Research Topics
Genomes and Genes | Jose R FernandezSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
| Collaborators
|
Detail Information
Publications
Improving the power of sib pair quantitative trait loci detection by phenotype winsorizationJose R Fernandez
Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, 35294 3360, USA
Hum Hered 53:59-67. 2002..We evaluated the robustness and power of reducing the influence of subjects with extreme phenotypic values by Winsorizing non-normal distributions in three versions of Haseman-Elston regression-based methods of QTL linkage analysis...- Is percentage body fat differentially related to body mass index in Hispanic Americans, African Americans, and European Americans?Jose R Fernandez
Obesity Research Center, St Luke s Roosevelt Hospital and the Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
Am J Clin Nutr 77:71-5. 2003.... 
The role of European genetic admixture in the etiology of the insulin resistance syndrome in children: are the effects mediated by fat accumulation?Krista Casazza
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
J Pediatr 157:50-56.e1. 2010..To evaluate the contribution of European genetic admixture (EUADM) to insulin resistance syndrome (IRS) in a multiethnic sample of children age 7-12 years, and to explore whether body fat affects this relationship...- Age-related changes in insulin sensitivity and β-cell function among European-American and African-American womenPaula C Chandler-Laney
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 19:528-35. 2011..To conclude, inherent ethnic differences in β-cell function exist independently of adiposity and S(I). Future research should examine whether ethnic differences in β-cell physiology contribute to disparities in T2D risk... - Body fat and racial genetic admixture are associated with aerobic fitness levels in a multiethnic pediatric populationAmanda L Willig
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 19:2222-7. 2011..01). In conclusion, aerobic fitness levels differ by percent body fat and genetic admixture irrespective of BMI classification, and such differences should be taken into account when evaluating outcomes of health interventions... - Fat distribution, aerobic fitness, blood lipids, and insulin sensitivity in African-American and European-American womenGary R Hunter
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 18:274-81. 2010..17 to -0.21). Maintenance of favorable fat distribution and aerobic fitness may be important strategies for healthy aging, at least in premenopausal EA and AA women... - Apolipoprotein A-II polymorphism and visceral adiposity in African-American and white womenCristina Lara-Castro
Division of Physiology and Metabolism, Department of Nutrition Sciences, University of Alabama, Birmingham, AL 35294, USA
Obes Res 13:507-12. 2005..These results indicate a significant association between the T265C APOA-II polymorphism and levels of VAT in premenopausal women. This association is present in white but not African-American women... - Longitudinal analysis of the insulin-like growth factor system in African-American and European American children and adolescentsKrista Casazza
Department of Nutrition Sciences, 1675 University Boulevard, Room WEBB 415, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
J Clin Endocrinol Metab 93:4917-23. 2008..IGF-I and its binding proteins influence growth, development, and disease risk. Studies have revealed ethnic variations in the IGF system... - Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humansMaria De Luca
Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, 3rd Avenue South, Birmingham, AL 35294 3360, USA
BMC Genet 9:52. 2008..Based on our results from Drosophila, we performed a human population-based association study to investigate the effect of natural variation in LAMA5 gene on body composition in humans... - Differential influence of diet and physical activity on components of metabolic syndrome in a multiethnic sample of childrenKrista Casazza
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
J Am Diet Assoc 109:236-44. 2009..Treatment of the metabolic syndrome in adults is generally approached with diet and physical activity. The influence of diet and physical activity on cardiometabolic outcomes in children has not been clearly established... - Parental feeding practices and socioeconomic status are associated with child adiposity in a multi-ethnic sample of childrenMichelle Cardel
Department of Nutrition Sciences, Clinical Nutrition Research Center, University of Alabama at Birmingham, 1675 University Blvd, WEBB 415, Birmingham, AL 35294 3360, USA
Appetite 58:347-53. 2012..Thus, parental feeding practices differ across racial/ethnic groups and SES and may contribute to population differences in child adiposity... - Adiponectin multimers and metabolic syndrome traits: relative adiponectin resistance in African AmericansCristina Lara-Castro
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 16:2616-23. 2008..Thus, HMW adiponectin may exert less bioactivity in explaining the metabolic syndrome trait cluster in populations of predominant African genetic background... - Adiposity and β-cell function: relationships differ with ethnicity and agePaula C Chandler-Laney
