R A Fenton

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Adenosine reduces the Ca2+ transients of isoproterenol-stimulated rat ventricular myocytes
    R A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester 01655
    Am J Physiol 261:C1107-14. 1991
  2. pmc Reduced adenosine release from the aged mammalian heart
    Richard A Fenton
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Physiol 227:3709-14. 2012
  3. ncbi request reprint Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 213:785-92. 2007
  4. pmc Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Heart Circ Physiol 297:H718-25. 2009
  5. ncbi request reprint Chronic ethanol enhances adenosine antiadrenergic actions in the isolated rat heart
    R A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Alcohol Clin Exp Res 25:968-75. 2001
  6. ncbi request reprint Aging reduces the cardioprotective effect of ischemic preconditioning in the rat heart
    R A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts, 01655, USA
    J Mol Cell Cardiol 32:1371-5. 2000
  7. pmc Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27
    Richard A Fenton
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 298:H1671-8. 2010
  8. ncbi request reprint Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Life Sci 77:3375-88. 2005
  9. ncbi request reprint Adenosine A2 receptor function in rat ventricular myocytes
    J G Dobson
    Department of Physiology, University of Massachusetts Medical School, Worcester, USA
    Cardiovasc Res 34:337-47. 1997
  10. ncbi request reprint The adenosine Ri agonist, phenylisopropyladenosine, reduces high affinity isoproterenol binding to the beta-adrenergic receptor of rat myocardial membranes
    F D Romano
    Department of Physiology, University of Massachusetts Medical School, Worcester 01655
    Second Messengers Phosphoproteins 12:29-43. 1988

