H J Federoff

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene
    Howard J Federoff
    Department of Neurology, Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neuron 53:315-7. 2007
  2. pmc Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons
    Marc W Halterman
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Neurosci 38:125-37. 2008
  3. ncbi request reprint Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism
    L A Henricksen
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Sciences, University of Rochester School of Medicine and Dentistry, Rochester, MN, USA
    J Alzheimers Dis 6:S43-6. 2004
  4. pmc Immune shaping and the development of Alzheimer's disease vaccines
    Howard J Federoff
    Department of Neurology, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Aging Knowledge Environ 2005:pe35. 2005
  5. ncbi request reprint Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers
    W J Bowers
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Gene Ther 8:111-20. 2001
  6. pmc Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice
    MICHELLE C JANELSINS
    Department of Microbiology and Immunology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Pathol 173:1768-82. 2008
  7. ncbi request reprint HSV vector-mediated gene delivery to the central nervous system
    K A Maguire-Zeiss
    Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Curr Opin Mol Ther 3:482-90. 2001
  8. ncbi request reprint Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency
    R M Miller
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA renee
    Neurobiol Aging 29:71-7. 2008
  9. ncbi request reprint HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses
    William J Bowers
    Department of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Neurobiol Aging 26:393-407. 2005
  10. ncbi request reprint Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD
    Renee M Miller
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, Rochester, NY 14642, USA
    Exp Neurol 204:421-32. 2007

Detail Information

Publications92

  1. ncbi request reprint Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene
    Howard J Federoff
    Department of Neurology, Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neuron 53:315-7. 2007
    ..A new study by Mallucci et al. in this issue of Neuron shows that prion disease may be reversed in mice by selective removal of the gene in neurons after early physiological, cognitive, and pathological features have developed...
  2. pmc Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons
    Marc W Halterman
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Neurosci 38:125-37. 2008
    ..These data indicate that the pathologic response in cortical neurons induced by hypoxia involves both the loss of c/EBP-beta-mediated survival signals and activation of pro-death pathways originating from the endoplasmic reticulum...
  3. ncbi request reprint Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism
    L A Henricksen
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Sciences, University of Rochester School of Medicine and Dentistry, Rochester, MN, USA
    J Alzheimers Dis 6:S43-6. 2004
    ..This analysis leads to the prediction that molecular genetic perturbations affecting the metabolism of nuclear NAD(+) and metabolites will be neuroprotective...
  4. pmc Immune shaping and the development of Alzheimer's disease vaccines
    Howard J Federoff
    Department of Neurology, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Aging Knowledge Environ 2005:pe35. 2005
    ....
  5. ncbi request reprint Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers
    W J Bowers
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Gene Ther 8:111-20. 2001
    ..Increased helper virus-free amplicon titers resulting from these modifications will make in vivo transduction experiments more feasible...
  6. pmc Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice
    MICHELLE C JANELSINS
    Department of Microbiology and Immunology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Pathol 173:1768-82. 2008
    ..Results presented here suggest that chronic neuronal TNF-alpha expression promotes inflammation and, ultimately, neuronal cell death in this AD mouse model, advocating the development of TNF-alpha-specific agents to subvert AD...
  7. ncbi request reprint HSV vector-mediated gene delivery to the central nervous system
    K A Maguire-Zeiss
    Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Curr Opin Mol Ther 3:482-90. 2001
    ..The versatility of this vector platform and its potential molecular therapeutic use in two CNS disorders, Alzheimer's disease and malignant brain tumors, will be discussed...
  8. ncbi request reprint Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency
    R M Miller
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA renee
    Neurobiol Aging 29:71-7. 2008
    ..Both of these factors are poised to impact neuronal viability, inflammation, and viral spread. Our data support the concept that HSV-1 and ApoE4 interact to provide an environment conducive to the development and/or spread of AD...
  9. ncbi request reprint HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses
    William J Bowers
    Department of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Neurobiol Aging 26:393-407. 2005
    ....
  10. ncbi request reprint Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD
    Renee M Miller
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, Rochester, NY 14642, USA
    Exp Neurol 204:421-32. 2007
    ..Analysis of mutant alpha-synuclein mice at a time point when pathology is advanced reveals several new candidate genes that may play a role in neuronal demise and/or protein accumulation...
  11. ncbi request reprint Somatic gene transfer approaches to manipulate neural networks
    H J Federoff
    Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Neurosci Methods 71:133-42. 1997
    ..Where possible examples of each approach are provided. In addition, the advantages and limitations of the approaches are discussed...
