Pedro Fernandez-Funez

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms
    Pedro Fernandez-Funez
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    PLoS Genet 5:e1000507. 2009
  2. pmc Drosophila models of proteinopathies: the little fly that could
    Diego E Rincon-Limas
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0236, USA
    Curr Pharm Des 18:1108-22. 2012
  3. pmc Sequence-dependent prion protein misfolding and neurotoxicity
    Pedro Fernandez-Funez
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 285:36897-908. 2010
  4. pmc The ER stress factor XBP1s prevents amyloid-beta neurotoxicity
    Sergio Casas-Tinto
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Hum Mol Genet 20:2144-60. 2011
  5. pmc Exploring prion protein biology in flies: genetics and beyond
    Diego E Rincon-Limas
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Prion 4:1-8. 2010
  6. doi request reprint p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila
    Yan Zhang
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA
    Mol Biol Rep 40:5407-15. 2013
  7. pmc Differential activation of the ER stress factor XBP1 by oligomeric assemblies
    Diana L Castillo-Carranza
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Neurochem Res 37:1707-17. 2012
  8. pmc FoxK mediates TGF-beta signalling during midgut differentiation in flies
    Sergio Casas-Tinto
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Cell Biol 183:1049-60. 2008

Collaborators

Detail Information

Publications8

  1. pmc In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms
    Pedro Fernandez-Funez
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    PLoS Genet 5:e1000507. 2009
    ..Overall, we provide new insight into the mechanisms of spontaneous accumulation of neurotoxic PrP and uncover the potential therapeutic role of Hsp70 in treating these devastating disorders...
  2. pmc Drosophila models of proteinopathies: the little fly that could
    Diego E Rincon-Limas
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0236, USA
    Curr Pharm Des 18:1108-22. 2012
    ..To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications...
  3. pmc Sequence-dependent prion protein misfolding and neurotoxicity
    Pedro Fernandez-Funez
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 285:36897-908. 2010
    ..How these properties are encoded in the amino acid sequence remains to be elucidated...
  4. pmc The ER stress factor XBP1s prevents amyloid-beta neurotoxicity
    Sergio Casas-Tinto
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Hum Mol Genet 20:2144-60. 2011
    ..These results underscore the functional relevance of XBP1s in Aβ toxicity, and uncover the potential of XBP1 and RyR as targets for AD therapeutics...
  5. pmc Exploring prion protein biology in flies: genetics and beyond
    Diego E Rincon-Limas
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Prion 4:1-8. 2010
    ....
  6. doi request reprint p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila
    Yan Zhang
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA
    Mol Biol Rep 40:5407-15. 2013
    ..We found that the modified 0.9 kb ΔTub promoter induced similar expression levels to the intact 2.6 kb α1t promoter, supporting the inclusion of all critical regulatory elements in the new and flexible ∆TubHA4C vector. ..
  7. pmc Differential activation of the ER stress factor XBP1 by oligomeric assemblies
    Diana L Castillo-Carranza
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Neurochem Res 37:1707-17. 2012
    ..These results illustrate the biological complexity of these structurally related assemblies and argue that oligomer toxicity depends on the activation of amyloid-specific cellular responses...
  8. pmc FoxK mediates TGF-beta signalling during midgut differentiation in flies
    Sergio Casas-Tinto
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Cell Biol 183:1049-60. 2008
    ..Thus, we propose that the combined activity of the TGF-beta target genes FoxK and Dfos is critical for the direct activation of lab in the endoderm...