JACK FELDMAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons
    Leanne C McKay
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095 1763, USA
    Nat Neurosci 8:1142-4. 2005
  2. pmc Understanding the rhythm of breathing: so near, yet so far
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1763, USA
    Annu Rev Physiol 75:423-52. 2013
  3. ncbi request reprint Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Appl Physiol 100:2096-7; discussion 2097-8, 2103-8. 2006
  4. pmc Looking for inspiration: new perspectives on respiratory rhythm
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Box 951763, Los Angeles, California 90095 1763, USA
    Nat Rev Neurosci 7:232-42. 2006
  5. ncbi request reprint Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades
    Jack L Feldman
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles Box 951763, Los Angeles, CA 90095 1763, USA
    Respir Physiol Neurobiol 147:131-43. 2005
  6. pmc Breathing: rhythmicity, plasticity, chemosensitivity
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Annu Rev Neurosci 26:239-66. 2003
  7. pmc Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Box 951763, Los Angeles, CA 90095 1763, USA
    J Physiol 587:1217-31. 2009
  8. ncbi request reprint Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 25:446-53. 2005
  9. pmc Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat
    Wenbin Tan
    Department of Neurobiology, Box 951763, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E Young Dr South, Los Angeles, California 90095, USA
    Nat Neurosci 11:538-40. 2008
  10. ncbi request reprint Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneurons
    Christopher M Bocchiaro
    Systems Neurobiology Laboratory, Department of Physiological Science, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 23:1099-103. 2003

Research Grants

  1. TRANSMISSION OF RESPIRATORY DRIVE TO MOTONEURONS
    JACK FELDMAN; Fiscal Year: 2002
  2. Generation of Respiratory Rhythm
    Jack L Feldman; Fiscal Year: 2010
  3. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    Jack L Feldman; Fiscal Year: 2010
  4. Functional dissection of medullary respiratory microcircuits
    Jack L Feldman; Fiscal Year: 2010
  5. Generation of Respiratory Rhythm
    JACK FELDMAN; Fiscal Year: 2006
  6. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    JACK FELDMAN; Fiscal Year: 2003
  7. Training Program in Neural Microcircuits
    JACK FELDMAN; Fiscal Year: 2007
  8. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    JACK FELDMAN; Fiscal Year: 2007
  9. Generation of Respiratory Rhythm
    JACK FELDMAN; Fiscal Year: 2007
  10. Functional Plasticity in Hypoglossal Motoneurons
    JACK FELDMAN; Fiscal Year: 2007

