M L Fernandez

Summary

Affiliation: University of Connecticut
Country: USA

Publications

  1. doi request reprint Habitual consumption of eggs does not alter the beneficial effects of endurance training on plasma lipids and lipoprotein metabolism in untrained men and women
    Lisa M Vislocky
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 20:26-34. 2009
  2. doi request reprint Rethinking dietary cholesterol
    Maria L Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Curr Opin Clin Nutr Metab Care 15:117-21. 2012
  3. pmc Effects of resistance training on the inflammatory response
    Mariana C Calle
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Ext, Storrs, CT 06269, USA
    Nutr Res Pract 4:259-69. 2010
  4. pmc Low HDL cholesterol is associated with increased atherogenic lipoproteins and insulin resistance in women classified with metabolic syndrome
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Ext, Storrs, CT 06269, USA
    Nutr Res Pract 4:492-8. 2010
  5. pmc Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet
    Jung Eun Kim
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd ext, Storrs, CT 06269, USA
    Nutr Res Pract 6:113-9. 2012
  6. pmc Effects of a carbohydrate-restricted diet on emerging plasma markers for cardiovascular disease
    Richard J Wood
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    Nutr Metab (Lond) 3:19. 2006
  7. doi request reprint Dietary approaches to improving atheroprotective HDL functions
    Catherine J Andersen
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Ext, Unit 4017, Storrs, CT 06269 4017, USA
    Food Funct 4:1304-13. 2013
  8. doi request reprint Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome
    Christopher N Blesso
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Food Funct 4:213-21. 2013
  9. pmc Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome
    Jacqueline Barona
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Nutrients 4:1945-57. 2012
  10. pmc Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
    Richard L Seip
    Genomas, Inc, 67 Jefferson St, Hartford, Connecticut, USA
    Nutr Metab (Lond) 5:4. 2008

Collaborators

Detail Information

Publications87

  1. doi request reprint Habitual consumption of eggs does not alter the beneficial effects of endurance training on plasma lipids and lipoprotein metabolism in untrained men and women
    Lisa M Vislocky
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 20:26-34. 2009
    ..These data demonstrate that endurance training improved the plasma lipid profiles of previously unfit, normolipidemic subjects independent of dietary cholesterol intake from eggs...
  2. doi request reprint Rethinking dietary cholesterol
    Maria L Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Curr Opin Clin Nutr Metab Care 15:117-21. 2012
    ..This study will review the recent evidence that challenges the current dietary restrictions regarding cholesterol while it presents some beneficial effects of eggs (an icon for dietary cholesterol) in healthy individuals...
  3. pmc Effects of resistance training on the inflammatory response
    Mariana C Calle
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Ext, Storrs, CT 06269, USA
    Nutr Res Pract 4:259-69. 2010
    ..Assuring adherence to the RT program is essential to get the benefits after overcoming the first acute RT responses. Hence RT could be an effective way to prevent, and delay low grade systemic inflammatory related diseases...
  4. pmc Low HDL cholesterol is associated with increased atherogenic lipoproteins and insulin resistance in women classified with metabolic syndrome
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Ext, Storrs, CT 06269, USA
    Nutr Res Pract 4:492-8. 2010
    ..327, P < 0.01). We concluded that L-HDL could be used as a marker for increased numbers of circulating atherogenic lipoproteins as well as increased insulin resistance in women who are already at risk for CVD...
  5. pmc Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet
    Jung Eun Kim
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd ext, Storrs, CT 06269, USA
    Nutr Res Pract 6:113-9. 2012
    ..Furthermore, results also suggest that lutein accumulates in the eyes of guinea pigs to protect against oxidative stress...
  6. pmc Effects of a carbohydrate-restricted diet on emerging plasma markers for cardiovascular disease
    Richard J Wood
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    Nutr Metab (Lond) 3:19. 2006
    ....
  7. doi request reprint Dietary approaches to improving atheroprotective HDL functions
    Catherine J Andersen
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Ext, Unit 4017, Storrs, CT 06269 4017, USA
    Food Funct 4:1304-13. 2013
    ..This review will highlight the bioactive nutrients, functional foods, and dietary programs known to modulate HDL function as a means of reducing CVD. ..
  8. doi request reprint Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome
    Christopher N Blesso
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Food Funct 4:213-21. 2013
    ..Egg yolk may represent an important food source to improve plasma carotenoid status in a population at high risk for cardiovascular disease and type 2 diabetes...
