Eva Feldman

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetes
    Manjusha Pande
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes 60:1981-9. 2011
  2. pmc Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis
    Claudia Figueroa-Romero
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e52672. 2012
  3. pmc Two dynamin-2 genes are required for normal zebrafish development
    Elizabeth M Gibbs
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e55888. 2013
  4. pmc The role of oxidative stress in nervous system aging
    Catrina Sims-Robinson
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e68011. 2013
  5. pmc Elevated triglycerides correlate with progression of diabetic neuropathy
    Timothy D Wiggin
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Diabetes 58:1634-40. 2009
  6. pmc Identification of factors associated with sural nerve regeneration and degeneration in diabetic neuropathy
    Junguk Hur
    Corresponding author Eva L Feldman
    Diabetes Care 36:4043-9. 2013
  7. pmc Peripheral neuropathy in adolescents and young adults with type 1 and type 2 diabetes from the SEARCH for Diabetes in Youth follow-up cohort: a pilot study
    Mamta Jaiswal
    Corresponding author Eva L Feldman
    Diabetes Care 36:3903-8. 2013
  8. pmc Neuromuscular effects of G93A-SOD1 expression in zebrafish
    Stacey A Sakowski
    Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor 5017 AAT BSRBMI, USA
    Mol Neurodegener 7:44. 2012
  9. pmc p38 mediates mechanical allodynia in a mouse model of type 2 diabetes
    Hsinlin T Cheng
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Mol Pain 6:28. 2010
  10. pmc Literature-based discovery of diabetes- and ROS-related targets
    Junguk Hur
    Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Med Genomics 3:49. 2010

Detail Information

Publications106 found, 100 shown here

  1. pmc Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetes
    Manjusha Pande
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes 60:1981-9. 2011
    ..We examined changes in global gene expression to define pathways regulated by diabetes in peripheral nerve...
  2. pmc Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis
    Claudia Figueroa-Romero
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e52672. 2012
    ..This study represents an initial identification of epigenetic regulatory mechanisms in sALS which may improve our understanding of sALS pathogenesis for the identification of biomarkers and new therapeutic targets...
  3. pmc Two dynamin-2 genes are required for normal zebrafish development
    Elizabeth M Gibbs
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e55888. 2013
    ..Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development...
  4. pmc The role of oxidative stress in nervous system aging
    Catrina Sims-Robinson
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e68011. 2013
    ....
  5. pmc Elevated triglycerides correlate with progression of diabetic neuropathy
    Timothy D Wiggin
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Diabetes 58:1634-40. 2009
    ..To evaluate mechanisms underlying diabetic neuropathy progression using indexes of sural nerve morphometry obtained from two identical randomized, placebo-controlled clinical trials...
  6. pmc Identification of factors associated with sural nerve regeneration and degeneration in diabetic neuropathy
    Junguk Hur
    Corresponding author Eva L Feldman
    Diabetes Care 36:4043-9. 2013
    ..Patients with diabetic neuropathy (DN) demonstrate variable degrees of nerve regeneration and degeneration. Our aim was to identify risk factors associated with sural nerve degeneration in patients with DN...
  7. pmc Peripheral neuropathy in adolescents and young adults with type 1 and type 2 diabetes from the SEARCH for Diabetes in Youth follow-up cohort: a pilot study
    Mamta Jaiswal
    Corresponding author Eva L Feldman
    Diabetes Care 36:3903-8. 2013
    ..To estimate the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in a pilot study among youth participating in the SEARCH for Diabetes in Youth study...
  8. pmc Neuromuscular effects of G93A-SOD1 expression in zebrafish
    Stacey A Sakowski
    Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor 5017 AAT BSRBMI, USA
    Mol Neurodegener 7:44. 2012
    ..Defects in the distal axon and at the neuromuscular junction are early events in the disease course, and zebrafish provide a promising in vivo system to examine cellular mechanisms and treatments for these events in ALS pathogenesis...
  9. pmc p38 mediates mechanical allodynia in a mouse model of type 2 diabetes
    Hsinlin T Cheng
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Mol Pain 6:28. 2010
    ..Using this timeline of PDN, we can investigate the signaling mechanisms underlying mechanical allodynia in the db/db mouse...
