Eric Fearon

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data
    Kerby Shedden
    Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA
    BMC Bioinformatics 6:26. 2005
  2. ncbi request reprint Cancer genetics: tumor suppressor meets oncogene
    E R Fearon
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, Human Genetics, University of Michigan Cancer Center, Ann Arbor, 48109 0638 USA
    Curr Biol 9:R62-5. 1999
  3. doi request reprint PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer
    Eric R Fearon
    Division of Molecular Medicine and Genetics, Departments of Internal Medicine, Human Genetics and Pathology, and the Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 22200, USA
    Cancer Cell 16:366-8. 2009
  4. ncbi request reprint Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer
    Eric R Fearon
    Division of Molecular Medicine and Genetics and the Cancer Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 3:307-10. 2003
  5. ncbi request reprint Defining the microsatellite instability phenotype in colorectal cancer through analysis of surrogate markers
    Eric R Fearon
    Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor 48109 2216, USA
    Cancer Biol Ther 3:79-81. 2004
  6. ncbi request reprint Cell biology. Wnt signaling glows with RNAi
    Eric R Fearon
    Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Science 308:801-3. 2005
  7. doi request reprint Molecular genetics of colorectal cancer
    Eric R Fearon
    The Cancer Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, 48109 2200, USA
    Annu Rev Pathol 6:479-507. 2011
  8. ncbi request reprint Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling
    Janet Y Leung
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    J Biol Chem 277:21657-65. 2002
  9. ncbi request reprint ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation
    Frank T Kolligs
    Department of Internal Medicine, Division of Medical Genetics and the Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 1:145-55. 2002
  10. ncbi request reprint TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling
    Ying Feng
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:8726-34. 2003

