M E Feder

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression
    O G Zatsepina
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, 117984 Moscow, Russia
    J Exp Biol 204:1869-81. 2001
  2. pmc Reverse transcriptional profiling: non-correspondence of transcript level variation and proximal promoter polymorphism
    Rebecca Petersen Brown
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    BMC Genomics 6:110. 2005
  3. ncbi request reprint The biological limitations of transcriptomics in elucidating stress and stress responses
    M E Feder
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    J Evol Biol 18:901-10. 2005
  4. ncbi request reprint Key issues in achieving an integrative perspective on stress
    Martin E Feder
    Department of Organismal Biology and Anatomy, The Committees on Evolutionary Biology, Genetics and Molecular Medicine, The College, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, USA
    J Biosci 32:433-40. 2007
  5. ncbi request reprint Evolvability of physiological and biochemical traits: evolutionary mechanisms including and beyond single-nucleotide mutation
    Martin E Feder
    Department of Organismal Biology and Anatomy and The Committees on Evolutionary Biology, Genetics, and Molecular Medicine, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, USA
    J Exp Biol 210:1653-60. 2007
  6. ncbi request reprint Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology
    M E Feder
    Department of Organismal Biology and Anatomy and Committee on Evolutionary Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Physiol 61:243-82. 1999
  7. doi request reprint Locomotion in response to shifting climate zones: not so fast
    Martin E Feder
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    Annu Rev Physiol 72:167-90. 2010
  8. ncbi request reprint Aims of undergraduate physiology education: a view from the University of Chicago
    Martin E Feder
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois, USA
    Adv Physiol Educ 29:3-10. 2005
  9. ncbi request reprint Evolvability of Hsp70 expression under artificial election for inducible thermotolerance in independent populations of Drosophila melanogaster
    Martin E Feder
    Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, IL 60637, USA
    Physiol Biochem Zool 75:325-34. 2002
  10. pmc Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel
    P Michalak
    Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, Chicago, IL 60637 1508, USA
    Proc Natl Acad Sci U S A 98:13195-200. 2001