  10. pmc Literature-based discovery of diabetes- and ROS-related targets
    Junguk Hur
    Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Med Genomics 3:49. 2010
    ..Reactive oxygen species (ROS) are known mediators of cellular damage in multiple diseases including diabetic complications. Despite its importance, no comprehensive database is currently available for the genes associated with ROS...
  11. pmc Kindlin-2 is required for myocyte elongation and is essential for myogenesis
    James J Dowling
    Department of Pediatrics, University of Michigan, Ann Arbor, USA
    BMC Cell Biol 9:36. 2008
    ..Unc-112 is an integrin-associated protein required for muscle development in C. elegans. To better understand the intracellular effectors of integrin signaling in muscle, we examined the mammalian homolog of Unc-112, kindlin-2...
  12. pmc Oxidative stress and diabetic neuropathy: a new understanding of an old problem
    Eva L Feldman
    Juvenile Diabetes Research Foundation Center for the Study of Complications in Diabetes, and the Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 111:431-3. 2003
  13. ncbi request reprint Insulin-like growth factor-I and central nervous system development
    B Anlar
    University of Michigan, Department of Neurology, Ann Arbor, USA
    Horm Metab Res 31:120-5. 1999
    ..IGF-I is among the molecules which affect several steps involved in development...
  14. pmc National Institute of Neurological Disorders and Stroke (NINDS): advances in understanding and treating neuropathy, 24-25 October 2006; Bethesda, Maryland
    Eva L Feldman
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Peripher Nerv Syst 13:1-6. 2008
    ..Short-term goals of the workshop were to form a working group for neuropathy, the Peripheral Neuropathy Study Group, and to translate new scientific findings into therapies and complete clinical trials...
  15. ncbi request reprint Pathogenesis of diabetic neuropathy
    E L Feldman
    University of Michigan Medical Center, Ann Arbor, USA
    Clin Neurosci 4:365-70. 1997
    ..In this review we will discuss these theories, their interrelationships and how, collectively, these ideas may begin to explain the etiology of DN...
  16. ncbi request reprint Type I insulin-like growth factor receptor activation regulates apoptotic proteins
    J R Singleton
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 271:31791-4. 1996
    ....
  17. pmc The identification of gene expression profiles associated with progression of human diabetic neuropathy
    Junguk Hur
    Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
    Brain 134:3222-35. 2011
    ..Our results identifying the unique gene signature of patients with progressive diabetic neuropathy will facilitate the development of new mechanism-based diagnostics and therapies...
  18. pmc SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, 5017 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 0588, USA
    Exp Neurol 208:216-27. 2007
    ..DN was observed in the C57BL/6Jdb/db mouse, and decreased expression of SOD2 in these animals increased DN. Our data suggest that SOD2 activity is an important cellular modifier of neuronal oxidative defense against hyperglycemic injury...
  19. ncbi request reprint Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons
    Gina M Leinninger
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    FASEB J 18:1544-6. 2004
    ..These data suggest that IGF-I prevents apoptosis in DRG neurons by regulating PI3K/Akt pathway effectors, including GSK-3beta, CREB, and FKHR, and by blocking caspase activation...
  20. pmc Vascular endothelial growth factor prevents G93A-SOD1-induced motor neuron degeneration
    J Simon Lunn
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Dev Neurobiol 69:871-84. 2009
    ..Overall, these studies validate the usefulness of VEGF as a potential therapeutic factor for the treatment of ALS and give valuable insight into the responsible signaling pathways and mechanisms involved...
  21. ncbi request reprint Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1
    Gina M Leinninger
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
    Neurobiol Dis 23:11-22. 2006
    ..We propose that mitochondria are compromised by convergence of Bim/Bax proteins with Drp1, which contributes to high glucose-induced injury in DRG neurons...
  22. ncbi request reprint Insulin-like growth factor I induces preferential degradation of insulin receptor substrate-2 through the phosphatidylinositol 3-kinase pathway in human neuroblastoma cells
    Bhumsoo Kim
    University of Michigan, Department of Neurology, Ann Arbor, Michigan 48109 0588, USA
    Endocrinology 146:5350-7. 2005
    ....
  23. pmc Mouse models of diabetic neuropathy
    Kelli A Sullivan
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Neurobiol Dis 28:276-85. 2007
    ..Our data support the hypothesis that genetic background and diet influence the development of DN and should be considered when developing new models of DN...
