. ..
  2. DIET, AROMATIC AMINO ACIDS, AND CNS NEUROTRANSMITTERS
    John Fernstrom; Fiscal Year: 1993
    ..Our data will also add important new information on the relative roles of TYR and PHE as substrates in CAM synthesis, and the impact of diet on CAM synthesis, acting via changes it produces in the neuronal pools of each substrate...
  3. DIET, AROMATIC AMINO ACIDS, AND CNS NEUROTRANSMITTERS
    John Fernstrom; Fiscal Year: 1991
    ....
  4. DIET, AROMATIC AMINO ACIDS, AND CNS NEUROTRANSMITTERS
    John Fernstrom; Fiscal Year: 1999
    ..abstract_text> ..
  5. Modeling Antipsychotic-Induced Weight Gain in Rats
    John Fernstrom; Fiscal Year: 2005
    ..abstract_text> ..