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 18:2086-92. 2010..57, P < 0.05) and Phi(TOT) (r = -0.68, P < 0.01). These results suggest that the impact of adiposity on insulin secretion and action differs with age and ethnicity... - Beyond thriftiness: independent and interactive effects of genetic and dietary factors on variations in fat deposition and distribution across populationsKrista Casazza
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
Am J Phys Anthropol 145:181-91. 2011..Interactive effects of genetic and non-genetic factors alter metabolic pathways and underlie some of the present population-based differences in fat storage... - Fasting and postprandial markers of inflammation in lean and overweight childrenJessica A Alvarez
Department of Nutrition Sciences, General Clinical Research Center, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Am J Clin Nutr 89:1138-44. 2009..Overweight children have greater circulating concentrations of markers of inflammation (MOI) than do lean children. Whether adiposity influences the postprandial MOI response is unknown... - Entero-insular axis and postprandial insulin differences in African American and European American childrenPaul B Higgins
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Clin Nutr 88:1277-83. 2008..African Americans have a greater insulin response after glucose challenge than do European Americans. Factors underlying this response are unknown... - Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucoseAmanda L Willig
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
Metabolism 58:877-81. 2009..These results indicate that AIRg is associated with the -55C/T UCP2 homozygous mutation and that the presence of this mutation could alter postchallenge insulin concentration... - Adiposity and genetic admixture, but not race/ethnicity, influence bone mineral content in peripubertal childrenKrista Casazza
Department of Nutrition Sciences, Clinical Nutrition Research Center, University of Alabama at Birmingham, 1530 3rd Ave S, Birmingham, AL 35294 3360, USA
J Bone Miner Metab 28:424-32. 2010..Further, there is a differential impact of percent fat on BMC that may be mediated by genetic admixture... - Does fat fuel the fire: independent and interactive effects of genetic, physiological, and environmental factors on variations in fat deposition and distribution across populationsLynae J Hanks
Department of Nutrition Sciences, University ofAlabama at Birmingham, Birmingham, AL, USA
J Pediatr Endocrinol Metab 23:1233-44. 2010..Our results suggest a potential inhibitory role of inflammation on bone as well as a negative impact of adiposity. Future investigations are warranted to further investigate these relationships... - Association of African genetic admixture with resting metabolic rate and obesity among womenJose R Fernandez
Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Obes Res 11:904-11. 2003.... - Association of the intestinal fatty acid-binding protein Ala54Thr polymorphism and abdominal adipose tissue in African-American and Caucasian womenCristina Lara-Castro
Department of Nutrition Sciences, University of Alabama, Birmingham, Alabama 35294, USA
J Clin Endocrinol Metab 90:1196-201. 2005..We conclude that women carriers of the FABP2 Thr allele have lower TAT and SAAT than noncarriers of the mutation. This association is present in Caucasian, but not in African-American, women... - Understanding racial differences in obesity and metabolic syndrome traitsJose R Fernandez
Clinical Nutrition Research Center, Department of Biostatistics, Section on Statistical Genetics, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
Nutr Rev 61:316-9. 2003..The effect of genetic and environmental factors on these differences is not completely understood; however, insightful information can be obtained by taking into account the degree of ancestral admixture in populations... - Using genetic admixture to study the biology of obesity traits and to map genes in admixed populationsJose R Fernandez
Division of Physiology and Metabolism, Department and Nutrition Sciences, University of Alabama at Birmingham, 1530 3rd Ave S, Birmingham, AL 35294 3360, USA
Nutr Rev 62:S69-74. 2004.... - Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic womenJulian Munoz
Department of Nutrition Sciences, 1675 Webb Nutrition Sciences Building, Room 241, University of Alabama, Birmingham, AL 35294, USA
Diabetes 55:3630-4. 2006..Our data suggest that the TCF7L2 gene is an important factor regulating insulin secretion, which could explain its association with type 2 diabetes... - Using genetic admixture to explain racial differences in insulin-related phenotypesBarbara A Gower
Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
Diabetes 52:1047-51. 2003.... - Shorter sleep may be a risk factor for impaired bone mass accrual in childhoodKrista Casazza
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
J Clin Densitom 14:453-7. 2011..Longer sleep duration may allow for optimal energy resource partitioning in which bone is favored. Sleep duration of less than 8h may impair bone mass accrual, particularly during periods of rapid growth... 