  24. pmc Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells
    Bhumsoo Kim
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 5:405-16. 2003
    ..Therefore, agents resulting in the dephosphorylation of FAK may be beneficial for therapeutic treatment, irrespective of FAK protein levels, as this may result in apoptosis, which cannot be prevented by growth factor signaling...
  25. pmc Hydrogen peroxide-induced Akt phosphorylation regulates Bax activation
    Mahdieh Sadidi
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Biochimie 91:577-85. 2009
    ..Collectively, these findings reveal a mechanism by which H(2)O(2)-induced activation of PI3K/Akt influences post-translational modification of Bax and inactivates a key component of the cell death machinery...
  26. pmc Integrin expression regulates neuroblastoma attachment and migration
    Amy Meyer
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 6:332-42. 2004
    ..These data suggest that specific classes of integrins in concert with IGF-IR regulate NBL attachment and migration...
  27. ncbi request reprint New insights into the mechanisms of diabetic neuropathy
    Andrea M Vincent
    Department of Neurology at University of Michigan, Ann Arbor, MI, 48109, USA
    Rev Endocr Metab Disord 5:227-36. 2004
  28. pmc Tests and expenditures in the initial evaluation of peripheral neuropathy
    Brian Callaghan
    Department of Neurology, University of Michigan, Ann Arbor, MI 48104, USA
    Arch Intern Med 172:127-32. 2012
    ..Peripheral neuropathy is a common disorder in which an extensive evaluation is often unrevealing...
  29. pmc Vibration perception threshold as a measure of distal symmetrical peripheral neuropathy in type 1 diabetes: results from the DCCT/EDIC study
    Catherine L Martin
    University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 33:2635-41. 2010
    ....
  30. pmc Oxidative injury and neuropathy in diabetes and impaired glucose tolerance
    James W Russell
    Department of Neurology, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA
    Neurobiol Dis 30:420-9. 2008
    ..Our study supports the hypothesis that neuropathy develops in an animal model of IGT and is associated with evidence of oxidative injury in DRG and peripheral nerves...
  31. pmc The design of electrospun PLLA nanofiber scaffolds compatible with serum-free growth of primary motor and sensory neurons
    Joseph M Corey
    Department of Neurology, The University of Michigan, Ann Arbor, MI 48109, USA
    Acta Biomater 4:863-75. 2008
    ..This substrate should facilitate investigating the behavior of many neuronal types on electrospun fibers in serum-free conditions...
  32. pmc Membrane traffic and muscle: lessons from human disease
    James J Dowling
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Traffic 9:1035-43. 2008
    ..This review highlights our current understanding of the trafficking genes responsible for human myopathies...
  33. ncbi request reprint The antioxidant response as a drug target in diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Drug Targets 9:94-100. 2008
    ..In combination with antihyperglycemic agents, agents that regulate the antioxidant response may afford superior protection against cellular oxidative injury in diabetes...
  34. pmc Criteria for creating and assessing mouse models of diabetic neuropathy
    Kelli A Sullivan
    University of Michigan, Departments of Neurology and Internal Medicine, USA
    Curr Drug Targets 9:3-13. 2008
    ..By applying standard protocols, we hope to facilitate the comparison and characterization of DN across different background strains in the hope of discovering the most human like model in which to test potential therapies...
  35. pmc Strategic approaches to developing drug treatments for ALS
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor 48109, United States
    Drug Discov Today 13:67-72. 2008
    ..We review recent progress in promoting therapeutics into clinical trials and highlight the value of moderate throughput screening for the acceleration and improvement of drug design...
  36. ncbi request reprint Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function
    James J Dowling
    Division of Pediatric Neurology, L3215 Women s Hospital, Ann Arbor, MI 48109 0203, USA
    Circ Res 102:423-31. 2008
    ..These findings provide the first characterization of the in vivo functions of this novel and critical regulator of cardiogenesis...
  37. ncbi request reprint Oxidative stress in the pathogenesis of diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Room 4414, Kresge III, 200 Zina Pitcher Place, Ann Arbor 48109, USA
    Endocr Rev 25:612-28. 2004
    ..We conclude that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients...
  38. pmc Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes 58:2376-85. 2009
    ..Dyslipidemia also correlates with the development of neuropathy, even in pre-diabetic patients. This study was designed to explore the contribution of dyslipidemia in neuropathy...
  39. doi request reprint Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Acta Neuropathol 120:477-89. 2010
    ..Our data suggest that an imbalance between mitochondrial biogenesis and fission may play a role in the pathogenesis of diabetic neuropathy...
  40. pmc DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history
    Rodica Pop-Busui
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Curr Diab Rep 10:276-82. 2010
    ..The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review...
  41. ncbi request reprint Mechanisms of disease: the oxidative stress theory of diabetic neuropathy
    Claudia Figueroa-Romero
    Department of Neurology, University of Michigan, 5017 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109 2200, USA
    Rev Endocr Metab Disord 9:301-14. 2008
    ..New bioinformatics approaches can augment current research and lead to new discoveries to understand the pathogenesis of diabetic neuropathy and to identify more effective molecular therapeutic targets...
  42. pmc Nerve growth factor mediates mechanical allodynia in a mouse model of type 2 diabetes
    Hsinlin T Cheng
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2200, USA
    J Neuropathol Exp Neurol 68:1229-43. 2009
    ..These results suggest that inhibition of NGF action is a potential strategy for treating painful diabetic neuropathy...
  43. pmc Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes
    Bhumsoo Kim
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Endocrinology 150:5294-301. 2009
    ....
  44. pmc Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC)
    Rodica Pop-Busui
    University of Michigan, Department of Internal Medicine, Division of Metabolism, Endocrinology, Diabetes, Ann Arbor, MI, USA
    Circulation 119:2886-93. 2009
    ..We evaluated the effects of prior intensive insulin therapy on the prevalence and incidence of cardiac autonomic neuropathy (CAN) in former DCCT intensive and conventional therapy subjects 13 to 14 years after DCCT closeout...
  45. doi request reprint Hyperlipidemia: a new therapeutic target for diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    J Peripher Nerv Syst 14:257-67. 2009
    ..We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration...
  46. pmc Computational methods for predicting sites of functionally important dynamics
    Adam D Schuyler
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Phys Chem B 113:6613-22. 2009
    ..These tools are suitable for allosteric investigations and may greatly enhance the speed and effectiveness of other computational and experimental methods...
  47. pmc Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study
    James W Albers
    Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes Care 33:1090-6. 2010
    ....
  48. doi request reprint Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis
    Bhumsoo Kim
    Department of Neurology, University of Michigan, 5371 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Apoptosis 14:665-73. 2009
    ....
  49. pmc Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy
    James J Dowling
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Genet 5:e1000372. 2009
    ..Based on our findings, we speculate that congenital myopathies, usually considered entities with similar clinical features but very disparate pathomechanisms, may at their root be disorders of calcium homeostasis...
  50. pmc SciMiner: web-based literature mining tool for target identification and functional enrichment analysis
    Junguk Hur
    Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 25:838-40. 2009
    ..8% F-measure. SciMiner's literature mining performance coupled with functional enrichment analyses provides an efficient platform for retrieval and summary of rich biological information from corpora of users' interests...
  51. pmc Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Antioxid Redox Signal 11:425-38. 2009
    ..Multiple cellular targets exist for the prevention of hyperglycemic oxidative stress in DRG neurons, and these form the basis for new therapeutic strategies against diabetic neuropathy...
  52. pmc Accelerated neuritogenesis and maturation of primary spinal motor neurons in response to nanofibers
    Caitlyn C Gertz
    Department of Neurology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Dev Neurobiol 70:589-603. 2010
    ..Aligned nanofibers were shown to affect the directionality and timing of motor neuron development, providing further evidence for the effective use of electrospun scaffolds in neural regeneration applications...
  53. pmc Rosiglitazone treatment reduces diabetic neuropathy in streptozotocin-treated DBA/2J mice
    Timothy D Wiggin
    University of Michigan, Department of Neurology, 5017 Basic Science Research Building, 109 Zina Pitcher Road, Ann Arbor, Michigan 48109 2200, USA
    Endocrinology 149:4928-37. 2008
    ..These targets may be useful in designing drugs with the same efficacy as Rosi in treating DN but with fewer undesirable effects...