  9. pmc Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome
    Jacqueline Barona
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Nutrients 4:1945-57. 2012
    ..642, p < 0.01), a key anti-oxidative enzyme. Grape consumption displayed anti-oxidative and increased anti-inflammatory markers in the absence of the inflammatory milieu associated with dyslipidemias...
  10. pmc Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
    Richard L Seip
    Genomas, Inc, 67 Jefferson St, Hartford, Connecticut, USA
    Nutr Metab (Lond) 5:4. 2008
    ..We used physiogenomics to explore associations among polymorphisms in candidate genes and changes in relative body fat (Delta%BF) to low fat and low carbohydrate diets...
  11. pmc Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines
    Michael J Puglisi
    Department of Nutritional Sciences University of Connecticut, Storrs, CT 06269, USA
    Lipids Health Dis 7:14. 2008
    ..The purpose of this study was to determine the effects of consuming raisins, increasing steps walked, or a combination of these interventions on blood pressure, plasma lipids, glucose, insulin and inflammatory cytokines...
  12. pmc Carbohydrate restriction and dietary cholesterol modulate the expression of HMG-CoA reductase and the LDL receptor in mononuclear cells from adult men
    Gisella Mutungi
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, 06269 USA
    Lipids Health Dis 6:34. 2007
    ..00 +/- 0.60 to 1.67 +/- 1.94 arbitrary units P < 0.05). The findings indicate that dietary cholesterol during a weight loss intervention alters the expression of genes regulating cholesterol homeostasis...
  13. pmc Validation of using gene expression in mononuclear cells as a marker for hepatic cholesterol metabolism
    Dimple Aggarwal
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Lipids Health Dis 5:22. 2006
    ..01) and the LDL receptor (r = 0.622, P < 0.01). These correlations suggest that monocytes can be used in humans as an index for liver to assess diet and drug effects on the expression of HMG-CoA reductase and the LDL receptor...
  14. pmc JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs
    Dimple Aggarwal
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    BMC Cardiovasc Disord 5:30. 2005
    ..The purpose of this study was to evaluate whether JTT-130, a unique MTPi, targeted to the intestine, would effectively reduce plasma lipids without inducing a fatty liver...
  15. pmc Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men
    Joseph C Ratliff
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    Nutr Metab (Lond) 5:6. 2008
    ..Here, as a follow up of our previous study, we examined the effects of eggs (a source of both dietary cholesterol and lutein) on adiponectin, a marker of insulin sensitivity, and on inflammatory markers in the context of a CRD...
  16. ncbi request reprint Mechanisms by which dietary fatty acids modulate plasma lipids
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 135:2075-8. 2005
    ..This article presents a summary of the major effects of various types of fatty acids on plasma lipid concentrations and the mechanisms involved...
  17. ncbi request reprint Dietary cholesterol provided by eggs and plasma lipoproteins in healthy populations
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Curr Opin Clin Nutr Metab Care 9:8-12. 2006
    ..The effects of egg intake on plasma lipids and low-density lipoprotein (LDL) atherogenicity in healthy populations need to be addressed...
  18. ncbi request reprint The metabolic syndrome
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Nutr Rev 65:S30-4. 2007
    ..This paper underlines the importance of weight loss and type of diet in reversing the symptoms of the metabolic syndrome...
  19. ncbi request reprint The LDL to HDL cholesterol ratio as a valuable tool to evaluate coronary heart disease risk
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Am Coll Nutr 27:1-5. 2008
    ..The following review provides evidence that the LDL-C/HDL-C ratio continues to be a valuable and standard tool to evaluate CVD risk in all populations...
  20. ncbi request reprint Acculturation and biomarkers for type 2 diabetes in Latinos
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 137:871-2. 2007
  21. ncbi request reprint Efficacy and safety of sitosterol in the management of blood cholesterol levels
    Maria Luz Fernandez
    University of Connecticut, Department of Nutritional Sciences, 3624 Horsebarn Road Ext, U 4017 Storrs, CT 06269, USA
    Cardiovasc Drug Rev 23:57-70. 2005
    ..Nevertheless, this plant sterol should be used with caution in certain individuals who have a higher absorption rate of sitosterol...
