WILLIAM H FENICAL

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint New pharmaceuticals from marine organisms
    W Fenical
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla 92093 0236, USA
    Trends Biotechnol 15:339-41. 1997
  2. doi request reprint Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94
    Lauge Farnaes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Org Biomol Chem 12:418-23. 2014
  3. ncbi request reprint Developing a new resource for drug discovery: marine actinomycete bacteria
    William Fenical
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Nat Chem Biol 2:666-73. 2006
  4. pmc Culture-dependent and culture-independent diversity within the obligate marine actinomycete genus Salinispora
    Tracy J Mincer
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Appl Environ Microbiol 71:7019-28. 2005
  5. pmc Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
    Daniel W Udwary
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    Proc Natl Acad Sci U S A 104:10376-81. 2007
  6. ncbi request reprint Culturable marine actinomycete diversity from tropical Pacific Ocean sediments
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Environ Microbiol 7:1039-48. 2005
  7. ncbi request reprint Marine actinomycete diversity and natural product discovery
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Antonie Van Leeuwenhoek 87:43-8. 2005
  8. pmc Phylogenetic diversity of gram-positive bacteria cultured from marine sediments
    Erin A Gontang
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0204, USA
    Appl Environ Microbiol 73:3272-82. 2007
  9. pmc Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora
    Paul R Jensen
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    Appl Environ Microbiol 73:1146-52. 2007
  10. pmc Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors
    Ryan P McGlinchey
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA
    J Am Chem Soc 130:7822-3. 2008

Collaborators

  • Paul R Jensen
  • Philip G Williams
  • Greg O Buchanan
  • David C Rowley
  • B S Moore
  • James J La Clair
  • P Andrew Evans
  • Lik Tong Tan
  • Kin S Lam
  • Julia Kubanek
  • Jon Clardy
  • Patrik Inderbitzin
  • Christopher A Kauffman
  • Dong Chan Oh
  • Chambers C Hughes
  • Ratnakar N Asolkar
  • Hak Cheol Kwon
  • Ji Young Cho
  • Tracy J Mincer
  • Erin A Gontang
  • Joel S Sandler
  • Katherine N Maloney
  • Mercedes Cueto
  • Wendy K Strangman
  • John B Macmillan
  • Lauge Farnaes
  • Hyuncheol Oh
  • Susana P Gaudêncio
  • Allan Spyere
  • Nina M Haste
  • Sang Jip Nam
  • Tamara P Kondratyuk
  • John M Pezzuto
  • Chollaratt Boonlarppradab
  • Gerald L Newton
  • Ryan P McGlinchey
  • Daniel W Udwary
  • Mohamed A Abdel-Wahab
  • Glenroy D A Martin
  • Matthew D Alexander
  • Tim S Bugni
  • A Richard Chamberlin
  • Brian M Gulledge
  • Ren Xiang Tan
  • Eliane Garo
  • Robert H Feling
  • Timothy Ramsey
  • Dan N Tran
  • John F Sullivan
  • Brian T Murphy
  • Varahenage R Perera
  • Laura E Marler
  • Victor Nizet
  • Catherine Fiorilla
  • Mary E Hensler
  • Pieter C Dorrestein
  • Arnold L Rheingold
  • Yu Liang Yang
  • David Broide
  • Wei Ting Liu
  • Kelle C Freel
  • Eun Jung Park
  • Antonio G DiPasquale
  • Markus Nett
  • Robert C Fahey
  • Alejandra Prieto-Davo
  • Alessandra S Eustáquio
  • Alla Lapidus
  • Vasanth Singan
  • Carmen Raventos-Suarez
  • Lisa Zeigler
  • Rosalba Encarnacion Dimayuga
  • Hak Chol Kwon
  • Craig R Fairchild
  • Santosh J Gharpure
  • Binh G Vong
  • Adam D Richardson
  • Michelle Kelly
  • Jian Cui
  • Emmanuel A Theodorakis
  • Mary Kay Harper
  • JOEL SANDLER
  • Alexei Polosukhin
  • Michael D Burkart
  • Xiaobin Ding
  • James B Aggen
  • Padma Portonovo
  • Thomas P Brady
  • Hai Ren Zhang
  • Bo Liang

Detail Information

Publications57

  1. ncbi request reprint New pharmaceuticals from marine organisms
    W Fenical
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla 92093 0236, USA
    Trends Biotechnol 15:339-41. 1997
    ..Current research activities, while primarily within the academic laboratories, have generated convincing evidence that marine drug discovery has an exceedingly bright future...