  12. pmc Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform
    S de Silva
    Department of Biochemistry, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Gene Ther 17:424-31. 2010
    ..Overall, our results indicate that SB is competent in stably integrating transgenon units of at least 12 kb in size within the human genome upon delivery of the platform via HSV amplicons...
  13. ncbi request reprint Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice
    R A Willis
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Hum Gene Ther 12:1867-79. 2001
    ..These results indicate that DCs transduced with HSV-1 amplicon vectors may provide a tool for investigation of the biology of CTL activation by DCs and a new modality for immunotherapy of cancer...
  14. ncbi request reprint Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra
    Renee M Miller
    Center for Aging and Developmental Biology, Aab Institute of Biomedical Sciences, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 24:7445-54. 2004
    ..The discovery and validation of these alterations provide molecular evidence for an evolving cascade of injury, dysfunction, and cell death...
  15. ncbi request reprint Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis
    Jill M Weimer
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Res 1162:98-112. 2007
    ..These data provide novel insights into the basis of motor deficits in JNCL and how alterations in dopamine catabolism may result in oxidative damage and localized neuronal loss in this disorder...
  16. pmc Mutant alpha-synuclein overexpression mediates early proinflammatory activity
    Xiaomin Su
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Neurotox Res 16:238-54. 2009
    ..Together, these data demonstrate that mutated alpha-synuclein mediates a proinflammatory response in microglia and this activity may participate in PD pathogenesis...
  17. pmc HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport
    Yan Li
    Department of Neurology, Center for Neural Development and Disease, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Cell Biol 185:1065-81. 2009
    ..These findings have broad implications for maintenance of neuronal viability and function during physiological and pathological states...
  18. pmc Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4
    Maria E Frazer
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 16:845-53. 2008
    ..Our study underscores the potential of Abeta immunotherapy for AD and highlights the potency of amplicons in facilitating the immune response modulation to a disease-relevant antigen...
  19. ncbi request reprint HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage
    X Chen
    Division of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 3:958-63. 2001
    ..The potency of NT-3 in protecting spiral ganglion neurons from degeneration suggests that in vivo neurotrophin-based gene therapy may be useful for the prevention and/or treatment of hearing disorders...
  20. ncbi request reprint Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons
    Stephanos Kyrkanides
    Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
    Brain Res Mol Brain Res 119:1-9. 2003
    ..Our observations indicate that relatively low doses of FIV(lacZ) administered intraperitoneally resulted in the transduction of immune cells in the brain, as well as a specific subset of cerebellar neurons...
  21. ncbi request reprint Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system
    Stephanos Kyrkanides
    Department of Dentistry, Rochester, New York 14620, USA
    Mol Ther 8:790-5. 2003
    ....
  22. ncbi request reprint beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration
    Stephanos Kyrkanides
    Department of Dentistry, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester NY 14642, United States
    Brain Res Mol Brain Res 133:286-98. 2005
    ..In conclusion, these results demonstrate the effective transfer of a beta-hexosaminidase lentiviral vector to the brain of Sandhoff mice and resolution of the GM2 gangliosidosis after neonatal intraperitoneal administration...
  23. ncbi request reprint In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage
    David A Rempe
    Department of Neurology, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Biol Chem 282:16187-201. 2007
    ..These data strongly suggest that p53 and MDM2 do not influence the hypoxia-induced transactivation of HIF-1alpha targets, regardless of p53 activation, in primary astrocytes...
  24. ncbi request reprint Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors
    Kathlyn Santos
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Hum Gene Ther 18:93-105. 2007
    ..From this and previous work, we conclude that amplicons may engender a potent immune response by directly transducing dendritic cells as well as by cross-priming of antigen produced by other transduced host cells...
  25. ncbi request reprint Current treatment for Alzheimer disease and future prospects
    Pierre N Tariot
    Department of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA
    Alzheimer Dis Assoc Disord 17:S105-13. 2003
    ..Cholinergic and emerging noncholinergic medications will likely prevail as the standards of treatment for years to come...
  26. ncbi request reprint Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector
    William J Bowers
    Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 645, Rochester, NY 14642, USA
    Mol Ther 13:580-8. 2006
    ....
  27. doi request reprint The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes
    Grace Vangeison
    Department of Neurology, Center for Neural Development and Disease, and Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 28:1988-93. 2008
    ..This study delineates, for the first time, a cell type-specific action for HIF-1alpha within astrocytes and neurons...