  22. doi request reprint Effects of eggs on plasma lipoproteins in healthy populations
    Maria Luz Fernandez
    Department of Nutritional Sciences, The University of Connecticut, 3624 Horsebarn Road Extension, Storrs, CT 06269, USA
    Food Funct 1:156-60. 2010
    ....
  23. ncbi request reprint Guinea pigs as models for cholesterol and lipoprotein metabolism
    M L Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269 4017, USA
    J Nutr 131:10-20. 2001
    ..A review of guinea pigs as models for early atherosclerosis development is also presented...
  24. ncbi request reprint Soluble fiber and nondigestible carbohydrate effects on plasma lipids and cardiovascular risk
    M L Fernandez
    Department of Nutritional Sciences, The University of Connecticut, Storrs, Connecticut 06269, USA
    Curr Opin Lipidol 12:35-40. 2001
    ....
  25. ncbi request reprint Beneficial effects of weight loss on plasma apolipoproteins in postmenopausal women
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Ext, Storrs, CT 06268, USA
    J Nutr Biochem 15:717-21. 2004
    ..436) and apo E (r=0.354) over 6 months. These results suggest that weight loss may have multifactorial effects on lipoprotein metabolism, resulting in better plasma lipid and apoprotein profiles...
  26. doi request reprint Revisiting dietary cholesterol recommendations: does the evidence support a limit of 300 mg/d?
    Maria Luz Fernandez
    Department of Nutritional Sciences, The University of Connecticut, Storrs, CT 06269, USA
    Curr Atheroscler Rep 12:377-83. 2010
    ..This article presents recent evidence from human studies documenting the lack of effect of DC on CHD risk, suggesting that guidelines for DC should be revisited...
  27. ncbi request reprint 1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane methanesulfonate (SC-435), an ileal apical sodium-codependent bile acid transporter inhibitor alte
    Kristy L West
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    J Pharmacol Exp Ther 303:293-9. 2002
    ..These results suggest that the reduction in total and LDL-cholesterol concentrations by the ASBT inhibitor is a result of alterations in hepatic cholesterol metabolism due to modifications in the enterohepatic circulation of bile acids...
  28. ncbi request reprint Weight loss favorably modifies anthropometrics and reverses the metabolic syndrome in premenopausal women
    Ingrid E Lofgren
    University of Connecticut, Department of Nutritional Sciences 3624 Horsebarn Road Extension, U 4017, Storrs, CT 06269, USA
    J Am Coll Nutr 24:486-93. 2005
    ....
  29. ncbi request reprint Cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase activities in hispanic and anglo postmenopausal women: associations with total and regional body fat
    Kathryn A Greaves
    Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA
    Metabolism 52:282-9. 2003
    ..In conclusion, results suggest a greater risk for coronary heart disease in Hispanic women compared to Anglo women...
  30. ncbi request reprint SC-435, an ileal apical sodium-codependent bile acid transporter inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in guinea pigs
    Kristy Lynn West
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 16:722-8. 2005
    ..These results suggest that both SC-435 monotherapy and combination therapy lower LDL cholesterol concentrations by altering both hepatic cholesterol homeostasis and the intravascular processing of lipoproteins in guinea pigs...
  31. doi request reprint Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate-restricted diet
    Gisella Mutungi
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 21:261-7. 2010
    ..These results indicate that CR favorably alters VLDL metabolism and apolipoprotein concentrations, while the components of the egg yolk favor the formation of larger LDL and HDL leading to an increase in plasma lutein and zeaxanthin...
  32. ncbi request reprint Sex and hormonal status influence the effects of psyllium on lipoprotein remodeling and composition
    Sonia Vega-Lopez
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Metabolism 51:500-7. 2002
    ..05). These results indicate an important role of sex and hormonal status in determining the effects of PSY on lipoprotein metabolism...
  33. ncbi request reprint Change in plasma lutein after egg consumption is positively associated with plasma cholesterol and lipoprotein size but negatively correlated with body size in postmenopausal women
    David Waters
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 137:959-63. 2007
    ..Lipoprotein size, but not number, also affects plasma response to dietary lutein...
  34. doi request reprint Carbohydrate restriction (with or without additional dietary cholesterol provided by eggs) reduces insulin resistance and plasma leptin without modifying appetite hormones in adult men
    Joseph Ratliff
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Nutr Res 29:262-8. 2009
    ..001) after the intervention. These results indicate that inclusion of eggs in the diet (additional dietary cholesterol) did not modify the multiple beneficial effects of CRD on insulin resistance and appetite hormones...