  2. doi request reprint Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94
    Lauge Farnaes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Org Biomol Chem 12:418-23. 2014
    ..The fact that the napyradiomycins CNQ525.510B and A80815C bind to hGrp94, and their associated probes localize within the ER, suggest the use of these materials as molecular probes for monitoring ER-based chaperone function. ..
  3. ncbi request reprint Developing a new resource for drug discovery: marine actinomycete bacteria
    William Fenical
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Nat Chem Biol 2:666-73. 2006
  4. pmc Culture-dependent and culture-independent diversity within the obligate marine actinomycete genus Salinispora
    Tracy J Mincer
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Appl Environ Microbiol 71:7019-28. 2005
    ..Challenges involved with the direct sequence-based detection of spore-forming microorganisms in environmental samples are discussed...
  5. pmc Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
    Daniel W Udwary
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    Proc Natl Acad Sci U S A 104:10376-81. 2007
    ..This study firmly establishes the genus Salinispora as a rich source of drug-like molecules and importantly reveals the powerful interplay between genomic analysis and traditional natural product isolation studies...
  6. ncbi request reprint Culturable marine actinomycete diversity from tropical Pacific Ocean sediments
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Environ Microbiol 7:1039-48. 2005
    ..These bacteria can be readily cultured using low nutrient media and represent an unexplored resource for pharmaceutical drug discovery...
  7. ncbi request reprint Marine actinomycete diversity and natural product discovery
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Antonie Van Leeuwenhoek 87:43-8. 2005
    ....
  8. pmc Phylogenetic diversity of gram-positive bacteria cultured from marine sediments
    Erin A Gontang
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0204, USA
    Appl Environ Microbiol 73:3272-82. 2007
    ..2%) are likely to represent new taxa. The high degree of phylogenetic novelty observed during this study highlights the fact that a great deal remains to be learned about the diversity of gram-positive bacteria in marine sediments...
  9. pmc Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora
    Paul R Jensen
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    Appl Environ Microbiol 73:1146-52. 2007
    ....
  10. pmc Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors
    Ryan P McGlinchey
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA
    J Am Chem Soc 130:7822-3. 2008
    ....
  11. pmc Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments
    Tracy J Mincer
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    Appl Environ Microbiol 68:5005-11. 2002
    ..Organic extracts from cultured members of this new group exhibit remarkable biological activity, suggesting that they represent a prolific resource for biotechnological applications...
  12. ncbi request reprint Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora
    Robert H Feling
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Angew Chem Int Ed Engl 42:355-7. 2003
  13. pmc Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
    William Fenical
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Bioorg Med Chem 17:2175-80. 2009
    ..This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule...
  14. pmc Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis
    Sang Jip Nam
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    J Nat Prod 73:1080-6. 2010
    ..Fijiolide B did not affect QR1 activity, indicating the importance of the nitrogen substitution pattern for biological activity. On the basis of these data, fijiolide A is viewed as a promising lead for more advanced anticancer testing...
  15. ncbi request reprint Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica
    Greg O Buchanan
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    Org Lett 7:2731-4. 2005
    ..The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography...
  16. ncbi request reprint Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis
    Ji Young Cho
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:1321-8. 2007
    ..Lucentamycins A (1) and B (2) showed significant in vitro cytotoxicity against HCT-116 human colon carcinoma...
  17. ncbi request reprint Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces
    Glenroy D A Martin
    Center for Marine Biotechnology, Scripps Insitution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:1406-9. 2007
    ..For marmycin A ( 1), tumor cell cytotoxicity appeared to coincide with induction of modest apoptosis and arrest in the G1 phase of the cell cycle...
