Research Topics
Genomes and Genes | Eva FeldmanSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Neuromuscular effects of G93A-SOD1 expression in zebrafishStacey A Sakowski
Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor 5017 AAT BSRBMI, USA
Mol Neurodegener 7:44. 2012..Defects in the distal axon and at the neuromuscular junction are early events in the disease course, and zebrafish provide a promising in vivo system to examine cellular mechanisms and treatments for these events in ALS pathogenesis...- p38 mediates mechanical allodynia in a mouse model of type 2 diabetesHsinlin T Cheng
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Mol Pain 6:28. 2010..Using this timeline of PDN, we can investigate the signaling mechanisms underlying mechanical allodynia in the db/db mouse... - Literature-based discovery of diabetes- and ROS-related targetsJunguk Hur
Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
BMC Med Genomics 3:49. 2010..Reactive oxygen species (ROS) are known mediators of cellular damage in multiple diseases including diabetic complications. Despite its importance, no comprehensive database is currently available for the genes associated with ROS... - Kindlin-2 is required for myocyte elongation and is essential for myogenesisJames J Dowling
Department of Pediatrics, University of Michigan, Ann Arbor, USA
BMC Cell Biol 9:36. 2008..Unc-112 is an integrin-associated protein required for muscle development in C. elegans. To better understand the intracellular effectors of integrin signaling in muscle, we examined the mammalian homolog of Unc-112, kindlin-2... 
Type I insulin-like growth factor receptor activation regulates apoptotic proteinsJ R Singleton
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 271:31791-4. 1996....- National Institute of Neurological Disorders and Stroke (NINDS): advances in understanding and treating neuropathy, 24-25 October 2006; Bethesda, MarylandEva L Feldman
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
J Peripher Nerv Syst 13:1-6. 2008..Short-term goals of the workshop were to form a working group for neuropathy, the Peripheral Neuropathy Study Group, and to translate new scientific findings into therapies and complete clinical trials... - Insulin-like growth factor-I and central nervous system developmentB Anlar
University of Michigan, Department of Neurology, Ann Arbor, USA
Horm Metab Res 31:120-5. 1999..IGF-I is among the molecules which affect several steps involved in development... - Oxidative stress and diabetic neuropathy: a new understanding of an old problemEva L Feldman
Juvenile Diabetes Research Foundation Center for the Study of Complications in Diabetes, and the Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Clin Invest 111:431-3. 2003 - Pathogenesis of diabetic neuropathyE L Feldman
University of Michigan Medical Center, Ann Arbor, USA
Clin Neurosci 4:365-70. 1997..In this review we will discuss these theories, their interrelationships and how, collectively, these ideas may begin to explain the etiology of DN... - The identification of gene expression profiles associated with progression of human diabetic neuropathyJunguk Hur
Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
Brain 134:3222-35. 2011..Our results identifying the unique gene signature of patients with progressive diabetic neuropathy will facilitate the development of new mechanism-based diagnostics and therapies... - SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, 5017 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 0588, USA
Exp Neurol 208:216-27. 2007..DN was observed in the C57BL/6Jdb/db mouse, and decreased expression of SOD2 in these animals increased DN. Our data suggest that SOD2 activity is an important cellular modifier of neuronal oxidative defense against hyperglycemic injury... - Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neuronsGina M Leinninger
Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
FASEB J 18:1544-6. 2004..These data suggest that IGF-I prevents apoptosis in DRG neurons by regulating PI3K/Akt pathway effectors, including GSK-3beta, CREB, and FKHR, and by blocking caspase activation... - Vascular endothelial growth factor prevents G93A-SOD1-induced motor neuron degenerationJ Simon Lunn
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
Dev Neurobiol 69:871-84. 2009..Overall, these studies validate the usefulness of VEGF as a potential therapeutic factor for the treatment of ALS and give valuable insight into the responsible signaling pathways and mechanisms involved... - Insulin-like growth factor I induces preferential degradation of insulin receptor substrate-2 through the phosphatidylinositol 3-kinase pathway in human neuroblastoma cellsBhumsoo Kim
University of Michigan, Department of Neurology, Ann Arbor, Michigan 48109 0588, USA
