Jian Feng

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism
    Eunice Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 25:5488-501. 2005
  2. ncbi request reprint Microtubule: a common target for parkin and Parkinson's disease toxins
    Jian Feng
    Department of Physiology and Biophysics, State University of New York, Buffalo, NY 14214, USA
    Neuroscientist 12:469-76. 2006
  3. ncbi request reprint Regulation of neurotransmitter release by synapsin III
    Jian Feng
    Laboratory of Molecular and Cellular Neuroscience and Laboratory of Endocrinology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 22:4372-80. 2002
  4. pmc Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
    Houbo Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Nat Commun 3:668. 2012
  5. pmc Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation
    Yong Ren
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 284:4009-17. 2009
  6. pmc Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome
    Qian Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 28:12993-3002. 2008
  7. ncbi request reprint Parkin stabilizes microtubules through strong binding mediated by three independent domains
    Fang Yang
    Department of Physiology and Biophysics, State University of New York at Buffalo 14214, USA
    J Biol Chem 280:17154-62. 2005
  8. doi request reprint Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1
    Jerome A Roth
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14214, USA
    J Neurochem 113:454-64. 2010
  9. ncbi request reprint Parkin suppresses the expression of monoamine oxidases
    Houbo Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 281:8591-9. 2006
  10. pmc Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell
    ALFRED J ROBISON
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 33:4295-307. 2013

Research Grants

  1. Parkin--In vivo Function and Role in Parkinson's Disease
    Jian Feng; Fiscal Year: 2004
  2. Cellular Functions of Parkin
    Jian Feng; Fiscal Year: 2010

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism
    Eunice Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 25:5488-501. 2005
    ..The 5-HT(1A)-NMDAR interaction provides a potential mechanism underlying the role of serotonin in controlling emotional and cognitive processes subserved by PFC...
  2. ncbi request reprint Microtubule: a common target for parkin and Parkinson's disease toxins
    Jian Feng
    Department of Physiology and Biophysics, State University of New York, Buffalo, NY 14214, USA
    Neuroscientist 12:469-76. 2006
    ....
  3. ncbi request reprint Regulation of neurotransmitter release by synapsin III
    Jian Feng
    Laboratory of Molecular and Cellular Neuroscience and Laboratory of Endocrinology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 22:4372-80. 2002
    ..Our data indicate that synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking...
  4. pmc Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
    Houbo Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Nat Commun 3:668. 2012
    ..Thus, the study provides novel targets and a physiologically relevant screening platform for disease-modifying therapies of PD...
  5. pmc Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation
    Yong Ren
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 284:4009-17. 2009
    ..Thus, the results suggest that parkin protects midbrain dopaminergic neurons against microtubule-depolymerizing PD toxins such as rotenone by stabilizing microtubules to attenuate MAP kinase activation...
  6. pmc Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome
    Qian Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 28:12993-3002. 2008
    ..The results suggest that HDAC6 acts as a sensor of proteasome inhibition and directs the trafficking of parkin by using different motor proteins...
  7. ncbi request reprint Parkin stabilizes microtubules through strong binding mediated by three independent domains
    Fang Yang
    Department of Physiology and Biophysics, State University of New York at Buffalo 14214, USA
    J Biol Chem 280:17154-62. 2005
    ..Because many misfolded proteins are transported on microtubules, the localization of parkin on microtubules may provide an important environment for its E3 ligase activity toward misfolded substrates...
  8. doi request reprint Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1
    Jerome A Roth
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14214, USA
    J Neurochem 113:454-64. 2010
    ..These results demonstrate that parkin is the E3 ligase responsible for ubiquitination of the 1B species of DMT1...
  9. ncbi request reprint Parkin suppresses the expression of monoamine oxidases
    Houbo Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 281:8591-9. 2006
    ..This function may limit the production of reactive oxygen species generated by MAO in dopamine oxidation and would, thus, be beneficial to the survival of dopaminergic neurons...
  10. pmc Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell
    ALFRED J ROBISON
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 33:4295-307. 2013
    ..These data establish that ΔFosB and CaMKII engage in a cell-type- and brain-region-specific positive feedforward loop as a key mechanism for regulating the reward circuitry of the brain in response to chronic cocaine...
