Xu Feng

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi RANKing intracellular signaling in osteoclasts
    Xu Feng
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    IUBMB Life 57:389-95. 2005
  2. ncbi Regulatory roles and molecular signaling of TNF family members in osteoclasts
    Xu Feng
    Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
    Gene 350:1-13. 2005
  3. ncbi Involvement of upstream stimulatory factors 1 and 2 in RANKL-induced transcription of tartrate-resistant acid phosphatase gene during osteoclast differentiation
    Yi Liu
    Department of Pathology, The University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 278:20603-11. 2003
  4. ncbi A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineage
    Duorong Xu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 281:4678-90. 2006
  5. ncbi YY1 is involved in RANKL-induced transcription of the tartrate-resistant acid phosphatase gene in osteoclast differentiation
    Zhenqi Shi
    Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
    Gene 343:117-26. 2004
  6. ncbi Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4
    Wei Liu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 280:43064-72. 2005
  7. ncbi Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and function
    Wei Liu
    Department of Pathology, University of Alabama at Birmingham, Alabama 35294, USA
    J Biol Chem 279:54759-69. 2004
  8. pmc Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis
    Joel Jules
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 287:15728-38. 2012
  9. pmc Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesis
    Jing Cheng
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Interferon Cytokine Res 32:34-45. 2012
  10. pmc Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535-538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesis
    Joel Jules
    Department of Pathology, University of Alabama at Birmingham, Alabama 35294, USA
    J Biol Chem 285:37427-35. 2010