Endocrinology 146:5350-7. 2005.... - Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1Gina M Leinninger
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
Neurobiol Dis 23:11-22. 2006..We propose that mitochondria are compromised by convergence of Bim/Bax proteins with Drp1, which contributes to high glucose-induced injury in DRG neurons... - Mouse models of diabetic neuropathyKelli A Sullivan
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Neurobiol Dis 28:276-85. 2007..Our data support the hypothesis that genetic background and diet influence the development of DN and should be considered when developing new models of DN... - Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cellsBhumsoo Kim
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Neoplasia 5:405-16. 2003..Therefore, agents resulting in the dephosphorylation of FAK may be beneficial for therapeutic treatment, irrespective of FAK protein levels, as this may result in apoptosis, which cannot be prevented by growth factor signaling... - Hydrogen peroxide-induced Akt phosphorylation regulates Bax activationMahdieh Sadidi
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Biochimie 91:577-85. 2009..Collectively, these findings reveal a mechanism by which H(2)O(2)-induced activation of PI3K/Akt influences post-translational modification of Bax and inactivates a key component of the cell death machinery... - Integrin expression regulates neuroblastoma attachment and migrationAmy Meyer
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Neoplasia 6:332-42. 2004..These data suggest that specific classes of integrins in concert with IGF-IR regulate NBL attachment and migration... - New insights into the mechanisms of diabetic neuropathyAndrea M Vincent
Department of Neurology at University of Michigan, Ann Arbor, MI, 48109, USA
Rev Endocr Metab Disord 5:227-36. 2004 
The association of exposure to lead, mercury, and selenium and the development of amyotrophic lateral sclerosis and the epigenetic implicationsBrian Callaghan
University of Michigan, Ann Arbor, MI 48109, USA
Neurodegener Dis 8:1-8. 2011..Perhaps an interaction between the metal exposure and an individual's genetic makeup is required to produce epigenetic changes that ultimately lead to ALS...- Rosiglitazone treatment reduces diabetic neuropathy in streptozotocin-treated DBA/2J miceTimothy D Wiggin
University of Michigan, Department of Neurology, 5017 Basic Science Research Building, 109 Zina Pitcher Road, Ann Arbor, Michigan 48109 2200, USA
Endocrinology 149:4928-37. 2008..These targets may be useful in designing drugs with the same efficacy as Rosi in treating DN but with fewer undesirable effects... - Oxidative injury and neuropathy in diabetes and impaired glucose toleranceJames W Russell
Department of Neurology, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA
Neurobiol Dis 30:420-9. 2008..Our study supports the hypothesis that neuropathy develops in an animal model of IGT and is associated with evidence of oxidative injury in DRG and peripheral nerves... - Diabetic neuropathiesAnn A Little
Peripheral Neuropathy Center, Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
Pract Neurol 7:82-92. 2007 - The design of electrospun PLLA nanofiber scaffolds compatible with serum-free growth of primary motor and sensory neuronsJoseph M Corey
Department of Neurology, The University of Michigan, Ann Arbor, MI 48109, USA
Acta Biomater 4:863-75. 2008..This substrate should facilitate investigating the behavior of many neuronal types on electrospun fibers in serum-free conditions... - Criteria for creating and assessing mouse models of diabetic neuropathyKelli A Sullivan
University of Michigan, Departments of Neurology and Internal Medicine, USA
Curr Drug Targets 9:3-13. 2008..By applying standard protocols, we hope to facilitate the comparison and characterization of DN across different background strains in the hope of discovering the most human like model in which to test potential therapies... - Aligned electrospun nanofibers specify the direction of dorsal root ganglia neurite growthJoseph M Corey
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biomed Mater Res A 83:636-45. 2007..The robust neurite guidance demonstrated here is a significant step toward the use of aligned, electrospun nanofibers for nerve regeneration. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007... - Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and functionJames J Dowling
Division of Pediatric Neurology, L3215 Women s Hospital, Ann Arbor, MI 48109 0203, USA
