Research Topics

Genomes and Genes

Hanping Feng


Affiliation: University of Maryland
Country: USA


  1. Li S, Shi L, Yang Z, Zhang Y, Perez Cordon G, Huang T, et al. Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis. Infect Immun. 2015;83:502-13 pubmed publisher
    ..Thus, glucosyltransferase but not cysteine protease activity is critical for TcdB-mediated cytopathic effects and TcdB systemic toxicity, highlighting the importance of targeting toxin glucosyltransferase activity for future therapy. ..
  2. Huang T, Perez Cordon G, Shi L, Li G, Sun X, Wang X, et al. Clostridium difficile toxin B intoxicated mouse colonic epithelial CT26 cells stimulate the activation of dendritic cells. Pathog Dis. 2015;73: pubmed publisher
    ..difficile infection. ..
  3. Zhang Y, Feng H. Pathogenic effects of glucosyltransferase from Clostridium difficile toxins. Pathog Dis. 2016;74:ftw024 pubmed publisher
    ..In this review, we summarize the pathogenic effects of glucosyltransferase domain of the toxins in the past years. ..
  4. Yang Z, Shi L, Yu H, Zhang Y, Chen K, Saint Fleur A, et al. Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice from Clostridium difficile infection. Pathog Dis. 2016;74: pubmed publisher
    ..Thus, replication-deficient adenoviral vector may be used to deliver neutralizing antibodies against the toxins in order to prevent CDI and recurrence. ..
  5. Hamza T, Zhang Z, Melnyk R, Feng H. Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis. Pathog Dis. 2016;74:ftv098 pubmed publisher
    ..These findings offer insights into the structure function of the toxin translocation pore, and inform novel therapeutic strategies against CDI. ..
  6. Chen S, Wang H, Gu H, Sun C, Li S, Feng H, et al. Identification of an Essential Region for Translocation of Clostridium difficile Toxin B. Toxins (Basel). 2016;8: pubmed publisher
    ..Our finding provides an insight into the molecular mechanisms of action of TcdB in the intoxication of host cells. ..
  7. Zhang Y, Hamza T, Gao S, Feng H. Masking autoprocessing of Clostridium difficile toxin A by the C-terminus combined repetitive oligo peptides. Biochem Biophys Res Commun. 2015;459:259-263 pubmed publisher
    ..Our data provides insights on the molecular mode of action of the C. difficile toxins. ..
  8. Chen S, Wang H, Gu H, Sun C, Li S, Feng H, et al. Correction: Chen, S., et al. Identification of an Essential Region for Translocation of Clostridium difficile Toxin B. Toxins 2016, 8, 241. Toxins (Basel). 2016;8: pubmed
    ..n/a. ..
  9. Yu H, Chen K, Sun Y, Carter M, Garey K, Savidge T, et al. Cytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..A functional GT domain of C. difficile toxins was required for the induction of a majority of cytokines investigated. ..

More Information


  1. Zhang Y, Yang Z, Gao S, Hamza T, Yfantis H, Lipsky M, et al. The role of purified Clostridium difficile glucosylating toxins in disease pathogenesis utilizing a murine cecum injection model. Anaerobe. 2017;48:249-256 pubmed publisher
    ..difficile bacterium, are able to cause disease that resembles CDI and highlights the importance of targeting both toxins for vaccines and therapeutics against the disease. ..