Wei Feng

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1
    Wei Feng
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Cell Calcium 43:307-14. 2008
  2. pmc Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1)
    Wei Feng
    Department of Molecular Biosciences, University of California, Davis, 95616, United States of America
    Biochem Pharmacol 80:512-21. 2010
  3. pmc Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene
    Gennady Cherednichenko
    Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
    Mol Pharmacol 73:1203-12. 2008
  4. pmc Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle
    Genaro C Barrientos
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 287:2863-76. 2012
  5. ncbi request reprint Homer regulates gain of ryanodine receptor type 1 channel complex
    Wei Feng
    Department of Molecular Biosciences, University of California, Davis, California 95616, USA
    J Biol Chem 277:44722-30. 2002
  6. pmc Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin
    Wei Feng
    Department of Molecular Biosciences, University of California, Davis, California, USA
    Mol Pharmacol 82:993-1000. 2012
  7. pmc Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice
    Wei Feng
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Mol Pharmacol 79:420-31. 2011
  8. pmc Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage
    Benjamin Yuen
    Department of Veterinary Molecular Biosciences, University of California, Davis, California, USA
    FASEB J 26:1311-22. 2012
  9. pmc Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle
    Gennady Cherednichenko
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:14158-63. 2012
  10. ncbi request reprint NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release
    Gennady Cherednichenko
    Department of Molecular Biosciences, Northern California Health Care System, University of California, Davis, Calif 95616, USA
    Circ Res 94:478-86. 2004