  18. pmc The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp
    Chambers C Hughes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    Org Lett 10:629-31. 2008
    ..The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus...
  19. pmc Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria
    Erin A Gontang
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Appl Environ Microbiol 76:2487-99. 2010
    ....
  20. pmc Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete
    Katherine N Maloney
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    Org Lett 11:5422-4. 2009
    ..Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM...
  21. pmc Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola
    Ratnakar N Asolkar
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 72:396-402. 2009
    ..Taken together, these data suggest that the chemoprevention and anti-inflammatory characteristics of arenamides A and B warrant further investigation...
  22. pmc Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 71:570-5. 2008
    ..This relationship was shown to be a consequence of the geometric isomerization of one double bond. The phenomenon of polyketide module skipping is proposed to explain the unusual biosynthesis of the salinipyrones and the pacificanones...
  23. ncbi request reprint Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica"
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, USA
    Org Lett 8:1021-4. 2006
    ..The cyanosporasides possess a new 3-keto-pyranohexose sugar as well as a cyano- and chloro-substituted cyclopenta[a]indene ring system. The cyanosporasides are proposed to be cyclization products of an enediyne precursor...
  24. ncbi request reprint Phylogenetic analyses and diterpenoid production by marine bacteria of the genus Saprospira
    Tracy J Mincer
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    Curr Microbiol 49:300-7. 2004
    ..grandis Gross, and the sole member of the closely related phylotype B. The discovery of two new neoverrucosane diterpenoids produced by phylotype B has also been documented...
  25. ncbi request reprint Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora"
    Hak Cheol Kwon
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    J Am Chem Soc 128:1622-32. 2006
    ..The discovery of these new compounds from a new, chemically rich genus further documents that marine actinomycetes are a significant resource for drug discovery...
  26. pmc Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria
    Hyuncheol Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 73:998-1001. 2010
    ..It also showed significant cytotoxicity against an HCT-116 human colon carcinoma cell line, indicating that the compound may be of value in exploring the Mcl-1 pathway as a target for cancer chemotherapy...
  27. pmc Structures, reactivities, and antibiotic properties of the marinopyrroles A-F
    Chambers C Hughes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 75:3240-50. 2010
    ..Halogenation of this material with N-bromosuccinimide cleanly furnished the 4,4',5,5'-tetrahalogenated core that characterizes this class of marine-derived metabolites...
  28. pmc Marinopyrrole A target elucidation by acyl dye transfer
    Chambers C Hughes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Am Chem Soc 131:12094-6. 2009
    ..In this study, the combination of cell, protein, and amino acid analysis arose from a single sample of material, thereby, suggesting a means to streamline and reduce material requirements involved in mode of action studies...
  29. pmc Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium
    Wendy K Strangman
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Med Chem 52:2317-27. 2009
    ..This study provides the foundation for the optimization of these potent anti-inflammatory compounds for development in the treatment of asthma...
  30. pmc Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomycete
    Chollaratt Boonlarppradab
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    Org Lett 10:5505-8. 2008
    ..5 microM for marineosin A) and selective activities in diverse cancer cell types...
  31. pmc An N-acyl homolog of mycothiol is produced in marine actinomycetes
    Gerald L Newton
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Arch Microbiol 190:547-57. 2008
    ..The results demonstrate that major thiol/disulfide changes accompany secondary metabolite production and suggest that mycothiol-dependent detoxification is important at this developmental stage...
  32. ncbi request reprint New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica
    Philip G Williams
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 70:6196-203. 2005
    ..New SAR data for all eight compounds, derived from extensive testing against the human colon carcinoma HCT-116 and the 60-cell-line panel at the NCI, indicate that the chloroethyl moiety plays a major role in the enhanced activity of 1...
  33. ncbi request reprint Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:515-20. 2007
    ..Emericellamides A and B show modest antibacterial activities against methicillin-resistant Staphylococcus aureus with MIC values of 3.8 and 6.0 microM, respectively...
