R J Fernandes

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Incorporation of structurally defective type II collagen into cartilage matrix in kniest chondrodysplasia
    R J Fernandes
    Department of Orthopaedics, University of Washington, Seattle, Washington, 98195, USA
    Arch Biochem Biophys 355:282-90. 1998
  2. ncbi Protein consequences of the Col2a1 C-propeptide mutation in the chondrodysplastic Dmm mouse
    Russell J Fernandes
    Orthopaedic Research Laboratories, Department of Orthopaedics and Sports Medicine, Box 356500, University of Washington, Seattle, WA 98195, USA
    Matrix Biol 22:449-53. 2003
  3. ncbi Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells
    Tomohiro Goto
    Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Bone Miner Res 21:661-73. 2006
  4. ncbi The heterozygous disproportionate micromelia (dmm) mouse: morphological changes in fetal cartilage precede postnatal dwarfism and compared with lethal homozygotes can explain the mild phenotype
    Robert E Seegmiller
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Histochem Cytochem 56:1003-11. 2008
  5. ncbi Incomplete processing of type II procollagen by a rat chondrosarcoma cell line
    R J Fernandes
    Department of Orthopaedics, University of Washington, Seattle 98195, USA
    Eur J Biochem 247:620-4. 1997
  6. ncbi Collagen XI chain misassembly in cartilage of the chondrodysplasia (cho) mouse
    Russell J Fernandes
    Departments of Orthopaedics and Sports Medicine, Orthopaedic Research Laboratory, University of Washington, Seattle, WA 98195, USA
    Matrix Biol 26:597-603. 2007
  7. ncbi The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells
    Russell J Fernandes
    Department of Orthopaedics and Sports Medicine, Box 356500, University of Washington, Seattle, WA 98195 6500, USA
    Bone 40:1343-51. 2007
  8. ncbi A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens
    Russell J Fernandes
    Orthopaedic Research Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98195 6500, USA
    J Biol Chem 286:30662-9. 2011
  9. ncbi Assembly of collagen types II, IX and XI into nascent hetero-fibrils by a rat chondrocyte cell line
    Russell J Fernandes
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle, WA 98195, USA
    Eur J Biochem 270:3243-50. 2003
  10. ncbi The elastin-like protein matrix of lamprey branchial cartilage is cross-linked by lysyl pyridinoline
    R J Fernandes
    Department of Orthopaedics, University of Washington, Seattle, Washington, 98195, USA
    Biochem Biophys Res Commun 261:635-40. 1999

Research Grants

  1. Collagen type II/IX/XI heteropolymer assembly
    RUSSELL FERNANDES; Fiscal Year: 2007
  2. Collagen Assembly in Tissue-Engineered Cartilage
    Russell J Fernandes; Fiscal Year: 2010