The association between the rs2234693 and rs9340799 estrogen receptor alpha gene polymorphisms and risk factors for cardiovascular disease: a reviewKrista Casazza
Department of Nutrition, University of Alabama at Birmingham, AL, USA
Biol Res Nurs 12:84-97. 2010....- A conserved role for syndecan family members in the regulation of whole-body energy metabolismMaria De Luca
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 5:e11286. 2010..035) and intra-abdominal fat (P = 0.049), and SNP rs2267871 with insulin sensitivity (P = 0.037). Collectively, our results in Drosophila and humans argue that syndecan family members play a key role in the regulation of body metabolism... - Adjusting adiposity and body weight measurements for height alters the relationship with blood pressure in childrenAmanda L Willig
Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, USA
Am J Hypertens 23:904-10. 2010..However, this correlation can be confounded by the relationship of both variables to height. We evaluated whether adiposity and anthropometric measures were associated with pediatric BP before and after adjusting each value for height... - A simple significance test for quantile regressionDavid T Redden
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Stat Med 23:2587-97. 2004.... - Resistance training conserves fat-free mass and resting energy expenditure following weight lossGary R Hunter
Department of Human Studies, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 16:1045-51. 2008.... - Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regionsYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, 1665 University Blvd, RPHB 327, Birmingham, AL 35294, USA
Hum Genet 129:407-18. 2011..Our findings suggest that there is an evolutionary genetic basis for population differences in these traits, and we have identified potential group-specific genetic risk factors... - Disruptions in energy balance: does nature overcome nurture?Jose R Fernandez
Department of Nutrition Sciences and Clinical Nutrition Research Center, United States
Physiol Behav 94:105-12. 2008..It is evident that more research is needed to elucidate the methodological and statistical issues that underlie the interactions between genes and environments in obesity and its related comorbidities... - Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear modelDavid T Redden
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS Genet 2:e137. 2006.... - Obesity attenuates the contribution of African admixture to the insulin secretory profile in peripubertal children: a longitudinal analysisKrista Casazza
Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 17:1318-25. 2009..EA; however, the influence of genetic factors is superseded by adiposity. The pubertal transition may affect the development of the beta-cell response to glucose in a manner that differs with ethnic/genetic background... - Early ethnic difference in insulin-like growth factor-1 is associated with African genetic admixturePaul B Higgins
Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Pediatr Res 58:850-4. 2005..01 for both). Thus, our data suggest that the greater IGF-1 of AA relative to EA children could have a genetic basis... - Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing biasDavid B Allison
Department of Biostatistics and Center for Research on Clinical Nutrition, University of Alabama at Birmingham, 35294 0022, USA
Am J Hum Genet 70:575-85. 2002..Finally, limitations of the MOM approach are noted, and we discuss some alternative procedures that may also reduce bias... - Neighborhood-level disadvantage is associated with reduced dietary quality in childrenAkilah Dulin Keita
Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, AL, USA
J Am Diet Assoc 109:1612-6. 2009..Future interventions should assess mechanisms to improve the availability of healthful foods, while taking into account neighborhood-level conditions... - Relationships between reported macronutrient intake and insulin dynamics in a multi-ethnic cohort of early pubertal childrenKrista Casazza
Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
Int J Pediatr Obes 4:249-56. 2009..Additionally, girls tend to be more insulin resistant than boys. Although the mechanism driving these differences is unclear, diet may be a contributor... - C677T methylene-H4-folate-reductase variant decreases binocular accommodationCarlos L Krumdieck
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Optom Vis Sci 85:196-200. 2008..In this study we examined 100 apparently normal subjects of both sexes (average age 25.6 +/- 4.25) for the genotypic presence of the T allele and its association with accommodative amplitude (AA)... - Rimonabant Sanofi-SynthélaboJose R Fernandez
University of Alabama at Birmingham, Department of Nutrition Sciences, Ryals Public Health Building, 1665 University Blvd, Birmingham, AL 35294-0022, USA
Curr Opin Investig Drugs 5:430-5. 2004..Phase III trials were initiated for obesity in August 2001 and were ongoing in September 2003. By September 2002, the compound had entered phase III trials for smoking cessation, and these trials were ongoing in September 2003... - Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescentsJose R Fernandez
Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
J Pediatr 145:439-44. 2004..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles...