Douglas Feinstein

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Norepinephrine protects cortical neurons against microglial-induced cell death
    Jose L M Madrigal
    Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA
    J Neurosci Res 81:390-6. 2005
  2. ncbi request reprint The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis
    Cinzia Dello Russo
    Department of Anesthesiology, University of Illinois, and Jesse Brown Veteran s Affairs Research Division, Chicago, Illinois 60612, USA
    J Neurochem 99:1351-62. 2006
  3. doi request reprint Effects of pioglitazone on diffusion tensor imaging indices in multiple sclerosis patients
    Dinesh K Shukla
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    Neurosci Lett 472:153-6. 2010
  4. pmc Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins
    Maria Vittoria Simonini
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, U S A
    ASN Neuro 2:e00025. 2010
  5. pmc Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production
    Cinzia Dello Russo
    Department of Anesthesiology, University of Illinois, and West Side Veteran s Affairs Research Division, Chicago, Illinois, U, S, A
    J Neuroinflammation 1:9. 2004
  6. pmc Sevoflurane reduces clinical disease in a mouse model of multiple sclerosis
    Paul E Polak
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    J Neuroinflammation 9:272. 2012
  7. pmc Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised
    Pierre Lacombe
    Laboratoire de Recherches C r brovasculaires, CNRS FRE 2363, Paris, France
    J Neuroinflammation 1:11. 2004
  8. pmc Effect of pioglitazone treatment on behavioral symptoms in autistic children
    Marvin Boris
    Woodbury, New York 11797, USA
    J Neuroinflammation 4:3. 2007
  9. pmc The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
    Lucia Lisi
    Istitute of Pharmacology, Catholic Medical School, Rome, Italy
    J Neuroinflammation 8:1. 2011
  10. pmc P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis
    Anthony J Sharp
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    J Neuroinflammation 5:33. 2008

Research Grants

Detail Information

Publications58

  1. ncbi request reprint Norepinephrine protects cortical neurons against microglial-induced cell death
    Jose L M Madrigal
    Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA
    J Neurosci Res 81:390-6. 2005
    ..These results suggest that microglial release of IL-1beta is an important activator of neuronal inflammatory responses, and that protective effects of NE upon neurons involve a reduction of microglial-derived IL-1beta...
  2. ncbi request reprint The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis
    Cinzia Dello Russo
    Department of Anesthesiology, University of Illinois, and Jesse Brown Veteran s Affairs Research Division, Chicago, Illinois 60612, USA
    J Neurochem 99:1351-62. 2006
    ..Together, these data suggest that HSP90 inhibitors could represent a new approach for therapeutic intervention in autoimmune diseases such as multiple sclerosis...
  3. doi request reprint Effects of pioglitazone on diffusion tensor imaging indices in multiple sclerosis patients
    Dinesh K Shukla
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    Neurosci Lett 472:153-6. 2010
    ..These findings suggest that baseline DTI parameters can provide a prognostic surrogate marker for lesions, and that pioglitazone can reduce conversion of normal appearing white matter to lesions...
  4. pmc Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins
    Maria Vittoria Simonini
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, U S A
    ASN Neuro 2:e00025. 2010
    ..In contrast, GW0742 reduced BMP2 and BMP4 mRNA levels in OPCs, with lesser effects in astrocytes. These findings demonstrate that PPARδ plays a role in OPC maturation, mediated, in part, by regulation of BMP and BMP antagonists...
  5. pmc Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production
    Cinzia Dello Russo
    Department of Anesthesiology, University of Illinois, and West Side Veteran s Affairs Research Division, Chicago, Illinois, U, S, A
    J Neuroinflammation 1:9. 2004
    ..These results suggest that dysregulation of the central cathecolaminergic system may contribute to detrimental inflammatory responses and brain damage in neurological disease or trauma...
  6. pmc Sevoflurane reduces clinical disease in a mouse model of multiple sclerosis
    Paul E Polak
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    J Neuroinflammation 9:272. 2012
    ....
  7. pmc Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised
    Pierre Lacombe
    Laboratoire de Recherches C r brovasculaires, CNRS FRE 2363, Paris, France
    J Neuroinflammation 1:11. 2004
    ..Identification of the thioflavin-S-positive material will facilitate the full appraisal of the clinical implication of the effects of anti-inflammatory drugs, and provide a more thorough understanding of TGF-beta1 actions in brain...