  34. ncbi request reprint Bohemamines from a marine-derived Streptomyces sp
    Tim S Bugni
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 69:1626-8. 2006
    ..The structures were elucidated using NMR methods, and the relative stereochemistry was determined using double-pulsed-field-gradient spin echo (DPFGSE) NOE studies...
  35. pmc Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales)
    Ji Young Cho
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Org Lett 8:2471-4. 2006
    ..The structure was rigorously determined by NMR spectroscopy and X-ray crystallography. A possible biosynthetic origin of this unusual ring system is proposed. [structure: see text]..
  36. pmc Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola
    Philip G Williams
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 72:5025-34. 2007
    ..The relative and absolute stereochemistries of 1-3 were assigned by a combination of J-based configurational analyses and chemical derivatization...
  37. ncbi request reprint Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085
    Ratnakar N Asolkar
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    J Nat Prod 69:1756-9. 2006
    ..The daryamides show weak to moderate cytotoxic activity against the human colon carcinoma cell line HCT-116 and very weak antifungal activities against Candida albicans...
  38. ncbi request reprint Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola
    Philip G Williams
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:83-8. 2007
    ..Saliniketals A and B were found to inhibit ornithine decarboxylase induction, an important target for the chemoprevention of cancer, with IC50 values of 1.95 +/- 0.37 and 7.83 +/- 1.2 microg/mL, respectively...
  39. ncbi request reprint Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira sp
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, USA
    Org Lett 9:1525-8. 2007
    ....
  40. pmc Seaweed resistance to microbial attack: a targeted chemical defense against marine fungi
    Julia Kubanek
    Center for Marine Biotechnology and Biomedicine, The Scripps Institution of Oceanography, La Jolla, CA 92037 0204, USA
    Proc Natl Acad Sci U S A 100:6916-21. 2003
    ....
  41. pmc Total synthesis of the ammosamides
    Chambers C Hughes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Am Chem Soc 132:2528-9. 2010
    ..Compared to synthetic deschloro ammosamide B, natural ammosamide B is much less susceptible to oxidative degradation...
  42. ncbi request reprint Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens
    Eliane Garo
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 66:423-6. 2003
    ..Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC(50) of 0.32 microg/mL...
  43. pmc Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus
    Nina M Haste
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    J Antibiot (Tokyo) 63:219-24. 2010
    ..These studies will also guide future isolation and preclinical development of depsipeptide anti-MRSA compounds from marine-derived actinomycetes...
  44. ncbi request reprint Cytotoxic macrolides from a new species of the deep-water marine sponge Leiodermatium
    Joel S Sandler
    Center for Marine Biotechnology and Biomedicine CMBB, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 71:7245-51. 2006
    ..Leiodolide A showed significant cytotoxicity (average GI(50) = 2.0 microM) in the National Cancer Institute's 60 cell line panel with enhanced activity against HL-60 leukemia and OVCAR-3 ovarian cancer cell lines...
  45. ncbi request reprint Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus Aspergillus
    Mercedes Cueto
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    Org Lett 4:1583-5. 2002
    ..The carbon skeleton of 1 represents a new addition to the architectural diversity of the sesterterpenoid (C25) class of secondary metabolites...
  46. ncbi request reprint A central strategy for converting natural products into fluorescent probes
    Matthew D Alexander
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Chembiochem 7:409-16. 2006
  47. pmc Marinisporolides, polyene-polyol macrolides from a marine actinomycete of the new genus Marinispora
    Hak Cheol Kwon
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 74:675-84. 2009
    ..Although polyenes, marinisporolides A (1) and B (2) showed weak to no antifungal activity against Candida albicans...
  48. ncbi request reprint New neoverrucosane diterpenoids produced by the marine gliding bacterium Saprospira grandis
    Allan Spyere
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    J Nat Prod 66:818-22. 2003
    ..This study adds to the rare observation of terpene production by prokaryotic microorganisms and suggests that marine gliding bacteria may be a significant source for new terpenoid secondary metabolites...