  54. ncbi request reprint Longitudinal assessment of noninvasive positive pressure ventilation adjustments in ALS patients
    Kirsten L Gruis
    TC 1920 0316, Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    J Neurol Sci 247:59-63. 2006
    ..10, 0.54]. The current data suggest that ALS patients who are tolerant to NIPPV typically need at least one upward change in pressure settings. Tolerance to relatively low NIPPV inspiratory pressures is associated with improved survival...
  55. ncbi request reprint High glucose-induced oxidative stress and mitochondrial dysfunction in neurons
    James W Russell
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 16:1738-48. 2002
    ..Glucotoxicity is blocked by inhibiting ROS induction, MMD, or caspase cleavage by specific inhibitors of electron transfer, or by stabilizing the ANT...
  56. ncbi request reprint Neuronal survival following remote adenovirus gene delivery
    Nicholas M Boulis
    Section of Neurosurgery and Department of Neurology, Center for Gene Therapy, University of Michigan, Ann Arbor, USA
    J Neurosurg 96:212-9. 2002
    ..In the present study, the authors examined gene expression and neuronal survival in the spinal cord after sciatic nerve administration of an adenovirus vector expressing a LacZ reporter gene...
  57. ncbi request reprint Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Antioxid Redox Signal 7:1494-506. 2005
    ..The data strengthen the rationale for the current clinical trial. In addition, we describe an effective tool for rapid preclinical testing of novel therapies against diabetic neuropathy...
  58. ncbi request reprint Identification of candidate drugs for the treatment of ALS
    Andrea M Vincent
    Department of Neorology, University of Michigan, Ann Arbor, Michigan, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:29-36. 2005
    ..These data extend the understanding of motor neuron degeneration and identify a number of cellular targets for the improvement of combined therapies for neurodegenerative disease...
  59. ncbi request reprint Differential regulation of insulin receptor substrate-1 degradation during mannitol and okadaic acid induced apoptosis in human neuroblastoma cells
    Bhumsoo Kim
    Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0588, United States
    Cell Signal 17:769-75. 2005
    ..These results suggest two independent pathways are involved in IRS-1 degradation; one pathway is dependent on caspase activation and is blocked by IGF-I, while a second pathway is caspase-independent and IGF-I-insensitive...
  60. ncbi request reprint Short-term hyperglycemia produces oxidative damage and apoptosis in neurons
    Andrea M Vincent
    University of Michigan, Department of Neurology, Ann Arbor, Michigan 48109, USA
    FASEB J 19:638-40. 2005
    ..Since oxidative stress is a common feature of the micro- and macrovascular complications of diabetes, the present findings have broad application to the treatment of diabetic patients...
  61. ncbi request reprint Schwann cell caveolin-1 expression increases during myelination and decreases after axotomy
    Daniel D Mikol
    Department of Neurology, University of Michigan, Ann Arbor 48109, USA
    Glia 38:191-9. 2002
    ..We speculate that caveolin-1 plays a role in the biology of myelinating Schwann cells...
  62. ncbi request reprint Substrate patterning: an emerging technology for the study of neuronal behavior
    Joseph M Corey
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Exp Neurol 184:S89-96. 2003
    ..Finally, the behavior of neurons on patterned substrates may prove helpful in the design of scaffoldings and nerve guides tailored for regeneration and repair of the nervous system...
  63. ncbi request reprint IGF-I prevents glutamate-induced motor neuron programmed cell death
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neurobiol Dis 16:407-16. 2004
    ..We discuss our results in terms of novel strategies for ALS therapy...
  64. ncbi request reprint Control of cell survival by IGF signaling pathways
    Andrea M Vincent
    Department of Neurology, University of Michigan, Room 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Growth Horm IGF Res 12:193-7. 2002
    ..This review describes current knowledge of the mechanisms utilized by the IGF system to promote cell survival...
  65. ncbi request reprint Insulin-like growth factor-I signaling in human neuroblastoma cells
    Bhumsoo Kim
    Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0588, USA
    Oncogene 23:130-41. 2004
    ..This detailed understanding of the 'biochemical signature' of N and S cells provides the background needed to target and disrupt specific IGF signaling pathways in an attempt to develop more effective therapies...
  66. ncbi request reprint Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone
    Cynthia M van Golen
    Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Cancer Res 66:6570-8. 2006
    ..These results support the hypothesis that IGF-IR expression in neuroblastoma cells increases tumor cell interaction with the bone microenvironment, resulting in greater formation of metastases...