Collaborators

Detail Information

Publications49

  1. pmc Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data
    Kerby Shedden
    Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA
    BMC Bioinformatics 6:26. 2005
    ....
  2. ncbi request reprint Cancer genetics: tumor suppressor meets oncogene
    E R Fearon
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, Human Genetics, University of Michigan Cancer Center, Ann Arbor, 48109 0638 USA
    Curr Biol 9:R62-5. 1999
    ..A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene...
  3. doi request reprint PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer
    Eric R Fearon
    Division of Molecular Medicine and Genetics, Departments of Internal Medicine, Human Genetics and Pathology, and the Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 22200, USA
    Cancer Cell 16:366-8. 2009
    ....
  4. ncbi request reprint Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer
    Eric R Fearon
    Division of Molecular Medicine and Genetics and the Cancer Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 3:307-10. 2003
    ....
  5. ncbi request reprint Defining the microsatellite instability phenotype in colorectal cancer through analysis of surrogate markers
    Eric R Fearon
    Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor 48109 2216, USA
    Cancer Biol Ther 3:79-81. 2004
  6. ncbi request reprint Cell biology. Wnt signaling glows with RNAi
    Eric R Fearon
    Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Science 308:801-3. 2005
  7. doi request reprint Molecular genetics of colorectal cancer
    Eric R Fearon
    The Cancer Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, 48109 2200, USA
    Annu Rev Pathol 6:479-507. 2011
    ....
  8. ncbi request reprint Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling
    Janet Y Leung
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    J Biol Chem 277:21657-65. 2002
    ....
  9. ncbi request reprint ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation
    Frank T Kolligs
    Department of Internal Medicine, Division of Medical Genetics and the Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 1:145-55. 2002
    ..We propose that ITF-2 is a TCF-regulated gene, which functions in concert with other TCF target genes to promote growth and/or survival of cancer cells with defects in beta-catenin regulation...
  10. ncbi request reprint TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling
    Ying Feng
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:8726-34. 2003
    ..We suggest that TIP49 is an important cofactor in beta-catenin/TCF gene regulation in normal and neoplastic cells, likely functioning in chromatin remodeling...
  11. ncbi request reprint Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas
    Donald R Schwartz
    Department of Pathology, College of Literature Science and the Arts, University of Michigan, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 63:2913-22. 2003
    ....
  12. ncbi request reprint The SLUG zinc-finger protein represses E-cadherin in breast cancer
    Karen M Hajra
    Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:1613-8. 2002
    ..Taken together, the data indicate the E-box elements in the proximal E-cadherin promoter are critical in transcriptional repression of the E-cadherin gene, and SLUG is a likely in vivo repressor of E-cadherin in breast cancer...
  13. ncbi request reprint Histologic type, organ of origin, and Wnt pathway status: effect on gene expression in ovarian and uterine carcinomas
    Kerby A Shedden
    Department of Statistics, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 11:2123-31. 2005
    ..A widely accepted view is that the accumulation of specific gene defects and gene expression changes underlies phenotypic traits of cancers, including their response to treatment...
  14. pmc Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas
    Yali Zhai
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Am J Pathol 160:1229-38. 2002
    ..Our findings indicate cyclin D1, MMP-7, connexin 43, PPAR-delta, and ITF-2, likely play important roles in the pathogenesis of those OEAs that manifest defects in beta-catenin regulation...
  15. pmc Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs
    R Grant Rowe
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 184:399-408. 2009
    ..These findings establish key functions for the EMT regulator Snail1 after terminal differentiation of mesenchymal cells...
  16. pmc Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization
    Lidong Wang
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Cancer Cell 15:207-19. 2009
    ..ATDC was found to stabilize beta-catenin via ATDC-induced effects on the Disheveled-2 protein, a negative regulator of glycogen synthase kinase 3beta in the Wnt/beta-catenin signaling pathway...
  17. pmc Colitis and cancer: a tale of inflammatory cells and their cytokines
    Ezra Burstein
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Clin Invest 118:464-7. 2008
    ..Importantly, the study also provides evidence that anti-TNF-alpha therapies, which are currently in clinical use, may interrupt the process...
  18. pmc Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework
    Kerby A Shedden
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1027, USA
    Am J Pathol 163:1985-95. 2003
    ..Our findings suggest that accurate and robust cancer diagnosis from gene expression profiles can be achieved by mimicking the classification strategies routinely used by surgical pathologists...
  19. ncbi request reprint Silencing of CDX2 expression in colon cancer via a dominant repression pathway
    Takao Hinoi
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    J Biol Chem 278:44608-16. 2003
    ..Our findings suggest CDX2 inactivation in colon cancer results from defects in trans-acting pathways regulating CDX2 transcription, and CDX2 silencing contributes to the altered phenotype of some colorectal cancers...
  20. pmc Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway
    Eduardo Vilar
    Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 15:2829-39. 2009
    ..Our objective was to identify low molecular weight compounds with preferential activity against MSI colorectal cancers using combined gene expression data sets...
  21. pmc Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas
    Rong Wu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Pathol 162:1603-10. 2003
    ..The data implicate L-MYC gene amplification and/or overexpression in human OvCa pathogenesis...
  22. pmc Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity
    Zhao Qiu Wu
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, and the Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 109:11312-7. 2012
    ..The further identification of Axin2 and nuclear Snail1 proteins at the invasive front of human CRCs supports a revised model wherein Axin2 acts as a potent tumor promoter in vivo...
  23. ncbi request reprint Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways
    Rong Wu
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 11:321-33. 2007
    ..The biological behavior and gene expression patterns of the murine cancers resemble those of human OEAs with defects in the Wnt/beta-catenin and PI3K/Pten pathways...
  24. pmc GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer
    Richard L Watson
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA
    Neoplasia 12:357-65. 2010
    ..In turn, release of cytosolic membrane beta-catenin with subsequent nuclear translocation promotes survival. Both GSK3beta and beta-catenin have been implicated in cancer cell proliferation and resistance to death...
  25. ncbi request reprint CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium
    Takao Hinoi
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Gastroenterology 128:946-61. 2005
    ..To enhance knowledge of CDX2 function, we sought to define CDX2-regulated genes...
  26. ncbi request reprint Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas
    Donald R Schwartz
    Departments of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4722-9. 2002
    ..Moreover, these studies provide a foundation for the development of new type-specific diagnostic strategies and treatments for ovarian cancer...
  27. ncbi request reprint Cadherin and catenin alterations in human cancer
    Karen M Hajra
    Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Genes Chromosomes Cancer 34:255-68. 2002