  28. pmc Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease
    Kelly L Sudol
    Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Ther 17:2031-40. 2009
    ..This approach may provide insights into the functional relevance of intraneuronal A beta accumulation in early AD and potentially lead to the development of new therapeutics...
  29. ncbi request reprint Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS
    John A Olschowka
    Departments of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Ther 7:218-27. 2003
    ....
  30. pmc The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death
    Marc W Halterman
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:21329-40. 2010
    ..Collectively, these findings indicate CHOP serves a more complex role in the neuronal response to hypoxic stress with involvement in both ischemic preconditioning and delayed neuroprotection...
  31. doi request reprint Development of vaccination approaches for the treatment of neurological diseases
    Howard J Federoff
    Department of Neurology, Georgetown University, Washington DC 20057, USA
    J Comp Neurol 515:4-14. 2009
    ....
  32. ncbi request reprint Reporter gene transfer induces apoptosis in primary cortical neurons
    Eric R Detrait
    Center for Aging and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York 14642, USA
    Mol Ther 5:723-30. 2002
    ..This work underscores the need for careful design of gene expression constructs. Moreover, in studies where cell injury or toxicity is being evaluated, their use should be carefully considered...
  33. ncbi request reprint Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity
    M W Halterman
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Gene Med 8:1320-8. 2006
    ..These findings offer a novel approach to improving the titer and toxicity profiles of HSV-based viral vectors...
  34. ncbi request reprint Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    Eric K Richfield
    Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Exp Neurol 175:35-48. 2002
    ..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers...
  35. pmc Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses
    Peter K Hocknell
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Virol 76:5565-80. 2002
    ..Taken together, these data strongly support the use of helper-free HSV-1 amplicon particles as vaccine delivery vectors...
  36. doi request reprint CNS delivery of vectored prion-specific single-chain antibodies delays disease onset
    Charles A Wuertzer
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mol Ther 16:481-6. 2008
    ....
  37. ncbi request reprint CNS gene therapy and a nexus of complexity: systems and biology at a crossroads
    Carolyn M Tyler
    Center for Aging and Developmental Biology, Aab Institute of Biomedical Sciences, Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester NY 14642, USA
    Cell Transplant 15:267-73. 2006
    ..Systematic efforts to acquire this new knowledge should compel clinically and biologically sophisticated efforts to advance gene therapy for neurodegenerative diseases...
  38. pmc HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime
    Cindy M P Duke
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Vaccine 25:7410-21. 2007
    ..This suggests that initial priming can shape immune response quality after a boost. Overall, these findings provide insight into effective vector combinations for HIV-1 vaccine development...
  39. pmc An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies
    Deborah A Ryan
    Interdepartmental Graduate Program in Neuroscience, Rochester, NY 14642, USA
    J Neurosci Methods 190:171-9. 2010
    ..These synthetic preparations should prove valuable to many studying Abeta-mediated mechanisms underlying AD...
  40. pmc Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag
    Kathlyn Santos
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States
    Vaccine 25:1634-46. 2007
    ..These findings may have implications for the generation of improved HSV-1 amplicon vectors for HIV-1 vaccine delivery...
  41. pmc Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition
    Elise B Peterson
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 15:1848-55. 2007
    ....
  42. pmc Effects of herpes simplex virus amplicon transduction on murine dendritic cells
    Yahui Grace Chiu
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Gene Ther 20:442-52. 2009
    ....
  43. ncbi request reprint Safety of viral vectors for neurological gene therapies
    Kathleen A Maguire-Zeiss
    University of Rochester School of Medicine and Dentistry, Department of Neurology and Center for Aging and Developmental Biology, 601 Elmwood Avenue, Rochester, New York, NY 14642, USA
    Curr Opin Mol Ther 6:473-81. 2004
    ..Different vector platforms manifest characteristic properties that affect their suitability for human gene therapy and among these are their propensity to integrate, elicit immune responses and enable regulated gene expression...
  44. ncbi request reprint Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy
    W J Bowers
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA Rochester, NY 14642, USA
    Gene Ther 10:941-5. 2003
    ....
  45. pmc Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging
    Kathlyn Santos
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    J Virol Methods 145:37-46. 2007
    ....