Collaborators

Detail Information

Publications16

  1. ncbi Incorporation of structurally defective type II collagen into cartilage matrix in kniest chondrodysplasia
    R J Fernandes
    Department of Orthopaedics, University of Washington, Seattle, Washington, 98195, USA
    Arch Biochem Biophys 355:282-90. 1998
    ..Short deletions (single or partial exon) clustered in one region of the alpha1(II) chain are favored, resulting in abnormal heterotrimeric molecules that become a significant component of the cartilage extracellular matrix...
  2. ncbi Protein consequences of the Col2a1 C-propeptide mutation in the chondrodysplastic Dmm mouse
    Russell J Fernandes
    Orthopaedic Research Laboratories, Department of Orthopaedics and Sports Medicine, Box 356500, University of Washington, Seattle, WA 98195, USA
    Matrix Biol 22:449-53. 2003
    ..The integrity of the C-propeptide is thus crucial for the biosynthesis of normal type II collagen by chondrocytes...
  3. ncbi Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells
    Tomohiro Goto
    Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Bone Miner Res 21:661-73. 2006
    ..The findings indicate both ubiquitous and osteoblast-specific mechanisms of collagen gene regulation...
  4. ncbi The heterozygous disproportionate micromelia (dmm) mouse: morphological changes in fetal cartilage precede postnatal dwarfism and compared with lethal homozygotes can explain the mild phenotype
    Robert E Seegmiller
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Histochem Cytochem 56:1003-11. 2008
    ..Thus, intracellular entrapment of proalpha1(II) seems to be primarily responsible for the dominant-negative effect of the Dmm mutation in the expression of dwarfism...
  5. ncbi Incomplete processing of type II procollagen by a rat chondrosarcoma cell line
    R J Fernandes
    Department of Orthopaedics, University of Washington, Seattle 98195, USA
    Eur J Biochem 247:620-4. 1997
    ..The findings indicate that the RCS-LTC cell line fails to express an active type II procollagen N-proteinase and, therefore, offers a useful culture system in which to study the role of N-propeptide removal in fibrillogenesis...
  6. ncbi Collagen XI chain misassembly in cartilage of the chondrodysplasia (cho) mouse
    Russell J Fernandes
    Departments of Orthopaedics and Sports Medicine, Orthopaedic Research Laboratory, University of Washington, Seattle, WA 98195, USA
    Matrix Biol 26:597-603. 2007
    ....
  7. ncbi The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells
    Russell J Fernandes
    Department of Orthopaedics and Sports Medicine, Box 356500, University of Washington, Seattle, WA 98195 6500, USA
    Bone 40:1343-51. 2007
    ....
  8. ncbi A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens
    Russell J Fernandes
    Orthopaedic Research Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98195 6500, USA
    J Biol Chem 286:30662-9. 2011
    ..The results imply that P3H2 has preferred substrate sequences among the classes of 3Hyp sites in clade A collagen chains...
  9. ncbi Assembly of collagen types II, IX and XI into nascent hetero-fibrils by a rat chondrocyte cell line
    Russell J Fernandes
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle, WA 98195, USA
    Eur J Biochem 270:3243-50. 2003
    ....
  10. ncbi The elastin-like protein matrix of lamprey branchial cartilage is cross-linked by lysyl pyridinoline
    R J Fernandes
    Department of Orthopaedics, University of Washington, Seattle, Washington, 98195, USA
    Biochem Biophys Res Commun 261:635-40. 1999
    ..Pyridinoline cross-links are considered to be characteristic of collagen, so their presence in an elastin-like protein in a primitive cartilage poses evolutionary questions about the tissue, the protein, and the cross-linking mechanism...
  11. ncbi Recent developments in cartilage research: matrix biology of the collagen II/IX/XI heterofibril network
    D R Eyre
    University of Washington, Orthopaedic Research Laboratories, Box 356500, Seattle 98195 6500, USA
    Biochem Soc Trans 30:893-9. 2002
    ..From the structure of the cartilage collagen heteropolymer we also predict a pivotal role for telopeptide (non-triple-helical) proteolytic cleavages in the remodelling and degradation of collagen fibrils...
  12. ncbi Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis
    R J Fernandes
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98195 6500, USA
    J Biol Chem 276:31502-9. 2001
    ..The findings provide an explanation for the sparing of cartilage in dermatosparaxis and, perhaps, for the relative sparing of some procollagen I-containing tissues...
  13. ncbi Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors
    J L Ellsworth
    ZymoGenetics, Inc, 1201 Eastlake Avenue East, Seattle, Washington 98102, USA
    Osteoarthritis Cartilage 10:308-20. 2002
    ..In addition, the expressions of Fgf18 and Fgf receptors (Fgfr) in adult human articular cartilage were examined...
  14. ncbi Tissue response and Msx1 expression after human fetal digit tip amputation in vitro
    Christopher H Allan
    Department of Orthopaedics and Sports Medicine, University of Washington School of Medicine Harborview Medical Center, Seattle, Washington 98104, USA
    Wound Repair Regen 14:398-404. 2006
    ..This process appears spatially associated with Msx1 expression. Msx1 expression appears increased at the regrowing tip of 57-day digits by 4 days after amputation...
  15. ncbi CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta
    Roy Morello
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 127:291-304. 2006
    ..In humans, CRTAP mutations are associated with the clinical spectrum of recessive osteogenesis imperfecta, including the type II and VII forms. Hence, dysregulation of prolyl 3-hydroxylation is a mechanism for connective tissue disease...
  16. ncbi Type XXVII collagen at the transition of cartilage to bone during skeletogenesis
    Rebecca Hjorten
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Bone 41:535-42. 2007
    ..The timing and location of synthesis suggest that type XXVII collagen plays a role during the calcification of cartilage and the transition of cartilage to bone...

Research Grants2

  1. Collagen type II/IX/XI heteropolymer assembly
    RUSSELL FERNANDES; Fiscal Year: 2007
    ....
  2. Collagen Assembly in Tissue-Engineered Cartilage
    Russell J Fernandes; Fiscal Year: 2010
    ..The goal of this study is to develop and authenticate a biomarker to monitor if this collagen heterofibrillar network assembled in bioengineered cartilage is typical of normal cartilage. ..