Research Topics
| JACK FELDMANSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Sleep-disordered breathing after targeted ablation of preBötzinger complex neuronsLeanne C McKay
Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-1763, USA
Nat Neurosci 8:1142-4. 2005..We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations...
Understanding the rhythm of breathing: so near, yet so farJack L Feldman
Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1763, USA
Annu Rev Physiol 75:423-52. 2013....
Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammalJack L Feldman
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Appl Physiol 100:2096-7; discussion 2097-8, 2103-8. 2006- Looking for inspiration: new perspectives on respiratory rhythmJack L Feldman
Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Box 951763, Los Angeles, California 90095 1763, USA
Nat Rev Neurosci 7:232-42. 2006..Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing... - Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascadesJack L Feldman
Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles Box 951763, Los Angeles, CA 90095 1763, USA
Respir Physiol Neurobiol 147:131-43. 2005..Blockade of Group 1 metabotropic glutamate receptors or protein kinase C (PKC) prevents the induction of ivLTF... - Breathing: rhythmicity, plasticity, chemosensitivityJack L Feldman
Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
Annu Rev Neurosci 26:239-66. 2003..Neurons with appropriate chemosensitivity are spread throughout the brainstem; their individual properties and collective role are just beginning to be understood... - Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitroChristopher A Del Negro
Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Box 951763, Los Angeles, CA 90095 1763, USA
J Physiol 587:1217-31. 2009..We propose that the respiratory network functions over a broad range of frequencies by engaging distinct mechanisms from those controlling inspiratory duration and pattern that specifically govern the interburst interval... - Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generationChristopher A Del Negro
Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095 1763, USA
J Neurosci 25:446-53. 2005..When I(NaP) and I(CAN) are removed pharmacologically, the rhythm can be maintained by boosting neural excitability, which is inconsistent with a pacemaker-essential mechanism of respiratory rhythmogenesis by the preBotzinger complex... - Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake ratWenbin Tan
Department of Neurobiology, Box 951763, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E Young Dr South, Los Angeles, California 90095, USA
Nat Neurosci 11:538-40. 2008..We hypothesize that breathing requires preBötC Sst neurons and that their sudden depression can lead to serious, even fatal, respiratory failure... - Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneuronsChristopher M Bocchiaro
Systems Neurobiology Laboratory, Department of Physiological Science, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1763, USA
J Neurosci 23:1099-103. 2003..The role of this modulation may be to keep the activity of motoneurons within a dynamic range that aids in responding to different physiological challenges affecting breathing, such as exercise, hypoxia, and sleep... - Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitabilityNatalia V Neverova
Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
J Neurosci 27:4435-42. 2007..Elucidating the mechanism underlying LTF can be of clinical importance to the patients suffering from sleep-disordered breathing... - Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulnessLeanne C McKay
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
Am J Respir Crit Care Med 178:89-95. 2008.... - Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouseConsuelo Morgado-Valle
Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
J Neurosci 30:3634-9. 2010..Testable and nontrivial predictions of the functional role of excitatory and inhibitory pacemaker neurons need to be proposed and the necessary experiments performed... - Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentialsXuesi M Shao
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
J Neurosci Methods 159:108-15. 2007..This method is easy to implement and provides long-term recording stability. The micro-agar salt bridge can fit in most commercial patch electrode holders and can be conveniently maintained... - Respiratory rhythm: an emergent network property?Christopher A Del Negro
Systems Neurobiology Laboratory, Department of Neurobiology, University of California Los Angeles, Box 95 1763, 90095, USA