Circ Res 102:423-31. 2008..These findings provide the first characterization of the in vivo functions of this novel and critical regulator of cardiogenesis... - The antioxidant response as a drug target in diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Curr Drug Targets 9:94-100. 2008..In combination with antihyperglycemic agents, agents that regulate the antioxidant response may afford superior protection against cellular oxidative injury in diabetes... - Membrane traffic and muscle: lessons from human diseaseJames J Dowling
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Traffic 9:1035-43. 2008..This review highlights our current understanding of the trafficking genes responsible for human myopathies... - Strategic approaches to developing drug treatments for ALSAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor 48109, United States
Drug Discov Today 13:67-72. 2008..We review recent progress in promoting therapeutics into clinical trials and highlight the value of moderate throughput screening for the acceleration and improvement of drug design... - Mechanisms of disease: the oxidative stress theory of diabetic neuropathyClaudia Figueroa-Romero
Department of Neurology, University of Michigan, 5017 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109 2200, USA
Rev Endocr Metab Disord 9:301-14. 2008..New bioinformatics approaches can augment current research and lead to new discoveries to understand the pathogenesis of diabetic neuropathy and to identify more effective molecular therapeutic targets... - Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Acta Neuropathol 120:477-89. 2010..Our data suggest that an imbalance between mitochondrial biogenesis and fission may play a role in the pathogenesis of diabetic neuropathy... - DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural historyRodica Pop-Busui
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Curr Diab Rep 10:276-82. 2010..The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review... - Accelerated neuritogenesis and maturation of primary spinal motor neurons in response to nanofibersCaitlyn C Gertz
Department of Neurology, The University of Michigan, Ann Arbor, Michigan 48109, USA
Dev Neurobiol 70:589-603. 2010..Aligned nanofibers were shown to affect the directionality and timing of motor neuron development, providing further evidence for the effective use of electrospun scaffolds in neural regeneration applications... - Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) StudyJames W Albers
Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Diabetes Care 33:1090-6. 2010.... - Hyperlipidemia: a new therapeutic target for diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
J Peripher Nerv Syst 14:257-67. 2009..We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration... - Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetesBhumsoo Kim
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Endocrinology 150:5294-301. 2009.... - Nerve growth factor mediates mechanical allodynia in a mouse model of type 2 diabetesHsinlin T Cheng
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2200, USA
J Neuropathol Exp Neurol 68:1229-43. 2009..These results suggest that inhibition of NGF action is a potential strategy for treating painful diabetic neuropathy... - Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1Andrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
Diabetes 58:2376-85. 2009..Dyslipidemia also correlates with the development of neuropathy, even in pre-diabetic patients. This study was designed to explore the contribution of dyslipidemia in neuropathy... - Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC)Rodica Pop-Busui
University of Michigan, Department of Internal Medicine, Division of Metabolism, Endocrinology, Diabetes, Ann Arbor, MI, USA
Circulation 119:2886-93. 2009..We evaluated the effects of prior intensive insulin therapy on the prevalence and incidence of cardiac autonomic neuropathy (CAN) in former DCCT intensive and conventional therapy subjects 13 to 14 years after DCCT closeout... - Computational methods for predicting sites of functionally important dynamicsAdam D Schuyler
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Phys Chem B 113:6613-22. 2009..These tools are suitable for allosteric investigations and may greatly enhance the speed and effectiveness of other computational and experimental methods... - Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosisBhumsoo Kim
Department of Neurology, University of Michigan, 5371 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
Apoptosis 14:665-73. 2009.... - Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathyJames J Dowling
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan, USA
PLoS Genet 5:e1000372. 2009..Based on our findings, we speculate that congenital myopathies, usually considered entities with similar clinical features but very disparate pathomechanisms, may at their root be disorders of calcium homeostasis... - SciMiner: web-based literature mining tool for target identification and functional enrichment analysisJunguk Hur
Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
Bioinformatics 25:838-40. 2009..edu/SciMiner/. A server version of the SciMiner is also available for download and enables users to utilize their institution's journal subscriptions. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online... - Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanismsAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
Antioxid Redox Signal 11:425-38. 2009..Multiple cellular targets exist for the prevention of hyperglycemic oxidative stress in DRG neurons, and these form the basis for new therapeutic strategies against diabetic neuropathy... - Vibration perception threshold as a measure of distal symmetrical peripheral neuropathy in type 1 diabetes: results from the DCCT/EDIC studyCatherine L Martin
University of Michigan, Ann Arbor, Michigan, USA
Diabetes Care 33:2635-41. 2010.... - Identification of candidate drugs for the treatment of ALSAndrea M Vincent
Department of Neorology, University of Michigan, Ann Arbor, Michigan, USA
Amyotroph Lateral Scler Other Motor Neuron Disord 6:29-36. 2005..These data extend the understanding of motor neuron degeneration and identify a number of cellular targets for the improvement of combined therapies for neurodegenerative disease... - Short-term hyperglycemia produces oxidative damage and apoptosis in neuronsAndrea M Vincent
University of Michigan, Department of Neurology, Ann Arbor, Michigan 48109, USA
FASEB J 19:638-40. 2005..Since oxidative stress is a common feature of the micro- and macrovascular complications of diabetes, the present findings have broad application to the treatment of diabetic patients... - Differential regulation of insulin receptor substrate-1 degradation during mannitol and okadaic acid induced apoptosis in human neuroblastoma cellsBhumsoo Kim
Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109-0588, United States
Cell Signal 17:769-75. 2005..These results suggest two independent pathways are involved in IRS-1 degradation; one pathway is dependent on caspase activation and is blocked by IGF-I, while a second pathway is caspase-independent and IGF-I-insensitive... - Insulin-like growth factor-I signaling in human neuroblastoma cellsBhumsoo Kim
Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0588, USA
Oncogene 23:130-41. 2004..This detailed understanding of the 'biochemical signature' of N and S cells provides the background needed to target and disrupt specific IGF signaling pathways in an attempt to develop more effective therapies... - Substrate patterning: an emerging technology for the study of neuronal behaviorJoseph M Corey
Department of Neurology, University of Michigan, Ann Arbor, MI, USA
Exp Neurol 184:S89-96. 2003..Finally, the behavior of neurons on patterned substrates may prove helpful in the design of scaffoldings and nerve guides tailored for regeneration and repair of the nervous system... - Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injuryAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Antioxid Redox Signal 7:1494-506. 2005..The data strengthen the rationale for the current clinical trial. In addition, we describe an effective tool for rapid preclinical testing of novel therapies against diabetic neuropathy... - Neuronal survival following remote adenovirus gene deliveryNicholas M Boulis
Section of Neurosurgery and Department of Neurology, Center for Gene Therapy, University of Michigan, Ann Arbor, USA
J Neurosurg 96:212-9. 2002..In the present study, the authors examined gene expression and neuronal survival in the spinal cord after sciatic nerve administration of an adenovirus vector expressing a LacZ reporter gene... - High glucose-induced oxidative stress and mitochondrial dysfunction in neuronsJames W Russell
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
FASEB J 16:1738-48. 2002..Glucotoxicity is blocked by inhibiting ROS induction, MMD, or caspase cleavage by specific inhibitors of electron transfer, or by stabilizing the ANT... - Longitudinal assessment of noninvasive positive pressure ventilation adjustments in ALS patientsKirsten L Gruis
TC 1920 0316, Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
J Neurol Sci 247:59-63. 2006..10, 0.54]. The current data suggest that ALS patients who are tolerant to NIPPV typically need at least one upward change in pressure settings. Tolerance to relatively low NIPPV inspiratory pressures is associated with improved survival... - Control of cell survival by IGF signaling pathwaysAndrea M Vincent