    ..In this review, we highlight some of the specific genetic and epigenetic defects responsible for altered cadherin and catenin function in cancer, as well as potential contributions of cadherin-catenin alterations to the cancer process...
  28. pmc IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype
    Guido T Bommer
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:1928-38. 2010
    ..Our findings add to the growing body of data implicating IRS1 as a critical signaling component in cancer development and progression...
  29. ncbi request reprint Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas
    Neali D Hendrix
    Department of Pathology, University of Michigan Medical School, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA
    Cancer Res 66:1354-62. 2006
    ..Our findings support the notion that FGF9 is a key factor contributing to the cancer phenotype of OEAs carrying Wnt/beta-catenin pathway defects...
  30. ncbi request reprint Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation
    Takao Hinoi
    Department of Internal Medicine, The Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 2200, USA
    Cancer Res 67:9721-30. 2007
    ....
  31. pmc Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
    David Van Mater
    Departments of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1219-24. 2003
    ..Our data lend strong support to the notion that a Wnt/beta-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen-anagen transition...
  32. ncbi request reprint CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia
    Takao Hinoi
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Gastroenterology 123:1565-77. 2002
    ..Conversely, aberrant CDX2 expression is often seen in intestinal metaplasias in the stomach and esophagus and in some gastric carcinomas. To better understand CDX2 function, we sought to define CDX2-regulated genes...
  33. pmc Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations
    Navneet Sangha
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Neoplasia 10:1362-72, following 1372. 2008
    ....
  34. pmc MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    Qing Ji
    Department of Radiation Oncolog, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 4:e6816. 2009
    ..Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2, suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells...
  35. ncbi request reprint Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion
    Yali Zhai
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Cancer Res 67:10163-72. 2007
    ..Other genes with differential expression in invasive SCC versus HSIL may contribute to tumor progression or may be useful as markers for cancer diagnosis or progression risk...
  36. ncbi request reprint Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning?
    Guido T Bommer
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Cancer Cell 11:391-4. 2007
    ..While these findings are very interesting, some questions remain about the assignment of c-Myc as the pre-eminent beta-catenin-regulated gene in intestinal epithelium...
  37. ncbi request reprint Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation
    Ying Feng
    Department of Internal Medicine, The Cancer Center, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Cancer Res 67:482-91. 2007
    ..In toto, our findings implicate SHARP as an important positive regulator of Wnt signaling in cancers with beta-catenin dysregulation...
  38. ncbi request reprint CDX2 polymorphisms, RNA expression, and risk of colorectal cancer
    Laura S Rozek
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 65:5488-92. 2005
    ....
  39. ncbi request reprint Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation
    Ira S Winer
    Cell and Molecular Biology Graduate Program, Division of Molecular Medicine and Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:26181-7. 2006
    ..Moreover, our results inform understanding of why single amino acid substitutions at lysine 19 or 49 have not been reported in human cancer...
  40. doi request reprint Heterogeneity in cancer: cancer stem cells versus clonal evolution
    Mark Shackleton
    Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 138:822-9. 2009
    ....
  41. pmc Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene
    Aytekin Akyol
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher, Ann Arbor, Michigan 48109, USA
    Nat Methods 5:231-3. 2008
    ..We demonstrated the utility of this approach by inducing colonic polyposis after Cre-mediated bi-allelic inactivation of the Apc gene...
  42. pmc Activation of FAK and Src are receptor-proximal events required for netrin signaling
    Weiquan Li
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Neurosci 7:1213-21. 2004
    ..On the basis of our observations, we suggest a model in which DCC functions as a kinase-coupled receptor, and FAK and Src act immediately downstream of DCC in netrin signaling...
  43. ncbi request reprint Survivin and molecular pathogenesis of colorectal cancer
    Paul J Kim
    Department of Cancer Biology and the Cancer Center, University of Massachusetts, Medical School, Worcester, MA, USA
    Lancet 362:205-9. 2003
    ..Survivin is a bifunctional regulator of cell death and cell proliferation expressed during embryonic development but undetectable in healthy adult tissues and re-expressed in many cancers, including colorectal cancer...
  44. pmc CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors
    Chi Ming Li
    Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 165:1943-53. 2004
    ..Beta-Catenin stabilization can initiate tumorigenesis in other systems, and this mechanism is likely critical in tumor formation after loss of WT1...
  45. ncbi request reprint DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells
    Guido T Bommer
    Department of Medicine II, University of Munich, 81377 Munich, Germany
    J Biol Chem 280:7962-75. 2005
    ..Our findings suggest that inhibition of DRO1 expression may be an important event in the development of colorectal and pancreatic cancers...
  46. ncbi request reprint Wnt-dependent regulation of the E-cadherin repressor snail
    Jong In Yook
    Department of Oral Pathology, BK21 Project for Medical Science, College of Dentistry, Yonsei University, Seoul 120 742, Korea
    J Biol Chem 280:11740-8. 2005
    ..These findings define a potential mechanism whereby Wnt signaling stabilizes Snail and beta-catenin proteins in tandem fashion so as to cooperatively engage transcriptional programs that control an epithelial-mesenchymal transition...
  47. ncbi request reprint A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
    Jong In Yook
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University, Seoul 120 752, Korea
    Nat Cell Biol 8:1398-406. 2006
    ..As dysregulated Wnt signalling marks a diverse array of cancerous tissue types, the identification of a beta-catenin-TCF-regulated Axin2-GSK3beta-Snail1 axis provides new mechanistic insights into cancer-associated EMT programmes...
  48. ncbi request reprint Role of the dependence receptor DCC in colorectal cancer pathogenesis
    Patrick Mehlen
    Apoptosis Differentiation Laboratory Equipe labelisée La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    J Clin Oncol 22:3420-8. 2004
    ..Here, we review DCC's candidacy as a tumor suppressor gene, with an emphasis on how recent molecular analyses of DCC have offered support for the notion that DCC may function as a tumor suppressor gene...
  49. ncbi request reprint Cancer: cell survival guide
    Eric R Fearon
    Nature 431:35-6. 2004

Research Grants19

  1. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2007
    ..Insights into new diagnostic markers and novel therapeutic targets and approaches for cancer are also expected. ..
  2. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric Fearon; Fiscal Year: 2007
    ..In addition to advancing knowledge of gastrointestinal cancer pathogenesis, the results may offer insights into novel strategies for improving the diagnosis and treatment of patients with colorectal and other cancers. ..
  3. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric Fearon; Fiscal Year: 2003
    ..In addition to furthering our understanding of colorectal cancer pathogenesis, the studies in our application may offer novel insights for improving the diagnosis and treatment of patients with colorectal cancer. ..
  4. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..Insights into new diagnostic markers and novel therapeutic targets and approaches for cancer are also expected. ..