Neuron 34:821-30. 2002..05) does not affect respiratory rhythm. These results suggest that voltage-dependent bursting in pacemaker neurons is not essential for respiratory rhythmogenesis, which may instead be an emergent network property... - Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLCXuesi M Shao
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
J Neurosci Methods 160:256-63. 2007..Our data also suggest that there is endogenous ACh release in spinal ventral motor columns at fourth cervical (C4) level that regulates the respiratory-related motor activity... - NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptorsConsuelo Morgado-Valle
Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
J Physiol 582:359-68. 2007..Under this condition, respiratory-related frequency is unaffected by changes in I(I), suggesting that the two can be independently regulated... - Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythmXuesi M Shao
Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
J Neurosci 28:519-28. 2008..Furthermore, functional alpha4* nAChRs are present in XII nucleus and mediate cholinergic/nicotinic modulation of tonic activity in XIIn... - Somatic Ca2+ transients do not contribute to inspiratory drive in preBötzinger Complex neuronsConsuelo Morgado-Valle
Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
J Physiol 586:4531-40. 2008..Given evidence that the Ca(2+) buffer BAPTA can significantly reduce inspiratory drive, we hypothesize that dendritic Ca(2+) transients amplify inspiratory-modulated synaptic currents... - Central cholinergic regulation of respiration: nicotinic receptorsXuesi M Shao
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
Acta Pharmacol Sin 30:761-70. 2009.... - Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparationNicholas M Mellen
Department of Neurobiology, School of Medicine, University of California, Los Angeles, California 90095 1763, USA
Am J Physiol Regul Integr Comp Physiol 282:R484-91. 2002..On being rewarmed, the motor output recorded at both sites was usually fractionated, initially suggesting that changes occurred in network synchronization either during cooling or during reactivation following hypothermic arrest... - Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKAShane A Saywell
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
J Physiol 554:879-89. 2004..We conclude that inspiratory-phased inhibition is prevalent in neonatal XII motoneurones and plays an important role in shaping motoneuronal output. These inhibitory inputs are modulated by PKA, which also modulates excitatory inputs... - Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitroConsuelo Morgado-Valle
Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
J Physiol 555:783-92. 2004..Our results suggest that depletion of SP (or other peptides) and/or glutamate by capsaicin causes a cessation of respiratory rhythm in neonatal rat slices... - Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanismsNicholas M Mellen
Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1763, USA
J Physiol 556:859-74. 2004..These findings are qualitatively similar to studies of the BHE in vivo. Where there are differences, they can largely be accounted for by developmental changes and experimental conditions... - Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal ratsLeanne C McKay
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
J Physiol 557:13-8. 2004..05). After the continuous protocol, there was no lasting increase in GG EMG burst amplitude. We conclude that LTF of upper airway muscles is an adaptive respiratory behaviour present from birth... - Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generationNicholas M Mellen
Department of Neurobiology, University of California, Los Angeles, P O Box 951763, Los Angeles, CA 90095, USA
Neuron 37:821-6. 2003..Thus, both I (in the slice), and pre-I neurons are sufficient for respiratory rhythmogenesis... - Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the ratXuesi M Shao
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
J Physiol 547:543-53. 2003..Moreover, the basal level of endogenous PKA activity appears to be a determinant of resting respiratory frequency... - Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn ratWiktor A Janczewski
Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, 10833 Le Conte Avenue, Los Angeles, CA 90095 1763, USA
J Physiol 545:1017-26. 2002..We propose that the same pathway is responsible for rhythmic activation of the abdominal muscles during opioid-induced apnoea in the newborn rat... - Distinct rhythm generators for inspiration and expiration in the juvenile ratWiktor A Janczewski
Department of Neurobiology, David Geffen School of Medicine, Los Angeles, CA 90095 1763, USA
J Physiol 570:407-20. 2006.... - Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory patternXuesi M Shao
Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
J Neurophysiol 88:1851-8. 2002..This study provides a useful model system for evaluating potential therapeutic cholinergic agents for their respiratory effects and side effects... - Projections of preBötzinger complex neurons in adult ratsWenbin Tan
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Comp Neurol 518:1862-78. 2010.... - Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneuronsChristopher M Bocchiaro
Systems Neurobiology Laboratory, Departments of Neurobiology and Physiological Science, University of California-Los Angeles, Los Angeles, CA 90095-1763, USA
Proc Natl Acad Sci U S A 101:4292-5. 2004..These results may provide the basis for rationale development of therapeutics for obstructive sleep apnea in humans... - Oscillations in endogenous inputs to neurons affect excitability and signal processingMarjorie A Parkis
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
J Neurosci 23:8152-8. 2003..We conclude that oscillations control the precise timing of action potentials, help to maximize synaptic drive efficiency, and constrain MN firing frequencies to those optimal for muscle contraction... - Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiration-related rhythmic activity in the rostral medulla of newborn rats"Wiktor A Janczewski
J Neurophysiol 96:1-2. 2006 - Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal miceRyland W Pace
Department of Applied Science, McGlothlin Street Hall, Room 303, The College of William and Mary, Williamsburg, VA 23187 8795, USA
J Physiol 582:113-25. 2007..We conclude that I(CAN) underlies robust inspiratory drive potentials in preBötC neurons, and is only fully evoked by ionotropic and metabotropic glutamatergic synaptic inputs, i.e. by network activity... - Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generationRyland W Pace
Department of Applied Science, The College of William and Mary, Williamsburg, VA 23187 8795, USA
J Physiol 580:485-96. 2007.... - The Last Word: Point:Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal"Jack L Feldman
J Appl Physiol 101:689. 2006 - Slip of the tongueJack L Feldman
Am J Respir Crit Care Med 170:581-2. 2004
Research Grants
- TRANSMISSION OF RESPIRATORY DRIVE TO MOTONEURONSJACK FELDMAN; Fiscal Year: 2002..Our unique advantage of making measurements in the context of behavior may reveal critical elements underlying control of neuronal excitability and its modulation in the normal transactions of the intact living brain. ..
- Generation of Respiratory RhythmJack L Feldman; Fiscal Year: 2010..The investigation and testing of the novel hypotheses arising from our recent discoveries should have fundamental impact on our understanding of breathing in humans in health and disease ..
- RESPIRATORY PATTERN GENERATION STUDIED IN VITROJack L Feldman; Fiscal Year: 2010..The proposed studies will significantly advance our understanding of the neural mechanisms generating respiratory rhythm and shed light on human disorders of breathing. ..
- Functional dissection of medullary respiratory microcircuitsJack L Feldman; Fiscal Year: 2010..The proposed studies will significantly advance our understanding of the neural mechanisms generating respiratory rhythm and shed light on human disorders of breathing. ..
- Generation of Respiratory RhythmJACK FELDMAN; Fiscal Year: 2006..If these pathologies are to be understood, the site(s) and mechanism(s) of respiratory rhythmogenesis must be revealed. ..
- RESPIRATORY PATTERN GENERATION STUDIED IN VITROJACK FELDMAN; Fiscal Year: 2003..abstract_text> ..
- Training Program in Neural MicrocircuitsJACK FELDMAN; Fiscal Year: 2007....
- RESPIRATORY PATTERN GENERATION STUDIED IN VITROJACK FELDMAN; Fiscal Year: 2007....
- Generation of Respiratory RhythmJACK FELDMAN; Fiscal Year: 2007..The investigation and testing of the novel hypotheses arising from our recent discoveries should have fundamental impact on our understanding of breathing in humans in health and disease ..
- Functional Plasticity in Hypoglossal MotoneuronsJACK FELDMAN; Fiscal Year: 2007..If these pathologies are to be understood, the mechanisms controlling the output of respiratory motoneurons needs to be determined. ..
- IN VITRO STUDIES OF THE NEURAL CONTROL OF BREATHINGJACK FELDMAN; Fiscal Year: 1993....
- RESPIRATORY PATTERN GENERATION STUDIED IN VITROJACK FELDMAN; Fiscal Year: 1999..Exploiting a measurable behavior under controlled in vitro conditions permits novel experiments that can reveal important features in the link between synapses/neurons and behavior. ..
- TRANSMISSION OF RESPIRATORY DRIVE TO PHRENIC MOTONEURONSJACK FELDMAN; Fiscal Year: 1992..Thus, we should be able to provide information relevant to the control of other important rhythmic motor acts such as locomotion mastication and nystagmus...