Department of Neurology, University of Michigan, Room 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Growth Horm IGF Res 12:193-7. 2002..This review describes current knowledge of the mechanisms utilized by the IGF system to promote cell survival... - Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stressAndrea M Vincent
Department of Neurology, Room 5017 BSRB, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
Endocrinology 148:548-58. 2007..Our data indicate that therapies aimed at decreasing RAGE ligands, blocking RAGE signaling, or preventing oxidative stress could significantly decrease the development of neuropathy in diabetic patients... - Schwann cell caveolin-1 expression increases during myelination and decreases after axotomyDaniel D Mikol
Department of Neurology, University of Michigan, Ann Arbor 48109, USA
Glia 38:191-9. 2002..We speculate that caveolin-1 plays a role in the biology of myelinating Schwann cells... - Oxidative stress in the pathogenesis of diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Room 4414, Kresge III, 200 Zina Pitcher Place, Ann Arbor 48109, USA
Endocr Rev 25:612-28. 2004..We conclude that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients... - Evaluation of sham non-invasive ventilation for randomized, controlled trials in ALSKirsten L Gruis
University of Michigan Health System, Department of Neurology, 1324 Taubman Center, 032221 500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Amyotroph Lateral Scler 7:96-9. 2006..Thus, sub-therapeutic (sham) continuous positive airway pressure is a promising placebo control for NIV trials in ALS... - Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to boneCynthia M van Golen
Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Cancer Res 66:6570-8. 2006..These results support the hypothesis that IGF-IR expression in neuroblastoma cells increases tumor cell interaction with the bone microenvironment, resulting in greater formation of metastases... - IGF-I prevents glutamate-induced motor neuron programmed cell deathAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Neurobiol Dis 16:407-16. 2004..We discuss our results in terms of novel strategies for ALS therapy... - Tests and expenditures in the initial evaluation of peripheral neuropathyBrian Callaghan
Department of Neurology, University of Michigan, Ann Arbor, MI 48104, USA
Arch Intern Med 172:127-32. 2012..Peripheral neuropathy is a common disorder in which an extensive evaluation is often unrevealing... - Integrin-linked kinase complexes with caveolin-1 in human neuroblastoma cellsAmy Meyer
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
Biochemistry 44:932-8. 2005..These data suggest that the cav-binding domain of ILK and the cav-scaffolding domain of cav-1 mediate complex formation in human neuroblastoma cells... - Rosiglitazone reduces renal and plasma markers of oxidative injury and reverses urinary metabolite abnormalities in the amelioration of diabetic nephropathyHongyu Zhang
Department of Internal Medicine, University of Michigan, 5520 MSRB1, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5680, USA
Am J Physiol Renal Physiol 295:F1071-81. 2008..Of these, 21 were returned to normal by rosiglitazone. Thus rosiglitazone has direct effects on the renal glomerulus to reduce reactive oxygen species accumulation to prevent type 1 diabetic mice from development of DN... - Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosisStacey A Sakowski
Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Amyotroph Lateral Scler 10:63-73. 2009..The knowledge obtained from these studies suggests that IGF-I has the potential to be a safe and efficacious therapy for ALS... - Adeno-associated viral-mediated insulin-like growth factor delivery protects motor neurons in vitroAndrea M Vincent
Department of Neurology, University of Michigan, MI, USA
Neuromolecular Med 6:79-85. 2004..This mechanism may explain the therapeutic effects observed in vivo despite relatively low affinity AAV spinal cord uptake... - Patterning N-type and S-type neuroblastoma cells with Pluronic F108 and ECM proteinsJoseph M Corey
Department of Neurology, The University of Michigan, 5013 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
J Biomed Mater Res A 93:673-86. 2010..This patterned substrate design should facilitate investigations of the role of cell shape in NBL cell behavior... - Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor deliveryJ Simon Lunn
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Growth Factors 27:133-40. 2009..Combination therapy consisting of stem cells expressing beneficial growth factors may provide a comprehensive treatment for ALS... - Capturing cases of distal symmetric polyneuropathy in a communityBrian Callaghan
Department of Neurology, University of Michigan, 109 Zina Pitcher Place, 4021 BSRB, Ann Arbor, Michigan 48104, USA