  67. ncbi request reprint Diabetic neuropathies
    Ann A Little
    Peripheral Neuropathy Center, Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Pract Neurol 7:82-92. 2007
  68. ncbi request reprint Evaluation of sham non-invasive ventilation for randomized, controlled trials in ALS
    Kirsten L Gruis
    University of Michigan Health System, Department of Neurology, 1324 Taubman Center, 032221 500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Amyotroph Lateral Scler 7:96-9. 2006
    ..Only 8 (20%) of all subjects were confident about their determination that they had received "real" or "pretend" NIV. Thus, sub-therapeutic (sham) continuous positive airway pressure is a promising placebo control for NIV trials in ALS...
  69. ncbi request reprint Aligned electrospun nanofibers specify the direction of dorsal root ganglia neurite growth
    Joseph M Corey
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biomed Mater Res A 83:636-45. 2007
    ..The robust neurite guidance demonstrated here is a significant step toward the use of aligned, electrospun nanofibers for nerve regeneration. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007...
  70. ncbi request reprint Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress
    Andrea M Vincent
    Department of Neurology, Room 5017 BSRB, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
    Endocrinology 148:548-58. 2007
    ..Our data indicate that therapies aimed at decreasing RAGE ligands, blocking RAGE signaling, or preventing oxidative stress could significantly decrease the development of neuropathy in diabetic patients...
  71. pmc The metabolic syndrome and neuropathy: therapeutic challenges and opportunities
    Brian Callaghan
    Department of Neurology, University of Michigan, Ann Arbor, MI
    Ann Neurol 74:397-403. 2013
    ..Just as importantly, we must continue to investigate the pathophysiology of metabolically induced nerve injury...
  72. doi request reprint Capturing cases of distal symmetric polyneuropathy in a community
    Brian Callaghan
    Department of Neurology, University of Michigan, 109 Zina Pitcher Place, 4021 BSRB, Ann Arbor, Michigan 48104, USA
    Muscle Nerve 46:943-7. 2012
    ..Little is known about what constitutes appropriate diagnostic testing in patients with distal symmetric polyneuropathy (DSP)...
  73. pmc Patterning N-type and S-type neuroblastoma cells with Pluronic F108 and ECM proteins
    Joseph M Corey
    Department of Neurology, The University of Michigan, 5013 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    J Biomed Mater Res A 93:673-86. 2010
    ..This patterned substrate design should facilitate investigations of the role of cell shape in NBL cell behavior...
  74. pmc Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosis
    Stacey A Sakowski
    Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Amyotroph Lateral Scler 10:63-73. 2009
    ..The knowledge obtained from these studies suggests that IGF-I has the potential to be a safe and efficacious therapy for ALS...
  75. ncbi request reprint Integrin-linked kinase complexes with caveolin-1 in human neuroblastoma cells
    Amy Meyer
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biochemistry 44:932-8. 2005
    ..These data suggest that the cav-binding domain of ILK and the cav-scaffolding domain of cav-1 mediate complex formation in human neuroblastoma cells...
  76. doi request reprint Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery
    J Simon Lunn
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Growth Factors 27:133-40. 2009
    ..Combination therapy consisting of stem cells expressing beneficial growth factors may provide a comprehensive treatment for ALS...
  77. pmc Rosiglitazone reduces renal and plasma markers of oxidative injury and reverses urinary metabolite abnormalities in the amelioration of diabetic nephropathy
    Hongyu Zhang
    Department of Internal Medicine, University of Michigan, 5520 MSRB1, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5680, USA
    Am J Physiol Renal Physiol 295:F1071-81. 2008
    ..Of these, 21 were returned to normal by rosiglitazone. Thus rosiglitazone has direct effects on the renal glomerulus to reduce reactive oxygen species accumulation to prevent type 1 diabetic mice from development of DN...
  78. ncbi request reprint Adeno-associated viral-mediated insulin-like growth factor delivery protects motor neurons in vitro
    Andrea M Vincent
    Department of Neurology, University of Michigan, MI, USA
    Neuromolecular Med 6:79-85. 2004
    ..This mechanism may explain the therapeutic effects observed in vivo despite relatively low affinity AAV spinal cord uptake...
