Polly J Ferguson

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis
    Polly J Ferguson
    Department of Pediatrics, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Bone 38:41-7. 2006
  2. doi request reprint New discoveries in CRMO: IL-1β, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2-deficient mice
    Polly J Ferguson
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Semin Immunopathol 37:407-12. 2015
  3. pmc Efficacy of anti-IL-1 treatment in Majeed syndrome
    Troels Herlin
    Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
    Ann Rheum Dis 72:410-3. 2013
  4. pmc Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis
    Polly J Ferguson
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA
    Curr Rheumatol Rep 14:130-41. 2012
  5. pmc Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?
    Catalina Matiz
    Division of Pediatric Rheumatology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Pediatr Rheumatol Online J 7:15. 2009
  6. ncbi request reprint Shrinking lung syndrome in a 14-year-old boy with systemic lupus erythematosus
    Polly J Ferguson
    Department of Pediatrics, Children s Hospital of Iowa, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Pulmonol 41:194-7. 2006
  7. ncbi request reprint Autoinflammatory bone disorders
    Polly J Ferguson
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Opin Rheumatol 19:492-8. 2007
  8. ncbi request reprint Chronic recurrent multifocal osteomyelitis: a concise review and genetic update
    Hatem I El-Shanti
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Orthop Relat Res 462:11-9. 2007
  9. pmc Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase
    Lily Paemka
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America Interdisciplinary Program in Genetics, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 11:e1005022. 2015
  10. pmc Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice
    SUZANNE L CASSEL
    Inflammation Program, Department of Internal Medicine, Graduate Program in Immunology, Department of Pediatrics, Department of Pathology, Department of Orthopedics, Dows Institute for Dental Research and Department of Periodontics, College of Dentistry, and Department of Epidemiology, University of Iowa, Iowa City, IA 52242
    Proc Natl Acad Sci U S A 111:1072-7. 2014

Research Grants

  1. Genetic Basis of chronic Multifocal Osteomyelitis
    Polly Ferguson; Fiscal Year: 2007

Collaborators

Detail Information

Publications17

  1. pmc A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis
    Polly J Ferguson
    Department of Pediatrics, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Bone 38:41-7. 2006
    ..These data suggest that mutations in pstpip2 may be the genetic explanation for the autoinflammatory phenotype seen in the cmo mouse...
  2. doi request reprint New discoveries in CRMO: IL-1β, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2-deficient mice
    Polly J Ferguson
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Semin Immunopathol 37:407-12. 2015
    ..Further investigation is needed to determine the specific components of the diet that result in protection from disease and if this finding can be translated into a treatment for human CRMO. ..
  3. pmc Efficacy of anti-IL-1 treatment in Majeed syndrome
    Troels Herlin
    Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
    Ann Rheum Dis 72:410-3. 2013
    ..Long-term outcome is poor. This is the first report detailing the treatment of Majeed syndrome with biological agents and demonstrates clinical improvement with IL-1blockade...
  4. pmc Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis
    Polly J Ferguson
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA
    Curr Rheumatol Rep 14:130-41. 2012
    ..This review briefly summarizes the main clinical and radiologic aspects of the disease and then focuses on genetics and pathophysiology and provides an update on treatment...
  5. pmc Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?
    Catalina Matiz
    Division of Pediatric Rheumatology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Pediatr Rheumatol Online J 7:15. 2009
    ..We review the different diagnoses that should be considered in children with xanthomas and arthritis as well as the different pharmacologic therapies used in children with multicentric reticulohistiocytosis...
  6. ncbi request reprint Shrinking lung syndrome in a 14-year-old boy with systemic lupus erythematosus
    Polly J Ferguson
    Department of Pediatrics, Children s Hospital of Iowa, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Pulmonol 41:194-7. 2006
    ..Shrinking lung syndrome should be included in the differential diagnosis of dyspnea in both children and adults with systemic lupus erythematosus...
  7. ncbi request reprint Autoinflammatory bone disorders
    Polly J Ferguson
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Opin Rheumatol 19:492-8. 2007
    ..This review provides an update on clinical, genetic, and immunologic aspects of the autoinflammatory bone disorders...
  8. ncbi request reprint Chronic recurrent multifocal osteomyelitis: a concise review and genetic update
    Hatem I El-Shanti
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Orthop Relat Res 462:11-9. 2007
    ..We emphasize the need to validate diagnostic clinical criteria and develop new pathogenesis-based targeted therapy...
  9. pmc Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase
    Lily Paemka
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America Interdisciplinary Program in Genetics, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 11:e1005022. 2015
    ..These studies point to a new target for anti-seizure therapy and illustrate the translational power of studying diseases in species across the evolutionary spectrum. ..
  10. pmc Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice
    SUZANNE L CASSEL
    Inflammation Program, Department of Internal Medicine, Graduate Program in Immunology, Department of Pediatrics, Department of Pathology, Department of Orthopedics, Dows Institute for Dental Research and Department of Periodontics, College of Dentistry, and Department of Epidemiology, University of Iowa, Iowa City, IA 52242
    Proc Natl Acad Sci U S A 111:1072-7. 2014
    ..These data provide a rationale for directly targeting IL-1RI or IL-1β as a therapeutic strategy in CRMO. ..
  11. pmc PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders
    Lily Paemka
    The University of Iowa, Iowa City, Iowa, United States of America Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America Interdisciplinary Program in Genetics, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e80737. 2013
    ..Taken together, these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. ..
  12. doi request reprint Autoinflammatory bone disorders: update on immunologic abnormalities and clues about possible triggers
    Manisha Sharma
    Divisions of Rheumatology in Internal Medicine and Pediatrics, University of Iowa, Iowa City, Iowa 52240, USA
    Curr Opin Rheumatol 25:658-64. 2013
    ..To provide an update on the genetics and immunologic basis of autoinflammatory bone disorders including chronic recurrent multifocal osteomyelitis including the monogenic forms of the disease...
  13. doi request reprint Primary multifocal osseous lymphoma in a child
    Takashi S P Sato
    Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Pediatr Radiol 38:1338-41. 2008
    ..We hope that awareness of this entity will help radiologists achieve timely diagnosis and intervention...
  14. pmc A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome
    Alexander G Bassuk
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 83:572-81. 2008
    ..PRICKLE1 is expressed in brain regions implicated in epilepsy and ataxia in mice and humans, and, to our knowledge, is the first molecule in the noncanonical WNT signaling pathway to be directly implicated in human epilepsy...
  15. doi request reprint A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis
    Laura C Whitmore
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242 Iowa Inflammation Program, University of Iowa, Iowa City, IA 52242
    J Immunol 196:1376-86. 2016
    ..Based on our finding that septic children with this SNP had longer pediatric intensive care unit stays, we speculate that this SNP results in hyperinflammation in diseases such as sepsis. ..
  16. pmc Presence of epilepsy-associated variants in large exome databases
    Natalya S Cherepanova
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa, USA
    J Neurogenet 27:1-4. 2013
    ..These databases also elucidate the array of genetic variation in putative epilepsy genes in the general population...
  17. ncbi request reprint A splice site mutation confirms the role of LPIN2 in Majeed syndrome
    Zakiya S Al-Mosawi
    Salmanyia Medical Complex, Manama, Kingdom of Bahrain
    Arthritis Rheum 56:960-4. 2007
    ..2327+1G>C) in the patient; her mother was heterozygous at this site. These data confirm the role of LPIN2 mutations in the etiology of Majeed syndrome...

Research Grants1

  1. Genetic Basis of chronic Multifocal Osteomyelitis
    Polly Ferguson; Fiscal Year: 2007
    ..abstract_text> ..