  8. pmc Effect of pioglitazone treatment on behavioral symptoms in autistic children
    Marvin Boris
    Woodbury, New York 11797, USA
    J Neuroinflammation 4:3. 2007
    ..We therefore tested the safety and therapeutic potential of oral pioglitazone in a small cohort of children with diagnosed autism...
  9. pmc The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
    Lucia Lisi
    Istitute of Pharmacology, Catholic Medical School, Rome, Italy
    J Neuroinflammation 8:1. 2011
    ..However, with respect to iNOS expression, both stimulatory and inhibitory actions involving the mTOR pathway have been described. In this study the effects of mTOR inhibition on iNOS regulation were evaluated in astrocytes...
  10. pmc P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis
    Anthony J Sharp
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    J Neuroinflammation 5:33. 2008
    ..These properties suggest a role in the development of autoimmune disease including multiple sclerosis...
  11. pmc Modulation of inducible nitric oxide synthase expression by sumoylation
    Candan A Akar
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA
    J Neuroinflammation 6:12. 2009
    ....
  12. ncbi request reprint Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?
    D L Feinstein
    Department of Anesthesiology, University of Illinois, VA Chicago Health Care System, Research and Development, Chicago, IL 60612, USA
    Biochem Pharmacol 70:177-88. 2005
    ....
  13. ncbi request reprint Local anesthetics potentiate nitric oxide synthase type 2 expression in rat glial cells
    D L Feinstein
    Department of Anesthesiology, University of Illinois at Chicago, 60607, USA
    J Neurosurg Anesthesiol 13:99-105. 2001
    ..These results demonstrate that submillimolar doses of two commonly used local anesthetics can increase glial NOS2 expression...
  14. ncbi request reprint Therapeutic potential of peroxisome proliferator-activated receptor agonists for neurological disease
    Douglas L Feinstein
    Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA
    Diabetes Technol Ther 5:67-73. 2003
    ....
  15. ncbi request reprint Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis
    Douglas L Feinstein
    Department of Anesthesiology, University of Illinois, 11819 West Polk Street, MC519, Chicago, IL 60612, USA
    Ann Neurol 51:694-702. 2002
    ..Pioglitazone also reduced the antigen-dependent interferon-gamma production from EAE-derived T cells. These results suggest that orally administered PPARgamma agonists could provide therapeutic benefit in demyelinating disease...
  16. ncbi request reprint Noradrenergic regulation of inflammatory gene expression in brain
    Douglas L Feinstein
    Department of Anesthesiology, University of Illinois, Chicago, IL, USA
    Neurochem Int 41:357-65. 2002
    ....
  17. ncbi request reprint Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease
    Sergey Kalinin
    Department of Anesthesiology, University of Illinois, and Jesse Brown Veteran s Affairs Research Division, Chicago, IL 60612, United States
    Neurobiol Aging 28:1206-14. 2007
    ..These findings suggest that noradrenergic innervation from LC are needed to maintain adequate Abeta clearance, and therefore that LC degeneration could contribute to AD pathogenesis...
  18. ncbi request reprint A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease
    Sergey Kalinin
    Department of Anethesiology, University of Illinois, and Jesse Brown Veterans Affairs Hospital, Chicago, IL 60612, USA
    Curr Alzheimer Res 6:431-7. 2009
    ..These results suggest that, as found for some PPARgamma agonists, PPARdelta agonists can also reduce amyloid burden likely to be mediated by effects on amyloid clearance...
  19. ncbi request reprint Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis
    Paul E Polak
    Department of Anesthesiology, University of Illinois, and Jesse Brown Veteran s Affairs Research Division, Chicago, IL 60612, USA
    J Neuroimmunol 168:65-75. 2005
    ..RTPCR analysis showed that GW0742 increased expression of some myelin genes. These data demonstrate that PPARdelta agonists, like other PPAR ligands, can exert protective actions in an autoimmune model of demyelinating disease...
  20. doi request reprint Increasing CNS noradrenaline reduces EAE severity
    Maria Vittoria Simonini
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Neuroimmune Pharmacol 5:252-9. 2010
    ..These data suggest that selective elevation of CNS NA levels could provide benefit in EAE and multiple sclerosis without influencing peripheral immune responses...
  21. doi request reprint Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect
    David B Hiller
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA
    Anesthesiology 111:498-505. 2009
    ..We compared escalating doses of epinephrine on recovery with lipid infusion in a rat model of bupivacaine overdose...