  35. ncbi request reprint Carbohydrate intake is correlated with biomarkers for coronary heart disease in a population of overweight premenopausal women
    Ingrid E Lofgren
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 16:245-50. 2005
    ..01) and a larger LDL diameter (P < .05) than the > or =53% group. These results suggest that the lower LDL-C in the LC group may be related to both the amount of carbohydrate and the type of fatty acids consumed by these subjects...
  36. ncbi request reprint High intake of cholesterol results in less atherogenic low-density lipoprotein particles in men and women independent of response classification
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    Metabolism 53:823-30. 2004
    ....
  37. doi request reprint Low-carbohydrate diet disrupts the association between insulin resistance and weight gain
    Jose O Leite
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Metabolism 58:1116-22. 2009
    ..The association between weight gain and insulin resistance seems to be dependent on high carbohydrate intake...
  38. ncbi request reprint Soluble fiber and soybean protein reduce atherosclerotic lesions in guinea pigs. Sex and hormonal status determine lesion extension
    E Cos
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    Lipids 36:1209-16. 2001
    ..These data indicate that dietary factors and sex/hormonal status play a role in determining plasma lipids and atherosclerosis in guinea pigs...
  39. ncbi request reprint Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
    Tosca L Zern
    Department of Nutritional Sciences, University of Connecticut, Storrs, 06269, USA
    J Nutr 135:1911-7. 2005
    ..Through alterations in lipoprotein metabolism, oxidative stress, and inflammatory markers, LGP intake beneficially affected key risk factors for coronary heart disease in both pre- and postmenopausal women...
  40. ncbi request reprint The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL receptor and lipoprotein lipase
    Madhu Patalay
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 135:735-9. 2005
    ..The results suggest that the increased expression of the LDL-R and LPL after the intervention might have contributed to the lower plasma LDL-C and TG observed in these women...
  41. ncbi request reprint Gender and hormonal status affect the regulation of hepatic cholesterol 7alpha-hydroxylase activity and mRNA abundance by dietary soluble fiber in the guinea pig
    Suheeta Roy
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Extension, U 17, Storrs, CT 06269, USA
    Atherosclerosis 163:29-37. 2002
    ..Gender and hormonal status influence metabolic responses to dietary SF with estrogen deprivation leading to the most detrimental lipid profile...
  42. ncbi request reprint A combination of psyllium and plant sterols alters lipoprotein metabolism in hypercholesterolemic subjects by modifying the intravascular processing of lipoproteins and increasing LDL uptake
    Sudeep Shrestha
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 137:1165-70. 2007
    ..03). These results indicate that the hypocholesterolemic action of PSY and PS can be explained in part by modifications in the intravascular processing of lipoproteins and by increases in LDL receptor-mediated uptake...
  43. ncbi request reprint Maintenance of the LDL cholesterol:HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge
    Christine M Greene
    Departments of Nutritional Science, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 135:2793-8. 2005
    ..We conclude from this study that dietary cholesterol provided by eggs does not increase the risk for heart disease in a healthy elderly population...
  44. ncbi request reprint Weight loss associated with reduced intake of carbohydrate reduces the atherogenicity of LDL in premenopausal women
    Ingrid Lofgren
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Metabolism 54:1133-41. 2005
    ..This study suggests that moderate weight loss (<5% of body weight) associated with reduced caloric intake, lower dietary carbohydrate, and increased physical activity impacts the atherogenicity of LDL...
  45. doi request reprint Low-carbohydrate diets reduce lipid accumulation and arterial inflammation in guinea pigs fed a high-cholesterol diet
    Jose O Leite
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Atherosclerosis 209:442-8. 2010
    ..Low-carbohydrate diets (LCD) efficiently induce weight loss and favorably affect plasma lipids, however, the effect of LCD on atherosclerosis is still argued...
  46. ncbi request reprint Sex and hormonal status influence plasma lipid responses to psyllium
    S Vega-Lopez
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    Am J Clin Nutr 74:435-41. 2001
    ..The primary mechanisms by which soluble fiber lowers plasma cholesterol are well known. However, specific effects of fiber on lipoprotein metabolism and how sex and hormonal status influence these effects are not well defined...