  46. ncbi request reprint VIP is a transcriptional target of Nurr1 in dopaminergic cells
    Yu Luo
    Dept of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14624, USA
    Exp Neurol 203:221-32. 2007
    ..Nurr1 regulation of VIP is also demonstrated in vivo as loss of Nurr1 function results in diminished VIP mRNA levels within the developing midbrain...
  47. pmc Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0
    Clark A Burris
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Gene Med 10:152-64. 2008
    ....
  48. pmc Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice
    Deborah A Ryan
    Interdepartmental Graduate Program in Neuroscience, University of Rochester Medical Center, Rochester, NY, USA
    Mol Ther 18:1471-81. 2010
    ..These results underscore the potential of gene-based passive vaccination for AD, and provide further rationale for the development of Abeta-targeting strategies for this debilitating disease...
  49. doi request reprint Identification of a novel nurr1-interacting protein
    Yu Luo
    Department of Environmental Medicine, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14624, USA
    J Neurosci 28:9277-86. 2008
    ..These results suggest NuIP interacts with and positively regulates the activity of Nurr1 protein and modulates the phenotype of dopaminergic cells...
  50. ncbi request reprint Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease
    Renee M Miller
    Center for Aging and Developmental Biology, Aab Institute of Biomedical Sciences, University of Rochester, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurobiol Dis 21:305-13. 2006
    ..Further, we identify several interesting patterns of gene expression that illuminate pathogenic cascades in Parkinson's disease. In particular is the robust loss of synaptic gene expression in diseased substantia nigra and striatum...
  51. ncbi request reprint Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea
    William J Bowers
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8629, USA
    Mol Ther 6:12-8. 2002
    ..The potency of NT-3 in SGN neuroprotection suggests that in vivo neurotrophin-based gene therapy is a promising preventative treatment for chemical-induced hearing disorders, and potentially for hearing degeneration due to normal aging...
  52. ncbi request reprint Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle
    Issam A Halaby
    Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 5:300-6. 2002
    ..This new iteration of VEGF gene delivery provides for fine-tuned angiogenic factor-based therapy for tissues requiring neovascularization...
  53. ncbi request reprint HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia
    Khaled A Tolba
    James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 6:455-63. 2002
    ..In aggregate, these data suggest that hf-HSV-LIGHT transduction may be useful for induction of immune responses to CLL and other B-cell lymphoid malignancies...
  54. ncbi request reprint HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury
    B K Harvey
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Exp Neurol 183:47-55. 2003
    ..Taken together, our data indicate that HSVgdnf pretreatment provides protection against cerebral ischemia and supports the utilization of the HSV amplicon for therapeutic delivery of trophic factors to the CNS...
  55. ncbi request reprint Temporal evolution of mouse striatal gene expression following MPTP injury
    R M Miller
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurobiol Aging 26:765-75. 2005
    ..Our findings reveal a time-dependent dysregulation in the striatum of a set of genes whose products may impact both the viability and ability to communicate of dopamine neurons in the SN...
  56. ncbi request reprint Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons
    H H DeCory
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Drug Metab Dispos 29:1256-62. 2001
    ....
  57. ncbi request reprint Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity
    Khaled A Tolba
    James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Cancer Res 62:6545-51. 2002
    ....
  58. ncbi request reprint Amyloid immunotherapy-engendered CNS inflammation
    William J Bowers
    Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurobiol Aging 23:675-6; discussion 683-4. 2002
  59. ncbi request reprint p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity
    Yan Zhang
    Department of Neurology and Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 23:7385-94. 2003
    ..Neuroprotection against Abeta is phosphatidylinositide 3-kinase dependent but Akt independent. These results are consistent with a neuroprotective role for p75NTR against extracellular Abeta toxicity in human neurons...
  60. pmc Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
    Byoung Dae Lee
    Neuroregeneration Program, Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:998-1000. 2010
    ..These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease...
  61. ncbi request reprint Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons
    Kuei Cheng Lim
    Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Biochem Biophys Res Commun 361:599-604. 2007
    ..These experiments demonstrate that hippocampal neurons harbor multiple pathways to process proNGF of which the furin consensus sequence is the preferred processing site...
  62. doi request reprint Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons
    Seung T Lim
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Comp Neurol 507:1228-44. 2008
    ..These data indicate that the synaptic localization of nectin-1 and l-afadin are F-actin-dependent and that the shedding of nectin-1 is a mechanism contributing to synaptic plasticity...