  22. ncbi request reprint Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts
    Alessandra Spagnolo
    Department of Anesthesiology, University of Illinois at Chicago, Illinois 60612, USA
    J Neurosurg 106:299-305. 2007
    ..Data from prior studies by these authors have revealed the immunotherapeutic properties of the IL-2-secreting fibroblasts in treating intracerebral gliomas in mice...
  23. ncbi request reprint Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta
    Jose L M Madrigal
    Department of Anesthesiology, University of Illinois and Jesse Brown Veteran s Affairs Hospital, Chicago, Illinois, USA
    J Neurochem 103:2092-101. 2007
    ..Together these data demonstrate that NA can protect neurons from Abeta-induced damage, and suggest that its actions may involve activation of PPARdelta and increases in GSH production...
  24. ncbi request reprint Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576
    Neelima B Chauhan
    Research and Development 151, VA Chicago Health Care System West Side Division, Jesse Brown VA Medical Center Chicago, 820 South Damen Avenue, Chicago, IL 60612, USA
    Neuropharmacology 48:93-104. 2005
    ..The new results reported here indicate that further testing of PPF as a potential therapy in AD is warranted...
  25. ncbi request reprint Adding bupivacaine to high-potassium cardioplegia improves function and reduces cellular damage of rat isolated hearts after prolonged, cold storage
    James D Ross
    Department of Physiology and Biophysics, University of Illinois College of Medicine at Chicago, and Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA
    Anesthesiology 105:746-52. 2006
    ..Bupivacaine retards myocardial acidosis during ischemia. The authors measured function of rat isolated hearts after prolonged storage to determine whether bupivacaine improves cardiac protection compared with standard cardioplegia alone...
  26. ncbi request reprint Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest
    Guido Di Gregorio
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, USA
    Crit Care Med 37:993-9. 2009
    ..Lipid emulsion infusion is an emerging antidotal therapy for toxin-induced cardiac arrest. To compare the efficacy of resuscitation from bupivacaine-induced asystole using lipid emulsion infusion vs. vasopressin, alone and with epinephrine...
  27. ncbi request reprint Beta-amyloid-dependent expression of NOS2 in neurons: prevention by an alpha2-adrenergic antagonist
    Sergey Kalinin
    Department of Anesthesiology, University of Illinois, Chicago, 60612, USA
    Antioxid Redox Signal 8:873-83. 2006
    ..These findings suggest that alpha2-adrenergic antagonists could provide therapeutic benefit in neurological diseases such as AD or PD where LC loss is known to occur...
  28. ncbi request reprint Pathomolecular effects of homocysteine on the aging process: a new theory of aging
    Felipe P Perez
    Geriatric Medicine Section, Department of Medicine, University of Illinois, College of Medicine, M C 717, 840 South Wood Street, Chicago, IL 60612, USA
    Med Hypotheses 69:149-60. 2007
    ..Most importantly, decreasing homocysteine levels by dietary or pharmacological interventions could prolong maximum life span in humans and/or delay the onset of the most common age-related diseases...
  29. doi request reprint Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago and Jesse Brown Veterans Administration Medical Center, Chicago, Illinois 60612, USA
    Anesthesiology 108:907-13. 2008
    ..The authors compared resuscitation with lipid, epinephrine, and saline control in a rat model of bupivacaine-induced cardiac toxicity to determine whether lipid provides a benefit over epinephrine...
  30. ncbi request reprint Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity
    Guy Weinberg
    Department of Anesthesiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    Reg Anesth Pain Med 28:198-202. 2003
    ..The present studies were undertaken to determine if this method is similarly effective in a non-rodent model using a larger animal...
  31. ncbi request reprint Differential effects of PPARgamma agonists on the metabolic properties of gliomas and astrocytes
    Alessandra Spagnolo
    Department of Anesthesiology, University of Illinois, 835 South Wolcott, Chicago, IL 60612, USA
    Neurosci Lett 417:72-7. 2007
    ..These results suggest that differences in metabolic responses could contribute to the selective resistance of astrocytes to cytotoxic effects of Trog. TZDs such as Trog should therefore be considered for testing in treatment of gliomas...
  32. ncbi request reprint Degeneration of noradrenergic fibres from the locus coeruleus causes tight-junction disorganisation in the rat brain
    Sergey Kalinin
    Department of Anaesthesiology, University of Illinois at Chicago, Illinois, USA
    Eur J Neurosci 24:3393-400. 2006
    ..Whether the vascular damage is the result of impaired noradrenergic transmission or secondary to the inflammatory reaction remains to be determined...
