Research Topics
Genomes and Genes | Wei FengSummaryAffiliation: University of California Country: USA Publications
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Publications
Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1Wei Feng
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Cell Calcium 43:307-14. 2008..These data provide a mechanism by which constitutively and transiently expressed H1 forms can tightly regulate RyR1 channel activity in response to changing levels of expression and degradation of H1 proteins...- Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1)Wei Feng
Department of Molecular Biosciences, University of California, Davis, 95616, United States of America
Biochem Pharmacol 80:512-21. 2010..The results identify RyR1 as a sensitive target for the major tea catechins EGCG and ECG, and this interaction is likely to contribute to their observed biological activities... - Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantroleneGennady Cherednichenko
Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
Mol Pharmacol 73:1203-12. 2008..The inhibitory potency of dantrolene on ECCE found in wild-type and MH-susceptible muscle is consistent with the drug's clinical potency for reversing the MH syndrome and is incomplete as predicted by its efficacy as a muscle relaxant... - Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscleGenaro C Barrientos
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
J Biol Chem 287:2863-76. 2012..Considering that both Het and Hom T4826I-RYR1 mice are viable, the remarkable isolated single channel dysfunction mediated through this mutation in S4-S5 cytoplasmic linker must be highly regulated in vivo... 
Homer regulates gain of ryanodine receptor type 1 channel complexWei Feng
Department of Molecular Biosciences, University of California, Davis, California 95616, USA
J Biol Chem 277:44722-30. 2002..This form of regulation may be important in other cell types that express Homer and RyR1...- Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechinWei Feng
Department of Molecular Biosciences, University of California, Davis, California, USA
Mol Pharmacol 82:993-1000. 2012.... - Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible miceWei Feng
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Mol Pharmacol 79:420-31. 2011..Dysregulated R163C channels produce a more overt phenotype in myotubes than in adult fibers in the absence of triggering agents, suggesting tighter negative regulation of R163C-RyR1 within the Ca(2+) release unit of adult fibers... - Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damageBenjamin Yuen
Department of Veterinary Molecular Biosciences, University of California, Davis, California, USA
FASEB J 26:1311-22. 2012..These data demonstrate that an MHS mutation within the S4-S5 cytoplasmic linker of RYR1 confers genotype- and sex-dependent susceptibility to pharmacological and environmental stressors that trigger fulminant MH and promote myopathy... - Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscleGennady Cherednichenko
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 109:14158-63. 2012.... - NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium releaseGennady Cherednichenko
Department of Molecular Biosciences, Northern California Health Care System, University of California, Davis, Calif 95616, USA
Circ Res 94:478-86. 2004.... - Detection of redox sensor of ryanodine receptor complexesWei Feng
Department of Molecular Biosciences, University of California, Davis, California 95616, USA
Methods Enzymol 353:240-53. 2002 - Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2Isaac N Pessah
Department of VM, Molecular Biosciences and UC Davis Center for Children s Environmental Health, University of California, One Shields Avenue, Davis, California 95616, USA
Chem Res Toxicol 22:201-7. 2009..Evidence for enantioselective enrichment of PCBs in biological tissues that express RyR1 and RyR2channels may provide new mechanistic leads about their toxicological impacts on human health.. - Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptorsTram Anh Ta
Center for Children s Environmental Health, University of California, Davis, 95616, USA
Mol Pharmacol 69:532-8. 2006..Hydroxylated bis-oxaquinolizadine derivatives isolated from Xestospongia species are novel bifunctional reagents that may be useful in ascertaining how IP(3)Rs and RyRs contribute to cell signaling... - Redox sensing properties of the ryanodine receptor complexIsaac N Pessah
Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
Front Biosci 7:a72-9. 2002..New data is presented that directly measure the pKa of hyperreactive thiols that occur when the closed conformation of the RyR channel complex is assumed, and that appear to be an integral component of the redox sensor... - The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channelsGenaro Barrientos
Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
Mol Pharmacol 76:560-8. 2009..Our results identify that KB-R7943 is a reversible, activity-dependent blocker of the two most broadly expressed RyR channel isoforms and contributes to its pharmacological and therapeutic activities... - Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptorsChristophe Morisseau
Department of Entomology and Cancer Center, University of California at Davis, Davis, California 95616, USA
Environ Health Perspect 117:1867-72. 2009..Whole-animal toxicologic studies cannot yield the necessary throughput in a cost-effective fashion, leading to a critical need for a faster and more cost-effective toxicologic evaluation of xenobiotics... 
Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in fathead minnow (Pimephales promelas)Erika B Fritsch
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Environ Sci Technol 47:2008-17. 2013..These results support TCS's impact on muscle function in vertebrates further exemplifying the need to re-evaluate the risks this pollutant poses to aquatic environments...- PDZ domains of Par-3 as potential phosphoinositide signaling integratorsHao Wu
Department of Biochemistry, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P R China
Mol Cell 28:886-98. 2007..The concatenation of the PIP-binding PDZ2 and the lipid phosphatase PTEN-binding PDZ3 endows Par-3 as an ideal scaffold protein for integrating PIP signaling events during cellular polarization... - Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction couplingWei Feng
Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
Biophys J 82:2428-35. 2002..In either case, Ca2+ activation of RyR1 does not appear to be necessary for the initiation of Ca2+ release during EC coupling in skeletal muscle... - Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscleChristopher W Ward
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 279:5781-7. 2004.... - Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1James D Fessenden
Department of Anesthesia Research, Brigham and Women s Hospital, Boston, MA 02115, USA
J Biol Chem 279:53028-35. 2004..However, in [(3)H]ryanodine binding experiments, the Ca(2+)-dependent activation and inactivation of mutated RyRs containing EF3, EF4, or EF5 was unaffected when compared with wtRyR1... - PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface areaWei Feng
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
J Biol Chem 277:41140-6. 2002..Our data uncover a novel PDZ domain-mediated protein interaction mode that may be responsible for multimerization of other PDZ domain-containing scaffold proteins... - Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target bindingWei Feng
Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People's Republic of China
Nat Struct Biol 10:972-8. 2003..PDZ4 contains a deformed aB-bB groove that is unlikely to bind to carboxyl peptides. Instead, the domain stabilizes the structure of PDZ5... - [Osteogenesis of rabbit skin fibroblast transfected with core binding factor a1/osteoblast specific transplanting factor-2 gene]De-Chang Xiao
Department of Orthopaedic, Ruijin Hospital, Shanghai Second University, Shanghai 200025, China
Zhonghua Wai Ke Za Zhi 43:247-51. 2005..CONCLUSIONS: New Zealand rabbit skin fibroblasts transfected with pSG5-Cbfa1/Osf2 can express osteogenesis-related genes and proteins, and form ossification nodules on their surface... - A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteinsWei Feng
Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Proc Natl Acad Sci U S A 102:6861-6. 2005..Our results provide a unified picture for L27 domain-mediated protein-protein interactions... - Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresolJames D Fessenden
Department of Anesthesia Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 281:21022-31. 2006.... - Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channelsDelavar Shahbazzadeh
Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, 13 Place Pasteur, Tunis, BP 74, 1002 Tunisia
Biochem J 404:89-96. 2007..Overall, these data identify a new biologically active toxin that belongs to a family of peptides active on the ryanodine-sensitive channel... - Analyses of very early hemopoietic regeneration after bone marrow transplantation: comparison of intravenous and intrabone marrow routesQing Li
First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
Stem Cells 25:1186-94. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Transmembrane TNF-alpha mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt lymphoma cellsHailong Zhang
Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, Hubei, 430030, PR China
J Leukoc Biol 84:789-97. 2008..On the contrary, tmTNF-alpha, when acting as a ligand, inhibits NF-kappaB activity through forward signaling, which is inclined to induce tumor cell death... - Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishmentWei Feng
Department of Biochemistry, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
J Biol Chem 283:23440-9. 2008..These results, together with earlier data, firmly establish that Par-3 functions as a scaffold in integrating phosphoinositide signaling events during cellular polarization... - Oleandrin produces changes in intracellular calcium levels in isolated cardiomyocytes: a real-time fluorescence imaging study comparing adult to neonatal cardiomyocytesBrian J Poindexter
Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Texas 77030, USA
J Toxicol Environ Health A 70:568-74. 2007..6.1.3], and/or dysfunction of sarcolemmal calcium release channels... - Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1Jiafu Long
Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
J Mol Biol 375:1457-68. 2008.... - The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localizationWei Feng
Department of Biochemistry, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
EMBO J 26:2786-96. 2007....