  11. pmc Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases
    Yong Ren
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Hum Mol Genet 20:1074-83. 2011
    ..The results reveal the molecular mechanism by which parkin suppresses the transcription of MAOs to control oxidative stress induced by dopamine oxidation...
  12. ncbi request reprint Selective vulnerability of dopaminergic neurons to microtubule depolymerization
    Yong Ren
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 280:34105-12. 2005
    ..Inhibition of dopamine metabolism significantly reduced rotenone toxicity. Thus, our results suggest that microtubule depolymerization induced by PD toxins such as rotenone plays a key role in the selective death of dopaminergic neurons...
  13. pmc Serum response factor and cAMP response element binding protein are both required for cocaine induction of ΔFosB
    Vincent Vialou
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurosci 32:7577-84. 2012
    ..Our results also establish a complex mode of regulation of ΔFosB induction in response to cocaine, which requires the concerted activities of both SRF and CREB...
  14. ncbi request reprint Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter
    Houbo Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 279:54380-6. 2004
    ..This function of parkin would enhance the precision of dopaminergic transmission, increase the efficiency of dopamine utilization, and reduce dopamine toxicity on neighboring cells...
  15. pmc RACK1 is involved in β-amyloid impairment of muscarinic regulation of GABAergic transmission
    Wenhua Liu
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Neurobiol Aging 32:1818-26. 2011
    ..Thus, RACK1 provides a potential therapeutic target that can restore some of the impaired cellular processes by Aβ...
  16. ncbi request reprint Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism
    Yong Ren
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York, USA
    J Neurochem 103:303-11. 2007
    ..The protective effects of parkin were abrogated by its PD-linked mutations. Together, our results suggest that rotenone and parkin affect the survival of serotonergic neurons by impacting on microtubules in opposing manners...
  17. pmc Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortex
    Eunice Y Yuen
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:17194-204. 2008
    ..These findings provide a framework for understanding the complex interactions between serotonin and NMDARs in PFC, which could be important for cognitive and emotional control in which both systems are highly involved...
  18. pmc BDNF is a negative modulator of morphine action
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 338:124-8. 2012
    ..These findings provide insight into the molecular basis of morphine-induced neuroadaptations in the brain's reward circuitry...
  19. ncbi request reprint Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons
    Qian Jiang
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 281:29391-400. 2006
    ..Thus, our results suggest that neurotrophic factors activate the microtubule-associated protein kinase pathway to stabilize microtubules, and this action significantly attenuates rotenone toxicity on dopaminergic neurons...
  20. pmc Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease
    Guojun Chen
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Neurobiol Aging 29:1795-804. 2008
    ..Loss of the regulation of synaptic NMDAR responses by endogenous ACh may contribute to the cognitive deficiency in AD...
  21. ncbi request reprint Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 14214, USA
    J Biol Chem 280:29420-7. 2005
    ..Taken together, these results suggest that interfering with microtubule assembly suppresses NMDAR function through a mechanism dependent on kinesin-based dendritic transport of NMDA receptors...
  22. ncbi request reprint Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease
    Ping Zhong
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    J Biol Chem 278:26888-96. 2003
    ..These results show that the muscarinic regulation of GABA transmission is impaired in the AD model, probably due to the Abeta-mediated interference of mAChR activation of PKC...
  23. ncbi request reprint Parkin is recruited to the centrosome in response to inhibition of proteasomes
    Jinghui Zhao
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Cell Sci 116:4011-9. 2003
    ..This process may provide a subcellular locale for parkin to ubiquitinate and degrade protein aggregates critically involved in the pathogenesis of Parkinson's disease...
  24. pmc diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates
    Li Shen
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
    PLoS ONE 8:e65598. 2013
    ..The results indicated that diffReps is a highly sensitive program in detecting differential sites from ChIP-seq data...
  25. pmc Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex
    Janine B Lee
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Physiol 590:1535-46. 2012
    ..These findings have identified HDAC6 as a key molecule gating the effects of acute stress on synaptic functions in the PFC...
