Research Topics
| David FeifelSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
The effects of intra-accumbens neurotensin on sensorimotor gatingD Feifel
Department of Psychiatry, University of California, San Diego, USA
Brain Res 760:80-4. 1997..The results suggest that intra-accumbens neurotensin has a significant, dose-dependent effect on sensorimotor gating in which lower doses (0.25-1.0 microg) exhibit a neuroleptic-like action...
Commentary: why diagnose and treat ADHD in adults?David Feifel
Department of Psychiatry, University of California, San Diego, San Diego, CA 92103, USA
Postgrad Med 120:13-5. 2008..An estimated 4% to 5% of the adult population is impaired by ADHD. However,less than one-quarter of these adults have been diagnosed as having ADHD..- Adjunctive intranasal oxytocin improves verbal memory in people with schizophreniaDavid Feifel
Department of Psychiatry, University of California, San Diego, United States
Schizophr Res 139:207-10. 2012..Oxytocin - though it has shown promise as a novel antipsychotic in multiple clinical trials - has as-yet poorly characterized effects on cognition, with some evidence indicating an amnestic profile... - The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gatingDavid Feifel
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 8218, United States
Eur Neuropsychopharmacol 22:374-8. 2012..In contrast to oxytocin, our data do not support the use of carbetocin as an antipsychotic drug... - Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effectsDavid Feifel
Department of Psychiatry, University of California, San Diego, San Diego, CA 92103 8218, USA
Neuropsychopharmacology 29:731-8. 2004.... - Inhibitory deficits in ocular motor behavior in adults with attention-deficit/hyperactivity disorderDavid Feifel
Adult ADHD Program, Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
Biol Psychiatry 56:333-9. 2004..The ability to suppress unwanted saccadic eye movements is mediated by prefrontal cortex-basal ganglia circuitry and thus constitutes a useful measure of inhibitory ability... 
Sensorimotor gating in neurotensin-1 receptor null miceD Feifel
Department of Psychiatry, University of California, San Diego, Medical Center, 200 West Arbor Drive, San Diego, CA 92103 8218, USA
Neuropharmacology 58:173-8. 2010..We also tested the effects of amphetamine and dizocilpine, a dopamine agonist and NMDA antagonist, respectively, that reduce PPI as well as the NT1 selective receptor agonist PD149163, known to increase PPI in rats...- The effects of cross-fostering on inherent sensorimotor gating deficits exhibited by Brattleboro ratsDavid Feifel
Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103 8218, USA
J Gen Psychol 134:173-82. 2007.... - The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro ratsDavid Feifel
Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States
Behav Brain Res 181:278-86. 2007..e., peptides) and reasonably model the therapeutic time course of antipsychotic drugs in humans... - The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit toleranceDavid Feifel
Department of Psychiatry, UCSD Medical Center, University of California, San Diego, 200 West Arbor Drive, San Diego, CA, USA
Psychopharmacology (Berl) 200:197-203. 2008.... - Prepulse inhibition of startle in adults with ADHDDavid Feifel
University of California San Diego, School of Medicine, Department of Psychiatry, San Diego, CA 92103 8218, USA
J Psychiatr Res 43:484-9. 2009..This distinction may be related to a relative sparing of pre-conscious attentional functions in ADHD compared to other disorders with PPI impairment... - Attention-deficit/hyperactivity disorder in adults: recognition and diagnosis of this often-overlooked conditionDavid Feifel
Department of Psychiatry, University of California, San Diego, San Diego, CA 92103, USA
Postgrad Med 120:39-47. 2008.... - The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analogD Feifel
Department of Psychiatry, University of California, San Diego Medical Center, San Diego, CA 92103 8218, USA
Neuropsychopharmacology 34:2011-8. 2009..The potential of neurotensin agonists as putative treatments for cognitive deficits of schizophrenia was also supported... - The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperatureDavid Feifel
Department of Psychiatry, University of California, San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103 8218, USA
Neuropharmacology 58:195-8. 2010..The results suggest that NT1 receptor agonists are candidates for treatment of obesity and that somewhat different mechanisms are involved in NT1-induced feeding regulation and temperature regulation... - Effects of neurotensin-2 receptor deletion on sensorimotor gating and locomotor activityDavid Feifel
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Behav Brain Res 212:174-8. 2010..05). These data support the regulation of baseline PPI, ASR and locomotor activity by endogenous NT acting at the NT2 receptor. Further studies investigating the role of NT2 receptors in the modulation of APD-like effects are warranted... - Promise and pitfalls of animal models of schizophreniaDavid Feifel
Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103 8218, USA
Curr Psychiatry Rep 12:327-34. 2010.... - Further characterization of the predictive validity of the Brattleboro rat model for antipsychotic efficacyD Feifel
Department of Psychiatry, University of California, San Diego, CA 92093 8218, USA
J Psychopharmacol 25:836-41. 2011..These results suggest that PPI in the BRAT rat responds specifically to drugs with APD efficacy but not psychotropic drugs of different therapeutic families... - Clozapine and PD149163 elevate prepulse inhibition in Brown Norway ratsDavid Feifel
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 8218, USA
Behav Neurosci 125:268-72. 2011..The results also add to the evidence suggesting that PD149163 may have antipsychotic properties... - Altered extracellular dopamine concentration in the brains of cholecystokinin-A receptor deficient ratsDavid Feifel
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neurosci Lett 348:147-50. 2003..These findings suggest that CCK-A receptors play an important role in the regulation of central DA transmission, and support the notion that the OLETF rat is a useful model to study this regulation... - A systemically administered neurotensin agonist blocks disruption of prepulse inhibition produced by a serotonin-2A agonistDavid Feifel
Department of Psychiatry, University of California, San Diego, USA
Neuropsychopharmacology 28:651-3. 2003..These findings suggest that, in addition to their established ability to inhibit dopamine transmission, neurotensin agonists may also inhibit 5-HT2A transmission, a pharmacological feature associated with atypical antipsychotic drugs... - Individual differences in prepulse inhibition of startle as a measure of individual dopamine functionD Feifel
Department of Psychiatry, University of California, San Diego 92103 8620, USA
Behav Neurosci 113:1020-9. 1999.... - Attitudes toward psychiatry as a prospective career among students entering medical schoolD Feifel
Department of Psychiatry, University of California, San Diego 92103 8620, USA
Am J Psychiatry 156:1397-402. 1999..In order to determine whether this disinclination toward psychiatry occurs before versus during medical school, this study surveyed medical students at the start of their freshman year... - Effects of neurotensin administered into the ventral tegmental area on prepulse inhibition of startleD Feifel
Department of Psychiatry, University of California, San Diego, Medical Center, 92103 8620, USA
Behav Brain Res 106:189-93. 1999..These results suggest that PPI and locomotor activity may have dissociable mesolimbic substrates and that neurotensin in the VTA does not play an important role in regulating PPI... - Rationale and guidelines for the inpatient treatment of acute psychosisD Feifel
Neuropsychiatry and Behavioral Medicine Unit, University of California, San Diego Medical Center, 92103 8218, USA
J Clin Psychiatry 61:27-32. 2000..This article presents the rationale and practical guidelines for selection of treatment regimens for patients hospitalized due to acute psychosis... - Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gatingD Feifel
Department of Psychiatry, University of California, San Diego, La Jolla 92093 8620, USA
Psychopharmacology (Berl) 141:93-8. 1999..These results suggest that oxytocin may play an important role in the modulation of dopaminergic and glutamatergic regulation of PPI, and that it may act as a novel endogenous antipsychotic... - Startle and sensorimotor gating in rats lacking CCK-A receptorsD Feifel
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 8218, USA
Neuropsychopharmacology 24:663-70. 2001.... - Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonistD Feifel
Department of Psychiatry, University of California, San Diego, La Jolla 92093 8620, USA
J Pharmacol Exp Ther 288:710-3. 1999..These findings suggest that PD149163 has novel antipsychotic-like properties that are distinct from known members of both the "typical" and "atypical" families of antipsychotics... - Pro-dopamine effects of neurotensin on sensorimotor gating deficitsD Feifel
Department of Psychiatry, University of California, San Diego, La Jolla, USA
Peptides 18:1457-60. 1997..This is the first report of a pro-dopamine action for intra-accumbens neurotensin, and suggests that a complex behavioral pharmacology is associated with this neuropeptide... - The effects of subchronic haloperidol on intact and dizocilpine-disrupted sensorimotor gatingD Feifel
Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103 8620, USA
Psychopharmacology (Berl) 146:175-9. 1999..Acute administration of antipsychotics tends to facilitate baseline PPI. However, the effect is generally not large enough in magnitude nor reliable enough to be considered a useful preclinical screen for antipsychotic activity... - The modulation of sensorimotor gating deficits by mesolimbic cholecystokininD Feifel
Department of Psychiatry, University of California, San Diego, La Jolla 92093 8620, USA
Neurosci Lett 229:5-8. 1997..Rather, these results suggest that antagonists of CCK may display neuroleptic-like actions on deficits in PPI and may hold greater promise as antipsychotics... - Attention-deficit hyperactivity disorder in adultsD Feifel
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla 92093 0603, USA
Postgrad Med 100:207-11, 215-8. 1996..When a definitive diagnosis is not possible, a trial of pharmacologic therapy may be appropriate... - A naturalistic study of intramuscular haloperidol versus intramuscular olanzapine for the management of acute agitationKai MacDonald
Department of Psychiatry, University of California, San Diego, CA 92093 0804, USA
J Clin Psychopharmacol 32:317-22. 2012..Therefore, we conducted a retrospective chart review to compare IM olanzapine and haloperidol in a "real-world" population with agitation... - The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patientsArpi Minassian
Department of Psychiatry, University of California, San Diego School of Medicine, USA
Schizophr Res 89:225-31. 2007..Our results suggest that PPI can be improved by short-term treatment, and that improvement in sensorimotor gating is associated with treatment-related improvement of symptoms of schizophrenia... - A comparison of the safety of olanzapine and haloperidol in combination with benzodiazepines in emergency department patients with acute agitationMichael P Wilson
Department of Emergency Medicine, University of California, San Diego Medical Center, San Diego, California 92103, USA
J Emerg Med 43:790-7. 2012..The combination of olanzapine + benzodiazepines is not recommended by the manufacturer, but a recent report suggested harm only if the patient was intoxicated. Whether this is also true for haloperidol + benzodiazepines is not known... - Sensorimotor gating effects produced by repeated dopamine agonists in a paradigm favoring environmental conditioningDavid Feifel
Department of Psychiatry, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103-8218, USA
Psychopharmacology (Berl) 162:138-46. 2002.... - Information processing deficits in acutely psychotic schizophrenia patients medicated and unmedicated at the time of admissionWilliam Perry
Neuropsychiatry and Behavioral Medicine Service, Department of Psychiatry, University of California San Diego, La Jolla 92093 8620, USA
Am J Psychiatry 159:1375-81. 2002..The present study investigated the effects of antipsychotics on prepulse inhibition and startle habituation in acutely hospitalized patients with schizophrenia... - Potential complications of combining intramuscular olanzapine with benzodiazepines in emergency department patientsMichael P Wilson
Department of Emergency Medicine, University of California, San Diego Medical Center, San Diego, California 92103, USA
J Emerg Med 43:889-96. 2012..The potential complications of the use of olanzapine in combination with a benzodiazepine have not been well characterized in ED patients with undifferentiated agitation... - Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patientsDavid Feifel
Department of Psychiatry, University of California, San Diego Medical Center, San Diego, California 92103 8218, USA
Biol Psychiatry 68:678-80. 2010..Both human and animal studies suggest oxytocin may have antipsychotic properties. Therefore, we conducted a clinical trial to directly test this notion... - A retrospective analysis of intramuscular haloperidol and intramuscular olanzapine in the treatment of agitation in drug- and alcohol-using patientsKai MacDonald
Department of Psychiatry, University of California, San Diego, San Diego, CA 92093, USA
Gen Hosp Psychiatry 32:443-5. 2010..The treatment of agitation in drug- and alcohol-using emergency patients is understudied... - Upregulation of striatal dopamine-2 receptors in Brattleboro rats with prepulse inhibition deficitsPaul D Shilling
Department of Psychiatry, University of California, San Diego, California 92103-8218, USA
Biol Psychiatry 60:1278-81. 2006..CONCLUSIONS: These findings suggest that the dopamine system in BRATs is dysregulated and these abnormalities may contribute to the PPI deficits observed in these rats... - The effects of systemic NT69L, a neurotensin agonist, on baseline and drug-disrupted prepulse inhibitionP D Shilling
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Behav Brain Res 143:7-14. 2003.... - SR146131, a cholecystokinin-A receptor agonist, antagonizes prepulse inhibition deficits produced by dizocilpine and DOIP D Shilling
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Psychopharmacology (Berl) 164:285-93. 2002..Possible mechanisms underlying these findings are discussed... - Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidolD Feifel
Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA
Biol Psychiatry 50:425-33. 2001.... - Decreased haloperidol-induced potentiation of zif268 mRNA expression in the nucleus accumbens shell and the dorsal lateral striatum of rats lacking cholecystokinin-A receptorsP D Shilling
Department of Psychiatry, University of California, San Diego, California 92093, USA
Synapse 43:134-8. 2002..05), but not in the NA core, in OLETF rats compared to LETO rats. These data suggest that CCK-A receptor mechanisms may contribute to the therapeutic and the extrapyramidal motor effects associated with antipsychotic drug treatment... - Extended release quetiapine fumarate monotherapy in major depressive disorder: a placebo- and duloxetine-controlled studyAndrew J Cutler
Department of Psychiatry, University of Florida, Gainesville, FL, USA
J Clin Psychiatry 70:526-39. 2009..To evaluate the efficacy and tolerability of once-daily extended release quetiapine fumarate (quetiapine XR) as monotherapy treatment for major depressive disorder (MDD)... - The neurotensin-1 receptor agonist PD149163 blocks fear-potentiated startlePaul D Shilling
Department of Psychiatry, UCSD, 200 West Arbor Drive, San Diego, CA 92103 8218, USA
Pharmacol Biochem Behav 90:748-52. 2008..05). These data suggest that systemically administered NT1 agonists modulate the neural circuitry that regulates fear and anxiety to produce dose-dependent anxiolytic-like effects on FPS... - Prepulse inhibition in patients with non-psychotic major depressive disorderWilliam Perry
Department of Psychiatry, University of California San Diego, 200 West Arbor Drive, Mailcode 8218, San Diego, CA 92103 8218, USA
J Affect Disord 81:179-84. 2004..Therefore, we assessed PPI in non-psychotic MDD patients and compared their results to schizophrenia patients and non-patients... - A Naturalistic, Single-blind Comparison of Rapid Dose Administration of Divalproex ER Versus Quetiapine in Patients with Acute Bipolar ManiaDavid Feifel
All from the Department of Psychiatry, University of California San Diego Medical Center, San Diego, California
Innov Clin Neurosci 8:29-35. 2011..Conclusion: Results of this small study indicate that rapid-dose administration of both quetiapine and divalproex ER produce rapid improvement in acute mania within the first seven days and both seem to be well tolerated... - Rapid oral loading of extended release divalproex in patients with acute maniaBrian P Miller
Neuropsychiatry and Behavioral Medicine Unit, University of California, San Diego Medical Center, San Diego, California 92103-8218, USA
Gen Hosp Psychiatry 27:218-21. 2005.... - A systematic review of modafinil: Potential clinical uses and mechanisms of actionJacob S Ballon
Department of Psychiatry, University of California, San Diego, CA, USA
J Clin Psychiatry 67:554-66. 2006..To date, the strongest evidence among off-label uses exists for the use of modafinil in attention-deficit disorder, postanesthetic sedation, and cocaine dependence and withdrawal and as an adjunct to antidepressants for depression... - Dramatic improvement in sexual function induced by intranasal oxytocinKai MacDonald
University of California, San Diego Medical Center Department of Psychiatry, San Diego, CA 92103 8218, USA
J Sex Med 9:1407-10. 2012..This is a case report on a male who had significant, broad-spectrum improvements in sexual function during a course of intranasal oxytocin treatment for social anxiety... - A double-blind, placebo-controlled trial of dexmethylphenidate hydrochloride and d,l-threo-methylphenidate hydrochloride in children with attention-deficit/hyperactivity disorderSharon Wigal
Irvine Child Development Center, University of California, Irvine, CA 92612, USA
J Am Acad Child Adolesc Psychiatry 43:1406-14. 2004.... - Sensorimotor gating deficits in bipolar disorder patients with acute psychotic maniaW Perry
Department of Psychiatry, University of California at San Diego, 200 West Arbor Drive, Mail Code 8218, La Jolla, CA 92093-8620, USA
Biol Psychiatry 50:418-24. 2001.... - Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT2A and an alpha1 agonistP D Shilling
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
Psychopharmacology (Berl) 175:353-9. 2004.... - The psychopharmacology of agitation: consensus statement of the american association for emergency psychiatry project Beta psychopharmacology workgroupMichael P Wilson
UC San Diego Health System, Department of Emergency Medicine, San Diego, California
West J Emerg Med 13:26-34. 2012..If agitation results from a delirium or other medical condition, clinicians should first attempt to treat the underlying cause instead of simply medicating with antipsychotics or benzodiazepines... - Acute treatment of psychotic agitation: a randomized comparison of oral treatment with risperidone and lorazepam versus intramuscular treatment with haloperidol and lorazepamGlenn W Currier
Departments of Psychiatry and Emergency Medicine, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, N Y 14642, USA
J Clin Psychiatry 65:386-94. 2004..We hypothesized that the efficacy and speed of action of both treatments would be similar... - Dosing of divalproex extended releaseDavid Feifel
J Clin Psychiatry 68:1146-7; author reply 1147. 2007
Research Grants
- Antipsychotic-Like Drug Effects of NeurotensinDavid Feifel; Fiscal Year: 2004....
- A Novel Animal Model of Relevance to SchizophreniaDavid Feifel; Fiscal Year: 2007..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
- A Novel Animal Model of Relevance to SchizophreniaDavid Feifel; Fiscal Year: 2009..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
- Neurotensin-1 Receptor as a Therapeutic Target for SchizophreniaDavid Feifel; Fiscal Year: 2010..The proposed experiments may help lead to completely novel and superior treatments for schizophrenia. ..