GABRIEL J FERNANDES

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Effects of conjugated linoleic acid and exercise on bone mass in young male Balb/C mice
    Jameela Banu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center, San Antonio, 78229 3900, USA
    Lipids Health Dis 5:7. 2006
  2. doi request reprint Progress in nutritional immunology
    Gabriel Fernandes
    University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 7868, USA
    Immunol Res 40:244-61. 2008
  3. ncbi request reprint Effects of n-3 fatty acids on autoimmunity and osteoporosis
    Gabriel Fernandes
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 7868, USA
    Front Biosci 13:4015-20. 2008
  4. ncbi request reprint Protective role of n-3 lipids and soy protein in osteoporosis
    Gabriel Fernandes
    Department of Medicine, Division of Clinical Immunology, Health Science Center at San Antonio, The University of Texas, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Prostaglandins Leukot Essent Fatty Acids 68:361-72. 2003
  5. ncbi request reprint The effects of dietary lipids on gene expression and apoptosis
    G Fernandes
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7874, USA
    Proc Nutr Soc 57:543-50. 1998
  6. ncbi request reprint Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice
    Dongxu Sun
    Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Bone Miner Res 18:1206-16. 2003
  7. ncbi request reprint Inhibition of osteoporosis in autoimmune disease prone MRL/Mpj-Fas(lpr) mice by N-3 fatty acids
    Arunabh Bhattacharya
    Division of Clinical Immunology, Department of Medicine, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Am Coll Nutr 24:200-9. 2005
  8. doi request reprint Beneficial effects of conjugated linoleic acid and exercise on bone of middle-aged female mice
    Jameela Banu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Bone Miner Metab 26:436-45. 2008
  9. doi request reprint Endogenously produced n-3 fatty acids protect against ovariectomy induced bone loss in fat-1 transgenic mice
    Jameela Banu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, Medical Research Division, E RAHC, University of Texas Health Science Center at San Antonio, 1214 W Schunior, Edinburg, TX 78541, USA
    J Bone Miner Metab 28:617-26. 2010
  10. pmc The fat-1 transgene in mice increases antioxidant potential, reduces pro-inflammatory cytokine levels, and enhances PPAR-gamma and SIRT-1 expression on a calorie restricted diet
    Mizanur Rahman
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Oxid Med Cell Longev 2:307-16. 2009