Collaborators

Detail Information

Publications34

  1. ncbi request reprint A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression
    O G Zatsepina
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, 117984 Moscow, Russia
    J Exp Biol 204:1869-81. 2001
    ..We hypothesize that the reduced Hsp70 expression in a Drosophila melanogaster strain living chronically at intermediate temperatures may represent an evolved suppression of the deleterious phenotypes of Hsp70...
  2. pmc Reverse transcriptional profiling: non-correspondence of transcript level variation and proximal promoter polymorphism
    Rebecca Petersen Brown
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    BMC Genomics 6:110. 2005
    ..Only genes whose regulation of expression was uncharacterized were chosen. At least one kB of the proximal promoters of 15-19 genes in each set was sequenced and compared between strains (Oregon R and Russian 2b)...
  3. ncbi request reprint The biological limitations of transcriptomics in elucidating stress and stress responses
    M E Feder
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    J Evol Biol 18:901-10. 2005
    ..In view of this outcome, transcriptomics should undergo careful cost-benefit analysis before investigators deploy it in studies of stress responses and their evolution...
  4. ncbi request reprint Key issues in achieving an integrative perspective on stress
    Martin E Feder
    Department of Organismal Biology and Anatomy, The Committees on Evolutionary Biology, Genetics and Molecular Medicine, The College, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, USA
    J Biosci 32:433-40. 2007
    ....
  5. ncbi request reprint Evolvability of physiological and biochemical traits: evolutionary mechanisms including and beyond single-nucleotide mutation
    Martin E Feder
    Department of Organismal Biology and Anatomy and The Committees on Evolutionary Biology, Genetics, and Molecular Medicine, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, USA
    J Exp Biol 210:1653-60. 2007
    ..The mechanisms beyond single-gene mutation offer considerable promise in detailing the evolution of complex physiological and biochemical traits, and have already done so for several morphological traits...
  6. ncbi request reprint Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology
    M E Feder
    Department of Organismal Biology and Anatomy and Committee on Evolutionary Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Physiol 61:243-82. 1999
    ....
  7. doi request reprint Locomotion in response to shifting climate zones: not so fast
    Martin E Feder
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    Annu Rev Physiol 72:167-90. 2010
    ..This work reveals how integration of physiology with population biology and functional genomics can be especially informative...
  8. ncbi request reprint Aims of undergraduate physiology education: a view from the University of Chicago
    Martin E Feder
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois, USA
    Adv Physiol Educ 29:3-10. 2005
    ..Such principles necessitate a coupling of physiology to diverse disciplines (i.e., "sciomics") and provide a basis for integrating discoveries in other disciplines...
  9. ncbi request reprint Evolvability of Hsp70 expression under artificial election for inducible thermotolerance in independent populations of Drosophila melanogaster
    Martin E Feder
    Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, IL 60637, USA
    Physiol Biochem Zool 75:325-34. 2002
    ..In both cases, however, the increase in Hsp70 level averaged only 15%, suggesting that pleiotropy in Hsp70 function constrains evolutionary increase in its expression...
  10. pmc Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel
    P Michalak
    Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, Chicago, IL 60637 1508, USA
    Proc Natl Acad Sci U S A 98:13195-200. 2001
    ..We hypothesize that adaptation to the contrasting microclimates overwhelms gene flow and is responsible for the genetic and phenotypic divergence between the populations...
  11. ncbi request reprint Hsp70 duplication in the Drosophila melanogaster species group: how and when did two become five?
    B R Bettencourt
    Department of Organismal Biology and Anatomy, University of Chicago, Illinois 60637, USA
    Mol Biol Evol 18:1272-82. 2001
    ..The proliferation, concerted evolution, and maintenance of functionality in the D. melanogaster hsp70 genes is consistent with the action of natural selection in this species...
  12. ncbi request reprint Response to natural and laboratory selection at the Drosophila hsp70 genes
    Brian R Bettencourt
    Department of Organismal Biology, University of Chicago, Illinois 60637, USA
    Evolution 56:1796-801. 2002
    ..Thermal extremes and average values are negatively correlated with latitude. These results suggest that natural selection imposed by temperature and thermal variability may affect hsp70 allele frequencies...
  13. ncbi request reprint Abundant, diverse, and consequential P elements segregate in promoters of small heat-shock genes in Drosophila populations
    B Chen
    Department of Organismal Biology and Anatomy, The Committees on Evolutionary Biology, Genetics, and Molecular Medicine, The University of Chicago, Chicago, IL, USA
    J Evol Biol 20:2056-66. 2007
    ..Transposable element insertions into small Hsp genes in Drosophila populations can have dramatic fitness consequences, and therefore create variation on which selection can act...
  14. ncbi request reprint Laboratory selection at different temperatures modifies heat-shock transcription factor (HSF) activation in Drosophila melanogaster
    D N Lerman
    The Committee on Evolutionary Biology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Biol 204:315-23. 2001
    ..We conclude that HSF activation evolves rapidly during laboratory culture at diverse temperatures and could play an important role in the evolution of the heat-shock response...
  15. ncbi request reprint Tissue-specific variation in Hsp70 expression and thermal damage in Drosophila melanogaster larvae
    R A Krebs
    Department of Organismal Biology and Anatomy, University of Chicago, IL 60637, USA
    J Exp Biol 200:2007-15. 1997
    ....
  16. pmc Heat-shock promoters: targets for evolution by P transposable elements in Drosophila
    Jean Claude Walser
    Department of Organismal Biology and Anatomy, The College, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 2:e165. 2006
    ..Thus in nature, P elements create significant and distinctive variation in heat-shock genes, upon which evolutionary processes may act...
  17. ncbi request reprint Naturally occurring transposable elements disrupt hsp70 promoter function in Drosophila melanogaster
    Daniel N Lerman
    Committee on Evolutionary Biology and Department of Organismal Biology and Anatomy, The University of Chicago, USA
    Mol Biol Evol 22:776-83. 2005
    ..That two different varieties of TEs in two different hsp70 genes have common effects suggests that TE insertion represents a general mechanism through which selection manipulates hsp70 gene expression...