Collaborators

Detail Information

Publications34

  1. pmc Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1
    Wei Feng
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Cell Calcium 43:307-14. 2008
    ..These data provide a mechanism by which constitutively and transiently expressed H1 forms can tightly regulate RyR1 channel activity in response to changing levels of expression and degradation of H1 proteins...
  2. pmc Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1)
    Wei Feng
    Department of Molecular Biosciences, University of California, Davis, 95616, United States of America
    Biochem Pharmacol 80:512-21. 2010
    ..The results identify RyR1 as a sensitive target for the major tea catechins EGCG and ECG, and this interaction is likely to contribute to their observed biological activities...
  3. pmc Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene
    Gennady Cherednichenko
    Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
    Mol Pharmacol 73:1203-12. 2008
    ..The inhibitory potency of dantrolene on ECCE found in wild-type and MH-susceptible muscle is consistent with the drug's clinical potency for reversing the MH syndrome and is incomplete as predicted by its efficacy as a muscle relaxant...
  4. pmc Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle
    Genaro C Barrientos
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 287:2863-76. 2012
    ..Considering that both Het and Hom T4826I-RYR1 mice are viable, the remarkable isolated single channel dysfunction mediated through this mutation in S4-S5 cytoplasmic linker must be highly regulated in vivo...
  5. ncbi request reprint Homer regulates gain of ryanodine receptor type 1 channel complex
    Wei Feng
    Department of Molecular Biosciences, University of California, Davis, California 95616, USA
    J Biol Chem 277:44722-30. 2002
    ..This form of regulation may be important in other cell types that express Homer and RyR1...
  6. pmc Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin
    Wei Feng
    Department of Molecular Biosciences, University of California, Davis, California, USA
    Mol Pharmacol 82:993-1000. 2012
    ....
  7. pmc Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice
    Wei Feng
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Mol Pharmacol 79:420-31. 2011
    ..Dysregulated R163C channels produce a more overt phenotype in myotubes than in adult fibers in the absence of triggering agents, suggesting tighter negative regulation of R163C-RyR1 within the Ca(2+) release unit of adult fibers...
  8. pmc Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage
    Benjamin Yuen
    Department of Veterinary Molecular Biosciences, University of California, Davis, California, USA
    FASEB J 26:1311-22. 2012
    ..These data demonstrate that an MHS mutation within the S4-S5 cytoplasmic linker of RYR1 confers genotype- and sex-dependent susceptibility to pharmacological and environmental stressors that trigger fulminant MH and promote myopathy...
  9. pmc Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle
    Gennady Cherednichenko
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:14158-63. 2012
    ....
  10. ncbi request reprint NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release
    Gennady Cherednichenko
    Department of Molecular Biosciences, Northern California Health Care System, University of California, Davis, Calif 95616, USA
    Circ Res 94:478-86. 2004
    ....
  11. ncbi request reprint Detection of redox sensor of ryanodine receptor complexes
    Wei Feng
    Department of Molecular Biosciences, University of California, Davis, California 95616, USA
    Methods Enzymol 353:240-53. 2002
  12. pmc Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in fathead minnow (Pimephales promelas)
    Erika B Fritsch
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Environ Sci Technol 47:2008-17. 2013
    ..These results support TCS's impact on muscle function in vertebrates further exemplifying the need to re-evaluate the risks this pollutant poses to aquatic environments...
  13. pmc Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2
    Isaac N Pessah
    Department of VM, Molecular Biosciences and UC Davis Center for Children s Environmental Health, University of California, One Shields Avenue, Davis, California 95616, USA
    Chem Res Toxicol 22:201-7. 2009
    ..Evidence for enantioselective enrichment of PCBs in biological tissues that express RyR1 and RyR2channels may provide new mechanistic leads about their toxicological impacts on human health..
  14. ncbi request reprint Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptors
    Tram Anh Ta
    Center for Children s Environmental Health, University of California, Davis, 95616, USA
    Mol Pharmacol 69:532-8. 2006
    ..Hydroxylated bis-oxaquinolizadine derivatives isolated from Xestospongia species are novel bifunctional reagents that may be useful in ascertaining how IP(3)Rs and RyRs contribute to cell signaling...
  15. pmc Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction
    Yassaman Niknam
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616
    Toxicol Sci 136:500-13. 2013
    ..NDL-PCBs and their 5-OH and 4-OH metabolites differentially influence RyR1 channel activity and ECC in embryonic skeletal muscle...
  16. pmc The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels
    Genaro Barrientos
    Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
    Mol Pharmacol 76:560-8. 2009
    ..Our results identify that KB-R7943 is a reversible, activity-dependent blocker of the two most broadly expressed RyR channel isoforms and contributes to its pharmacological and therapeutic activities...
  17. ncbi request reprint Redox sensing properties of the ryanodine receptor complex
    Isaac N Pessah
    Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
    Front Biosci 7:a72-9. 2002
    ..New data is presented that directly measure the pKa of hyperreactive thiols that occur when the closed conformation of the RyR channel complex is assumed, and that appear to be an integral component of the redox sensor...
  18. pmc Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors
    Christophe Morisseau
    Department of Entomology and Cancer Center, University of California at Davis, Davis, California 95616, USA
    Environ Health Perspect 117:1867-72. 2009
    ..Whole-animal toxicologic studies cannot yield the necessary throughput in a cost-effective fashion, leading to a critical need for a faster and more cost-effective toxicologic evaluation of xenobiotics...
  19. ncbi request reprint Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle
    Christopher W Ward
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:5781-7. 2004
    ....
  20. ncbi request reprint Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1
    James D Fessenden
    Department of Anesthesia Research, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 279:53028-35. 2004
    ..However, in [(3)H]ryanodine binding experiments, the Ca(2+)-dependent activation and inactivation of mutated RyRs containing EF3, EF4, or EF5 was unaffected when compared with wtRyR1...
  21. pmc Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction coupling
    Jennifer J O'Brien
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Biophys J 82:2428-35. 2002
    ..In either case, Ca2+ activation of RyR1 does not appear to be necessary for the initiation of Ca2+ release during EC coupling in skeletal muscle...
  22. ncbi request reprint PDZ domains of Par-3 as potential phosphoinositide signaling integrators
    Hao Wu
    Department of Biochemistry, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P R China
    Mol Cell 28:886-98. 2007
    ..The concatenation of the PIP-binding PDZ2 and the lipid phosphatase PTEN-binding PDZ3 endows Par-3 as an ideal scaffold protein for integrating PIP signaling events during cellular polarization...
  23. ncbi request reprint Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment
    Wei Feng
    Department of Biochemistry, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    J Biol Chem 283:23440-9. 2008
    ..These results, together with earlier data, firmly establish that Par-3 functions as a scaffold in integrating phosphoinositide signaling events during cellular polarization...
  24. pmc The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization
    Wei Feng
    Department of Biochemistry, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
    EMBO J 26:2786-96. 2007
    ....
  25. ncbi request reprint PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area
    Wei Feng
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    J Biol Chem 277:41140-6. 2002
    ..Our data uncover a novel PDZ domain-mediated protein interaction mode that may be responsible for multimerization of other PDZ domain-containing scaffold proteins...
  26. ncbi request reprint Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding
    Wei Feng
    Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Nat Struct Biol 10:972-8. 2003
    ..PDZ4 contains a deformed aB-bB groove that is unlikely to bind to carboxyl peptides. Instead, the domain stabilizes the structure of PDZ5...
  27. ncbi request reprint Analyses of very early hemopoietic regeneration after bone marrow transplantation: comparison of intravenous and intrabone marrow routes
    Qing Li
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Stem Cells 25:1186-94. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  28. ncbi request reprint [Osteogenesis of rabbit skin fibroblast transfected with core binding factor a1/osteoblast specific transplanting factor-2 gene]
    De chang Xiao
    Department of Orthopaedic, Ruijin Hospital, Shanghai Second University, Shanghai 200025, China
    Zhonghua Wai Ke Za Zhi 43:247-51. 2005
    ..To study osteoblastic phenotype expression of New Zealand rabbit skin fibroblasts transfected with mouse core binding factor a1/osteoblast specific transplanting factor-2 gene (Cbfa1/Osf2)...
  29. pmc A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins
    Wei Feng
    Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Proc Natl Acad Sci U S A 102:6861-6. 2005
    ..Our results provide a unified picture for L27 domain-mediated protein-protein interactions...
  30. ncbi request reprint Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1
    Jiafu Long
    Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    J Mol Biol 375:1457-68. 2008
    ....
  31. pmc Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels
    Delavar Shahbazzadeh
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, 13 Place Pasteur, Tunis, BP 74, 1002 Tunisia
    Biochem J 404:89-96. 2007
    ..Overall, these data identify a new biologically active toxin that belongs to a family of peptides active on the ryanodine-sensitive channel...
  32. ncbi request reprint Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol
    James D Fessenden
    Department of Anesthesia Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 281:21022-31. 2006
    ....
  33. pmc Transmembrane TNF-alpha mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt lymphoma cells
    Hailong Zhang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, Hubei, 430030, PR China
    J Leukoc Biol 84:789-97. 2008
    ..On the contrary, tmTNF-alpha, when acting as a ligand, inhibits NF-kappaB activity through forward signaling, which is inclined to induce tumor cell death...
  34. ncbi request reprint Oleandrin produces changes in intracellular calcium levels in isolated cardiomyocytes: a real-time fluorescence imaging study comparing adult to neonatal cardiomyocytes
    Brian J Poindexter
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Texas 77030, USA
    J Toxicol Environ Health A 70:568-74. 2007
    ..6.1.3], and/or dysfunction of sarcolemmal calcium release channels...