David M Feldser
Affiliation: University of Pennsylvania
Stokes K, Cortez Retamozo V, Acosta J, Lauderback B, Robles Oteiza C, Cicchini M, et al
. Natural killer cells limit the clearance of senescent lung adenocarcinoma cells. Oncogenesis. 2019;8:24 pubmed publisher
..Further, our data provide an impetus to understand the broader mechanisms that regulate cancer cell destruction by multiple cell types of the innate immune system and distinct cancer contexts. ..
Li Y, Park A, Mou H, Colpan C, Bizhanova A, Akama Garren E, et al
. A versatile reporter system for CRISPR-mediated chromosomal rearrangements. Genome Biol. 2015;16:111 pubmed publisher
..Moreover, we detect Cas9 cleavage at the fourth nucleotide on the non-complementary strand, leading to staggered instead of blunt DNA breaks. These reporters allow mechanisms of chromosomal rearrangements to be investigated. ..
Acosta J, Wang W, Feldser D. Off and back-on again: a tumor suppressor's tale. Oncogene. 2018;37:3058-3069 pubmed publisher
..This review discusses the development and implementation of genetic systems designed to toggle tumor suppressor genes off and back-on again and their potential to uncover the tumor suppressor's tale. ..
Walter D, Venancio O, Buza E, Tobias J, Deshpande C, Gudiel A, et al
. Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma. Cancer Res. 2017;77:1719-1729 pubmed publisher
..i>Cancer Res; 77(7); 1719-29. ©2017 AACR. ..
Cicchini M, Buza E, Sagal K, Gudiel A, Durham A, Feldser D. Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma Initiation and Progression. Cell Rep. 2017;18:1958-1969 pubmed publisher
..Thus, MAPK signaling in the lung is thresholded not only during malignant progression but also at the moment of tumor initiation. ..