  33. ncbi request reprint Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties
    Vitaliy Gavrilyuk
    Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA
    J Neurochem 92:1140-9. 2005
    ..Changes in DST11 levels in diseased brain could therefore contribute to the progression of inflammatory damage...
  34. ncbi request reprint Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytes
    Cinzia Dello Russo
    Veterans Affairs Chicago Health Care System West Side Division, Chicago, Illinois, 60680, USA
    J Biol Chem 278:5828-36. 2003
    ..These results demonstrate that TZDs modify astrocyte metabolism and mitochondrial function, which could be beneficial in neurological conditions where glucose availability is reduced...
  35. ncbi request reprint Effects of noradrenaline on neuronal NOS2 expression and viability
    Jose L M Madrigal
    Department of Anesthesiology, University of Illinois, and VA Chicago Health Care System, 60612, USA
    Antioxid Redox Signal 8:885-92. 2006
    ..Perturbations of NA could exacerbate neuronal damage by allowing for increased inflammatory responses...
  36. ncbi request reprint Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis
    Patricia Murphy
    Department of Anesthesiology, University of Illinois, 1819 West Polk Street, Chicago, IL 60612, USA
    J Neurosci Res 67:461-70. 2002
    ..These results indicate that ansamycins can exert potent anti-inflammatory effects on brain glial cells which may provide therapeutic benefit in neuroinflammatory diseases...
  37. ncbi request reprint Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA
    Reg Anesth Pain Med 31:296-303. 2006
    ..The mechanism of lipid rescue is unknown. These studies address the possibility that lipid infusion reduces cardiac bupivacaine content in the context of cardiac toxicity...
  38. ncbi request reprint Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain
    Neelima B Chauhan
    VA Chicago Health Care System West Side Division, Chicago, IL 60612, USA
    Neurochem Res 29:1897-911. 2004
    ..These data show that pravastatin can reduce amyloid burden without potentiating inflammatory responses in brain and, therefore, may have a wider dose-range of safety than have lipophilic statins in the treatment or prevention of AD...
  39. doi request reprint Investigation of immunosuppressive mechanisms in a mouse glioma model
    Alexander Ksendzovsky
    Chicago Medical School, North Chicago, IL, USA
    J Neurooncol 93:107-14. 2009
    ....
  40. ncbi request reprint Norepinephrine increases I kappa B alpha expression in astrocytes
    Vitaliy Gavrilyuk
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 277:29662-8. 2002
    ..These results demonstrate that I kappa B alpha expression is regulated by NE at both transcriptional and post-transcriptional levels, which could contribute to the observed anti-inflammatory properties of NE in vitro and in vivo...
  41. ncbi request reprint Estrogen inhibits NF kappa B-dependent inflammation in brain endothelium without interfering with I kappa B degradation
    Elena Galea
    Neuroanesthesia Research Laboratory, Department of Anesthesiology MC 519, University of Illinois at Chicago, 1819 W Polk St, Chicago, IL 60612, USA
    Neuroreport 13:1469-72. 2002
    ..The stereoselectivity of the E(2) effect is consistent with an estrogen receptor-mediated mechanism...
  42. ncbi request reprint The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation
    Guy Weinberg
    Department of Anesthesiology, University of Illinois at Chicago College of Medicine and the Chicago VA Hospital Westside Division, Chicago, Illinois 60612, USA
    Anesth Analg 98:790-5, table of contents. 2004
    ..This potentially beneficial effect may be a result of bupivacaine's ability to inhibit myocardial lactate and carbon dioxide production. This suggests a potential clinical application of bupivacaine for myocardial preservation...
  43. doi request reprint A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis
    Claudia C Kaiser
    Department of Anesthesiology, University of Illinois, Chicago, 60612, United States
    J Neuroimmunol 211:124-30. 2009
    ..These results show that pioglitazone was well tolerated in RRMS patients with indications of beneficial effects, warranting further trials to establish clinical efficacy...
  44. ncbi request reprint The role of the glia limitans in ADP-induced pial arteriolar relaxation in intact and ovariectomized female rats
    Hao Liang Xu
    Neuroanesthesia Research Laboratory, University of Illinois at Chicago, 900 S Ashland Ave, Molecular Biology Research Bldg, Rm 4314, M C513, Chicago, IL 60607, USA
    Am J Physiol Heart Circ Physiol 288:H382-8. 2005
    ....