  47. doi request reprint Carbohydrate restriction and dietary cholesterol distinctly affect plasma lipids and lipoprotein subfractions in adult guinea pigs
    Moises Torres-Gonzalez
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 19:856-63. 2008
    ..The results also indicate that the atherogenicity of lipoproteins induced by high dietary cholesterol is attenuated by carbohydrate restriction in guinea pigs...
  48. doi request reprint Raisins and walking alter appetite hormones and plasma lipids by modifications in lipoprotein metabolism and up-regulation of the low-density lipoprotein receptor
    Michael J Puglisi
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Metabolism 58:120-8. 2009
    ..These data suggest that walking and raisin consumption decrease plasma LDL cholesterol by up-regulating the LDL receptor and that raisin consumption may reduce hunger and affect dietary intake by altering hormones influencing satiety...
  49. doi request reprint Carbohydrate restriction, as a first-line dietary intervention, effectively reduces biomarkers of metabolic syndrome in Emirati adults
    Taif Al-Sarraj
    Department of Nutritional Sciences and 4Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 139:1667-76. 2009
    ..05) group than in the CRD + AHA group. Results from this study suggest that a 6-wk CRD can effectively be used as a first-line diet therapy to rapidly improve features of MetS and cardiovascular risk in adult Emirati...
  50. ncbi request reprint Carbohydrate restriction alters hepatic cholesterol metabolism in guinea pigs fed a hypercholesterolemic diet
    Moises Torres-Gonzalez
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 137:2219-23. 2007
    ..Carbohydrate restriction in the presence of high cholesterol is associated with lower hepatic ACAT activity and an attenuation of hepatic cholesterol accumulation...
  51. ncbi request reprint Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein cholesterol and other clinical markers of cardiovascular risk
    Richard J Wood
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269 4017, USA
    Metabolism 56:58-67. 2007
    ..Furthermore, a CRD led to clinically important positive alterations in cardiovascular disease risk factors...
  52. doi request reprint Consuming eggs for breakfast influences plasma glucose and ghrelin, while reducing energy intake during the next 24 hours in adult men
    Joseph Ratliff
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Nutr Res 30:96-103. 2010
    ..05). These findings suggest that consumption of eggs for breakfast results in less variation of plasma glucose and insulin, a suppressed ghrelin response, and reduced energy intake...
  53. ncbi request reprint Are the current dietary guidelines regarding egg consumption appropriate?
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 134:187-90. 2004
  54. ncbi request reprint Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Atherosclerosis 184:113-20. 2006
    ..The presence of individual alleles in this population was associated with differences in plasma lipids and LDL size. However, these relationships were independent of dietary cholesterol...
  55. doi request reprint Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati subjects classified with the metabolic syndrome
    T Al-Sarraj
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Nutr Metab Cardiovasc Dis 20:720-6. 2010
    ..Carbohydrate restriction (CR) has been shown to improve dyslipidemias associated with metabolic syndrome (MetS). We evaluated the effects of CR on lipoprotein subfractions and apolipoproteins in Emirati adults classified with the MetS...
  56. ncbi request reprint The role of nutrition in the prevention of coronary heart disease in women of the developed world
    Christine M Greene
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Hill Road, Storrs, CT 06269, USA
    Asia Pac J Clin Nutr 16:1-9. 2007
    ..This review attempts to highlight nutrition as a prescription that can be utilized to reduce the significant risk factors that women, who live in developed nations, face throughout their lifetime...
  57. ncbi request reprint SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs
    Kristy L West
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Atherosclerosis 171:201-10. 2003
    ....
  58. doi request reprint Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet
    Jeff S Volek
    Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Storrs, CT 06269 1110, USA
    Lipids 44:297-309. 2009
    ..The results support the use of dietary carbohydrate restriction as an effective approach to improve features of MetS and cardiovascular risk...
  59. ncbi request reprint Guinea pigs as models to study the hypocholesterolemic effects of drugs
    Kristy L West
    University of Connecticut, Department of Nutritional Sciences, 3624 Horsebarn Road Ext U 4017, Storrs, CT 06269, USA
    Cardiovasc Drug Rev 22:55-70. 2004
    ....
  60. ncbi request reprint Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women
    Ingrid Lofgren
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 134:1071-6. 2004
    ..01). These results suggest that WC is a stronger predictor of CHD risk than BMI and is more closely associated with the level of exercise in premenopausal women...
  61. ncbi request reprint Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs
    Tosca L Zern
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 133:2268-72. 2003
    ..These results suggest that grape intake in ovariectomized guinea pigs alters hepatic cholesterol metabolism, which may affect VLDL secretion rates and result in less accumulation of cholesterol in the aorta...