  18. ncbi request reprint Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements
    Daniel N Lerman
    Committee on Evolutionary Biology, The University of Chicago, Chicago, Illinois, USA
    Mol Biol Evol 20:135-44. 2003
    ..Thus, transposition can create quantitative genetic variation in gene expression within populations, on which natural selection can act...
  19. ncbi request reprint Thermal preconditioning and heat-shock protein 72 preserve synaptic transmission during thermal stress
    Jonathan D Kelty
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 22:RC193. 2002
    ..That preconditioning and exogenous Hsp72 can affect and preserve normal physiological function has important therapeutic implications...
  20. pmc Location of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster
    Bing Chen
    Department of Organismal Biology and Anatomy, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, USA
    Cell Stress Chaperones 13:11-7. 2008
    ....
  21. pmc Contrasting patterns of transposable element insertions in Drosophila heat-shock promoters
    Robert A Haney
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e8486. 2009
    ..melanogaster. These results suggest that D. melanogaster heat-shock promoters are unique in terms of their interaction with transposable elements, and confirm that Hsp70 promoters are distinctive in TE insertions across Drosophila...
  22. ncbi request reprint Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster
    M E Feder
    Department of Organismal Biology and Anatomy, University of Chicago, IL 60637, USA
    J Exp Biol 199:1837-44. 1996
    ..Thus, these findings represent the best evidence to date that the amount of a heat-shock protein affects the fitness of a complex animal in the wild...
  23. pmc Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae
    R A Krebs
    Department of Organismal Biology and Anatomy, University of Chicago, IL 60637, USA
    Cell Stress Chaperones 2:60-71. 1997
    ..While extra Hsp70 provides additional protection against the immediate damage from heat stress, abnormally high concentrations can decrease growth, development and survival to adulthood...
  24. pmc Phylogeny disambiguates the evolution of heat-shock cis-regulatory elements in Drosophila
    Sibo Tian
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e10669. 2010
    ..The broad dimensions of variation uncovered are particularly important as they suggest a substantial challenge for functional studies...
  25. ncbi request reprint Effect of heat shock, pretreatment and hsp70 copy number on wing development in Drosophila melanogaster
    Karen D Williams
    Department of Organismal Biology and Anatomy, Committee on Evolutionary Biology, and The College, University of Chicago, 1027 East 57th Street, Chicago IL 60637, USA
    Mol Ecol 12:1165-77. 2003
    ....
  26. pmc Overcoming cytoplasmic incompatibility in Drosophila
    T L Karr
    University of Chicago, Department of Organismal Biology and Anatomy, IL 60637, USA
    Proc Biol Sci 265:391-5. 1998
    ..This restoration of fertility in premated infected males could have important implications for Wolbachia transmission and persistence in nature and for its exploitation as an agent of biological pest control...
  27. ncbi request reprint Evolutionary and ecological functional genomics
    Martin E Feder
    Committee on Evolutionary Biology, and Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, Chicago, Illinois 60637, USA
    Nat Rev Genet 4:651-7. 2003
    ..However, future advances will necessitate the re-engineering of scientific attitudes, training and institutions, to achieve extensive multidisciplinarity...
  28. ncbi request reprint Evidence-based appointment and promotion of academic faculty at the University of Chicago
    Martin E Feder
    University of Chicago, Division of the Biological Sciences, Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Acad Med 83:85-95. 2008
    ..This change interposed a "firewall" between academic and institutional review. These changes have attenuated dissatisfaction with the appointments and promotions process both within and outside the AMC...
  29. pmc Remarkable site specificity of local transposition into the Hsp70 promoter of Drosophila melanogaster
    Victoria Y Shilova
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    Genetics 173:809-20. 2006
    ....
  30. ncbi request reprint Evolution of thermotolerance and the heat-shock response: evidence from inter/intraspecific comparison and interspecific hybridization in the virilis species group of Drosophila. I. Thermal phenotype
    David Garbuz
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str 32, 117984 Moscow, Russia
    J Exp Biol 206:2399-408. 2003
    ..Interspecific hybrids are intermediate to the parental species in basal thermotolerance and inducible thermotolerance and resemble D. virilis in Hsp concentrations after intense heat shock and Hsp70 protein electromorphs...
  31. ncbi request reprint Unusual arrangement of the hsp68 locus in the virilis species group of Drosophila implicates evolutionary loss of an hsp68 gene
    Vera V Velikodvorskaia
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    Genome 48:234-40. 2005
    ..Therefore, we suggest that the hsp68 locus may have arisen via duplication of the hsp70 locus (or vice versa) early in the history of the genus Drosophila, with 1 hsp68 copy subsequently lost in most other Drosophila species groups...
  32. ncbi request reprint Dropping like flies: environmentally induced impairment and protection of locomotor performance in adult Drosophila melanogaster
    Stephen P Roberts
    Department of Biological Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154 4004, USA
    Physiol Biochem Zool 76:615-21. 2003
    ..HS dramatically reduced walking velocity, however, but this effect occurred primarily in the excision flies. These results suggest that Hsp70 and other mechanisms protect against heat-induced locomotor impairment...
  33. ncbi request reprint What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?
    Armand M Leroi
    Department of Biological Sciences, Imperial College London, Silwood Park Campus, Ascot, Berks, SL5 7PY, UK
    Mech Ageing Dev 126:421-9. 2005
    ..This is particularly true of human studies. Very little is known about the early-life fitness effects of longevity loci. Given the possible medical importance of such effects we urge their future study...
  34. ncbi request reprint Evolution and arrangement of the hsp70 gene cluster in two closely related species of the virilis group of Drosophila
    Michael B Evgen'ev
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str 32, 117984 Moscow, Russia
    Chromosoma 113:223-32. 2004
    ..virilis and D. lummei followed by loss of hsp70 genes in D. lummei. These and other data for hsp70 in Drosophila suggest that evolutionary adaptation has repeatedly modified hsp70 copy number by several different genetic mechanisms...