Collaborators

Detail Information

Publications48

  1. ncbi RANKing intracellular signaling in osteoclasts
    Xu Feng
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    IUBMB Life 57:389-95. 2005
    ..This review is focused on discussing the current understanding of RANK signaling and signaling crosstalk between RANK and the various factors in osteoclasts...
  2. ncbi Regulatory roles and molecular signaling of TNF family members in osteoclasts
    Xu Feng
    Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
    Gene 350:1-13. 2005
    ..This review will focus on our current understanding of the regulatory roles and molecular signaling of these TNF family members in osteoclasts...
  3. ncbi Involvement of upstream stimulatory factors 1 and 2 in RANKL-induced transcription of tartrate-resistant acid phosphatase gene during osteoclast differentiation
    Yi Liu
    Department of Pathology, The University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 278:20603-11. 2003
    ..In summary, our data show that USF1 and USF2 play a functional role in RANKL-dependent TRAP expression during osteoclast differentiation...
  4. ncbi A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineage
    Duorong Xu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 281:4678-90. 2006
    ....
  5. ncbi YY1 is involved in RANKL-induced transcription of the tartrate-resistant acid phosphatase gene in osteoclast differentiation
    Zhenqi Shi
    Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
    Gene 343:117-26. 2004
    ..In conclusion, our data demonstrated that YY1 plays a functional role in RANKL-mediated TRAP gene expression during osteoclast differentiation...
  6. ncbi Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4
    Wei Liu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 280:43064-72. 2005
    ..Taken together, we conclude that Motif 1 plays a predominant role in mediating osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4...
  7. ncbi Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and function
    Wei Liu
    Department of Pathology, University of Alabama at Birmingham, Alabama 35294, USA
    J Biol Chem 279:54759-69. 2004
    ....
  8. pmc Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis
    Joel Jules
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 287:15728-38. 2012
    ..This study reveals a novel mechanism of IL-1-mediated osteoclastogenesis and supports the promising potential of the IVVY motif to serve as a therapeutic target for inflammatory bone loss...
  9. pmc Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesis
    Jing Cheng
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Interferon Cytokine Res 32:34-45. 2012
    ..Taken together, these findings provide important mechanistic insights into the biphasic effects of IFN-γ on osteoclastogenesis...
  10. pmc Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535-538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesis
    Joel Jules
    Department of Pathology, University of Alabama at Birmingham, Alabama 35294, USA
    J Biol Chem 285:37427-35. 2010
    ....
  11. ncbi Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells
    Jianzhong Liu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Cell Biochem 96:716-27. 2005
    ..Moreover, the mutation of both sites abrogated the RANKL basal promoter activity, indicating that Sp1 and Sp3 play a key role in the RANKL basal transcription in osteoblasts and bone marrow stromal cells...
  12. pmc Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: a novel mechanism mediating its blockade of osteoclastogenesis
    Jing Cheng
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    J Cell Biochem 112:3385-92. 2011
    ..The inhibitory effect is ultimately regulated at the gene expression transcriptional level...
  13. pmc Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts
    Jason W Ashley
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e25838. 2011
    ..These findings demonstrate a role for CD68 in the function of osteoclasts, and future studies will determine the mechanistic nature of the defects seen in CD68(-/-) osteoclasts...
  14. pmc Development of a chimaeric receptor approach to study signalling by tumour necrosis factor receptor family members
    Duorong Xu
    Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
    Biochem J 383:219-25. 2004
    ..Moreover, we also showed that the chimaeric receptor approach can be used to study signalling at any stage of cell differentiation or function...
  15. pmc Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis
    Yabing Chen
    Department of Pathology, University of Alabama at Birmingham and Veterans Affairs Medical Center, Birmingham, Alabama 35294, USA
    J Biol Chem 283:29593-601. 2008
    ..Taken together, PLCgamma2 is essential for RANK signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation...
  16. pmc Interleukin-3 plays dual roles in osteoclastogenesis by promoting the development of osteoclast progenitors but inhibiting the osteoclastogenic process
    Huixian Hong
    Department of Hematology, Guangzhou First People s Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem Biophys Res Commun 440:545-50. 2013
    ..These findings provide a better understanding of the role of IL-3 in osteoclastogenesis. ..
  17. pmc IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells
    Erin M McCoy
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Cancer 13:16. 2013
    ..This work aims to further investigate the role of IL-11 in metastasis-induced osteolysis by addressing a new hypothesis that IL-11 exerts effects on osteoclast progenitor cells...
  18. pmc Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis
    Jianzhong Liu
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 284:12512-23. 2009
    ....
  19. ncbi Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis
    Yalei Wu
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Arthritis Rheum 52:3257-68. 2005
    ..This study was undertaken to explore the roles of hyperproliferating synovial fibroblasts and macrophages in abnormal osteoclast formation, using the recently described BXD2 mouse model of RA...
  20. ncbi The role of calmodulin in the regulation of osteoclastogenesis
    Liang Zhang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Endocrinology 144:4536-43. 2003
    ..Taken together, our data indicate that calmodulin mediates osteoclast differentiation, possibly via modulating specific receptor activator of NF-kappaB-signaling pathways...
  21. ncbi Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2
    Shuxia Wang
    Department of Pathology, Division of Molecular and Cellular Pathology, The Cell Adhesion and Matrix Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    J Biol Chem 279:34311-22. 2004
    ....
  22. pmc TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB
    Ping Zhang
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 286:24159-69. 2011
    ..Our findings reveal novel aspects of the interactions between TLR and RANK signaling and provide a new model for understanding the mechanism underlying the pathogenesis of bacteria-mediated bone loss...
  23. pmc Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine model
    James J Cody
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Lab Invest 93:268-78. 2013
    ..In a murine model, progression of advanced prostate cancer bone metastases was inhibited by treatment with Ad5-Δ24-sOPG-Fc-RGD but not by an unarmed control CRAd...
  24. pmc TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
    Yi Tang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Med 15:757-65. 2009
    ..Thus, as TGF-beta1 functions to couple bone resorption and formation, modulation of TGF-beta1 activity could be an effective treatment for bone remodeling diseases...
  25. pmc Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer
    Anandi Sawant
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 2182, USA
    Cancer Res 73:672-82. 2013
    ..Overall, our results identify a wholly new facet to the multifunctionality of MDSC in driving tumor progression, in this case as a novel osteoclast progenitor that specifically drives bone metastasis during cancer progression...
  26. ncbi High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animals