  26. ncbi request reprint Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis
    Houbo Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, 14214, USA
    Hum Mol Genet 13:1745-54. 2004
    ..This protective function of parkin, which is greatly attenuated by its PD-linked mutations, may be uniquely important for the survival of DA neurons, as they are constantly threatened by oxyradicals produced during dopamine oxidation...
  27. pmc Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin
    Wenhua Liu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 103:18338-43. 2006
    ..The effect of alpha1-ARs is modified by RGS2/4 that are recruited to the receptor complex by spinophilin, whereas the effect of alpha2-ARs is modified by RGS4 independent of spinophilin...
  28. pmc Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation
    Pamela J Kennedy
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 16:434-40. 2013
    ..Our findings suggest a new mechanism by which prolonged and selective HDAC inhibition can alter behavioral and molecular adaptations to cocaine and inform the development of therapeutics for cocaine addiction...
  29. pmc Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation
    Michael D Garrick
    Department of Biochemistry, University at Buffalo, Buffalo, NY, USA
    Biometals 25:787-93. 2012
    ..Mutant Parkin serves as a control that does not affect DMT1 levels. Thus DMT1 regulation in an isoform specific fashion can occur by ubiquitination and the events involved have implications for DMT1 function and disease processes...
  30. pmc Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 106:14075-9. 2009
    ....
  31. pmc Epigenetic mechanisms of depression and antidepressant action
    Vincent Vialou
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Pharmacol Toxicol 53:59-87. 2013
    ....
  32. pmc Paternal transmission of stress-induced pathologies
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 70:408-14. 2011
    ..Here, we focused on possible paternal transmission with the social defeat stress paradigm...
  33. pmc Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation
    Yong Ren
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 23:3316-24. 2003
    ..Its ability to enhance the ubiquitination and degradation of misfolded tubulins may play a significant role in protecting neurons from toxins that cause PD...
  34. ncbi request reprint Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism
    Qian Jiang
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Neurosci 26:4318-28. 2006
    ..These findings may offer a novel neuroprotective approach against rotenone-induced parkinsonism...
  35. ncbi request reprint Aberrant regulation of NMDA receptors by dopamine D4 signaling in rats after phencyclidine exposure
    Xun Wang
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 124 Sherman Hall, Buffalo, NY 14214, USA
    Mol Cell Neurosci 31:15-25. 2006
    ....
  36. doi request reprint Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of ΔFosB
    Vincent Vialou
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, Department of Physiology, Michigan State University, Lansing, Michigan 48824, Department of Pharmacology and Toxicology, University of Buffalo, Buffalo, New York 14214, Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada, Department of Psychiatry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, and Institut National de la Sante et de la Recherche Medicale, U1130, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8246, and Universite Pierre et Marie Curie, UM CR18, Sorbonne Université, Paris, France
    J Neurosci 34:3878-87. 2014
    ..Together, these results indicate that social stress-induced behavioral deficits are mediated partly by molecular adaptations in mPFC involving ΔFosB and CCK through cortical projections to distinct subcortical targets. ..
  37. doi request reprint Nucleolar molecular signature of pluripotent stem cells
    Artem Pliss
    Institute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York, Buffalo, New York 14260, United States
    Anal Chem 85:3545-52. 2013
    ..The approach described here shows the potential for spectroscopically monitoring changes in macromolecular organization of the cell at different stages of reprogramming...
  38. pmc Protein kinase C inhibits autophagy and phosphorylates LC3
    Houbo Jiang
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, United States
    Biochem Biophys Res Commun 395:471-6. 2010
    ....
  39. pmc Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens
    Ian Maze
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 108:3035-40. 2011
    ..Such increases likely reflect global patterns of genomic destabilization in this brain region after repeated cocaine administration and open the door for future investigations into the epigenetic and genetic basis of drug addiction...
  40. doi request reprint Substrate properties of ubiquitin carboxyl-terminally derived peptide probes for protein ubiquitination
    Michael M Madden
    Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260 3000, USA
    Biochemistry 47:3636-44. 2008
    ....