Muscle Nerve 46:943-7. 2012..Little is known about what constitutes appropriate diagnostic testing in patients with distal symmetric polyneuropathy (DSP)... - Novel model to assess laryngeal function, innervation, and reinnervationMatthew O Old
Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
Ann Otol Rhinol Laryngol 120:331-8. 2011..The aim of the present study was to develop a reliable, accurate, and multifaceted animal model for study of laryngeal function, innervation, and reinnervation... - From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathyYing Qian
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0680, USA
Diabetes 57:1439-45. 2008 - Triglycerides and amputation risk in patients with diabetes: ten-year follow-up in the DISTANCE studyBrian C Callaghan
University of Michigan, Ann Arbor, Michigan, USA
Diabetes Care 34:635-40. 2011..To determine the association between triglyceride levels and lower-extremity amputation (LEA) risk in a large diabetic cohort... - Surgical decompression for diabetic sensorimotor polyneuropathyDavid R Cornblath
Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Diabetes Care 30:421-2. 2007 - Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetesManjusha Pande
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
Diabetes 60:1981-9. 2011..We examined changes in global gene expression to define pathways regulated by diabetes in peripheral nerve... - Mechanisms of disease: mitochondria as new therapeutic targets in diabetic neuropathyGina M Leinninger
University of Michigan, Ann Arbor, MI 48109-2200, USA
Nat Clin Pract Neurol 2:620-8. 2006..This Review will survey the mechanisms of mitochondrial degeneration in the pathogenesis of DN, highlighting potential mitochondrial sites for therapeutic intervention... - N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cellsDaniel Noujaim
Department of Neurology, University of Michigan, Ann Arbor 48109, USA
Oncogene 21:4549-57. 2002..These data imply that N-Myc and Bcl-2 cooperate to increase the expression, secretion, and activation of MMP-2, which likely leads to a more tumorigenic phenotype due to increased MMP-2 mediated invasion... - Diabetic neuropathyEva L Feldman
Curr Drug Targets 9:1-2. 2008 - Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene deliveryNicholas M Boulis
Department of Neurosurgery, The Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, Ohio 44195, USA
Neurosurgery 52:381-7; discussion 387. 2003..The present experiment demonstrates that intraneural injection of colchicine is capable of inhibiting remote delivery of both adenoviral and adeno-associated viral (AAV) vectors, implicating axonal transport in this process... - Can drug screening lead to candidate therapies for testing in diabetic neuropathy?Andrea M Vincent
Antioxid Redox Signal 10:387-93. 2008..Such studies may lead to the design of rational therapeutic approaches for this severe complication of diabetes... - Adeno-associated viral vector gene expression in the adult rat spinal cord following remote vector deliveryNicholas M Boulis
Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Neurobiol Dis 14:535-41. 2003..In summary, rAAV genes are expressed in CNS neurons following peripheral nerve injection at levels exceeding those seen following remote adenovirus injection... - Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic miceKarra A Muller
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Diabetes 57:1693-701. 2008..In addition, diabetic mice were treated with insulin to assess whether sensorimotor and spindle deficits were reversible... - Neuroinflammation, COX-2, and ALS--a dual role?Christopher Consilvio
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Exp Neurol 187:1-10. 2004..We will also discuss how this duality may affect future treatments for neurodegenerative diseases such as ALS... - Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathyAlan R Berger
Department of Neurology, University of Florida, USA
J Peripher Nerv Syst 8:282-4. 2003 - Applying database technology to clinical and basic research bioinformatics projectsThomas P Nadeau
Department of Computer Science and Engineering, University of Michigan, Ann Arbor, MI 48109-0580, USA
J Integr Neurosci 2:201-17. 2003..Bioinformatics is a useful tool in both basic research and clinical settings. The advantages of relational databases and an approach to managing bioinformatics projects are discussed... - Diabetic neuropathies: a statement by the American Diabetes AssociationAndrew J M Boulton
Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U.K
Diabetes Care 28:956-62. 2005 - Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and AktBhumsoo Kim
Department of Neurology, University of Michigan, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