  62. ncbi request reprint Hypo- and hyperresponse to egg cholesterol predicts plasma lutein and beta-carotene concentrations in men and women
    Richard M Clark
    Department of Nutritional Sciences, University of Connecticut, Storrs, 06269 4017, USA
    J Nutr 136:601-7. 2006
    ..07 +/- 0.07 micromol/L). We conclude that plasma responses to cholesterol and carotenoids are related and that gender influences the beta-carotene response to a greater degree than the lutein response...
  63. ncbi request reprint Dietary carbohydrate and cholesterol influence the number of particles and distributions of lipoprotein subfractions in guinea pigs
    Moises Torres-Gonzalez
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 17:773-9. 2006
    ..These results indicate that dietary cholesterol increased the atherogenicity of both VLDL and HDL while CHO restriction increased the number of large LDL and decreased the concentrations of the more atherogenic smaller LDL subfractions...
  64. ncbi request reprint The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    J Nutr 136:1161-5. 2006
    ..These results, although obtained from a small number of subjects, suggest that the ABCG5 polymorphism may play a role in the plasma response to dietary cholesterol and carotenoids...
  65. ncbi request reprint Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs
    Dimple Aggarwal
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Metabolism 55:794-802. 2006
    ..Low RAPA was found to decrease cholesterol accumulation in tissue (liver and aorta) compared to high RAPA, suggesting that lower doses could be less detrimental to transplant patients...
  66. ncbi request reprint Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome
    Jeff S Volek
    Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110, Storrs, CT 06269 1110, United States
    Prog Lipid Res 47:307-18. 2008
    ....
  67. ncbi request reprint Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    J Nutr 133:1036-42. 2003
    ..These data suggest that additional dietary cholesterol does not increase the risk of developing an atherogenic lipoprotein profile in healthy men, regardless of their response classification...
  68. ncbi request reprint Pre-menopausal women, classified as hypo- or hyperresponders, do not alter their LDL/HDL ratio following a high dietary cholesterol challenge
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    J Am Coll Nutr 21:250-8. 2002
    ..Individual response variation can be due to factors such as ethnicity, hormonal status, obesity and genetic predisposition...
  69. ncbi request reprint Corn fiber oil lowers plasma cholesterol by altering hepatic cholesterol metabolism and up-regulating LDL receptors in guinea pigs
    Tripurasundari Ramjiganesh
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 132:335-40. 2002
    ..As a response to the depleted microsomal free cholesterol pool, the LDL receptor was up-regulated, drawing more cholesterol from plasma, thus leading to the observed decrease in plasma LDL cholesterol concentrations...
  70. ncbi request reprint Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation
    Cassandra E Forsythe
    Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110, Storrs, CT, 06269 1110, USA
    Lipids 43:65-77. 2008
    ..In summary, a very low carbohydrate diet resulted in profound alterations in fatty acid composition and reduced inflammation compared to a low fat diet...
  71. doi request reprint Effects of dietary carbohydrate restriction versus low-fat diet on flow-mediated dilation
    Jeff S Volek
    Department of Kinesiology and the Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269 1110, USA
    Metabolism 58:1769-77. 2009
    ..9% to 5.2% in the LFD group (P = .004). These findings show that a 12-week low-carbohydrate diet improves postprandial vascular function more than a LFD in individuals with atherogenic dyslipidemia...
  72. ncbi request reprint Carbohydrate restriction alters lipoprotein metabolism by modifying VLDL, LDL, and HDL subfraction distribution and size in overweight men
    Richard J Wood
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 136:384-9. 2006
    ..01). We conclude that weight loss induced by CR favorably alters the secretion and processing of plasma lipoproteins, rendering VLDL, LDL, and HDL particles associated with decreased risk for atherosclerosis and coronary heart disease...
  73. doi request reprint Maintenance of resting energy expenditure after weight loss in premenopausal women: potential benefits of a high-protein, reduced-calorie diet
    Stefan M Pasiakos
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Metabolism 57:458-64. 2008
    ....
  74. doi request reprint Modulation of C-reactive protein, tumor necrosis factor-alpha, and adiponectin by diet, exercise, and weight loss
    Michael J Puglisi
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 138:2293-6. 2008
    ..Although it is clear from the literature that these cytokines play a major role in the development of chronic disease, the best strategy to favorably alter the inflammatory response is still debatable...