  41. pmc Redefining Parkinson's disease research using induced pluripotent stem cells
    Jiali Pu
    Department of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA
    Curr Neurol Neurosci Rep 12:392-8. 2012
    ....
  42. pmc Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1137-43. 2010
    ..These data establish the importance of Dnmt3a in the NAc in regulating cellular and behavioral plasticity to emotional stimuli...
  43. ncbi request reprint Alzheimer's disease: interactions between cholinergic functions and beta-amyloid
    Zhen Yan
    Dept of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Curr Alzheimer Res 1:241-8. 2004
    ....
  44. ncbi request reprint Muscarinic potentiation of GABA(A) receptor currents is gated by insulin signaling in the prefrontal cortex
    Xiao Hong Ma
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 23:1159-68. 2003
    ..Given the significance of GABAergic transmission in regulating PFC functions, our results provide a novel mechanism for understanding the role of cholinergic systems and insulin signaling in learning and memory...
  45. pmc Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons
    Xiang Cai
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    J Physiol 540:743-59. 2002
    ..This modulation provides a unique and flexible mechanism for 5-HT(4) receptors to dynamically regulate synaptic transmission and neuronal excitability in the PFC network...
  46. ncbi request reprint Molecular determinants of synapsin targeting to presynaptic terminals
    Daniel Gitler
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:3711-20. 2004
    ..Domain D inhibited targeting, but this inhibition was overcome by domain E. Thus, multiple intermolecular and intramolecular interactions are required for synapsins to target to presynaptic terminals...
  47. doi request reprint Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus
    Hung Teh Kao
    Nathan Kline Institute for Psychiatric Research and the Department of Psychiatry, New York University School of Medicine, Orangeburg, New York 10962, USA
    J Comp Neurol 507:1860-70. 2008
    ..These findings suggest a distinct function for this synaptic vesicle protein, in addition to its role in neurotransmission...
  48. ncbi request reprint Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain
    Vincent A Pieribone
    The John B Pierce Laboratory, Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Comp Neurol 454:105-14. 2002
    ..These results suggest that synapsin III may also play a role in adult neurogenesis...
  49. ncbi request reprint Different presynaptic roles of synapsins at excitatory and inhibitory synapses
    Daniel Gitler
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:11368-80. 2004
    ..Thus, synapsins maintain the reserve pool of glutamatergic vesicles but regulate the size of the readily releasable pool of GABAergic vesicles...
  50. ncbi request reprint Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors
    Qin Wang
    Department of Pharmacology and Center of Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 304:1940-4. 2004
    ..The reciprocal interactions of GPCRs with spinophilin and arrestin represent a regulatory mechanism for fine-tuning complex receptor-orchestrated cell signaling and responses...
  51. ncbi request reprint Epigenetic regulation of neural gene expression and neuronal function
    Jian Feng
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA
    Pediatr Res 61:58R-63R. 2007
    ..We postulate that DNA methylation- and histone modification-mediated gene regulation is not only important for neural cell differentiation but also crucial for high-order cognitive functions such as learning and memory...
  52. ncbi request reprint Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system
    Jian Feng
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Neurosci Res 79:734-46. 2005
    ..Our data suggest that whereas Dnmt3b may be important for the early phase of neurogenesis, Dnmt3a likely plays a dual role in regulating neurogenesis prenatally and CNS maturation and function postnatally...
  53. pmc Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein
    Nick Carpino
    Department of Biochemistry, St Jude Children s Research Hospital, and University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Mol Cell Biol 22:7491-500. 2002
    ..In addition, no impairment in B- and T-cell development and proliferative ability was detected...

Research Grants7

  1. Parkin--In vivo Function and Role in Parkinson's Disease
    Jian Feng; Fiscal Year: 2004
    ..This animal model would also be a valuable tool for the development of more effective therapeutic strategies for PD patients. ..
  2. Cellular Functions of Parkin
    Jian Feng; Fiscal Year: 2010
    ..Our studies will also provide novel targets for the development of more effective therapies for Parkinson's disease. ..