Research Grants

Collaborators

Detail Information

Publications34

  1. pmc Effects of conjugated linoleic acid and exercise on bone mass in young male Balb/C mice
    Jameela Banu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center, San Antonio, 78229 3900, USA
    Lipids Health Dis 5:7. 2006
    ..In conclusion, CLA increases bone mass in both cancellous and cortical bones, and the effects of CLA on bone is not further improved by EX in pure cortical bone of young male mice...
  2. doi request reprint Progress in nutritional immunology
    Gabriel Fernandes
    University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 7868, USA
    Immunol Res 40:244-61. 2008
    ....
  3. ncbi request reprint Effects of n-3 fatty acids on autoimmunity and osteoporosis
    Gabriel Fernandes
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 7868, USA
    Front Biosci 13:4015-20. 2008
    ..Together, the available evidence show that increased daily intake of dietary n-3 FA decreases the severity of autoimmune disorders, lessens the chance of developing CVD, and protects against bone loss during post-menopause...
  4. ncbi request reprint Protective role of n-3 lipids and soy protein in osteoporosis
    Gabriel Fernandes
    Department of Medicine, Division of Clinical Immunology, Health Science Center at San Antonio, The University of Texas, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Prostaglandins Leukot Essent Fatty Acids 68:361-72. 2003
    ....
  5. ncbi request reprint The effects of dietary lipids on gene expression and apoptosis
    G Fernandes
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7874, USA
    Proc Nutr Soc 57:543-50. 1998
    ..Understanding the molecular mechanism(s) modified by dietary FO will ultimately lead to improved dietary strategies to aid in the prevention of autoimmune disease, CVD and/or certain types of cancer...
  6. ncbi request reprint Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice
    Dongxu Sun
    Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Bone Miner Res 18:1206-16. 2003
    ..This study showed FO decreased bone loss in ovariectomized mice because of inhibition of osteoclastogenesis. This finding supports a beneficial effect of FO on the attenuation of osteoporosis...
  7. ncbi request reprint Inhibition of osteoporosis in autoimmune disease prone MRL/Mpj-Fas(lpr) mice by N-3 fatty acids
    Arunabh Bhattacharya
    Division of Clinical Immunology, Department of Medicine, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Am Coll Nutr 24:200-9. 2005
    ..Anti-inflammatory omega-3 fatty acids may prevent arthritis and bone loss in MRL/lpr mice model of arthritis and in humans...
  8. doi request reprint Beneficial effects of conjugated linoleic acid and exercise on bone of middle-aged female mice
    Jameela Banu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Bone Miner Metab 26:436-45. 2008
    ..We conclude that CLA, when consumed as a dietary supplement along with moderate treadmill EX, significantly increases bone mass in middle-aged female mice...
  9. doi request reprint Endogenously produced n-3 fatty acids protect against ovariectomy induced bone loss in fat-1 transgenic mice
    Jameela Banu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, Medical Research Division, E RAHC, University of Texas Health Science Center at San Antonio, 1214 W Schunior, Edinburg, TX 78541, USA
    J Bone Miner Metab 28:617-26. 2010
    ..We conclude that endogenously produced n-3 fatty acids can attenuate ovariectomy induced bone loss in the different bone sites studied, mainly as a consequence of decreased bone resorption at the endosteal surface...
  10. pmc The fat-1 transgene in mice increases antioxidant potential, reduces pro-inflammatory cytokine levels, and enhances PPAR-gamma and SIRT-1 expression on a calorie restricted diet
    Mizanur Rahman
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Oxid Med Cell Longev 2:307-16. 2009
    ..These data suggest that n-3 FA along with moderate CR may prolong lifespan by attenuating inflammation and oxidative stress...
  11. ncbi request reprint Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet
    Arunabh Bhattacharya
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 349:925-30. 2006
    ..These results suggest that n-3 lipids with moderate CR may confer protection in autoimmune and inflammatory diseases...
  12. pmc Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice
    Ganesh V Halade
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, TX 78229 3900, USA
    Pharmacol Res 63:300-7. 2011
    ..Our results suggest that RSG treatment has context-dependent effects on cardiac remodeling and serves a negative cardiac role when given with a corn oil enriched diet...
  13. ncbi request reprint Biological effects of conjugated linoleic acids in health and disease
    Arunabh Bhattacharya
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Nutr Biochem 17:789-810. 2006
    ..This review also discusses the latest available information from clinical studies in these areas of research...
  14. ncbi request reprint Inhibition of intracellular peroxides and apoptosis of lymphocytes in lupus-prone B/W mice by dietary n-6 and n-3 lipids with calorie restriction
    C P Reddy Avula
    University of Texas Health Science Center, Department of Medicine, San Antonio 78229 3900, USA
    J Clin Immunol 22:206-19. 2002
    ..In summary, CR resulted in decreased apoptosis accompanied by alterations in Fas, Fas-L, and Bcl-2 expression in old mice, increased life span, and delayed onset of kidney disease...
  15. ncbi request reprint The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice
    Arunabh Bhattacharya
    Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Nutr 135:1124-30. 2005
    ....
  16. ncbi request reprint Effect of dietary n-3 and n-6 oils with and without food restriction on activity of antioxidant enzymes and lipid peroxidation in livers of cyclophosphamide treated autoimmune-prone NZB/W female mice
    Arunabh Bhattacharya
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Am Coll Nutr 22:388-99. 2003
    ....
  17. ncbi request reprint Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high-fat-diet-fed mice
    Arunabh Bhattacharya
    Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Lipids 41:437-44. 2006
    ..In summary, CLA + Cr decreased body weight and fat mass in high-fat-diet-fed mice, which may be associated with decreased leptin levels and higher EE and OC...
  18. pmc Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis
    Md Mizanur Rahman
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Cell Mol Med 13:1833-44. 2009
    ..In conclusion, we offer further insight into the mechanisms involved in preventing the BMD loss in Ovx mice by n-3 FA using a Fat-1 transgenic mouse model...
  19. doi request reprint Effect of CLA isomers and their mixture on aging C57Bl/6J mice
    Ganesh V Halade
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Eur J Nutr 48:409-18. 2009
    ..The combined effect of CLA isomers have been studied extensively in animals and humans, however, the role of individual isomers remains unraveled...
  20. ncbi request reprint Food restriction and fish oil suppress atherogenic risk factors in lupus-prone (NZB x NZW) F1 mice
    Alagarraju Muthukumar
    Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Clin Immunol 23:23-33. 2003
    ..Thus, beneficial effects of fish oil and food restriction on lupus nephritis and survival could be, at least in part, due to their selective effect on atherogenic risk factors...
  21. ncbi request reprint Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice
    Md Mizanur Rahman
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Nutr Biochem 18:467-74. 2007
    ..In conclusion, these findings suggest that CLA may prevent the loss of bone and muscle mass by modulating markers of inflammation and osteoclastogenic factors...
  22. ncbi request reprint Age associated alterations in costimulatory and adhesion molecule expression in lupus-prone mice are attenuated by food restriction with n-6 and n-3 fatty acids
    Alagarraju Muthukumar
    Division of Clinical Immunology, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Clin Immunol 24:471-80. 2004
    ..In summary, food restriction and fish oil delay the onset of lupus disease and increase life span in B/W mice by prolonging the maintenance of a youthful immune phenotype...
  23. ncbi request reprint Different ratios of eicosapentaenoic and docosahexaenoic omega-3 fatty acids in commercial fish oils differentially alter pro-inflammatory cytokines in peritoneal macrophages from C57BL/6 female mice
    Arunabh Bhattacharya
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Nutr Biochem 18:23-30. 2007
    ..The study suggests that anti-inflammatory activity may vary among different sources of FO due to variations in EPA/DHA content...
  24. ncbi request reprint Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management
    Rita Ghosh
    Department of Urology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Anticancer Res 30:857-65. 2010
    ..009) and prevented the development of metastatic lesions. Nexrutine treatment also significantly (p=0.005) inhibited invasion of androgen-independent prostate cancer cells...
  25. pmc Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice
    Ganesh V Halade
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Immunol 184:5280-6. 2010
    ....
  26. ncbi request reprint Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signaling
    Md Mizanur Rahman
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Lipid Res 47:1739-48. 2006
    ..Thus, CLA may have important therapeutic implications for the treatment of bone diseases associated with enhanced bone resorption by excessive osteoclastogenesis...
  27. ncbi request reprint Effect of fish oil on bone mineral density in aging C57BL/6 female mice
    Arunabh Bhattacharya
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Nutr Biochem 18:372-9. 2007
    ..In conclusion, these findings suggest that providing n-3 fatty acids may have a beneficial effect on bone mass during aging by modulating bone formation and bone resorption factors...
  28. doi request reprint Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6J mice
    Ganesh V Halade
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Nutr Biochem 21:332-7. 2010
    ..The t10c12 isomer is found to reduce the fat mass and increase the lean mass but significantly contributed to increase insulin resistance and liver steatosis, whereas c9t11 isomer prevented the insulin resistance...
  29. pmc Conjugated linoleic acid (CLA) prevents age-associated skeletal muscle loss
    M Rahman
    Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, TX 78229 3900, USA
    Biochem Biophys Res Commun 383:513-8. 2009
    ..Thus, CLA may be a novel dietary supplement that will prevent sarcopenia by maintaining redox balance during aging...
  30. ncbi request reprint Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production
    Dongxu Sun
    Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Cell Immunol 223:52-62. 2003
    ..These results indicate that lovastatin may inhibit BM-DC maturation and up-regulate cytokine production through a mevalonate dependent pathway, and may cause adverse effects on either innate or adaptive immunity...
  31. pmc Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth
    Triparna Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Breast Cancer Res Treat 118:213-28. 2009
    ..Taken together, our data reveals a novel signaling pathway linking the fish oil diet to increased PTEN expression that attenuates the growth promoting signals and augments the apoptotic signals, resulting in breast tumor regression...
  32. ncbi request reprint Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice
    Dongxu Sun
    Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Cell Immunol 228:54-65. 2004
    ..We concluded that both CR and CTX can delay the onset of autoimmune disease, in part by maintaining higher numbers of naïve T cells and the immune responsiveness of T cells and decreasing the proportion of B cells...
  33. ncbi request reprint Inhibition of H2O2-induced apoptosis of lymphocytes by calorie restriction during aging
    C P Reddy Avula
    Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Microsc Res Tech 59:282-92. 2002
    ..In summary, lymphocytes in aged AL-fed mice were much more susceptible to oxidative stress-induced apoptosis whereas CR normalized apoptosis by preventing the increase in TNF-alpha and the decrease in Bcl-2 associated with aging...
  34. ncbi request reprint The modulation of prostate cancer risk with alpha-tocopherol: a pilot randomized, controlled clinical trial
    Javier Hernáandez
    Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Urol 174:519-22. 2005
    ....