Collaborators

Detail Information

Publications38

  1. pmc Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons
    Leanne C McKay
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095 1763, USA
    Nat Neurosci 8:1142-4. 2005
    ..We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations...
  2. pmc Understanding the rhythm of breathing: so near, yet so far
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1763, USA
    Annu Rev Physiol 75:423-52. 2013
    ....
  3. ncbi request reprint Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Appl Physiol 100:2096-7; discussion 2097-8, 2103-8. 2006
  4. pmc Looking for inspiration: new perspectives on respiratory rhythm
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Box 951763, Los Angeles, California 90095 1763, USA
    Nat Rev Neurosci 7:232-42. 2006
    ..Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing...
  5. ncbi request reprint Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades
    Jack L Feldman
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles Box 951763, Los Angeles, CA 90095 1763, USA
    Respir Physiol Neurobiol 147:131-43. 2005
    ..Blockade of Group 1 metabotropic glutamate receptors or protein kinase C (PKC) prevents the induction of ivLTF...
  6. pmc Breathing: rhythmicity, plasticity, chemosensitivity
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Annu Rev Neurosci 26:239-66. 2003
    ..Neurons with appropriate chemosensitivity are spread throughout the brainstem; their individual properties and collective role are just beginning to be understood...
  7. pmc Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Box 951763, Los Angeles, CA 90095 1763, USA
    J Physiol 587:1217-31. 2009
    ..We propose that the respiratory network functions over a broad range of frequencies by engaging distinct mechanisms from those controlling inspiratory duration and pattern that specifically govern the interburst interval...
  8. ncbi request reprint Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 25:446-53. 2005
    ..When I(NaP) and I(CAN) are removed pharmacologically, the rhythm can be maintained by boosting neural excitability, which is inconsistent with a pacemaker-essential mechanism of respiratory rhythmogenesis by the preBotzinger complex...
  9. pmc Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat
    Wenbin Tan
    Department of Neurobiology, Box 951763, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E Young Dr South, Los Angeles, California 90095, USA
    Nat Neurosci 11:538-40. 2008
    ..We hypothesize that breathing requires preBötC Sst neurons and that their sudden depression can lead to serious, even fatal, respiratory failure...
  10. ncbi request reprint Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneurons
    Christopher M Bocchiaro
    Systems Neurobiology Laboratory, Department of Physiological Science, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 23:1099-103. 2003
    ..The role of this modulation may be to keep the activity of motoneurons within a dynamic range that aids in responding to different physiological challenges affecting breathing, such as exercise, hypoxia, and sleep...
  11. ncbi request reprint Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability
    Natalia V Neverova
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 27:4435-42. 2007
    ..Elucidating the mechanism underlying LTF can be of clinical importance to the patients suffering from sleep-disordered breathing...
  12. pmc Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness
    Leanne C McKay
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Am J Respir Crit Care Med 178:89-95. 2008
    ....
  13. pmc Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse
    Consuelo Morgado-Valle
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 30:3634-9. 2010
    ..Testable and nontrivial predictions of the functional role of excitatory and inhibitory pacemaker neurons need to be proposed and the necessary experiments performed...
  14. ncbi request reprint Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Neurosci Methods 159:108-15. 2007
    ..This method is easy to implement and provides long-term recording stability. The micro-agar salt bridge can fit in most commercial patch electrode holders and can be conveniently maintained...
  15. ncbi request reprint Respiratory rhythm: an emergent network property?
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, University of California Los Angeles, Box 95 1763, 90095, USA
    Neuron 34:821-30. 2002
    ..05) does not affect respiratory rhythm. These results suggest that voltage-dependent bursting in pacemaker neurons is not essential for respiratory rhythmogenesis, which may instead be an emergent network property...
  16. pmc Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Neurosci Methods 160:256-63. 2007
    ..Our data also suggest that there is endogenous ACh release in spinal ventral motor columns at fourth cervical (C4) level that regulates the respiratory-related motor activity...
  17. pmc NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors
    Consuelo Morgado-Valle
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
    J Physiol 582:359-68. 2007
    ..Under this condition, respiratory-related frequency is unaffected by changes in I(I), suggesting that the two can be independently regulated...
  18. pmc Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 28:519-28. 2008
    ..Furthermore, functional alpha4* nAChRs are present in XII nucleus and mediate cholinergic/nicotinic modulation of tonic activity in XIIn...
  19. pmc Somatic Ca2+ transients do not contribute to inspiratory drive in preBötzinger Complex neurons
    Consuelo Morgado-Valle
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
    J Physiol 586:4531-40. 2008
    ..Given evidence that the Ca(2+) buffer BAPTA can significantly reduce inspiratory drive, we hypothesize that dendritic Ca(2+) transients amplify inspiratory-modulated synaptic currents...
  20. doi request reprint Central cholinergic regulation of respiration: nicotinic receptors
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Acta Pharmacol Sin 30:761-70. 2009
    ....
  21. ncbi request reprint Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation
    Nicholas M Mellen
    Department of Neurobiology, School of Medicine, University of California, Los Angeles, California 90095 1763, USA
    Am J Physiol Regul Integr Comp Physiol 282:R484-91. 2002
    ..On being rewarmed, the motor output recorded at both sites was usually fractionated, initially suggesting that changes occurred in network synchronization either during cooling or during reactivation following hypothermic arrest...
  22. pmc Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA
    Shane A Saywell
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Physiol 554:879-89. 2004
    ..We conclude that inspiratory-phased inhibition is prevalent in neonatal XII motoneurones and plays an important role in shaping motoneuronal output. These inhibitory inputs are modulated by PKA, which also modulates excitatory inputs...
  23. pmc Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitro
    Consuelo Morgado-Valle
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
    J Physiol 555:783-92. 2004
    ..Our results suggest that depletion of SP (or other peptides) and/or glutamate by capsaicin causes a cessation of respiratory rhythm in neonatal rat slices...
  24. pmc Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms
    Nicholas M Mellen
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    J Physiol 556:859-74. 2004
    ..These findings are qualitatively similar to studies of the BHE in vivo. Where there are differences, they can largely be accounted for by developmental changes and experimental conditions...
  25. pmc Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats
    Leanne C McKay
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Physiol 557:13-8. 2004
    ..05). After the continuous protocol, there was no lasting increase in GG EMG burst amplitude. We conclude that LTF of upper airway muscles is an adaptive respiratory behaviour present from birth...
  26. pmc Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation
    Nicholas M Mellen
    Department of Neurobiology, University of California, Los Angeles, P O Box 951763, Los Angeles, CA 90095, USA
    Neuron 37:821-6. 2003
    ..Thus, both I (in the slice), and pre-I neurons are sufficient for respiratory rhythmogenesis...
  27. pmc Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Physiol 547:543-53. 2003
    ..Moreover, the basal level of endogenous PKA activity appears to be a determinant of resting respiratory frequency...
  28. pmc Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat
    Wiktor A Janczewski
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, 10833 Le Conte Avenue, Los Angeles, CA 90095 1763, USA
    J Physiol 545:1017-26. 2002
    ..We propose that the same pathway is responsible for rhythmic activation of the abdominal muscles during opioid-induced apnoea in the newborn rat...
  29. pmc Distinct rhythm generators for inspiration and expiration in the juvenile rat
    Wiktor A Janczewski
    Department of Neurobiology, David Geffen School of Medicine, Los Angeles, CA 90095 1763, USA
    J Physiol 570:407-20. 2006
    ....
  30. ncbi request reprint Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory pattern
    Xuesi M Shao
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
    J Neurophysiol 88:1851-8. 2002
    ..This study provides a useful model system for evaluating potential therapeutic cholinergic agents for their respiratory effects and side effects...
  31. pmc Projections of preBötzinger complex neurons in adult rats
    Wenbin Tan
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Comp Neurol 518:1862-78. 2010
    ....
  32. pmc Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons
    Christopher M Bocchiaro
    Systems Neurobiology Laboratory, Departments of Neurobiology and Physiological Science, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Proc Natl Acad Sci U S A 101:4292-5. 2004
    ..These results may provide the basis for rationale development of therapeutics for obstructive sleep apnea in humans...
  33. ncbi request reprint Oscillations in endogenous inputs to neurons affect excitability and signal processing
    Marjorie A Parkis
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 23:8152-8. 2003
    ..We conclude that oscillations control the precise timing of action potentials, help to maximize synaptic drive efficiency, and constrain MN firing frequencies to those optimal for muscle contraction...
  34. ncbi request reprint Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiration-related rhythmic activity in the rostral medulla of newborn rats"
    Wiktor A Janczewski
    J Neurophysiol 96:1-2. 2006
  35. pmc Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice
    Ryland W Pace
    Department of Applied Science, McGlothlin Street Hall, Room 303, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 582:113-25. 2007
    ..We conclude that I(CAN) underlies robust inspiratory drive potentials in preBötC neurons, and is only fully evoked by ionotropic and metabotropic glutamatergic synaptic inputs, i.e. by network activity...
  36. pmc Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation
    Ryland W Pace
    Department of Applied Science, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 580:485-96. 2007
    ....
  37. ncbi request reprint The Last Word: Point:Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal"
    Jack L Feldman
    J Appl Physiol 101:689. 2006
  38. ncbi request reprint Slip of the tongue
    Jack L Feldman
    Am J Respir Crit Care Med 170:581-2. 2004

Research Grants50

  1. TRANSMISSION OF RESPIRATORY DRIVE TO MOTONEURONS
    JACK FELDMAN; Fiscal Year: 2002
    ..Our unique advantage of making measurements in the context of behavior may reveal critical elements underlying control of neuronal excitability and its modulation in the normal transactions of the intact living brain. ..
  2. Generation of Respiratory Rhythm
    Jack L Feldman; Fiscal Year: 2010
    ..The investigation and testing of the novel hypotheses arising from our recent discoveries should have fundamental impact on our understanding of breathing in humans in health and disease ..
  3. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    Jack L Feldman; Fiscal Year: 2010
    ..The proposed studies will significantly advance our understanding of the neural mechanisms generating respiratory rhythm and shed light on human disorders of breathing. ..
  4. Functional dissection of medullary respiratory microcircuits
    Jack L Feldman; Fiscal Year: 2010
    ..The proposed studies will significantly advance our understanding of the neural mechanisms generating respiratory rhythm and shed light on human disorders of breathing. ..
  5. Generation of Respiratory Rhythm
    JACK FELDMAN; Fiscal Year: 2006
    ..If these pathologies are to be understood, the site(s) and mechanism(s) of respiratory rhythmogenesis must be revealed. ..
  6. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    JACK FELDMAN; Fiscal Year: 2003
    ..abstract_text> ..
  7. Training Program in Neural Microcircuits
    JACK FELDMAN; Fiscal Year: 2007
    ....
  8. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    JACK FELDMAN; Fiscal Year: 2007
    ....
  9. Generation of Respiratory Rhythm
    JACK FELDMAN; Fiscal Year: 2007
    ..The investigation and testing of the novel hypotheses arising from our recent discoveries should have fundamental impact on our understanding of breathing in humans in health and disease ..
  10. Functional Plasticity in Hypoglossal Motoneurons
    JACK FELDMAN; Fiscal Year: 2007
    ..If these pathologies are to be understood, the mechanisms controlling the output of respiratory motoneurons needs to be determined. ..
  11. IN VITRO STUDIES OF THE NEURAL CONTROL OF BREATHING
    JACK FELDMAN; Fiscal Year: 1993
    ....
  12. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    JACK FELDMAN; Fiscal Year: 1999
    ..Exploiting a measurable behavior under controlled in vitro conditions permits novel experiments that can reveal important features in the link between synapses/neurons and behavior. ..
  13. TRANSMISSION OF RESPIRATORY DRIVE TO PHRENIC MOTONEURONS
    JACK FELDMAN; Fiscal Year: 1992
    ..Thus, we should be able to provide information relevant to the control of other important rhythmic motor acts such as locomotion mastication and nystagmus...