  75. pmc A-002 (Varespladib), a phospholipase A2 inhibitor, reduces atherosclerosis in guinea pigs
    Jose O Leite
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    BMC Cardiovasc Disord 9:7. 2009
    ..Thus, A-002 (varespladib), an inhibitor of sPLA2enzymes, is proposed to modulate the development of atherosclerosis...
  76. ncbi request reprint Cardioprotective effects of dietary polyphenols
    Tosca L Zern
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 135:2291-4. 2005
    ....
  77. pmc Dietary green tea extract lowers plasma and hepatic triglycerides and decreases the expression of sterol regulatory element-binding protein-1c mRNA and its responsive genes in fructose-fed, ovariectomized rats
    Sudeep Shrestha
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 139:640-5. 2009
    ..The results suggest that the lipid-lowering effect of GT is mediated partly by its inhibition of hepatic lipogenesis involving SREBP-1c and its responsive genes without affecting lipoprotein assembly...
  78. ncbi request reprint Sex and hormonal status modulate the effects of psyllium on plasma lipids and monocyte gene expression in humans
    Sonia Vega-Lopez
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    J Nutr 133:67-70. 2003
    ..These results suggest that the LDL-C lowering induced by PSY was related to changes in HMG-CoA reductase gene expression in monocytes while the expression of LPL in this system was affected by sex and hormonal status...
  79. doi request reprint Inflammation and type 2 diabetes
    M C Calle
    Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road, ext U 4017, Storrs, CR 06269, USA
    Diabetes Metab 38:183-91. 2012
    ....
  80. doi request reprint Metabolic syndrome prevalence, dietary intake, and cardiovascular risk profile among overweight and obese adults 18-50 years old from the United Arab Emirates
    Taif Al-Sarraj
    Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Metab Syndr Relat Disord 8:39-46. 2010
    ..The prevalence of diabetes mellitus is among the highest worldwide, and metabolic syndrome predisposes to diabetes...
  81. ncbi request reprint Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted diet
    Gisella Mutungi
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 138:272-6. 2008
    ..These results suggest that including eggs in a CRD results in increased HDL-C while decreasing the risk factors associated with MetS...
  82. ncbi request reprint The seeds from Plantago ovata lower plasma lipids by altering hepatic and bile acid metabolism in guinea pigs
    Ana Lourdes Romero
    Department of Food Science, University of Sonora, Hermosillo, Sonora State, Mexico
    J Nutr 132:1194-8. 2002
    ..02). Fecal bile acids were 3 times higher in the PO groups than in the control group. These results suggest that PO exerts its hypolipidemic effect by affecting bile acid absorption and altering hepatic cholesterol metabolism...
  83. doi request reprint Replacing dietary carbohydrate with protein and fat decreases the concentrations of small LDL and the inflammatory response induced by atherogenic diets in the guinea pig
    Matthew J Sharman
    Centre of Excellence for Alzheimer s Disease Research and Care, Edith Cowan University, Joondalup WA 6027, Australia
    J Nutr Biochem 19:732-8. 2008
  84. ncbi request reprint Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population from northern Mexico
    Martha Nydia Ballesteros
    Centro de Investigacion y Desarrollo AC, Hermosillo, Sonora, Mexico
    Am J Clin Nutr 80:855-61. 2004
    ..An increased incidence of coronary artery disease (CAD) is prevalent in northern Mexico. Effects of specific dietary components on risk factors for CAD have not been evaluated in children...
  85. ncbi request reprint A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals
    Sudeep Shrestha
    LipoScience Inc, Raleigh, NC 27616
    J Nutr 136:2492-7. 2006
    ..In addition, the evaluation of lipoprotein subfractions resulting from the action of the fiber and plant sterols in the intestinal lumen provides an insight on the secondary mechanisms of plasma LDL-C lowering...
  86. ncbi request reprint High intake of saturated fat and early occurrence of specific biomarkers may explain the prevalence of chronic disease in northern Mexico
    Martha Nydia Ballesteros
    Centro de Investigacion de Alimentos y Desarrollo CIAD, Hermosillo, Mexico
    J Nutr 135:70-3. 2005
    ..A second component, related to the insulin resistance syndrome, may be principally genetic and associated with the high TG, low HDL, and LDL phenotype B observed in these Mexican children...