    Hee Kyung Kim
    Department of Dermatology, University of Alabama at Birmingham, VH 566B, 1670 University Blvd, Birmingham, AL 35294, USA
    J Leukoc Biol 79:686-95. 2006
    ..The ability of B7-H1/DC to inhibit the function of preactivated T cells in vivo suggests novel strategies for the treatment of immune response-mediated disorders...
  27. ncbi Osteoclast apoptosis: the role of Fas in vivo and in vitro
    Xiaojun Wu
    Department of Pathology, Nutrition Sciences, University of Alabama at Birmingham, Alabama 35294 0007, USA
    Endocrinology 144:5545-55. 2003
    ..Taken together, these data demonstrate that the Fas/Fas ligand system is important in the regulation of bone turnover and may represent a critical link between the immune system and bone remodeling in development and in various diseases...
  28. doi R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
    Wenyan Lu
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA
    FEBS Lett 582:643-50. 2008
    ..Finally, we demonstrated that Rspo1 synergized with Wnt3A to induce primary mouse osteoblast differentiation. Together, these findings suggest that Rpos1 may play an important role in bone remodeling...
  29. pmc Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing
    Shunqing Wang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Biotechnol 6:50. 2006
    ..However, most of the available vectors contain only one siRNA expression cassette...
  30. pmc Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling
    Jason W Ashley
    Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35294, USA
    Assay Drug Dev Technol 9:40-9. 2011
    ..55. Our assays will be used to screen compound libraries for molecules that exhibit inhibitory activity. Follow-up assays will refine hits to a smaller group of more specific inhibitors of RANK signaling...
  31. pmc Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis
    Joel Jules
    University of Alabama at Birmingham, Department of Pathology, 35294, USA
    Expert Opin Ther Targets 14:923-34. 2010
    ..Take home message: Several RANK signaling components have the potential to serve as potent and specific therapeutic targets for osteoporosis...
  32. pmc Disorders of bone remodeling
    Xu Feng
    Department of Pathology, Center for Metabolic Bone Disease, The University of Alabama at Birmingham, 35294 0007, USA
    Annu Rev Pathol 6:121-45. 2011
    ..We review the major diseases of bone remodeling, emphasizing our current understanding of the underlying pathophysiological mechanisms...
  33. ncbi PYK2 and FAK in osteoclasts
    Wen Cheng Xiong
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Front Biosci 8:d1219-26. 2003
    ..Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review...
  34. ncbi In vitro investigation of the roles of the proinflammatory cytokines tumor necrosis factor-α and interleukin-1 in murine osteoclastogenesis
    Joel Jules
    Department of Pathology, University of Alabama at Birmingham, Shelby Building, Room 870, 1825 University Blvd, Birmingham, AL, 35294, USA
    Methods Mol Biol 1155:109-23. 2014
    ..Moreover, this method can be used to further elucidate the signaling mechanisms by which these two cytokines act in concert with RANKL or with each other to modulate osteoclastogenesis. ..
  35. pmc Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin
    Qiang Wang
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Cell Biol 160:565-75. 2003
    ..Together, our results suggest that PYK2 is a regulator of gelsolin, revealing a novel PYK2-gelsolin pathway in regulating actin cytoskeletal organization in multiple cells, including osteoclasts...
  36. ncbi PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4
    Ulrich Kintscher
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, School of Medicine, Los Angeles, Calif 90095, USA
    Circ Res 91:e35-44. 2002
    ..The full text of this article is available at http://www.circresaha.org...
  37. ncbi AZT enhances osteoclastogenesis and bone loss
    George Pan
    The Department of Pathology, The University of Alabama at Birmingham, 35294 0007, USA
    AIDS Res Hum Retroviruses 20:608-20. 2004
    ..Bone mineral density (BMD) in AZT-treated mice is decreased and histopathology shows marked osteopenia. These results support an important role of AZT-stimulated osteoclastogenesis in HAART-induced osteopenia...
  38. ncbi Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function
    Xu Feng
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 143:4868-74. 2002
    ..Thus, we have identified specific tyrosine residues in the cytoplasmic tail of c-Fms that are critical for transmitting M-CSF-initiated signals individually required for OC formation or function, respectively...
  39. ncbi Osteoclastogenesis: the role of calcium and calmodulin
    Liang Zhang
    Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, Rockford, IL 61107, USA
    Crit Rev Eukaryot Gene Expr 15:1-13. 2005
    ..Collectively, these reports highlight the importance of Ca2+/calmodulin signaling in osteoclastogenesis, which may present novel targets for the new therapeutic agents to combat bone loss...
  40. ncbi Thyroid hormone action at the cellular, genomic and target gene levels
    Paul M Yen
    Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue Rm B114, Baltimore, MD, USA
    Mol Cell Endocrinol 246:121-7. 2006
    ....
  41. pmc Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators
    Taixing Cui
    Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:35686-98. 2006
    ..These observations indicate that nitroalkenes such as LNO2 and OA-NO2, derived from reactions of unsaturated fatty acids and oxides of nitrogen, are a class of endogenous anti-inflammatory mediators...
  42. pmc Regulation of osteoclast function and bone mass by RAGE
    Zheng Zhou
    Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, GA, 30912, USA
    J Exp Med 203:1067-80. 2006
    ....
  43. ncbi [The effects of two TCM prescriptions, Tonifying Kidney and Strengthening Vital Energy, on NF-kappaB activing in aged mouse T cells]
    Shu xia Song
    Department of Experimental Zoology, Hebei Medical University, Shijiazhuang 050017, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:239-41. 2004
    ..The aim of the present study was to explore the immunologic mechanism of delaying senescence by Strengthening Vital Energy(SVE), Tonifying Kidney (TK) and combined TK and SVE...
  44. pmc Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice
    Paul M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Room 8D12, Building 10, Bethesda, MD 20892, USA
    EMBO Rep 4:581-7. 2003
    ..This large-scale study of hormonal regulation reveals the functions of Th and of Tr isoforms in the regulation of gene expression patterns...
  45. ncbi Cell-based assay strategy for identification of motif-specific RANK signaling pathway inhibitors
    Taosheng Chen
    Lead Discovery and Profiling, Bristol Myers Squibb Company, Wallingford, CT 06492, USA
    Assay Drug Dev Technol 4:473-82. 2006
    ....
  46. ncbi Sex-related differences in neuronal cell survival and signaling in rats
    Lei Zhang
    Behavioral Endocrinology Branch, National Institute of Mental Health, NIH, Building 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda, MD 20892 1276, USA
    Neurosci Lett 337:65-8. 2003
    ..Further, the appearance of sex-related differences at cellular and signaling levels in cortical neuronal cultures demonstrates that the effects of gender are not limited to parts of the brain mediating reproduction...
  47. ncbi AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase
    Yi Zang
    National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Biol Chem 283:6201-8. 2008
    ..Taken together, these results suggest that the astroglial differentiation effect of AICAR on neural stem cells was acting independently of AMPK and that the JAK-STAT3 pathway is essential for the gliogenic effect of AICAR...
  48. pmc HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE
    Zheng Zhou
    Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, Georgia GA 30912, USA
    J Bone Miner Res 23:1084-96. 2008
    ..Taken together, these observations show a novel function of HMGB1 in osteoclastogenesis and provide a new link between inflammatory mechanisms and bone resorption...