Detail Information

Publications21

  1. ncbi request reprint Adenosine reduces the Ca2+ transients of isoproterenol-stimulated rat ventricular myocytes
    R A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester 01655
    Am J Physiol 261:C1107-14. 1991
    ....
  2. pmc Reduced adenosine release from the aged mammalian heart
    Richard A Fenton
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Physiol 227:3709-14. 2012
    ..It is concluded that a reduced mitochondrial AMP synthesis is in part responsible for the attenuation in ADO release from the adrenergic-stimulated aged heart...
  3. ncbi request reprint Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 213:785-92. 2007
    ..Together, these results indicate that A1R exert an antiadrenergic action at the level of beta1R stimulated G(s)-protein cycling and that A2AR reduce this action...
  4. pmc Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Heart Circ Physiol 297:H718-25. 2009
    ..In conclusion, A(1)R stimulation of the heart is associated with PLC-initiated PKC-epsilon translocation and association with RACK2...
  5. ncbi request reprint Chronic ethanol enhances adenosine antiadrenergic actions in the isolated rat heart
    R A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Alcohol Clin Exp Res 25:968-75. 2001
    ..Adenosine attenuates adrenergic stimulation via an adenosine receptor-mediated antiadrenergic action. This study investigated the effect of ethanol on adenosine antiadrenergic actions and adenosine release in the rat heart...
  6. ncbi request reprint Aging reduces the cardioprotective effect of ischemic preconditioning in the rat heart
    R A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts, 01655, USA
    J Mol Cell Cardiol 32:1371-5. 2000
    ..These data suggest that aging reduces the effectiveness of preconditioning in providing cardioprotection against ischemic-induced myocardial necrosis...
  7. pmc Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27
    Richard A Fenton
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 298:H1671-8. 2010
    ..Attenuation of beta-adrenergic-induced contractile function by A(1)R may involve the activation of p38 MAPK, but not HSP27...
  8. ncbi request reprint Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Life Sci 77:3375-88. 2005
    ..In conclusion, aging-induced changes in protein dephosphorylation may be one mechanism reducing the manifestation of preconditioning in the aged heart...
  9. ncbi request reprint Adenosine A2 receptor function in rat ventricular myocytes
    J G Dobson
    Department of Physiology, University of Massachusetts Medical School, Worcester, USA
    Cardiovasc Res 34:337-47. 1997
    ..This study was undertaken to investigate the functional significance of adenosine A2 receptor stimulation in a mammalian ventricular myocyte preparation...
  10. ncbi request reprint The adenosine Ri agonist, phenylisopropyladenosine, reduces high affinity isoproterenol binding to the beta-adrenergic receptor of rat myocardial membranes
    F D Romano
    Department of Physiology, University of Massachusetts Medical School, Worcester 01655
    Second Messengers Phosphoproteins 12:29-43. 1988
    ....
  11. ncbi request reprint Rabbit heart can be "preconditioned" via transfer of coronary effluent
    E W Dickson
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol 277:H2451-7. 1999
    ..Although adenosine and norepinephrine are apparently not responsible, these results suggest that remote protection is initiated by a humoral mechanism...
  12. ncbi request reprint Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts
    Eugene I Tikh
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 290:H348-56. 2006
    ..In addition, A2AR supports myocardial contractility in a setting of low-flow ischemia...
  13. doi request reprint Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart
    Eugene I Tikh
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 216:83-90. 2008
    ..These data show that A(2A)R and A(1)R regulate PP2A activity, thus suggesting an important mechanism for modulating myocardial contractility...
  14. ncbi request reprint Fluorometric quantitation of adenosine concentration in small samples of extracellular fluid
    R A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester 01655
    Anal Biochem 207:134-41. 1992
    ..Thus, this assay is useful for determining the adenosine concentration in microliter samples of extracellular fluid and should facilitate investigations dealing with the functions of adenosine...
  15. ncbi request reprint Endogenous adenosine inhibits CNS terminal Ca(2+) currents and exocytosis
    Thomas K Knott
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 210:309-14. 2007
    ..This could be a general mechanism for controlling transmitter release in these and other CNS terminals...
  16. ncbi request reprint Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation
    James G Dobson
    Department of Physiology, University Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655 0127, USA
    Am J Physiol Heart Circ Physiol 285:H1471-8. 2003
    ..These results indicate that the cardioprotective effect of adenosine afforded by its antiadrenergic action is facilitated by cardiac membrane phosphorylation...
  17. pmc Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes
    James G Dobson
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 295:H2364-72. 2008
    ..Although PKC is important in the A1R antiadrenergic action, it does not seem to play a role in A2AR-elicited Ca transient and contractile events...
  18. ncbi request reprint "Preconditioning at a distance" in the isolated rabbit heart
    E W Dickson
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, USA
    Acad Emerg Med 7:311-7. 2000
    ..If a preconditioning hormone exists, the authors hypothesize that the IP effect should be transferable, via administration of coronary effluent, from a preconditioned donor heart to a virgin non-preconditioned acceptor heart...
  19. ncbi request reprint Receptors subtypes involved in adenosine-mediated modulation of norepinephrine release from cardiac nerve terminals
    Mojca Lorbar
    Department of Medicine, St Vincent Hospital, Worcester, MA 01608, USA
    Can J Physiol Pharmacol 82:1026-31. 2004
    ..This effect of adenosine was of short duration. Adenosine A2A and A3 receptors were either absent or functionally insignificant in the regulation of norepinephrine release in the rat heart...
  20. ncbi request reprint Protein kinase Cepsilon and the antiadrenergic action of adenosine in rat ventricular myocytes
    Koji Miyazaki
    Dept of Physiology, S4 242, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 287:H1721-9. 2004
    ..These results suggest that the translocation of PKCepsilon to the t-tubular system plays an important role in A(1)R-mediated antiadrenergic actions in the heart...
  21. ncbi request reprint Anoxia-induced changes in purine nucleoside metabolism of in vitro aged human fibroblasts
    Patricia S Reisert
    Department of Natural Sciences, Assumption College, Worcester, MA 01615 0005, USA
    Life Sci 70:1369-82. 2002
    ..Immediately following anoxia (time 0), adenosine release by young AF was 29% greater than for young NF, whereas both the youn..