Andrew Feranchak

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Liver involvement in cystic fibrosis
    Catherine Brigman
    Pediatric Gastroenterology, Hepatology and Nutrition, Children s Medical Center and the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Curr Treat Options Gastroenterol 9:484-96. 2006
  2. pmc Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium
    Andrew P Feranchak
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9030, USA
    J Biol Chem 285:8138-47. 2010
  3. ncbi request reprint Comparison of indices of vitamin A status in children with chronic liver disease
    Andrew P Feranchak
    Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Children s Hospital, Denver, CO, USA
    Hepatology 42:782-92. 2005
  4. ncbi request reprint Characterization of ionotrophic purinergic receptors in hepatocytes
    Daniel S Emmett
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9030, USA
    Hepatology 47:698-705. 2008
  5. ncbi request reprint Adenosine triphosphate release and purinergic regulation of cholangiocyte transport
    Andrew P Feranchak
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Semin Liver Dis 22:251-62. 2002
  6. ncbi request reprint Molecular characterization of volume-sensitive SK(Ca) channels in human liver cell lines
    Richard Roman
    Department of Medicine, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Gastrointest Liver Physiol 282:G116-22. 2002
  7. ncbi request reprint Volume-sensitive tyrosine kinases regulate liver cell volume through effects on vesicular trafficking and membrane Na+ permeability
    Andrew P Feranchak
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:44632-8. 2003
  8. pmc Identification and functional characterization of the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) in biliary epithelium
    Amal K Dutta
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1009-18. 2009
  9. ncbi request reprint Purinergic regulation of cholangiocyte secretion: identification of a novel role for P2X receptors
    R Brian Doctor
    UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Am J Physiol Gastrointest Liver Physiol 288:G779-86. 2005
  10. ncbi request reprint Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels
    Andrew P Feranchak
    University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, Colorado 80262, USA
    Gastroenterology 127:903-13. 2004

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Liver involvement in cystic fibrosis
    Catherine Brigman
    Pediatric Gastroenterology, Hepatology and Nutrition, Children s Medical Center and the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Curr Treat Options Gastroenterol 9:484-96. 2006
    ....
  2. pmc Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium
    Andrew P Feranchak
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9030, USA
    J Biol Chem 285:8138-47. 2010
    ..Collectively, these findings are most consistent with an essential role for exocytosis in regulated release of ATP and initiation of purinergic signaling in liver cells...
  3. ncbi request reprint Comparison of indices of vitamin A status in children with chronic liver disease
    Andrew P Feranchak
    Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Children s Hospital, Denver, CO, USA
    Hepatology 42:782-92. 2005
    ..Our data suggest that serum retinol level as an initial screen followed by confirmation with a modified oral RDR test is the most effective means of identifying vitamin A deficiency in these subjects...
  4. ncbi request reprint Characterization of ionotrophic purinergic receptors in hepatocytes
    Daniel S Emmett
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9030, USA
    Hepatology 47:698-705. 2008
    ..3-3 microM) each increased intracellular [Ca(2+)]. Exposure to BzATP decreased cellular glycogen content; and P2X4 receptor messenger RNA increased in glycogen-rich liver samples...
  5. ncbi request reprint Adenosine triphosphate release and purinergic regulation of cholangiocyte transport
    Andrew P Feranchak
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Semin Liver Dis 22:251-62. 2002
    ..This article highlights important developments in our understanding of the role of purinergic signaling in cholangiocyte transport and bile formation...
  6. ncbi request reprint Molecular characterization of volume-sensitive SK(Ca) channels in human liver cell lines
    Richard Roman
    Department of Medicine, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Gastrointest Liver Physiol 282:G116-22. 2002
    ..Accordingly, the hSK2 protein is a potential target for pharmacological modulation of liver transport and metabolism through effects on membrane K(+) permeability...
  7. ncbi request reprint Volume-sensitive tyrosine kinases regulate liver cell volume through effects on vesicular trafficking and membrane Na+ permeability
    Andrew P Feranchak
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:44632-8. 2003
    ....
  8. pmc Identification and functional characterization of the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) in biliary epithelium
    Amal K Dutta
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1009-18. 2009
    ..Together these studies demonstrate that IK channels are present in biliary epithelial cells and contribute to ATP-stimulated secretion through a P2Y-IP3 receptor pathway...
  9. ncbi request reprint Purinergic regulation of cholangiocyte secretion: identification of a novel role for P2X receptors
    R Brian Doctor
    UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Am J Physiol Gastrointest Liver Physiol 288:G779-86. 2005
    ..Functional studies indicate that P2X4 is likely the primary isoform involved, representing a novel and functionally important component of the purinergic signaling complex modulating biliary secretion...
  10. ncbi request reprint Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels
    Andrew P Feranchak
    University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, Colorado 80262, USA
    Gastroenterology 127:903-13. 2004
    ..We have identified a Ca 2+ -activated K + channel (SK2) in biliary epithelium that is inhibited by apamin. The purpose of the present studies was to define the role of SK channels in Ca 2+ -dependent cholangiocyte secretion...
  11. pmc Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl- transport in biliary epithelial cells through a PKCzeta-dependent pathway
    Kangmee Woo
    UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    J Physiol 586:2779-98. 2008
    ....
  12. pmc Extracellular nucleotides stimulate Cl- currents in biliary epithelia through receptor-mediated IP3 and Ca2+ release
    Amal K Dutta
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Gastrointest Liver Physiol 295:G1004-15. 2008
    ....
  13. pmc Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes
    Kangmee Woo
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX
    Hepatology 52:1819-28. 2010
    ..Mechanosensitive ATP release was two-fold greater in MSCs compared to MLCs. ATP release was significantly inhibited by disruption of vesicular trafficking by monensin in both cell types...
  14. ncbi request reprint Hepatobiliary complications of cystic fibrosis
    Andrew P Feranchak
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Children s Hospital and the University of Colorado Health Sciences Center, 1056 East 19th Avenue, B290, Denver, CO 80218, USA
    Curr Gastroenterol Rep 6:231-9. 2004
    ..This review focuses on the pathogenesis, clinical manifestations, screening, diagnosis, and treatment of CF hepatobiliary disease...

Research Grants4

  1. Regulation of biliary secretion by purinergic signaling
    Andrew Feranchak; Fiscal Year: 2006
    ..The Mentored Clinical Scientist Development Award will provide the protected time, resources, and mentored environment to allow the applicant to achieve these goals. ..
  2. MECHANOSENSITIVE ATP RELEASE AND SIGNALING IN CHOLANGIOCYTE SECRETION
    Andrew Feranchak; Fiscal Year: 2009
    ....
  3. MECHANOSENSITIVE ATP RELEASE AND SIGNALING IN CHOLANGIOCYTE SECRETION
    Andrew P Feranchak; Fiscal Year: 2010
    ....