  45. pmc Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis
    Paul E Polak
    Department of Anaesthesiology, University of Illinois at Chicago, Jesse Brown Medical Centre, Chicago, IL 60612, USA
    Brain 134:665-77. 2011
    ....
  46. pmc A novel fluorescent probe that is brain permeable and selectively binds to myelin
    Chunying Wu
    Department of Medical Chemistry and Pharmacognosy, University of Illinois at Chicago, USA, and Biologie des Interactions Neurones Glie, Hopital de la Salpetriere, Paris, France
    J Histochem Cytochem 54:997-1004. 2006
    ..These studies justified further investigation of BDB as a potential myelin-imaging probe to monitor myelin pathology in vivo...
  47. ncbi request reprint Intrinsic regulation of brain inflammatory responses
    Elena Galea
    Department of Anesthesiology, University of Illinois, Chicago, Illinois, USA
    Cell Mol Neurobiol 23:625-35. 2003
    ....
  48. ncbi request reprint Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression
    Michael T Heneka
    Department of Neurology, University of Bonn, Germany
    J Neurochem 85:387-98. 2003
    ..These findings suggest one mechanism by which PPARgamma agonists could provide benefit in neurological diseases having an inflammatory component...
  49. ncbi request reprint Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment
    Christian Grommes
    Department of Neurosciences, Alzheimer Research Laboratory, Case Western Reserve University, Cleveland, Ohio, USA
    Mol Pharmacol 70:1524-33. 2006
    ..Together, these data indicate that pioglitazone may be of potential use in treatment of malignant gliomas...
  50. pmc 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway
    Nirmal K Phulwani
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Neurochem 99:1389-1402. 2006
    ..Collectively, these results suggest that 15d-PGJ2 and ciglitazone exert their anti-inflammatory actions on astrocytes primarily independent of the PPAR-gamma pathway...
  51. ncbi request reprint Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease
    Michael T Heneka
    Department of Neurology, University of Bonn, Germany 53127
    J Neurosci 22:2434-42. 2002
    ..These data demonstrate that LC loss and NE depletion augment inflammatory responses to Abeta and suggest that LC loss in AD is permissive for increased inflammation and neuronal cell death...
  52. ncbi request reprint Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents
    Kudret Tureyen
    Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Neurochem 101:41-56. 2007
    ..Thus, PPARgamma activation with TZDs might be a potent therapeutic option for preventing inflammation and neuronal damage after stroke with promise in diabetic and hypertensive subjects...
  53. ncbi request reprint p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription fact
    Narayan R Bhat
    Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 277:29584-92. 2002
    ....
  54. ncbi request reprint Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients
    Stephan Schmidt
    Department of Neurology, University of Bonn, Germany
    J Leukoc Biol 75:478-85. 2004
    ..In summary, the data support the potential use of PPAR-gamma agonists as immunomodulatory, therapeutic agents for autoimmune diseases...
  55. ncbi request reprint The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS
    Hakima Zekki
    CHUL Research Center and Department of Anatomy and Physiology, Laval University, Laurier, Quebec, Canada
    Brain Pathol 12:308-19. 2002
    ....
  56. ncbi request reprint Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons
    Luisa Klotz
    Department of Neurology, University of Bonn, Bonn, Germany
    J Neurochem 86:907-16. 2003
    ..Conversely, decreased NA due to LC cell death in AD may reduce endogenous PPARgamma expression and therefore potentiate neuroinflammatory processes...
  57. doi request reprint Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    George J Siegel
    Neurology 71:383; author reply 383. 2008

Research Grants9

  1. The role of I-kappaB in control of glial inflammation
    Douglas Feinstein; Fiscal Year: 2003
    ..These experiments will provide targets for therapeutic intervention to reduce pathological NOS2 in brain, and help develop a new animal model for examining brain inflammatory in the context of diminished NE levels. ..
  2. The role of I-kappaB in control of glial inflammation
    Douglas Feinstein; Fiscal Year: 2006
    ..These experiments will provide targets for therapeutic intervention to reduce pathological NOS2 in brain, and help develop a new animal model for examining brain inflammatory in the context of diminished NE levels. ..
  3. Treatment of Demyelinating Disease with HSP90 Inhibitors
    Douglas Feinstein; Fiscal Year: 2007
    ....
  4. Treatment of Demyelinating Disease with HSP90 Inhibitors
    Douglas Feinstein; Fiscal Year: 2009
    ....
  5. Treatment of Demyelinating Disease with HSP90 Inhibitors
    Douglas L Feinstein; Fiscal Year: 2010
    ....