Research Topics
Genomes and Genes
| Xu FengSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
| Collaborators
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Detail Information
Publications
Regulatory roles and molecular signaling of TNF family members in osteoclastsXu Feng
Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
Gene 350:1-13. 2005..This review will focus on our current understanding of the regulatory roles and molecular signaling of these TNF family members in osteoclasts...- Involvement of upstream stimulatory factors 1 and 2 in RANKL-induced transcription of tartrate-resistant acid phosphatase gene during osteoclast differentiationYi Liu
Department of Pathology, The University of Alabama, Birmingham, Alabama 35294, USA
J Biol Chem 278:20603-11. 2003..In summary, our data show that USF1 and USF2 play a functional role in RANKL-dependent TRAP expression during osteoclast differentiation... - RANKing intracellular signaling in osteoclastsXu Feng
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
IUBMB Life 57:389-95. 2005..This review is focused on discussing the current understanding of RANK signaling and signaling crosstalk between RANK and the various factors in osteoclasts... - A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineageDuorong Xu
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 281:4678-90. 2006.... - YY1 is involved in RANKL-induced transcription of the tartrate-resistant acid phosphatase gene in osteoclast differentiationZhenqi Shi
Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
Gene 343:117-26. 2004..In conclusion, our data demonstrated that YY1 plays a functional role in RANKL-mediated TRAP gene expression during osteoclast differentiation... - Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4Wei Liu
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 280:43064-72. 2005..Taken together, we conclude that Motif 1 plays a predominant role in mediating osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4... - Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and functionWei Liu
Department of Pathology, University of Alabama at Birmingham, Alabama 35294, USA
J Biol Chem 279:54759-69. 2004.... 
Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesisJoel Jules
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 287:15728-38. 2012..This study reveals a novel mechanism of IL-1-mediated osteoclastogenesis and supports the promising potential of the IVVY motif to serve as a therapeutic target for inflammatory bone loss...- Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesisJing Cheng
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Interferon Cytokine Res 32:34-45. 2012..Taken together, these findings provide important mechanistic insights into the biphasic effects of IFN-γ on osteoclastogenesis... - Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535-538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesisJoel Jules
Department of Pathology, University of Alabama at Birmingham, Alabama 35294, USA
J Biol Chem 285:37427-35. 2010.... - Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cellsJianzhong Liu
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Cell Biochem 96:716-27. 2005..Moreover, the mutation of both sites abrogated the RANKL basal promoter activity, indicating that Sp1 and Sp3 play a key role in the RANKL basal transcription in osteoblasts and bone marrow stromal cells... 
Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: a novel mechanism mediating its blockade of osteoclastogenesisJing Cheng
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
J Cell Biochem 112:3385-92. 2011..The inhibitory effect is ultimately regulated at the gene expression transcriptional level...- Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclastsJason W Ashley
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 6:e25838. 2011..These findings demonstrate a role for CD68 in the function of osteoclasts, and future studies will determine the mechanistic nature of the defects seen in CD68(-/-) osteoclasts... - Development of a chimaeric receptor approach to study signalling by tumour necrosis factor receptor family membersDuorong Xu
Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
Biochem J 383:219-25. 2004..Moreover, we also showed that the chimaeric receptor approach can be used to study signalling at any stage of cell differentiation or function... - Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesisYabing Chen
Department of Pathology, University of Alabama at Birmingham and Veterans Affairs Medical Center, Birmingham, Alabama 35294, USA
J Biol Chem 283:29593-601. 2008..Taken together, PLCgamma2 is essential for RANK signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation... - Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritisYalei Wu
University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Arthritis Rheum 52:3257-68. 2005..This study was undertaken to explore the roles of hyperproliferating synovial fibroblasts and macrophages in abnormal osteoclast formation, using the recently described BXD2 mouse model of RA... - Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesisJianzhong Liu
Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
J Biol Chem 284:12512-23. 2009.... - The role of calmodulin in the regulation of osteoclastogenesisLiang Zhang
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Endocrinology 144:4536-43. 2003..Taken together, our data indicate that calmodulin mediates osteoclast differentiation, possibly via modulating specific receptor activator of NF-kappaB-signaling pathways... - Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2Shuxia Wang
Department of Pathology, Division of Molecular and Cellular Pathology, The Cell Adhesion and Matrix Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
J Biol Chem 279:34311-22. 2004.... - TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaBPing Zhang
Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 286:24159-69. 2011..Our findings reveal novel aspects of the interactions between TLR and RANK signaling and provide a new model for understanding the mechanism underlying the pathogenesis of bacteria-mediated bone loss... - TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formationYi Tang
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Nat Med 15:757-65. 2009..Thus, as TGF-beta1 functions to couple bone resorption and formation, modulation of TGF-beta1 activity could be an effective treatment for bone remodeling diseases... - High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animalsHee Kyung Kim
Department of Dermatology, University of Alabama at Birmingham, VH 566B, 1670 University Blvd, Birmingham, AL 35294, USA
J Leukoc Biol 79:686-95. 2006..The ability of B7-H1/DC to inhibit the function of preactivated T cells in vivo suggests novel strategies for the treatment of immune response-mediated disorders... - R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expressionWenyan Lu
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA
FEBS Lett 582:643-50. 2008..Finally, we demonstrated that Rspo1 synergized with Wnt3A to induce primary mouse osteoblast differentiation. Together, these findings suggest that Rpos1 may play an important role in bone remodeling... - Osteoclast apoptosis: the role of Fas in vivo and in vitroXiaojun Wu
Department of Pathology, Nutrition Sciences, University of Alabama at Birmingham, Alabama 35294-0007, USA
Endocrinology 144:5545-55. 2003..Taken together, these data demonstrate that the Fas/Fas ligand system is important in the regulation of bone turnover and may represent a critical link between the immune system and bone remodeling in development and in various diseases... 
Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencingShunqing Wang
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
BMC Biotechnol 6:50. 2006..However, most of the available vectors contain only one siRNA expression cassette...- Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signalingJason W Ashley
Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35294, USA
Assay Drug Dev Technol 9:40-9. 2011..55. Our assays will be used to screen compound libraries for molecules that exhibit inhibitory activity. Follow-up assays will refine hits to a smaller group of more specific inhibitors of RANK signaling... - Disorders of bone remodelingXu Feng
Department of Pathology, Center for Metabolic Bone Disease, The University of Alabama at Birmingham, 35294 0007, USA
Annu Rev Pathol 6:121-45. 2011..We review the major diseases of bone remodeling, emphasizing our current understanding of the underlying pathophysiological mechanisms... - Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosisJoel Jules
University of Alabama at Birmingham, Department of Pathology, 35294, USA
Expert Opin Ther Targets 14:923-34. 2010..Take home message: Several RANK signaling components have the potential to serve as potent and specific therapeutic targets for osteoporosis... - PYK2 and FAK in osteoclastsWen-Cheng Xiong
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Front Biosci 8:d1219-26. 2003..Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review... - Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolinQiang Wang
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Cell Biol 160:565-75. 2003..Together, our results suggest that PYK2 is a regulator of gelsolin, revealing a novel PYK2-gelsolin pathway in regulating actin cytoskeletal organization in multiple cells, including osteoclasts... - Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and functionXu Feng
Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Endocrinology 143:4868-74. 2002..Thus, we have identified specific tyrosine residues in the cytoplasmic tail of c-Fms that are critical for transmitting M-CSF-initiated signals individually required for OC formation or function, respectively... - PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4Ulrich Kintscher
Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, School of Medicine, Los Angeles, Calif 90095, USA
Circ Res 91:e35-44. 2002..The full text of this article is available at http://www.circresaha.org... - AZT enhances osteoclastogenesis and bone lossGeorge Pan
The Department of Pathology, The University of Alabama at Birmingham, 35294-0007, USA
AIDS Res Hum Retroviruses 20:608-20. 2004..Bone mineral density (BMD) in AZT-treated mice is decreased and histopathology shows marked osteopenia. These results support an important role of AZT-stimulated osteoclastogenesis in HAART-induced osteopenia... - Osteoclastogenesis: the role of calcium and calmodulinLiang Zhang
Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, Rockford, IL 61107, USA
Crit Rev Eukaryot Gene Expr 15:1-13. 2005..Collectively, these reports highlight the importance of Ca2+/calmodulin signaling in osteoclastogenesis, which may present novel targets for the new therapeutic agents to combat bone loss... - Regulation of osteoclast function and bone mass by RAGEZheng Zhou
Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, GA, 30912, USA
J Exp Med 203:1067-80. 2006.... - Thyroid hormone action at the cellular, genomic and target gene levelsPaul M Yen
Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue Rm B114, Baltimore, MD, USA
Mol Cell Endocrinol 246:121-7. 2006.... - Nitrated fatty acids: Endogenous anti-inflammatory signaling mediatorsTaixing Cui
Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Biol Chem 281:35686-98. 2006..These observations indicate that nitroalkenes such as LNO2 and OA-NO2, derived from reactions of unsaturated fatty acids and oxides of nitrogen, are a class of endogenous anti-inflammatory mediators... - Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout micePaul M Yen
Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Room 8D12, Building 10, Bethesda, MD 20892, USA
EMBO Rep 4:581-7. 2003..This large-scale study of hormonal regulation reveals the functions of Th and of Tr isoforms in the regulation of gene expression patterns... - Cell-based assay strategy for identification of motif-specific RANK signaling pathway inhibitorsTaosheng Chen
Lead Discovery and Profiling, Bristol Myers Squibb Company, Wallingford, CT 06492, USA
Assay Drug Dev Technol 4:473-82. 2006.... - [The effects of two TCM prescriptions, Tonifying Kidney and Strengthening Vital Energy, on NF-kappaB activing in aged mouse T cells]Shu xia Song
Department of Experimental Zoology, Hebei Medical University, Shijiazhuang 050017, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:239-41. 2004..The aim of the present study was to explore the immunologic mechanism of delaying senescence by Strengthening Vital Energy(SVE), Tonifying Kidney (TK) and combined TK and SVE... - Sex-related differences in neuronal cell survival and signaling in ratsLei Zhang
Behavioral Endocrinology Branch, National Institute of Mental Health, NIH, Building 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda, MD 20892 1276, USA
Neurosci Lett 337:65-8. 2003..Further, the appearance of sex-related differences at cellular and signaling levels in cortical neuronal cultures demonstrates that the effects of gender are not limited to parts of the brain mediating reproduction... - AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinaseYi Zang
National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
J Biol Chem 283:6201-8. 2008..Taken together, these results suggest that the astroglial differentiation effect of AICAR on neural stem cells was acting independently of AMPK and that the JAK-STAT3 pathway is essential for the gliogenic effect of AICAR... - HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGEZheng Zhou
Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, Georgia GA 30912, USA
J Bone Miner Res 23:1084-96. 2008..Taken together, these observations show a novel function of HMGB1 in osteoclastogenesis and provide a new link between inflammatory mechanisms and bone resorption...