  49. pmc Secondary metabolite chemistry of the marine-derived fungus Massarina sp., strain CNT-016
    Mohamed A Abdel-Wahab
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Phytochemistry 68:1212-8. 2007
    ..The fungal strain was isolated as a sterile mycelium from an ocean mud sample and identified using ITS sequence analysis...
  50. ncbi request reprint Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus
    Mercedes Cueto
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego La Jolla, CA 92093 0204, USA
    Phytochemistry 67:1826-31. 2006
    ..Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 microg/mL...
  51. ncbi request reprint Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Bioorg Med Chem 13:5267-73. 2005
    ..The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 microM)...
  52. ncbi request reprint Fluorescent profiling of natural product producers
    Joel S Sandler
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Am Chem Soc 127:9320-1. 2005
    ..Through real-time multicolor microscopy, the processing, storage, and effects of a natural product are rapidly screened at the level of the strain and individual organism...
  53. ncbi request reprint Halovirs A-E, new antiviral agents from a marine-derived fungus of the genus Scytalidium
    David C Rowley
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Bioorg Med Chem 11:4263-74. 2003
    ..A qualitative analysis of the secondary structures of these molecules using variable temperature NMR experiments and NOE analyses is also reported...
  54. ncbi request reprint Synthesis and structure-activity relationships of the halovirs, antiviral natural products from a marine-derived fungus
    David C Rowley
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Bioorg Med Chem 12:4929-36. 2004
    ..Results demonstrate that an N(alpha)-acyl chain of at least 14 carbons and an Aib-Pro dipeptide are critical for maintaining the antiviral activity...
  55. ncbi request reprint Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum
    Ren Xiang Tan
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 67:1374-82. 2004
    ..Rostratins A, B, C, and D showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 8.5, 1.9, 0.76, and 16.5 microg/mL, respectively...
  56. ncbi request reprint Scytalidamides A and B, new cytotoxic cyclic heptapeptides from a marine fungus of the genus Scytalidium
    Lik Tong Tan
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    J Org Chem 68:8767-73. 2003
    ..Scytalidamides A (1) and B (2) showed moderate in vitro cytotoxicity toward HCT-116 human colon adenocarcinoma with IC(50) values of 2.7 and 11.0 microM, respectively...
  57. ncbi request reprint Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus streptomyces (actinomycetales)
    Ji Young Cho
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, 92093 0204, USA
    J Nat Prod 69:425-8. 2006
    ....

Research Grants27

  1. The Discovery of New Antibiotics from Deep Sea Actinomycete Bacteria
    William Fenical; Fiscal Year: 2010
    ....
  2. NMR Instrumentation for Marine Natural Product Chemistry
    William Fenical; Fiscal Year: 2003
    ..The acquisition of a high field instrument (500 MHz) will allow this group of researchers to undertake experiments currently unavailable at SIO. ..
  3. ANTITUMOR ANTIBIOTICS FROM MARINE ORGANISMS
    William Fenical; Fiscal Year: 2003
    ..The collection will grow with respect to the new fungi and gliding bacteria we will add during this project period. ..
  4. ANTITUMOR-ANTIBIOTICS FROM MARINE MICROORGANISMS
    William Fenical; Fiscal Year: 2007
    ..abstract_text> ..
  5. Training Program in Marine Biotechnology
    William Fenical; Fiscal Year: 2007
    ..Together, these resources will create a multidisciplinary training experience difficult to achieve elsewhere. ..
  6. The Discovery of New Antibiotics from Deep Sea Actinomycete Bacteria
    William Fenical; Fiscal Year: 2009
    ....
  7. ANTITUMOR-ANTIBIOTICS FROM MARINE MICROORGANISMS
    William Fenical; Fiscal Year: 1993
    ..New projects will be identified and prioritized as the discovery process continues. It is anticipated that approximately 20 active leads can be chemically investigated per year...
  8. The Discovery of New Antibiotics from Deep Sea Actinomycete Bacteria
    William Fenical; Fiscal Year: 2009
    ....