J Biol Chem 277:27393-400. 2002.... - Dysfunction of the recurrent laryngeal nerve and the potential of gene therapyS Brett Heavner
Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor 48109 2200, USA
Ann Otol Rhinol Laryngol 116:441-8. 2007..The purpose of this review is to discuss the potential role for gene therapy in treatment of the unsolved problem of vocal fold paralysis... - In situ imaging of mitochondrial outer-membrane pores using atomic force microscopyBradley E Layton
University of Michigan, Ann Arbor, MI 48109-2125, USA
Biotechniques 37:564-70, 572-3. 2004..We have also begun to correlate 3-D surface features of mitochondria dotted with open membrane pores with features previously viewed with electron microscopy (EM) of fixed sections... - The role of growth factors in diabetic peripheral neuropathyGina M Leinninger
Neuroscience Programand Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
J Peripher Nerv Syst 9:26-53. 2004..Finally, the potential of growth factors as therapeutic agents is addressed, including an assessment of past growth factor clinical trials and other potential avenues of growth factor therapy... - Lifestyle intervention for pre-diabetic neuropathyA Gordon Smith
Department of Neurology, University of Utah School of Medicine, 50 N Medical Drive, SOM 3R152, Salt Lake City, UT 84132, USA
Diabetes Care 29:1294-9. 2006.... - Update on diabetic neuropathyZachary Simmons
Division of Neurology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Curr Opin Neurol 15:595-603. 2002..Some new information in the areas of diabetic amyotrophy and diabetic autonomic neuropathy will also be reviewed... - Signaling mechanisms that regulate actin-based motility processes in the nervous systemGary Meyer
Department of Neurology, University of Michigan, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
J Neurochem 83:490-503. 2002..The signaling mechanisms by which extracellular cues that guide axons to their targets lead to direct effects on actin filament dynamics are becoming better understood... - Insulin-like growth factors in the treatment of neurological diseaseGina M Leinninger
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
Endocr Dev 9:135-59. 2005..This review surveys the current understanding of IGF-I pleiotrophism, the underlying signaling conferring these effects, and the status of IGF-I in treatment of human neurological disorders... - Neuropathy among the diabetes control and complications trial cohort 8 years after trial completionCatherine L Martin
Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) Research Group, Bethesda, MD 20892, USA
Diabetes Care 29:340-4. 2006..CONCLUSIONS: The benefits of 6.5 years of intensive therapy on neuropathy status extended for at least 8 years beyond the end of the DCCT, similar to the findings described for diabetic retinopathy and nephropathy... - N-Myc overexpression leads to decreased beta1 integrin expression and increased apoptosis in human neuroblastoma cellsCynthia M van Golen
Department of Neurology, University of Michigan, Ann Arbor, MI 48109-0588, USA
Oncogene 22:2664-73. 2003..We speculate that N-Myc repression of beta1 integrin expression leads to a less differentiated phenotype, resulting in increased growth and tumorigenesis if properly supported or apoptosis if deprived of growth sustaining molecules... - Microvascular complications of impaired glucose toleranceJ Robinson Singleton
Department of Neurology, University of Utah, Salt Lake City, Utah, USA
Diabetes 52:2867-73. 2003..To what degree intervention will limit recognized complications is not known... - Establishment, maintenance, and transfection of in vitro cultures of human retinal pigment epitheliumMartin J Stevens
Sierra Sciences Inc, Reno, NV, USA
Methods Mol Med 107:343-51. 2005
Research Grants
- Mitochondrial SOD as a Target for Diabetic NeuropathyEva Feldman; Fiscal Year: 2007..Our studies will identify cellular targets for treatment of DN and have the potential to benefit all patients with diabetes. ..
- TRAINING IN CLINICAL AND BASIC NEUROSCIENCEEva Feldman; Fiscal Year: 2007..Efforts are made to recruit qualified women and minority students for training at all levels. ..
- GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHYEva Feldman; Fiscal Year: 2005..Use genetically altered mice to characterize the death pathway in clinical diabetic neuropathy and determine the point of IGF-I protection ..
- IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLSEva Feldman; Fiscal Year: 2002..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..
- GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHYEva Feldman; Fiscal Year: 1999..The ultimate goal is to understand the pathogenesis of diabetic neuropathy, and develop new treatment strategies for this problem. ..