  79. doi request reprint From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy
    Ying Qian
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0680, USA
    Diabetes 57:1439-45. 2008
  80. pmc Triglycerides and amputation risk in patients with diabetes: ten-year follow-up in the DISTANCE study
    Brian C Callaghan
    University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 34:635-40. 2011
    ..To determine the association between triglyceride levels and lower-extremity amputation (LEA) risk in a large diabetic cohort...
  81. doi request reprint The association of exposure to lead, mercury, and selenium and the development of amyotrophic lateral sclerosis and the epigenetic implications
    Brian Callaghan
    University of Michigan, Ann Arbor, MI 48109, USA
    Neurodegener Dis 8:1-8. 2011
    ..Perhaps an interaction between the metal exposure and an individual's genetic makeup is required to produce epigenetic changes that ultimately lead to ALS...
  82. ncbi request reprint Novel model to assess laryngeal function, innervation, and reinnervation
    Matthew O Old
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Ann Otol Rhinol Laryngol 120:331-8. 2011
    ..The aim of the present study was to develop a reliable, accurate, and multifaceted animal model for study of laryngeal function, innervation, and reinnervation...
  83. ncbi request reprint Surgical decompression for diabetic sensorimotor polyneuropathy
    David R Cornblath
    Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Diabetes Care 30:421-2. 2007
  84. ncbi request reprint Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery
    Nicholas M Boulis
    Department of Neurosurgery, The Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Neurosurgery 52:381-7; discussion 387. 2003
    ..The present experiment demonstrates that intraneural injection of colchicine is capable of inhibiting remote delivery of both adenoviral and adeno-associated viral (AAV) vectors, implicating axonal transport in this process...
  85. ncbi request reprint N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells
    Daniel Noujaim
    Department of Neurology, University of Michigan, Ann Arbor 48109, USA
    Oncogene 21:4549-57. 2002
    ..These data imply that N-Myc and Bcl-2 cooperate to increase the expression, secretion, and activation of MMP-2, which likely leads to a more tumorigenic phenotype due to increased MMP-2 mediated invasion...
  86. ncbi request reprint Adeno-associated viral vector gene expression in the adult rat spinal cord following remote vector delivery
    Nicholas M Boulis
    Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurobiol Dis 14:535-41. 2003
    ..In summary, rAAV genes are expressed in CNS neurons following peripheral nerve injection at levels exceeding those seen following remote adenovirus injection...
  87. ncbi request reprint Diabetic neuropathy
    Eva L Feldman
    Curr Drug Targets 9:1-2. 2008
  88. ncbi request reprint Mechanisms of disease: mitochondria as new therapeutic targets in diabetic neuropathy
    Gina M Leinninger
    University of Michigan, Ann Arbor, MI 48109 2200, USA
    Nat Clin Pract Neurol 2:620-8. 2006
    ..This Review will survey the mechanisms of mitochondrial degeneration in the pathogenesis of DN, highlighting potential mitochondrial sites for therapeutic intervention...
  89. ncbi request reprint Can drug screening lead to candidate therapies for testing in diabetic neuropathy?
    Andrea M Vincent
    Antioxid Redox Signal 10:387-93. 2008
    ..Such studies may lead to the design of rational therapeutic approaches for this severe complication of diabetes...
  90. ncbi request reprint Neuroinflammation, COX-2, and ALS--a dual role?
    Christopher Consilvio
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Exp Neurol 187:1-10. 2004
    ..We will also discuss how this duality may affect future treatments for neurodegenerative diseases such as ALS...
  91. doi request reprint Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice
    Karra A Muller
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Diabetes 57:1693-701. 2008
    ..In addition, diabetic mice were treated with insulin to assess whether sensorimotor and spindle deficits were reversible...
  92. ncbi request reprint Lifestyle intervention for pre-diabetic neuropathy
    A Gordon Smith
    Department of Neurology, University of Utah School of Medicine, 50 N Medical Drive, SOM 3R152, Salt Lake City, UT 84132, USA
    Diabetes Care 29:1294-9. 2006
    ....
  93. ncbi request reprint Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt
    Bhumsoo Kim
    Department of Neurology, University of Michigan, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    J Biol Chem 277:27393-400. 2002
    ....
  94. ncbi request reprint Update on diabetic neuropathy
    Zachary Simmons
    Division of Neurology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Curr Opin Neurol 15:595-603. 2002
    ..Some new information in the areas of diabetic amyotrophy and diabetic autonomic neuropathy will also be reviewed...