  63. pmc Synuclein activates microglia in a model of Parkinson's disease
    Xiaomin Su
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurobiol Aging 29:1690-701. 2008
    ..Furthermore, we provide evidence that the CD36 scavenger receptor and downstream kinases are involved in SYN-mediated microglial activation. Together, our data suggest an early role for SYN and inflammation in PD pathogenesis...
  64. pmc Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons
    Jill M Weimer
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurobiol Dis 22:284-93. 2006
    ..This study defines a novel path of degeneration within the LGNd, providing a mechanism for causation of JNCL visual deficits...
  65. ncbi request reprint Translational considerations for CNS gene therapy
    Deborah A Ryan
    University of Rochester School of Medicine and Dentistry, Interdepartmental Graduate Program in Neuroscience, Rochester, New York, USA
    Expert Opin Biol Ther 7:305-18. 2007
    ..Alzheimer's and Parkinson's disease are employed as models, in which much research has already been performed, to address disease-specific questions about gene therapy approaches...
  66. ncbi request reprint Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems
    Renee M Miller
    Center for Aging and Developmental Biology, Aab Institute of Biomedical Sciences, Department of Neurology and University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Neuroscientist 11:539-49. 2005
    ..The time course of the authors' experiments indicates that if the synaptic changes could be prevented, this may alleviate some cell death, in that these changes precede neuronal loss...
  67. ncbi request reprint Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming
    Xiuqing Wang
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Vaccine 21:2288-97. 2003
    ..Collectively, these results demonstrate the utility of HSV amplicon vectors in prime-boost regimens for HIV vaccine development...
  68. ncbi request reprint Somatic mosaic approaches and the aging brain
    Kathleen A Maguire-Zeiss
    Department of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Neurobiol Aging 23:977-84. 2002
    ..We will also highlight potential uses for this approach in Alzheimer's disease, a complex pathophysiological state involving changes in many cellular pathways...
  69. doi request reprint Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease
    Howard J Federoff
    Department of Neurology, Georgetown University Medical Center, 4000 Reservoir Road NW, 120 Building D, Washington, DC 20057, USA
    Neurotox Res 16:261-70. 2009
    ....
  70. pmc Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium
    Timothy R Mhyre
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurobiol Aging 29:1631-43. 2008
    ..These data also suggest the potential of using peripheral leukocytes to monitor pharmaceutical action for neurodegenerative diseases...
  71. pmc Microarrays in Parkinson's disease: a systematic approach
    Renee M Miller
    Center for Aging and Developmental Biology, University of Rochester, New York 14642, USA
    NeuroRx 3:319-26. 2006
    ..The elucidation of important gene expression patterns during disease will make possible identification of genetic susceptibility markers, biomarkers of disease progression, and new therapeutic targets...
  72. ncbi request reprint HSV amplicons: neuro applications
    Carolyn M Tyler
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Gene Ther 6:337-50. 2006
    ..This discourse highlights the successes and challenges encountered using HSV amplicon vectors as tools for the dissection of neural network function and as therapeutics directed against a variety of neurologic disorders...
  73. ncbi request reprint Convergent pathobiologic model of Parkinson's disease
    Kathleen A Maguire-Zeiss
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann N Y Acad Sci 991:152-66. 2003
    ..We end with a discussion of a potential alternative therapy for Parkinson's disease...
  74. ncbi request reprint The role of the THY1 gene in human ovarian cancer suppression based on transfection studies
    Harindra R Abeysinghe
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 608 Rochester, NY 14642, USA
    Cancer Genet Cytogenet 149:1-10. 2004
    ..Taken together, the data suggest that THY1 is necessary but not sufficient to suppress ovarian tumorigenicity. Therefore, THY1 can be designated as a putative tumor suppressor gene for human ovarian cancer...
  75. ncbi request reprint Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer
    Diana Casper
    Department of Neurological Surgery, Montefiore Medical Center, Bronx, NY 10467, USA
    Cell Transplant 11:331-49. 2002
    ..9-fold. Taken together these experiments provide convincing evidence that the rate of vascularization may be a major determinant of neuronal survival that can be manipulated by VEGF gene transduction...
  76. pmc Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 chal
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Virol 79:2124-32. 2005
    ..This mouse model may be a useful tool to evaluate human immune responses and protection against viral infection following vaccination...
  77. ncbi request reprint Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo
    Kyung H Yi
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, and University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    Cancer Res 67:10027-37. 2007
    ..Tumor-specific T cells stimulated ex vivo using tumor transduced with HSV.4-1BBL expand in vivo following adoptive transfer, resulting in tumor eradication and the generation of tumor-specific CD44+Ly-6C+CD62L- effector memory T cells...