Research Grants21

  1. EFFECTS OF n-3 FATTY ACIDS AND EXERCISE ON OSTEOPOROSIS
    Gabriel Fernandes; Fiscal Year: 2007
    ..In summary, the proposed studies will investigate the dietary and molecular mechanisms of bone loss during aging in OVX mice and its attenuation by low-cost n-3 lipid supplements with moderate exercise as alternatives to HRT. ..
  2. Benefits of conjugated linoleic acid on aging
    Gabriel Fernandes; Fiscal Year: 2007
    ....
  3. Therapeutic Value of Fish Oil Rx on SLE and Bone Loss in Mice
    Gabriel Fernandes; Fiscal Year: 2009
    ..The proposed studies will also help to gain insight to undertake clinical studies to prevent renal and CVD as well as bone loss in SLE patients. ..
  4. Therapeutic Value of Fish Oil Rx on SLE and Bone Loss in Mice
    GABRIEL J FERNANDES; Fiscal Year: 2010
    ..The proposed studies will also help to gain insight to undertake clinical studies to prevent renal and CVD as well as bone loss in SLE patients. ..
  5. OMEGA 3 LIPIDS AND CALORIES EFFECT ON SLE AND AGING
    Gabriel Fernandes; Fiscal Year: 2003
    ....
  6. Effect of Calorie Restriction on Infection During Aging
    Gabriel Fernandes; Fiscal Year: 2004
    ..This new information may become very useful to prevent any sudden onset of infection during CR studies and/or studies of weight reduction either by diet or by drugs in humans. ..
  7. Prolongation of lifespan by n-3 fatty acids and calorie restriction
    GABRIEL J FERNANDES; Fiscal Year: 2010
    ..n-3 (fish oil) fatty acids containing diets fed to mice ad-libitum and 40% or 20% calorie restriction to measure optimal lifespan, anti-inflammatory cytokines and bone mass, in long-lived C57BL/6 and fat-1 tg mice. ..