  95. ncbi request reprint Establishment, maintenance, and transfection of in vitro cultures of human retinal pigment epithelium
    Martin J Stevens
    Sierra Sciences Inc, Reno, NV, USA
    Methods Mol Med 107:343-51. 2005
  96. ncbi request reprint Signaling mechanisms that regulate actin-based motility processes in the nervous system
    Gary Meyer
    Department of Neurology, University of Michigan, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    J Neurochem 83:490-503. 2002
    ..The signaling mechanisms by which extracellular cues that guide axons to their targets lead to direct effects on actin filament dynamics are becoming better understood...
  97. ncbi request reprint Dysfunction of the recurrent laryngeal nerve and the potential of gene therapy
    S Brett Heavner
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor 48109 2200, USA
    Ann Otol Rhinol Laryngol 116:441-8. 2007
    ..The purpose of this review is to discuss the potential role for gene therapy in treatment of the unsolved problem of vocal fold paralysis...
  98. pmc Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion
    Catherine L Martin
    Diabetes Control and Complications Trial DCCT Epidemiology of Diabetes Intervention and Complications EDIC Research Group, Bethesda, MD 20892, USA
    Diabetes Care 29:340-4. 2006
    ..To evaluate the impact of prior intensive diabetes therapy on neuropathy among former Diabetes Control and Complications Trial (DCCT) participants...
  99. ncbi request reprint Insulin-like growth factors in the treatment of neurological disease
    Gina M Leinninger
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
    Endocr Dev 9:135-59. 2005
    ..This review surveys the current understanding of IGF-I pleiotrophism, the underlying signaling conferring these effects, and the status of IGF-I in treatment of human neurological disorders...
  100. ncbi request reprint Diabetic neuropathies: a statement by the American Diabetes Association
    Andrew J M Boulton
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U K
    Diabetes Care 28:956-62. 2005
  101. ncbi request reprint In situ imaging of mitochondrial outer-membrane pores using atomic force microscopy
    Bradley E Layton
    University of Michigan, Ann Arbor, MI 48109 2125, USA
    Biotechniques 37:564-70, 572-3. 2004
    ..We have also begun to correlate 3-D surface features of mitochondria dotted with open membrane pores with features previously viewed with electron microscopy (EM) of fixed sections...

Research Grants18

  1. Mitochondrial SOD as a Target for Diabetic Neuropathy
    Eva Feldman; Fiscal Year: 2007
    ..Our studies will identify cellular targets for treatment of DN and have the potential to benefit all patients with diabetes. ..
  2. TRAINING IN CLINICAL AND BASIC NEUROSCIENCE
    Eva Feldman; Fiscal Year: 2007
    ..Efforts are made to recruit qualified women and minority students for training at all levels. ..
  3. GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHY
    Eva Feldman; Fiscal Year: 2005
    ..Use genetically altered mice to characterize the death pathway in clinical diabetic neuropathy and determine the point of IGF-I protection ..
  4. GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHY
    Eva Feldman; Fiscal Year: 2004
    ..Use genetically altered mice to characterize the death pathway in clinical diabetic neuropathy and determine the point of IGF-I protection ..
  5. GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHY
    Eva Feldman; Fiscal Year: 2003
    ..Use genetically altered mice to characterize the death pathway in clinical diabetic neuropathy and determine the point of IGF-I protection ..
  6. IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLS
    Eva Feldman; Fiscal Year: 2002
    ..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..
  7. GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHY
    Eva Feldman; Fiscal Year: 2002
    ..Use genetically altered mice to characterize the death pathway in clinical diabetic neuropathy and determine the point of IGF-I protection ..
  8. IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLS
    Eva Feldman; Fiscal Year: 2001
    ..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..
  9. IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLS
    Eva Feldman; Fiscal Year: 2001
    ..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..
  10. IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLS
    Eva Feldman; Fiscal Year: 2000
    ..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..
  11. IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLS
    Eva Feldman; Fiscal Year: 2000
    ..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..
  12. GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHY
    Eva Feldman; Fiscal Year: 1999
    ..The ultimate goal is to understand the pathogenesis of diabetic neuropathy, and develop new treatment strategies for this problem. ..
  13. IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLS
    Eva Feldman; Fiscal Year: 1999
    ..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..