  78. ncbi request reprint Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
    Seong Woon Yu
    Department of Neurology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Science 297:259-63. 2002
    ..These data support a model in which PARP-1 activation signals AIF release from mitochondria, resulting in a caspase-independent pathway of programmed cell death...
  79. ncbi request reprint Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat
    Victor L Arvanian
    Department of Neurobiology and Behavior, SUNY at Stony Brook, Life Sciences Building, Stony Brook, NY 11794 5230, USA
    Exp Neurol 197:347-52. 2006
    ....
  80. ncbi request reprint Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing
    Jennifer E Snyder
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, New York, USA
    Nat Med 9:231-5. 2003
    ..The simultaneous enumeration of cytokine-secreting and cytotoxic cells should be invaluable for ex vivo analysis of immune responses during infection and autoimmunity...
  81. ncbi request reprint Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction
    Hovav Nechushtan
    Department of Medicine, Miller School of Medicine at the University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Cancer Immunol Immunother 57:663-75. 2008
    ....
  82. pmc Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors
    Andrew I Brooks
    Department of Internal Medicine, University of Iowa Program in Gene Therapy, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 99:6216-21. 2002
    ..These data suggest that enzyme replacement to the MPS VII central nervous system goes beyond restoration of beta-glucuronidase activity in the lysosome, and imparts improvements in plasticity and spatial learning...
  83. pmc Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival
    Caryl E Sortwell
    Department of Neurology University of Cincinnati, PO Box 670537, ML0537, Cincinnati, OH 45267 0537, USA
    Brain Res 1134:33-44. 2007
    ..Even with highly efficient viral vector-mediated transduction, our results demonstrate that ex vivo gene transfer of bcl-2 to mesencephalic reaggregates is ineffective in increasing grafted DA neuron survival...
  84. pmc Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases
    Maura Reinblatt
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg 239:892-9; discussion 899-902. 2004
    ..To determine the effects of hypoxia-induced ribonucleotide reductase (RR) production on herpes oncolytic viral therapy...
  85. ncbi request reprint Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death
    Hongmin Wang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:10963-73. 2004
    ..These results link PARP-1 activation with AIF translocation in NMDA-triggered excitotoxic neuronal death and provide a paradigm in which AIF can substitute for caspase executioners...
  86. ncbi request reprint Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons
    Victor L Arvanian
    Dept of Neurobiology and Behavior, SUNY at Stony Brook, Life Sciences Bldg Rm 550, Stony Brook, NY 11794 5230, USA
    J Neurophysiol 92:2394-404. 2004
    ..This approach might be useful for enhancing the function of fibers surviving in the damaged spinal cord...
  87. ncbi request reprint Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma
    Maura Reinblatt
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 12:1025-36. 2005
    ..We attempted to attenuate angiogenesis and inhibit pancreatic tumor growth through HSV amplicon-mediated expression of sFlk-1 under hypoxic control...
  88. ncbi request reprint Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia
    Mara H de Pina-Benabou
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Stroke 36:2232-7. 2005
    ..We investigated the contribution of gap junctions to brain damage and delayed neuronal death produced by oxygen-glucose deprivation (OGD)...
  89. ncbi request reprint Gazing into the future: Parkinson's disease gene therapeutics to modify natural history
    Kathleen A Maguire-Zeiss
    Department of Neuroscience, Georgetown University, Washington, DC 20007, USA
    Exp Neurol 209:101-13. 2008
    ..However, for the most part the etiopathogenesis of PD is unknown making early intervention a challenge and the development of early biomarker diagnostics imperative...
  90. ncbi request reprint Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma
    Richard H Pin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Gastrointest Surg 8:812-22; discussion 822-3. 2004
    ..the control group (P < 0.000001). HSV amplicon-mediated delivery of a hypoxia-inducible soluble VEGF receptor substantially reduces new vessel formation and tumor growth in hepatoma...
  91. ncbi request reprint Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?
    Kathleen A Maguire-Zeiss
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Res Mol Brain Res 134:18-23. 2005
    ..Likely players have emerged that may form the basis for this common pathway model of disease. In this review, we examine the role of three most implicated PD pathogenic conspirators: synuclein, dopamine and oxidative stress...
  92. pmc Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84. 2004
    ..These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart...